21. HCMC - Huntingtons Disease Group home for Huntington s disease has HCMC connection huntingtons disease Society of huntingtons disease Society of Minnesota Chapter www.hdsa.mn http://www.hcmc.org/depts/hd/hdhome.htm

Clinic Team Wellness Program Research ... Fundraising HDSA Center of Excellence for Families and Service Hennepin County Medical Center is committed to finding a cure for Huntingtion's Disease (HD) while providing education and services to those affected by the disease and their families. We provide services and referrals to families trying to cope with the devastating effects of the disease, and educate the public and health care professionals about Huntington's Disease. We provide the vital link between the laboratory bench and the patient's bedside. Group home for Huntington's disease has HCMC connection Huntingtons Disease Society of America www.hdsa.org Huntingtons Disease Society of Minnesota Chapter www.hdsa.mn Home ... Multilingual welcome Hennepin County Medical Center info@hcmc.org

22. CMGS-HUNTINGTON’S DISEASE/17.12.98 huntingtons disease (HD) is an autosomal dominant untreatable neurodegenerative disorder The Huntington s Disease Collaborative Research Group. http://www.ich.ucl.ac.uk/cmgs/hunt98.htm

HUNTINGTON'S DISEASE Huntingtons Disease (HD) is an autosomal dominant untreatable neurodegenerative disorder associated with expansions of the CAG repeat found in the Huntingtin gene. HD occurs equally in both sexes and is found in all races but most frequently in West Europeans where it affects 1 in 10,000 individuals. Clinical Symptoms Huntington's Disease is characterised by : Progressive chorea Psychiactric changes Intellectual decline 'Chorea' refers to the characteristic peculiar movement disorder which begins subtly and progresses to exaggerated dance like motions that involves the entire body. The clinical progression of HD is paralleled by neuronal degeneration in the brain: The hallmark in HD is loss of the medium spiny neurons of the striatum which begins in the caudate nucleus and spreads to the putamen and deep layers of the cerebral cortex (Fig.1). Recurved dendritic endings and changes in spine density, shape and size are associated with loss of function and ultimately neuronal cell death. The extensive neuronal loss may reduce the overall brain weight by 25% or more.

23. CMGS-Huntingtons Disease/14.12.99 9, pp13551361; Chapter 23 Huntington’s Disease in Genetic Instabilities and Hereditary Neurological Diseases , edited by RD Wells and ST Warren (Academic http://www.ich.ucl.ac.uk/cmgs/hd99.htm

MRCPath Self Help 1999 Genevieve Creed Huntingtons Disease (HD) Clinical HD Incidence HD HD gene spans ~185 kb of genomic DNA contains 67 exons. (CAG repeat in exon 1) 2 major mRNA transcripts (13.5 and 10.5 kb) encodes ~350 kDa "huntingtin" protein. CAG repeat size ranges Majority (95%) of adult onset cases = 40-55 repeats. Genotype / Phenotype correlations : repeat length / age of onset For low repeat numbers ( and older ages at onset) the correlation is weaker. This implies that CAG repeat length is the major determinant of age of onset in juvenile HD. But in HD which only develops at an elderly age other factors are involved in determining the age of onset. Intergenerational Instability of the CAG repeat Instability occurs during gametogenesis, showing a greater instability in male transmissions. This could be influenced by the continual mitotic divisions during spermatogenesis. For example,a sperm gaining an extra 20 CAG repeats could be due to: one mutation event at one cell division multiple smaller expansions at several different divisions (a cumulative effect) a history of several expansions and contractions shows mutation spectra of sperm samples from donors with different somatic CAG repeat lengths (Ref 1). The larger the somatic allele, the greater the average allele length of the mutant sperm.

24. UK Psychiatrists Huntington's Disease Group huntingtons disease the UK Psychiatrists huntingtons disease Group - with links, information and contacts. http://www.huntingtons.org.uk/

UK Psychiatrists Huntington's Disease Group UK Psychiatrists Huntington's Disease Group

25. BrainTalk Communities - Huntingtons Disease Reload this Page huntingtons disease. User Name, Remember Me? Threads in Forum huntingtons disease, Forum Tools, Search this Forum. Announcement http://brain.hastypastry.net/forums/forumdisplay.php?f=150

26. BrainTalk Communities - Huntingtons Disease Online patient support groups for healthcare and neurology. http://brain.hastypastry.net/forums/archive/index.php/f-150.html

BrainTalk Communities Specific Neurological Conditions (A - L) PDA View Full Version : Huntingtons Disease Useful Websites Testing adolescence Not yet diagnosed ... Clioquinol for treatment (antibiotic)

27. Foogle Business - What Is Huntingtons Disease - Hereditary Chorea - Dominant Fau Popular Cult Figured Political Site that shows Information and Facts on Foogle Business huntingtons disease - Hereditary Chorea - Dominant Faulty Genetic http://www.thesahara.net/huntingtons_disease.htm

Huntington's Disease D ominant and Faulty Genetic Disorder Hereditary Chorea " LEARN MORE, BE MORE " Last-Modified: Foogle Business - Huntington's Disease - Huntingtons - Huntingdons Learn More, Be More What is Huntington's Disease What is Huntington's Disease? It is due to a dominant and faulty genetic disorder on chromosome 4 The consequence of the fault with this gene starts around or just before middle age, and leads to a gradual physical, mental and emotional change in its victim. Huntington's Disease was named after the American, Dr. George Huntington, because in 1872 he was the first person to document an accurate description of the symptoms and the route of the disease. The cause was then unknown. Huntington's Disease - Hereditary Chorea George Huntington (1850-1916) George Huntington was born on 9 April 1850 in the drowsy secluded village of East Hampton, CT, United States. Both his father and grandfather were doctors, and George Huntington junior followed in their footsteps. At an early age, Huntington accompanied his father on his rounds and sick calls and during one of these visits, he gained his first experience of hereditary chorea. At the time he called it Hereditary Chorea.

28. Digital Termpapers: Term Papers On Huntingtons Disease huntingtons disease huntingtons disease, also known as Huntingtons chorea is a genetic disorder that usually shows up in. http://www.digitaltermpapers.com/a2312.htm

Term Papers Count: Home Join Login Sign Out ... Contact for: Huntingtons Disease Term Paper Title Huntingtons Disease # of Words # of Pages (250 words per page double spaced) Huntington's Disease Huntington's disease, also known as Huntington's chorea is a genetic disorder that usually shows up in someone in their thirties and forties, destroys the mind and body and leads to insanity and death within ten to twenty years. The disease works by degenerating the ganglia (a pair of nerve clusters deep in the brain that controls movement, thought, perception, and memory) and cortex by using energy incorrectly. The brain will starve the neurons (brain cells), and sometimes make them work harder than usual, causing extreme mental stress. The result is jerky, random, uncontrollable, rapid movement such as grimacing of the face, flailing of arms and legs, and other such movement. This is known as chorea. Huntington's chorea is hereditary and is caused by a recently discovered abnormal gene, IT15. IT stands for "interesting transcript" because of the fact that researchers have no idea what the gene does in the body. Huntington's

29. Digital Termpapers: Term Papers On Huntingtons Disease huntingtons disease Background huntingtons disease is inherited as an autosomal dominant disease that gives rise to pr. http://www.digitaltermpapers.com/a1993.htm

Term Papers Count: Home Join Login Sign Out ... Contact for: Huntingtons Disease Term Paper Title Huntingtons Disease # of Words # of Pages (250 words per page double spaced) Huntington's Disease Background Huntington's disease is inherited as an autosomal dominant disease that gives rise to progressive, elective (localized) neural cell death associated with choleric movements (uncontrollable movements of the arms, legs, and face) and dementia. It is one of the more common inherited brain disorders. About 25,000 Americans have it and another 60,000 or so will carry the defective gene and will develop the disorder as they age. Physical deterioration occurs over a period of 10 to 20 years, usually beginning in a person's 30's or 40's. The gene is dominant and thus does not skip generations. Having the gene means a 92 percent chance of getting the disease. The disease is associated with increases in the length of a CAG triplet repeat present in a gene called 'huntington' located on chromosome 4. The classic signs of Huntington disease are progressive Research Studies were done to determine if somatic mtDNA (mitochondria DNA) mutations might contribute to the neurodegeneration observed in Huntington's disease. Part of the research was to analyze cerebral deletion levels in the

30. Coenzyme Q10 Info On Huntingtons Disease, Co Q10 Coenyzme Information on Coenzyme Q10 Supplements and Huntington s Disease. Coenzyme Q10 Huntington s Disease Coenzyme Q10 Protects Brain Cells Antioxidants http://www.coenzymeq10supplement.com/Huntingtons-disease-coq10.htm

Information on Coenzyme Q10 Supplements and Huntington's Disease. Benefits of Coenzyme Q10 Treatment of Heart Disease with CoenzymeQ10 Coenzyme Q10 Protects Brain Cells Neuroprotective Effects of Coenzyme Q10 ... Future of Coenzyme Q10 Huntington’s is an inherited genetic disease that destroys neurons in brain regions governing movement. Symptoms include involuntary movements, lack of coordination and cognitive difficulties. Huntington’s disease is thought to involve a bioenergetic defect. A pilot study conducted by Beal and associates showed that energy production in the central nervous system and muscle of Huntington’s disease patients is impaired. After two or more months of Coenzyme Q10 supplementation (360 mg per day), 83% of patients showed significant improvements in biochemical markers of energy production. See References back to top Natrol Coenzyme Q10 30mg Qnty: 60 softgels Retail: $17.94

31. Huntingtons Disease IMMUNE SYSTEM LINK DIRECTORY huntingtons disease. http://www.artritis.net/links/huntingtonsdisease.html

Arthritis Problems? The Ideal Cancer Clinic Rejuvenate!! Huntingtons Disease Home Page Aging Allergies Ankylosing Spondylitis ... Huntingtons Disease Association Online... HDA Online provides news of fund raising events, health care information and details of research into curing Huntingtons Disease... 49 Pages Found, 17 Links Found, 2356 Score, http://www.hda.org.uk Information on adding your web site to the Link Directory These web site links are listed as a convenience to our visitors. If you use these links, we take no responsibility and give no guarantees, warranties or representations, implied or otherwise, for the content or accuracy of these third-party sites. Arthritis Problems? The Ideal Cancer Clinic Rejuvenate!! Top of page

32. Huntingtons Disease, Current Research - Health And Medical Information Produced Doctorproduced health and medical information written for you to make informed decisions about your health concerns. http://www.medicinenet.com/script/main/art.asp?articlekey=9733

33. WE MOVE Discussion Forum: Huntingtons Disease I have just in the last year found out that huntingtons disease runs in my family. huntingtons disease can only be inherited to you if your mother or http://www.wemove.org/ubb/ultimatebb.php?/topic/2/11.html

34. WE MOVE Discussion Forum: Huntington's Disease Icon 5, huntingtons disease, lafscd, 8. June 30, 2005 0900 PM. Icon 1, no subject, lovefishen, 2. January 16, 2005 0629 PM http://www.wemove.org/ubb/ultimatebb.php?/forum/2.html

35. Huntingtons Disease & Families This Webring is for all people who are connected in some way with huntingtons disease. For carers and caregivers, sufferers and families affected requiring http://r.webring.com/hub?ring=huntingtons

36. Huntington's Disease Memorial Quilt The Huntington s Disease Memorial Quilt is available for loan from HuntDis to For information on obtaining the quilt for a huntingtons disease event, http://endoflifecare.tripod.com/huntdisscholarshipfund/id15.html

Lou Wilkinson HD Convention Scholarship Fund Huntington's Disease Memorial Quilt Home HD Ad Index About Us ... Index The Hunt-Dis "Huntington's Disease Memorial Quilt" "The Quilt" I Am The "Huntingtons Disease" Memorial Quilt On Display For All Mankind Look Upon My Patchwork And These Memories Unwind Each Square was Wrought With Loving Hands All Are Different You Can See Each Tells A Story Of Love And Loss Then All Were Intrusted To Me Will Travel This Wide World Over My Beauty For All To See Spreading The Word Of A Cruel Disease And The Message "Remember Me" Ron C. About The Quilt Members of the Hunt-Dis internet support group initiated a national Huntington's Disease Memorial Quilt project to honor loved ones with Huntington's Disease. This was a major undertaking and through the support of HDSA Chapters, HD Support Groups and HD Centers of Excellence Phase I of the Quilt is 120 squares! The Quilt was unveiled at the 2001 HDSA Convention in San Diego. Phase II of the Quilt project has been intiated with plans to unveil this section, along with the orginal (Phase I Quilt), at the 2003 HDSA National Convention in Houston, Texas.

37. Archives Of Huntingtons Disease From The The Neurology And Neurosurgery Forum Collection of patient medical questions and answers about huntingtons disease, which are replied to by online doctors from leading medical institutions. http://www.medhelp.org/forums/neuro/archive/Huntingtons_Disease1.html

The Archive of Huntingtons Disease Questions from The Neurology and Neurosurgery Forum at Med Help International Listed below are our archive of questions and answers from the forum for the medical topic: Huntingtons Disease. Please feel free to browse our huntingtons disease archive below, search our site for additional information about huntingtons disease, or browse the full archives for this forum. Need opinion support/information chance of having Huntingtons disease Re: Kennedy's disease ... Med Help International Revised 9/21/2005

38. Huntington's Disease Links southern indiana lady,washington indiana,huntingtons disease,southern indiana, big beautiful women, big blonde beautiful women in indiana. http://www.angelfire.com/in2/bbwdj2/hd.html

setAdGroup('67.18.104.18'); var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" Search: Lycos Angelfire Free Games Share This Page Report Abuse Edit your Site ... Next Personal Pages of People Affected by Huntington's Pages are listed in no particular order, there are personal and professional pages listed. Please give the page time to load, since there are many links listed. Come back as often as your heart will allow. And please pray for a cure. Pictures of Kelly Elizabeth Miller A Webpage for Young People and HD Caregivers Web Directory Pictures of Ardie and Bobbie the Quail ... Huntington's Dance Other Huntington's Links Huntington's Disease - The Granddaddy Of Them All!! Huntington's Disease - Suite101.com Caring for People with Huntington's Disease Archives of HUNT-DIS@MAELSTROM.STJOHNS.EDU The best support system you can find on the net for Huntington's Disease. You can join the list at this link.

39. Caring For People With Huntington's Disease Information about caring for people with Huntington's disease, for patients, families and professionals. http://www.kumc.edu/hospital/huntingtons/

Caring for People with Huntington's Disease Huntington's Disease is an inherited degenerative neuropsychiatric disorder which affects both body and mind. Symptoms most commonly begin between the ages of 35 and 50, although onset may occur any time from childhood to old age. Research is progressing rapidly, but there is currently no cure. Huntington's disease is inherited in an autosommal dominant fashion. Each child of an affected parent has a 50 % chance of inheriting the disease and is said to be at risk . The discovery of the HD gene in 1993 has made it possible to test at-risk individuals for Huntington's disease before symptoms occur. In the absence of a cure, however, the decision to be tested or not remains a difficult one, and there are many important legal, financial and personal considerations. For more information about the genetic basis of Huntington's disease, you may wish to visit the Online Mendellian Inheritance in Man (OMIN) to learn about the genetic basis or the DNA library at the National Library of Medicine to see the actual gene sequence. The clinical features of Huntington's disease can be thought of as a triad of emotional, cognitive and motor disturbances. Symptoms include chorea (dance-like involuntary movements), clumsiness, slurred speech, depression, irritability and apathy. Cognitive losses include intellectual speed, attention and short-term memory.

40. Huntington's Disease - Neurologychannel Introduction to Huntington's disease, and an ask a doctor forum. http://www.neurologychannel.com/huntingtons/

Home Search SiteMap Ask the Dr. ... Medical Store HUNTINGTON'S DISEASE Overview Symptoms Diagnosis Treatment ... Find a Neurologist CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo DIAGNOSTIC TESTS CT Scan MRI Scan TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES Clinical Trials Glossary Links MDLocator ... What Is a Neurologist? Videos FOR DOCTORS ONLY Website Services Get Listed in MDLocator CME ABOUT US Healthcommunities.com Testimonials print this email this Overview Huntington’s disease (HD) is a fatal hereditary disease that destroys neurons in areas of the brain involved in the emotions, intellect, and movement. The course of Huntington’s is characterized by jerking uncontrollable movement of the limbs, trunk, and face (chorea); progressive loss of mental abilities; and the development of psychiatric problems. Huntington’s disease progresses without remission over 10 to 25 years and patients ultimately are unable to care for themselves. Huntington’s disease usually appears in middle age (30-50 years), but can develop in younger and older people.

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