141. SGTC :: Plasmodium Falciparum Chromosome 12 :: This work was done as part of the malaria Genome Sequencing Consortium. Genome sequence of the human malaria parasite Plasmodium falciparum. http://sequence-www.stanford.edu/group/malaria/

STANFORD UNIVERSITY STANFORD UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF BIOCHEMISTRY lab :: Research Projects : : The Malaria Genome Project SGTC Malaria Genome Project The sequencing of Plasmodium falciparum chromosome 12 (clone 3D7) began in 1997 and was successfully completed in 2002 with a publication in Nature Funding for the work was provided by the Burroughs Wellcome Fund Personnel Ron W. Davis Richard W. Hyman Molly Miranda Eula Fung Don Rowley Related Information PlasmoDB Nature: focus on malaria The Malaria Genome Sequencing Consortium This work was done as part of the Malaria Genome Sequencing Consortium. Sequencing was separated by chromosome among three centers: The Wellcome Trust Sanger Institute (chromosomes 1, 3-9, 13), The Institute for Genomic Research /Naval Medical Research Institute (chromosomes 2, 10-11, 14), and Stanford University (chromosome 12). The project work in the USA was funded by the Burroughs Wellcome Fund , the National Institute of Allergy and Infectious Diseases , and the US Department of Defense. The project work in the UK was funded by

142. Malaria Toll 'outrageously High' CNN http://cnn.com/2003/WORLD/africa/04/25/malaria.who.reut/index.html

143. SMRU-Shoklo Malaria Research Unit malaria research along the ThaiBurmese border. Includes location, publications, malaria task force, and photograph album. http://www.shoklo-unit.com/

Shoklo Malaria Research Unit Welcome to SMRU Malaria Research Web Site!

144. NetMark: Public-Private Partnership For Sustainable Malaria Prevention Managed by the Academy for Educational Development (AED), a Washington, D.C.based nonprofit organization. Goal is to make affordable, lifesaving insecticide-treated nets commercially available on a national scale in Ghana, Nigeria, Senegal and Zambia. http://www.netmarkafrica.org/

Skip to Flash-free page Targeted Subsidies TV Spot September 27-29, 2005 in Nairobi, Kenya Skip to Flash-free page Targeted Subsidies TV Spot September 27-29, 2005 in Nairobi, Kenya

145. Malaria Prophylaxis-Review Any fever up to 1218months after leaving a malaria area should arouse suspicion The WHO no longer recommends this combination for malaria prophylaxis. http://www.priory.com/malaria.htm

Current Views on Malaria Prophylaxis A Review Article Dr Arlene Goldman MB.BCh. MRCP(UK) MACP The development of resistance to familiar anti-malarials has created confusion both for Doctors and travellers as to what is the best and most effective anti-malarial to take and which areas of the World require special precautions. Further difficulties are created by the serious side-effects encountered on using the newer drugs. This review will endeavour to elucidate current areas of resistance and recommendations for prophylaxis and treatment. Great stress is given to the warning that no prophylaxis is foolproof and failures arise most commonly from not taking the drugs as prescribed. In particular they must be started 1 week before departure and continued for 4-6 weeks after leaving the malaria area. Any fever up to 12-18months after leaving a malaria area should arouse suspicion of malaria and be investigated accordingly. Appropriate advice must be sought prior to departure from a reputable travel advice centre. Antimalarial drugs Newer drugs Areas of Drug Resistant Plasmodium falciparum and Plasmodium vivax malaria.

146. Anti-malaria Drug Brewed From Microbes CNN http://cnn.com/2003/HEALTH/06/08/malaria.microbes.ap/index.html

147. Spread Of Major Tropical Vector-borne Diseases - Climate Change of endemic malaria areas and at higher altitudes within malaria areas. The changes in malaria risk must be interpreted on the basis of local environment http://www.grida.no/climate/vital/41.htm

Vital Climate Graphics Potential Impacts of Climate Change End of series 40. Malaria Plasmodium vivax, with the Anopheles mosquito as a vector, is an organism causing malaria. The main climate factors that have bearing on the malarial transmission potential of the mosquito population are temperature and precipitation. Assessments of the potential impact of global climate change on the incidence of malaria suggests a widespread increase of risk due to expansion of the areas suitable for malaria transmission. The predicted increase is most pronounced at the borders of endemic malaria areas and at higher altitudes within malaria areas. The changes in malaria risk must be interpreted on the basis of local environment conditions, the effects of socioeconomic development and malaria control programs or capabilities. The incidence of infection is sensitive to climate changes in areas of Southeast Asia, South America and parts of Africa. In these areas the number of years of healthy life lost may increase significantly. End of series Vital Climate Graphics Potential Impacts of Climate Change United Nations Environment Programme GRID-Arendal Text and graphics may be reproduced in whole or in part and in any form for educational or non-profit purposes, provided that credit is given to the source.

148. Manipulative Malaria Parasite Makes You More Attractive (to New research has shown that the malaria parasite makes infected humans smell more attractive to mosquitoes. http://www.nytimes.com/2005/08/09/science/09para.html

149. Study Smallpox Vaccine Can Boost Malaria Resistance CNN http://cnn.com/2003/HEALTH/conditions/05/26/vaccine.boost.ap/index.html

150. Malaria Special - Main News Page swissinfo s malaria Special was awarded the prestigious Prix Italia for Web Another prize for the malaria Special, the Prix Italia 2004 prize for Web http://www.swissinfo.org/sen/swissinfo.html?siteSect=670

151. MalariaNet Sponsored by USAID's Office of Health, Infectious Diseases and Nutrition. Resources available include regular bulletins and reports outlining antimalaria strategies and policy recommendations, assessments of past programs, studies and conference proceedings. http://www.ehproject.org/Library/MalariaNet.htm

Home This Is EHP EHP News EHP Activities ... Site Map EHP Malaria Reports Library Malaria Bulletins - 2004 EHP Info Center Malaria Bulletins - 2004/2003 EHP II Malaria and Other Vector-borne Disease Reports June 17, 2004 (pdf) May 20, 2004 (pdf) Apr 13 (pdf) Feb 2 (pdf) Jan 19-Feb 2004 (pdf) Jan 1-18, 2004 (pdf) Dec 15-28 (pdf) Dec 1-14 (pdf) Nov 17-30 (pdf) Nov 1-16 (pdf) Oct 20-31 (pdf) Oct 6-19 (pdf) Sep 22-Oct 5 (pdf) Sep 8-21 (pdf) Aug 25-Sep 7 (pdf) Aug 4-24 (pdf) July 21-Aug 3 (pdf) July 1-20 (pdf) June 16-30 (pdf) June 2-15 (pdf) Activity Report 137. Combining Hygiene Behavior Change with Water and Sanitation: Monitoring Progress in Hato Mayor, Dominican Republic Activity Report 136. Intercountry Collaboration for Improving Surveillance and Control of Vector-borne Diseases Activity Report 131.

152. Malaria Mechanism Revealed By determining the molecular structure of a protein that enables malaria parasites to invade red blood cells, researchers have uncovered valuable clues for http://www.eurekalert.org/pub_releases/2005-07/cshl-mmr072505.php

Public release date: 28-Jul-2005 E-mail Article Contact: Peter Sherwood sherwood@cshl.edu Cold Spring Harbor Laboratory Malaria mechanism revealed Molecular 'handshake' of key parasite protein seen as target for drug design and vaccine development By determining the molecular structure of a protein that enables malaria parasites to invade red blood cells, researchers have uncovered valuable clues for rational antimalarial drug design and vaccine development. The findings are reported in the July 29 issue of the journal Cell. Malaria causes approximately 400 million clinical cases and 2 million deaths annually, with more than 80% of deaths occurring among children. The disease is caused by mosquito-borne parasites of the genus Plasmodium (primarily Plasmodium falciparum). Following the initial stages of infection, merozoite-stage parasites ("merozoites") invade red blood cells, leading to clinical symptoms and in many cases, death. "Niraj Tolia [the first author of the study] had malaria when he was young. So when he joined my lab as a graduate student, it didn't take long for me to convince him that this was a good project," says structural biologist Leemor Joshua-Tor of Cold Spring Harbor Laboratory, who led the research. A major pathway through which malaria parasites invade red blood cells is the binding of a protein on the surface of merozoites called EBA-175 to a receptor protein on the surface of red blood cells called glycophorin A. Merozoites die if they do not invade red blood cells soon after their release (from liver cells) into the bloodstream. Thus, the binding of EBA-175 to glycophorin A is a prominent target for the development of therapies to control malaria.

153. Japan Closing On Malaria Vaccine CNN http://cnn.com/2003/WORLD/asiapcf/east/05/07/japan.malaria.reut/index.html

154. Malaria Research Group malaria research in the Leiden University Medical Center (Netherlands). Detailed description of the malaria parasite Plasmodium berghei, one of the four http://www.lumc.nl/1040/research/malaria/malaria.html

Parasitologie Research Malaria last update: Leiden Malaria Research Group Andy Waters ( Waters@Lumc.nl ) and Chris Janse ( C.J.Janse@Lumc.nl Deze site bevat wetenschappelijke informatie over het onderzoek van de Malaria-groep Algemene informatie over malaria. Background information on malaria. Scientific information Research of the Leiden Malaria Group The Plasmodium berghei model of malaria NEWS news archive The Leiden Malaria Group and collaborators published in PNAS van Dijk, M.R. et al (2005). Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proc Natl Acad Sci U S A (in press) read more The Leiden Malaria Group used Plasmodium berghei as a model to investigate genetically modified, attenuated sporozoites as a vaccine van Dijk, M.R. et al (2005). Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proc Natl Acad Sci U S A (in press). read more Information on standard plasmids for genetic modification of P. berghei

155. Roll Back Malaria Department Global Partnership hosted by the World Health Organization enabling countries to take effective, sustainable action against malaria, focusing on prompt access to effective treatment, prevention and control of malaria during pregnancy, promotion of insecticidetreated mosquito nets as a means of prevention, and anti-malaria strategies for emergency and epidemic situations. http://mosquito.who.int/

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156. UNICEF Warns Of Malaria Epidemic In Ethiopia CNN http://cnn.com/2003/HEALTH/08/12/ethiopia.malaria.reut/index.html

157. Malaria - MayoClinic.com malaria is one of the oldest diseases on Earth, but still one of its leading killers. http://www.mayoclinic.com/invoke.cfm?id=DS00475

158. MIMCom Malaria Research Resources Communications working group of the Multilateral Initiative on malaria, from the National Library of Medicine. http://www.mimcom.net/

Skip to Content Search NLM Web Site NLM Home Contact NLM Site Map FAQs MIMCom Malaria Research Resources MIMCom Home About Us Contact Us MIMCom Site Map ... MIMCom "We must develop a communications system so that the miraculous triumphs of modern science can be taken from the laboratory and transmitted to all in need." Senator Lister Hill, 1965 About MIMCom About MIMCom News and New Resources Databases ClinicalTrials.gov CRISP MedlinePlus PubMed ... Publishers Medical Reference Resources General Medical Resources Genomics Malaria Acronyms Malaria Reference ... Vaccines Internet Resources Discussion Groups General Internet Resources Internet Search Miscellaneous Library Resources Organisations Surveying Training Materials Current News WASHINGTON, June 10, 2005 GAO Highlights The full report, Global Health: The Global Fund to Fight AIDS, TB and Malaria Is Responding to Challenges but Needs Better Information and Documentation for Performance-Based Funding , is available as a PDF at: http://www.gao.gov/new.items/d05639.pdf Featured Site Malaria Vaccine Initiative (MVI) A focused vaccine development program created in 1999. Its mission is to accelerate the development of promising malaria vaccines and ensure their availability and accessibility in the developing world.

159. EMVI Home Page Established in 1998 by the European Commission and interested European Union Member States, in order to address identified structural deficiencies in public http://www.emvi.org/

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160. Malaria Drugs For Travelers Under Debate CNN http://cnn.com/2002/HEALTH/conditions/11/30/malaria.debate.ap/index.html

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