41. HD Blog Weblog with the latest information on research and news. http://www.huntingtons.info

HD Blog September 12, 2005 FDA Blesses HD Phase III Trial The Miraxion/LAX-101 trial, TREND-HD, now has the FDA's green light. If you or a loved one has got mild- to moderate-HD then call 1-800-487-7671 to see about enrolling in this study. ( More Info Here.) Here's some key information from Amarin's press release: The U.S. and European trials will be multi-centre, randomized, double blind, placebo –controlled studies of Miraxion at 43 sites in the U.S. and up to 28 sites in Europe. The trials are expected to involve a total of up to 540 Huntington’s disease patients with approximately 300 in the U.S. Phase III trial and approximately 240 in the European Phase III trial over a 6 month period. Patients in the U.S. trial will participate in a further 6-month extension period. ... The primary endpoint of the trials will be to determine whether Miraxion taken 2 grams per day (1gram twice daily) results in clinically and statistically significant changes in the Total Motor Score-4 subscale of the Unified Huntington’s Disease Rating Scale (UHDRS). Here's the full press release: Continue reading "FDA Blesses HD Phase III Trial" Posted by Dave at 10:42 AM Comments (0) TrackBack (0) Bad Science (Writing) ...or why the media often gets in wrong in reporting science. Several good points from this excellent article that should be read by all. An excerpt:

42. Auto-forward To Hungtington's Disease Page Services of the Huntington's disease program of the University of Connecticut Health Center. http://psychiatry.uchc.edu/huntingtons.php

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43. Auto-forward To Hungtington's Disease Page Services of the Huntington's disease program of the University of Connecticut Health Center. http://huntingtons.uchc.edu

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44. Genetics Of Huntington's Disease Huntington disease (HD) is a genetic disorder of the central nervous system with Huntington disease is inherited as an autosomal dominant condition. http://www.kumc.edu/hospital/huntingtons/genetics.html

Genetics of Huntington disease Debra Collins, M.S., CGC Genetic Counselor Division of Endocrinology, Metabolism and Genetics University of Kansas Medical Center Huntington disease (HD) is a genetic disorder of the central nervous system with symptoms usually appearing in adults within the third or fourth decade of life, although symptoms can occur in individuals younger or older than this. Within the same family, the symptoms vary both in their rate of progression and in the age of onset. Symptoms may include involuntary movements and loss of motor control. In addition, personality changes may occur, with loss of memory and decreased mental capacity. Symptoms in individuals, as well as confirmation of diagnosis in other family members, are used to determine the diagnosis. Huntington disease is inherited as an autosomal dominant condition. The human body contains 100 trillion cells. A nucleus is inside each human cell (except red blood cells). Each nucleus contains 46 chromosome arranged in 23 pairs. One chromosome of every pair is from each parent. The chromosome are filled from each tightly coiled strands of DNA. Genes are segments of DNA that contain instructions to make proteins and other building blocks of life. An affected parent passes either the HD gene, or the other working gene, to their off spring. There is a 50% (1 in 2) chance at each pregnancy that a child of an affected parent will receive the gene for Huntington disease. The age of onset, degree and type of clinical symptoms, as well as rate of progression varies with HD.

45. Healthubs.com Links to overviews, clinical trials, case reports, diagnosis, treatment, research programs on Huntington's disease. http://www.healthubs.com/huntingtons

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46. Huntington's Disease - Symptoms - Neurologychannel Huntington’s disease produces three types of symptoms movement, cognitive, and psychiatric. The sequence in which Huntington s symptoms develop varies from http://www.neurologychannel.com/huntingtons/symptoms.shtml

Home Search SiteMap Ask the Dr. ... Medical Store HUNTINGTON'S DISEASE Overview Symptoms Diagnosis Treatment ... Find a Neurologist CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo DIAGNOSTIC TESTS CT Scan MRI Scan TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES Clinical Trials Glossary Links MDLocator ... What Is a Neurologist? Videos FOR DOCTORS ONLY Website Services Get Listed in MDLocator CME ABOUT US Healthcommunities.com Testimonials print this email this Signs and Symptoms Huntington’s disease produces three types of symptoms: movement, cognitive, and psychiatric. The sequence in which symptoms develop varies from person to person. Movement Uncontrolled movement, or tics, may develop in the fingers, feet, face, or trunk. This is the beginning stage of chorea — involuntary, rapid, ceaseless movement. Chorea can become more intense when the person is anxious or disturbed. Over time other symptoms, such as the following, emerge:

47. HD Blog: Molecular Trigger For Huntington's Disease Found Every day researchers understand Huntington s disease better and better. And, once again, the research shows potential to help in the treatment of other http://www.huntingtons.info/MT/archives/2005/07/molecular_trigg.html

HD Blog Main July 07, 2005 Molecular Trigger For Huntington's Disease Found That's the headline of a press release for a study published in the journal "Neuron". Every day researchers understand Huntington's Disease better and better. And, once again, the research shows potential to help in the treatment of other diseases. Here's the press release: Molecular trigger for Huntington's disease found Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other genes. This abnormal gene activation damages the cells' power plants, called the mitochondria, and kills brain cells. The researchers also speculated that disturbances in p53 may also play a role in some forms of Parkinson's disease and amyotrophic lateral sclerosis, or Lou Gehrig's disease. Ironically, p53 is the same regulatory protein that is inactivated in a large fraction of cancers. This inactivation allows abnormal cancer cells to escape the cell's protective "suicide program" that would normally kill them. The researchers theorize that the lower incidence of cancer in HD patients could be caused by the protective effect of overactive p53. In the July 7, 2005, issue of Neuron, Akira Sawa and colleagues at Johns Hopkins University School of Medicine reported experiments ranging from molecular studies in cultured brain cells to analysis of the brains of human HD patients that demonstrated the central role of p53 in the pathologies of HD.

48. Huntington S Disease Genetics The identification of the Huntington s disease gene in 1993 has spawned a They are signs of the fatal neurological disorder, Huntington s disease (HD). http://apu.sfn.org/content/Publications/BrainBriefings/huntingtons.html

Login Directory Merchandise Contact Us ... Abstracts/Annual Meeting Publications Full size image available below Huntington's Disease Genetics The identification of the Huntington's disease gene in 1993 has spawned a variety of novel insights that may improve treatment or even cure this disorder. Researchers are deciphering the lethal gene's structure in order to determine how its makeup plays a role in disease development. Violent, uncontrollable movements. Repetitious fidgeting. In the 1800s clinicians compared it to a dance. But these wildly jerky movements are far from a hip hop move or tango. They are signs of the fatal neurological disorder, Huntington's disease (HD). Some 30,000 Americans are affected and another 150,000 run the risk of displaying HD. The disease, notorious for killing folk singer Woody Guthrie, ends the life of its victims within eight to 25 years. Symptoms of the disease include rapid, jerky involuntary movements, difficulty in speaking and swallowing, cognitive decline, depression, and occasionally delusions, hallucinations and obsessive compulsive disorders. Currently HD has no cure or treatment. However, researchers are developing new approaches to treat this disorder thanks to the discovery of the HD gene in 1993.

49. Glaxo Centre Alliance Charities Huntington's Disease The Glaxo Neurological Centre, Non medical advice and information for people with neurological conditions and those who care for them. http://glaxocentre.merseyside.org/huntingtons.html

Charity No 296453 Contact: National Head Office Huntington's Disease Association 108 Battersea High St. London SW11 3HP England Tel: Fax: Email: info@hda.org.uk Website: www.hda.org.uk Merseyside Huntington's Disease Association c/o Glaxo Neurological Centre Norton St Liverpool L3 8LR England Tel: Fax: The Huntington's Disease Association is a national charity with the aims of promoting research, relief and treatment; disseminating knowledge about the disease; and providing information, comfort and support (including financial support where appropriate) to families and their associated professionals. The Huntington's Disease Association's Cheshire and Merseyside Regional Care Advisor holds bi-monthly advice sessions at the Glaxo Centre for people with Huntington's Disease and their carers. Please see the Glaxo Centre's newsletter to find out when the next appointment is: Glance Index . You will need to make an appointment, either ring the Glaxo Centre on 0151 298 2999 or email: mnt@gnc.u-net.com The Huntington's Disease Association - Flintshire and District Branch Tel: Ewart Cassel on 01244 534878.

50. Huntington's Disease Association Of Ireland http://www.huntingtons.ie/

51. Huntington's Disease Association Of Ireland The Huntington s disease Association of Ireland (HDAI) provides consultation, information and individualised support to those diagnosed with Huntington s http://www.huntingtons.ie/disease.html

Huntington's Disease, there's a lot to hope for: Dr. Gill Bates. MSC Ph.D.. Professor in Neurogenetics, Guys Hospital, London. Guest Speaker at HDAI AGM on 3rd June. Marker for Huntington’s Disease (HD) gene found. Formal Launch of Huntington’s Disease Association of Ireland. Mary Robinson, President of Ireland becomes Patron of HDAI. First full-time worker employed. Scientist finds HD gene. HDAI hosts European Huntington Association meeting in Trinity College. Scientists discover HAP-1 a protein that binds to huntingtin (the protein expressed by the HD gene) and may work with it to cause HD. Dr. Gill Bates develops transgenic mouse model. Breakthrough in HD research announced in Cell and Nature publications. Dr. Andrew Greene appointed Clinical Geneticist, National Genetics Centre, Dublin. Mary McAleese, President of Ireland becomes Patron of HDAI. Home Page Association Aims Hope Newsletter Huntington's Disease ... Contact HDAI 'Eligible Charity' Serial No: 0015 Incorporated 1998. Reg. Charity No. CHY 10130. Built by Rewind Design.

52. Huntingtons Chorea Huntington disease. This is an autosomallyinherited, dominant disorder in Patients with Huntington disease (HD) initially have a tendency to fidget http://www.sci.uidaho.edu/med532/Huntington.htm

Med.Sci 532 Structure-Function Huntington Disease This is an autosomally-inherited, dominant disorder in which the patient begins to exhibit symptoms in the third to fourth decades. Patients with Huntington Disease (HD) initially have a tendency to fidget which over months or years develops into jerky, choreiform movements. HD usually progresses over a 10 to 25 year period. As the disease progresses it leads to dementia and usually death from incurrent infection. There is a high incidence of suicide among patients with HD. Pathologically, there is atrophy of certain forebrain structures including the entire cerebral cortex and even more notably of the caudate nucleus and putamen The head of the caudate is reduced to a narrow brownish band of tissue that is flattened or concave. In normal brain the ratio of small neurons to large neurons in the corpus striatum is approximately 160:1 in Huntingtons patients the ratio is reduced to 40:1 with a marked decrease in the number of astrocytes. The gene for this disease has been isolated to the short arm of chromosome 4. For more information concerning Huntington Disease. Please visit the web-site below.

53. AllRefer Health - Huntington's Disease (Huntington Chorea) Huntington s disease (Huntington Chorea) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, http://health.allrefer.com/health/huntingtons-disease-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Huntington's Disease Huntington's Disease Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Huntington Chorea Definition Huntington's disease is an inherited condition characterized by abnormal body movements, dementia , and psychiatric problems. Huntington's disease is a progressive disorder involving wasting (degeneration) of nerve cells in the brain. The disorder was first described in 1872 by George Huntington, an American physician. Huntington's disease is inherited as a single faulty gene on chromosome #4. There is a part of the gene that is repeated in multiple copies. The greater the number of repeats, the more likely it is that the person will develop symptoms and the greater the chance they will occur at a younger age. The disease may occur earlier and more severely in each succeeding affected generation because the number of repeats can increase. Every child of a parent with the disorder has a 50% chance of inheriting Huntington's Disease. Symptoms do not usually appear until adulthood, typically between ages 35 and 50 years old but this depends on the number of repeats found in the gene so it may also appear in younger people. In children it may appear to be Parkinson's disease with rigidity, slow movements, and tremor.

54. AllRefer Health - Huntington's Disease Treatment (Huntington Chorea) Huntington s disease (Huntington Chorea) information center covers Treatment. http://health.allrefer.com/health/huntingtons-disease-treatment.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Huntington's Disease : Treatment of Huntington's Disease Huntington's Disease Definition Prevention Treatment Expectations or Prognosis Complications Support Groups Calling Your Health Care Provider ... Go To Main Page Alternate Names : Huntington Chorea Huntington's Disease Treatment There is no cure for Huntington's disease, and there is no known way to stop progression of the disorder. Treatment is aimed at slowing progression and maximizing ability to function for as long as possible. Medications vary depending on the symptoms. Dopamine blockers such as haloperidol or phenothiazine medications may reduce abnormal behaviors and movements. Reserpine and other medications have been used, with varying success. Drugs like Tetrabenazine and Amantadine are used to try to control extra movements. There has been some evidence to suggest that Co-Enzyme Q10 may minimally decrease progression of the disease.

55. Huntington's Disease My topic would be on Huntington s disease. Huntington s (HD) is a genetic neurological brain disease for which there is no cure. dewey decimal 616.851. http://www.suite101.com/welcome.cfm/huntingtons

Topics Articles Links Free Courses Home Directory 22 Communities What's New ... Free e-Courses Search Suite101.com Within: Huntington's Disease Health Member Central Join Our Community! Login SuiteMail What's New ... Become a Feature Writer Discussion Rooms The Forum The Lounge SuiteChat New Topics The Secret Of Intuition Self-Empowerment Eating Disorders Depression ... More... New Articles Fibers and plant cells Why Science Failed to Unravel the Mind Development in Preschoolers: What's Normal? Understanding TSH Receptor Antibodies ... More... New Discussions Stories of hope, please! DUMPED (AGAIN) BY MY N BOYFRIEND Needing Help Running into the ex-N ... More... Related Online Courses Introduction to Alternative Healing Methods 102 Coping with Fibromyalgia Coping With Hypothyroidism More about Suite101 About Suite101.com Advertise With Suite For more information Welcome To: Huntington's Disease Home Applied sciences Medicine and health Diseases Huntington's Disease Note: We are actively seeking a new Feature Writer to adopt this Retired Topic. If interested, please Contact

56. Testing For Huntington's Disease - Part One This is an article on testing for Huntington s disease. The information in this article comes from the booklet entitled, Testing for Huntington s disease http://www.suite101.com/article.cfm/huntingtons/30924

Topics Articles Links Free Courses Home Directory 22 Communities What's New ... Free e-Courses Search Suite101.com Within: Huntington's Disease Health New Topics The Secret Of Intuition Self-Empowerment Eating Disorders Depression ... More... New Articles Fibers and plant cells Why Science Failed to Unravel the Mind Development in Preschoolers: What's Normal? Understanding TSH Receptor Antibodies ... More... New Discussions Stories of hope, please! DUMPED (AGAIN) BY MY N BOYFRIEND Needing Help Running into the ex-N ... More... My Recent Articles Men Dealing With Huntington's Disease Gerry's Story A MOTHERS PAIN Related Online Courses Creating An Online Support Group Hyperthyroid Disorders How To Survive An Abusive Relationship Testing for Huntington's Disease - Part One Home Applied sciences Medicine and health Diseases Author: Julie Sando Published on: January 12, 2000 Note: We are actively seeking a new Feature Writer to adopt this Retired Topic. If interested, please Contact Member Services for more information.

57. Huntington's Disease And Chorea Treatment Options At Mayo Clinic Treatment for Huntington s disease, chorea and other degenerative disorders at Mayo Clinic. http://www.mayoclinic.org/huntingtons-disease/

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Huntington's Disease Huntington's Disease Overview Diagnosis Treatment Options Appointments ... Medical Services Treatment of Huntington's Disease at Mayo Clinic (Synonyms: Huntington disease, Huntington's chorea, chorea, Saint Vitus' dance, akinetic-rigid HD, Westphal HD, juvenile-onset HD) Mayo Clinic has experience treating Huntington's disease and is extensively involved in clinical and genetic research to better understand its cause and progression, and to increase treatment options. A diagnosis of Huntington's disease can be very difficult for both the patient and family. At Mayo Clinic, a team of specialists across the fields of genetic counseling, psychology, psychiatry, behavioral neurology and movement disorders collaborate to provide the best possible combination of support and treatment, all within the nurturing Mayo Clinic environment. Diagnosis Professional genetic counseling is important in the diagnosis of Huntington's disease. While genetic testing (from a blood sample) makes confirmation of the disease relatively easy, it can create difficult questions for patients and their families. Read more about diagnosis of Huntington's disease Treatment Options Although the disease's progression cannot be stopped or reversed, therapies and support are available to partially alleviate symptoms and improve quality of life. Treatments include medication, mental health care, and speech, swallowing and physical therapies. Read more about

58. Diagnosis Of Huntington's Disease Diagnosis of Huntington s disease. Professional genetic counseling is important in the diagnosis of Huntington s disease. While genetic testing (from a http://www.mayoclinic.org/huntingtons-disease/diagnosis.html

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Huntington's Disease Huntington's Disease Overview Diagnosis Symptoms Treatment Options ... Medical Services Diagnosis of Huntington's Disease Professional genetic counseling is important in the diagnosis of Huntington's disease. While genetic testing (from a blood sample) makes confirmation of the disease relatively easy, it can create difficult questions for patients and families. Depending on their circumstances, patients may be tested either after developing symptoms that point to Huntington's disease or due to family history. Patients who have symptoms will also be tested to rule out other possible causes of the symptoms. Additional tools doctors may use in diagnosis are brain scans such as CT (computerized tomography), MRI (magnetic resonance imaging) or EEG (electroencephalography). Home About Mayo Clinic Contact Mayo About This Site ... Search E-mail this Page

59. At Risk For Huntington's Disease: Huntington's Disease: An Early Date With Morta My name is Gene Veritas and I am at risk for Huntington’s disease. My mum is currently in the late stages of Huntington s disease, she has been in a http://curehd.blogspot.com/2005/01/huntingtons-disease-early-date-with.html

@import url("http://www.blogger.com/css/blog_controls.css"); @import url("http://www.blogger.com/dyn-css/authorization.css?blogID=10081281"); @import url(http://www.blogger.com/css/navbar/main.css); @import url(http://www.blogger.com/css/navbar/2.css); BlogThis! At Risk for Huntington's Disease HD is a genetically caused brain disorder that causes uncontrollable bodily movements and robs people's ability to walk, talk, eat, and think. The final result is a slow, ugly death. Children of parents with HD have a 50-50 chance of inheriting the disease. There is no cure or treatment. Monday, January 10, 2005 Huntington's disease: an early date with mortality My name is Gene Veritas and I am at risk for Huntington’s disease. I have been thinking of starting this blog for some time. Something happened last Friday evening, January 7, 2005, that helped me put things in perspective and finally pushed me into sharing my story with the world. I was having a beer with an old friend who happened to be attending the same professional convention as I. We go back twenty-five years and hadn’t seen each other in more than a year. We talked about writing and publishing, our passions. We had only thirty minutes to talk, because I had to catch a plane back home so that I could get in some volunteer work in the campaign to stop Huntington’s disease. Our conversation quickly turned to HD. My friend wanted to know how my health was. I explained that I had just started taking a dietary supplement that is part of a new “treatment now” HD program that aims to cut through the bureaucracy and lethargy of other HD organizations. I told my friend that I would be taking additional supplements, all over-the-counter or FDA-approved, in the coming months, including creatine, for which I will have to get blood tests to make sure it doesn’t damage my liver or kidneys. Just thinking about this scares me, but I feel I have no choice.

60. Huntington's Disease Group Of Maine HUNTINGTON S disease SUPPORT GROUP MAINE. HUNTINGTON S disease GROUP of MAINE. The Tapestry. Weaving the threads of commons concern http://www.pccs-nh.com/huntingtons/

Please Support Our Sponsors By Following the Link HUNTINGTON'S DISEASE GROUP of MAINE The Tapestry Weaving the threads of commons concern Meeting at 7:00 p.m. the Barron Center 1145 Brighton Ave. - Portland, ME Second Monday Each Month Exit 8, Maine Turnpike, left on Brighton Look for Barron Center on the left (Get directions from Mapquest.) Support Group Coordinator Lillian Dyhrberg 797-0566 Additional Contact Persons Southern Maine Area Steve Brantley 1-800-838-7462 166 Simpson Road Saco, ME 04072 e-mail: sjb9946@aol.com Central Maine Area Gordon Harris 1054 Lisbon Street Lewiston, ME 04240 e-mail: GHarris@megalink.net HDSA Patient Services and Information Department Concerning: Genes, genetic, markers and tests Home care/nursing/management Clinical care/evaluations/therapies Research/Videos Counseling/support/financial/legal issues Dedicated to the detection and care of those who have Huntington's Disease Website design and layout by:

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