41. Graft Vs. Host Disease: Pediatric Bone Marrow Tranplant Program graft vs. host disease (GVHD) is a complication that may occur during the posttransplant period in children who receive marrow stem cells from other http://www.pediatrics.medschool.ucsf.edu/bmt/bmt/process/gvhd.htm

Pediatric Bone Marrow Transplant Program BMT Home The BMT Transplant Process The Donor ... Next (Discharge) Graft Vs. Host Disease (GVHD) Graft vs. host disease ( GVHD T lymphocytes ) are infused (via a blood or platelet transfusion or a bone marrow transplant) into the recipient (i.e., the host) who has received conditioning therapy. Blood and platelets are irradiated to prevent GVHD, but the donor graft cannot be treated this way since irradiation would also kill the normal bone marrow stem cells. Types and manifestations of GVHD GVHD can take two forms, acute and chronic Prevention and treatment of GVHD There are several medications that are used to help reduce the occurrence and severity of GVHD as well as to treat it when it does occur. Two drugs that are used frequently to help minimize the reaction are methotrexate and cyclosporin A . These drugs may be given singly or in combination depending upon the type of transplant and the disease. Like all drugs, these medications may have side effects including kidney and liver injury. Drugs which may be used to treat a reaction once it occurs include steroids (prednisone or methylprednisilone), cyclosporin A (if not already being administered), and anti-thymocyte globulin (ATG). In addition, there are several experimental drugs which may be offered if these standard therapies are ineffective. In a mismatched bone marrow stem cell transplant

42. Log In Problems graftvs-host disease (GVHD), a common complication of allogeneic bone marrow transplantation, also may be seen after solid organ transplantation and in http://www.medscape.com/viewarticle/452197

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43. Log In Problems graftvs-host disease. GVHD is a significant posttransplantation complication that occurs in about 50% of allogeneic transplants. While most cases are mild, http://www.medscape.com/viewarticle/417694_2

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44. Graft-vs-Host Disease After Solid Organ Transplant : Key Words, graftvs-host disease; Solid organ; Transplant; Chimerism transplant recipients with a histologic diagnosis of graft-vs-host disease (GVHD). http://www.ajcp.com/previews/abstracts/202247.html

Anatomic Pathology / Original Article Graft-vs-Host Disease After Solid Organ Transplant H. Evin Gulbahce, MD, Charlotte A. Brown, PhD, FACMG, Myra Wick, PhD, Miriam Segall, PhD, and Jose Jessurun, MD Key Words: Graft-vs-host disease; Solid organ; Transplant; Chimerism DOI: 10.1309/395BX683QFN6CJBC Abstract DOI: 10.1309/395BX683QFN6CJBC We value your input... If you have something to say regarding this article or ajcp.com in general, share it with us. If you would like to give us feedback on the Web site in general or make corrections to this article, click on Feedback below. To write correspondence to the editor regarding this article, please click on Comment below. Thank you. April 2003 Articles TOC Feedback Comment American Society for Clinical Pathology 2100 West Harrison Street Chicago, Illinois 60612 Last Modified: September 7, 2005

45. Gastric Bleeding Due To Graft-vs-Host Disease : Discrepancy Between Endoscopic A Key Words, graftvs- host disease; GVHD; Stomach; Endoscopy; Transplantation Gastric bleeding due to graft-vs-host-disease (GVHD) is rare after http://www.ajcp.com/previews/abstracts/204180.html

Anatomic Pathology / Original Article Gastric Bleeding Due to Graft-vs-Host Disease Discrepancy Between Endoscopic and Histologic Assessment Su-Peng Yeh, MD, Yu-Mine Liao, MD, Chang-Hu Hsu, MD, Chi-Long Chen, MD, Ying-Chun Shen, MD, Chung-Tsen Hsueh, MD, PhD, Hsin-Hui Huang, MD, and Chang-Fang Chiu, MD, PhD Key Words: Graft-vs- host disease; GVHD; Stomach; Endoscopy; Transplantation DOI: 10.1309/23DAL9F6P74XWJHL Abstract DOI: 10.1309/23DAL9F6P74XWJHL We value your input... If you have something to say regarding this article or ajcp.com in general, share it with us. If you would like to give us feedback on the Web site in general or make corrections to this article, click on Feedback below. To write correspondence to the editor regarding this article, please click on Comment below. Thank you. December 2004 Articles TOC Feedback Comment American Society for Clinical Pathology 2100 West Harrison Street Chicago, Illinois 60612 Last Modified: September 7, 2005

46. T-Cells Can Help Fight Graft-vs-Host Disease graftvs-host disease is like a whole-body immune response against the marrow These same cells can prevent graft-vs-host disease, but bone marrow http://healthlink.mcw.edu/article/1031002401.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Cancer Transplants/Organ Donations Immune Disorders By keywords: bone marrow transplantation graft vs. host disease T-Lymphocytes Receive Health Link via email! Subscribe now >> T-Cells Can Help Fight Graft-vs-Host Disease Patients given bone marrow transplants to treat cancers of the blood, such as leukemia and lymphoma, or to treat congenital immune deficiency diseases and aplastic anemia, are often afflicted with a debilitating and sometimes lethal immune response known as graft-vs-host disease. In this condition, while some cells in donor bone marrow go to work to defeat disease, others actually attack - to a devastating effect - the body of the recipient, or host. Led by Robert L. Truitt, PhD , Professor of Pediatrics, researchers at the Medical College of Wisconsin MACC Fund Research Center have identified a type of T-lymphocyte (one kind of white blood cell) that turns off immune responses. They are working on a method of using these "regulatory T-cells" to prevent graft-vs-host disease in cancer and other diseases. "Normally," said Dr. Truitt, "when you transplant an organ like a kidney or lung, you have to suppress the immune response of the recipient to tissue antigens on the grafted organ to prevent rejection. When you do a bone marrow transplant, it's just the opposite. Lymphocytes in the donor bone marrow react against the host. You're actually transplanting cells from the donor's immune system, and these cells may actually 'reject' the body they are put into.

47. Graft-vs-Host Disease: Nutrition Therapy In A Challenging Condition -- Roberts A graftvs-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Both acute and chronic forms of GVHD are http://ncp.aspenjournals.org/cgi/content/abstract/20/4/440

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager PubMed Articles by Roberts, S. Articles by Thompson, J. Nutrition in Clinical Practice , Vol. 20, No. 4, 440-450 American Society for Parenteral and Enteral Nutrition Clinical Observations Graft- vs -Host Disease: Nutrition Therapy in a Challenging Condition Susan Roberts, MS, RD, LD, CNSD and Jennifer Thompson, RD, LD, CNSD Baylor University Medical Center, Dallas, Texas Correspondence: Susan Roberts, MS, RD, LD, CNSD, Baylor University Medical Center Nutrition Services, 3500 Gaston Avenue, Dallas, TX 75246. Electronic mail may be sent to Graft- vs -host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Both acute and chronic forms of GVHD are challenging to manage medically and nutritionally. Patients with advanced GVHD commonly become depleted nutritionally

48. Blood And Tissue Resources Program At Wadsworth Center, New York State Departmen Posttransfusion graft-vs-host disease (GVHD) is a serious risk for certain severely immunosuppressed or immunodeficient patients. http://www.wadsworth.org/labcert/blood_tissue/irradiate.htm

Navigate Wadsworth Center Blood and Tissue Resources Program Guidelines For Irradiation of Blood and Blood Components New York State Council on Human Blood and Transfusion Services New York State Department of Health Wadsworth Center Empire State Plaza - P.O. Box 509 Albany, New York 12201-0509 Committee Members Guidelines (.pdf - 115KB) Second Edition Introduction Recommendations Requirements Pertinent Literature ... Committee Members INTRODUCTION Post-transfusion graft-vs-host disease (GVHD) is a serious risk for certain severely immunosuppressed or immunodeficient patients. Cellular components and fresh plasma for at-risk patients should be irradiated with a minimum of 2,500 cGy prior to transfusion. Medical evidence suggests that irradiation is not necessary for plasma components that have been frozen, such as fresh frozen plasma (FFP) and cryoprecipitate. GVHD has been reported in immunocompetent recipients who have received HLAmatched components or blood from an individual with a similar HLA haplotype, such as a close relative. Scientific evidence suggests that donor lymphocytes of similar HLA type are not perceived as foreign and therefore not destroyed by the recipient's immune system. Leukoreduction does not adequately reduce the risk of GVHD. Acute transfusion-associated GVHD is caused by engrafted donor lymphocytes that produce an almost invariably fatal syndrome, usually including dermatitis, high fever, hepatitis, severe gastrointestinal symptoms, and panmarrow suppression however, all of these conditions may have various other causes in such patients. The symptoms arise within four to 30 days after transfusion, and death usually ensues within the first month after symptoms. The disease cannot be treated effectively. Occasionally, chronic GVHD may appear some 100 days after transfusion, producing a scleroderma-like syndrome.

49. Graft-vs.-host Disease Blood transfusion graftvs.-host disease affects mostly the blood. Bone marrow graft-vs.-host disease comes in an acute and a chronic form. http://www.lifesteps.com/gm/Atoz/ency/graft-vs-host_disease.jsp

50. Graft-vs.-host Disease URL http//www.lifesteps.com/gm/Atoz/ency/graftvs-host_disease.jsp Blood transfusion graft-vs.-host disease affects mostly the blood. http://www.lifesteps.com/gm/Atoz/ency/graft-vs-host_disease_pr.jsp

51. Targeting The Signaling Molecule, LAT, For Preventing Graft-vs.-host Disease Targeting the signaling molecule, LAT, for preventing graftvs.-host disease graft versus-host disease (GVHD) remains one of the major complications http://www.surgery.wisc.edu/transplant/research/grant_mmh_lrf.shtml

"Targeting the signaling molecule, LAT, for preventing graft-vs.-host disease " Funding: Funding: Leukemia Research Foundation Principal Investigator: Majed M. Hamawy, PhD Lab Website: (Lab website not available at this time) Project Summary: Administration Maps Affiliated Hospitals Med Student Information ... University of Wisconsin Department of Surgery First published: 07/15/02 Last updated: 09/21/05 webmaster@surgery.wisc.edu

52. Graft-vs.-host Disease -- Woo Et Al. 8 (2): 201 -- Critical Reviews In Oral Biol graftvs.-host disease. SB Woo, SJ Lee and MM Schubert graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to http://crobm.iadrjournals.org/cgi/content/abstract/8/2/201

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text (PDF) Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager PubMed Articles by Woo, S. B. Articles by Schubert, M. M. ARTICLES Graft-vs.-host disease S. B. Woo, S. J. Lee and M. M. Schubert Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Bone marrow transplantation (BMT) is the treatment of choice for many leukemias, lymphomas, bone marrow failure syndromes, and immunodeficiency disorders, and is the primary and salvage therapy for many solid malignancies. With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing frequency. Graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to 70% of patients despite GVHD prophylaxis, with the skin, gastro-intestinal tract, and liver as primary target organs. Oral findings are seen in both acute and chronic GVHD. In

53. Graft-Vs.-Host Disease Elicits Expression Of Class I And Class II Histocompatibi graftvs.-host disease Elicits Expression of Class I and Class II Cerebral involvement in graft-versus-host disease after murine bone marrow http://www.pnas.org/cgi/content/abstract/84/7/2082

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My File Cabinet ... Cited by other online articles PubMed PubMed Citation Articles by Hickey, W. F. Articles by Kimura, H. April 1, 1987 Graft-Vs.-Host Disease Elicits Expression of Class I and Class II Histocompatibility Antigens and the Presence of Scattered T Lymphocytes in Rat Central Nervous System William F. Hickey and Hiromitsu Kimura In the central nervous system (CNS) of healthy animals, T lymphocytes and cellular expression of major histocompatibility complex (MHC) gene products are virtually undetectable. Yet, in CNS immunological diseases, such as multiple sclerosis in humans, these constituents of the immune response must appear by some mechanism. Immunohistochemical examination of the CNS of F hybrid rats following induction of graft-vs.-host disease by parental lymphocytes revealed extensive parenchymal and vascular expression of host class I and II (Ia) MHC-encoded cell surface molecules. In addition, occasional scattered T lymphocytes were detected in the CNS of these animals. F hybrid rats reconstituted during the neonatal period with bone marrow cells from one parental strain also expressed increased levels of MHC antigens in the CNS. Thus, evidence is presented that the ``immunological privilege'' of the CNS seems to decrease or disappear during a strong systemic immune response such as graft-vs.-host disease. These findings may have important implications concerning the mechanism of induction of human CNS immunological diseases.

54. JAMA -- Abstract: Treatment Of Steroid-resistant Acute Graft-vs-host Disease By Treatment of steroidresistant acute graft-vs-host disease by in vivo administration of an anti-T-cell ricin A chain immunotoxin. NA Kernan, V. Byers, http://jama.ama-assn.org/cgi/content/abstract/259/21/3154

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 259 No. 21, June 3, 1988 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Kernan NA O'Reilly RJ Articles that cite this article Contact me when this article is cited Treatment of steroid-resistant acute graft-vs-host disease by in vivo administration of an anti-T-cell ricin A chain immunotoxin N. A. Kernan, V. Byers, P. J. Scannon, R. P. Mischak, J. Brochstein, N. Flomenberg, B. Dupont and R. J. O'Reilly Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021. The A chain of the toxin ricin has been conjugated by a disulfide bond to a murine monoclonal antibody that recognizes the CD5 (T,p67) antigen present on 95% of peripheral blood T lymphocytes. This immunotoxin was used to

55. Diseases Similar To Scleroderma (EF, EMS, Scleromyxedema ) Chronic graftvs-host disease is the major complication after bone marrow transplantation and mimics some autoimmune diseases, such as scleroderma, http://www.sclero.org/medical/symptoms/associated/similar/a-to-z.html

www.sclero.org So you'd like to learn more about scleroderma? an Amazon guide by Shelley Ensz, ISN President Our site menu requires pop-ups and javascript enabled. About the ISN Join/Donate Languages Medical Scleroderma Experts Symptoms Newsroom Message Board Support Stories Support Groups SWA Sites to Surf!

56. Fasciitis In Chronic Graft-versus-Host Disease: A Clinicopathologic Study Of 14 Sclerodermatous graftvs-host disease Clinical and Pathological Study of 17 Patients Arch Dermatol, July 1, 2002; 138(7) 924 - 934. http://www.annals.org/cgi/content/abstract/120/12/993

Search Annals: Advanced search Home Current Issue Past Issues ... ACP Online Article Table of Contents Full Text of this article Figures/Tables List Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Janin, A. Gluckman, E. Related Articles in PubMed PubMed Citation ... PubMed ARTICLE Fasciitis in Chronic Graft-versus-Host Disease A Clinicopathologic Study of 14 Cases Anne Janin Gerard Socie Agnes Devergie Selim Aractingi ... Eliane Gluckman Objective: To describe the clinicopathologic features of fasciitis in patients with chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation from human leukocyte antigen (HLA)-identical donors. Design: A retrospective cohort study. Setting: Tertiary care center. Patients: Patients who had allogeneic bone marrow transplantation and developed chronic GVHD with clinical and pathologic signs of fasciitis. Main Outcome Measure: Analysis of clinical presentations and of deep cutaneo-muscular biopsy specimens.

57. Graft Versus Host Disease - Pathophysiology & Management Pathophysiologic mechanism of acute graftvs.-host disease. Biology of Blood and Bone Marrow Transplantation. 1999;(5)347-356. http://www.dcmsonline.org/jax-medicine/2000journals/nov2000/graft.htm

Graft Versus Host Disease Introduction First described in irradiated mice infused with donor cells in the 1950's, graft versus host disease has been the bane of scientists' existence from the beginning of allogeneic bone marrow transplantation (BMT). The presence of immunocompetent donor cells in an immunocompromised host may cause a number of symptoms and cellular changes often leading to acute or chronic rejection, termed Graft Versus Host Disease (GvHD). In the intervening years, as our understanding of the immune system has progressed, so has our ability to control, or limit the process of GvHD. As well, over the last 50 years, we have unearthed a beneficial phenomenon termed "Graft versus Tumor" (GvT), a consequence of GvHD that may lead us down new paths of cancer therapy. GvHD Billingham in 1966 proposed the requirements under which GvHD can occur, later summarized by Ferrara and Deeg: `the graft must contain immunologically competent cells, the recipient must express tissue antigens that are not present in the transplant donor, and the recipient must be incapable of mounting an effective response to destroy the transplanted cells.' Today we know that the mediators of GvHD are T cells, human leukocyte antigens (HLAs) in the host, and the host being typically immunocompromised either chemically or physiologically (as in the case of neonates). While there are cases of GvH-like syndromes in autologous and syngeneic transplants, these are typically mild.

58. Florida State University College Of Medicine Digital Library Miscellaneous graft vs. host disease Patient/Family Resources Additional graft Versus host disease resources (These sites have not been reviewed. http://fsumed-dl.slis.ua.edu/patientinfo/dermatology/immunedisorders/grafthostdi

Patient/Family Resources by Topic: Hematology Graft vs. Host Disease Patient/Family Resources Spanish Miscellaneous See also: General Hematology Patient/Family Resources Graft vs. Host Disease Clinical Resources MedlinePlus Medical Encyclopedia: Table of contents Graft-versus-Host Disease: English Spanish Spanish MedlinePlus Medical Encyclopedia: Table of contents Graft-versus-Host Disease: English Spanish Miscellaneous Graft vs. Host Disease Patient/Family Resources YAHOO - Health:Diseases and Conditions:Graft Versus Host Disease Additional Graft Versus Host Disease resources ( These sites have not been reviewed. YAHOO - Health:Medicine:Hematology Additional Hematology resources ( These sites have not been reviewed. Medical Library Florida State University College of Medicine Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

59. Studies For Prevention And Treatment Of Graft Vs. Host Disease After Allogeneic Keywords graft vs. host disease, prevention, treatment My research has focused on supportive care issues in hematopoietic stem cell transplantation and http://research.medicine.wustl.edu/ocfr/Research.nsf/s/6716B585098797AC8625677D0

Studies for Prevention and Treatment of Graft vs. Host Disease after Allogeneic Hematopoeitic Stem Cell Transplantation Hanna Khoury, M.D. DEPARTMENT OF Internal Medicine Keywords: graft vs. host disease, prevention, treatment Faculty Research by Subject: Aging Biochemistry and Biophysics Bone/Joint Health and Disease Cancer Cell Biology and Regulation Child Health Clinical Sciences Diabetes and Endocrinology Gastrointestinal Diseases Genetics and Genome Analysis Health Care Services and Policy Heart and Vascular Disease Imaging Immunology and Inflammation Infectious Diseases Kidney Disease Lung Disease Neuroscience Pharmacology Psychiatry and Behavioral Medicine Visual Sciences Faculty Research by Department: Anesthesiology Biostatistics Genetics Health Administration Internal Medicine Molecular Microbiology Neurological Surgery Neurology Occupational Therapy Orthopaedic Surgery Otolaryngology Pediatrics Physical Therapy Psychiatry Radiation Oncology Radiology Surgery Faculty Research by Name: A B C D ... Z

60. Immunologic Diseases - NIAID Net News Articles targeted at the general public on allergy and asthma, graftvs-host diseases, immune deficiency diseases and autoimmune diseases. Also contains information on how the immune system works. http://www.niaid.nih.gov/final/immds/immds.htm

50 YEARS NIAID HOMEPAGE INFECTIOUS DISEASES IMMUNOLOGIC DISEASES AIDS ... NIH HOMEPAGE T he immune system is a complex network of specialized cells and organs. When it malfunctions, it can cause a wide array of problems. Scientists are making great strides in detecting, treating, and preventing disorders of the immune system. T Cell The healthy T cell is one type of immune system cell. How does the immune system work? Allergy and Asthma Usually harmless substances can provoke inappropriate immune responses. Graft-vs-Host Disease Transplantation of tissues and organs can cause life-threatening reactions in recipients. Immune Deficiency Diseases These diseases can be inherited or result from infections or drug treatments. Autoimmune Diseases The immune system mistakenly attacks the body. Looking Ahead Gene therapy and improved transplant procedures.

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