1. Immunologic Diseases Graft Vs Host Disease transplanted immune cells can attack the tissues of the recipient, a potentially lifethreatening reaction called graft-vs-host disease. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

2. Graft Vs Host Disease Graft vs. Host Disease (GVHD) a frequent complication of allogeneic bone marrow transplant in which the engrafted donor cells attacks the patient s organs http://www.lymphomation.org/bmt-gvhd.htm

ask question or sign Guest Book About Lymphoma Advocacy Art Clinical trials ... WebCasts Graft vs Host Disease Main Allogeneic Autologous Cord Blood ... Treatments Last update: PubMed TOPIC SEARCH : Donor CD4+CD25 Regulatory T-cells Approaches Novel Resources ... Research News Graft vs. Host Disease (GVHD) a frequent complication of allogeneic bone marrow transplant in which the engrafted donor cells attacks the patient's organs and tissue. GVHD tends to be more severe in patients receiving mismatched transplants from family member or unrelated donors. GVHD is two diseases: acute GVHD and chronic GVHD. "Patients may develop one, both or neither. Acute and chronic GVHD differ in their symptoms, clinical signs and time of onset." Acute GVHD usually occurs during the first three months following an allogeneic BMT. "T-cells present in the donor's bone marrow at the time of transplant identify the BMT patient as "non-self' and attack the patient's skin, liver, stomach, and/or intestines. The earliest sign of acute GVHD is often a skin rash that usually first appears on the patient's hands and feet." - medicalistes.org

3. Improved Management Of Graft-Versus-Host-Disease GVHD Goker H, Haznedaroglu IC, Chao NJ. Acute graftvs-host disease pathobiology and management. Exp Hematol. 2001; http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Herpes Labialis (oral Herpes Simplex) Injury. Disease. Nutrition. Poison. Symptoms. Surgery Test. Special Topic. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Graft-vs.-host Disease a CHORUS notecard document about graftvs.-host disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. The Molecular Basis Of Salivary Gland Involvement In The Molecular Basis of Salivary Gland Involvement in Graftvs.-Host Disease R.M. Nagler1 * , and A. Nagler2 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Arch Dermatol Abstract Cutaneous Graft-versus-Host Disease Sclerodermatous Graftvs-Host Disease Clinical and Pathological Study of 17 Patients Penas et al. Arch Dermatol 2002;138924-934. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. Arch Dermatol Abstract Sclerodermatous Graft-vs-Host Disease . Topic Collection Alerts Sclerodermatous Graftvs-Host Disease Clinical and Pathological Study of 17 Patients Pablo F. Pe as, MD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Idiopathic Pneumonia Syndrome In Mice After Allogeneic Bone Marrow Results. Top Abstract Introduction Materials Methods Results Discussion References Induction of Murine Graftversus-Host Disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Target Antigens Determine Graft-versus-Host Disease Phenotype Similarly, graftvs-host disease (GVHD) is distinct in inbred murine donorrecipient pairings, indicating a genetic component to disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Graft-vs.-host Disease Graftvs.-host disease Definition. Graft-vs.-host disease is an immune attack on the recipient by cells from a donor. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. CCHS Clinical Digital Library Graft vs. Host Disease (Keyword search) List of documents Immune System Diseases Trials Table of contents. graft vs host disease List of documents http://cchs-dl.slis.ua.edu/clinical/dermatology/immunedisorders/grafthostdisease

Clinical Resources by Topic: Hematology Graft vs. Host Disease Clinical Resources Pediatrics Atlases Radiology Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Graft vs. Host Disease Patient/Family Resources Harrison's Principles of Internal Medicine 16th Ed.-2005: Table of contents Health Sciences Library subscription INFO Chapter 99. Transfusion Biology and Therapy: Table of contents Adverse Reactions to Blood Transfusion: Access document Hoffman: Hematology: Basic Principles and Practice 4th Ed.-2005 (MD Consult): Table of contents Health Sciences Library subscription INFO Part VII - Transplantation: Access document Chapter 100 - Graft-versus-Host Disease And Graft-Versus-Leukemia Effect: Access document Introduction: Access document Graft-Versus-Host Disease: Access document Graft-Versus-Leukemia Effect: Access document Summary: Access document References: Access document References: Access document Chapter 101 - Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host-Disease, and Provide a Graft-versus-Tumor Effect: Access document Introduction: Access document Graft-versus-Host-Disease: Access document Graft-versus-Leukemia Responses: Access document Blood versus Marrow as the Graft Source: Access document Target T Lymphocyte Dose: Access document Methods for T-Cell Depletion: Access document Clinical Results from Phenotypic Depletions: Access document Functional Depletions: Access document Evaluation of Allografts Ex Vivo: Access document Engineering Antitumor Responses: Access document Summary and Future Directions:

13. Clinical Trial: Extracorporeal Photopheresis To Treat Chronic Graft-Versus-Host Condition, Intervention, Phase. graft vs host disease, Procedure Extracorporeal Photopheresis, Phase II MedlinePlus related topics Immune System and http://www.clinicaltrials.gov/ct/gui/show/NCT00048789

Home Search Browse Resources ... About Extracorporeal Photopheresis to Treat Chronic Graft-Versus-Host Disease This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center (CC) May 31, 2005 Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This study will examine the safety and effectiveness of extracorporeal photopheresis (ECP) for treating chronic graft-versus-host disease (GvHD). GvHD is a common complication of stem cell transplantation using donated stem cells. It occurs when the donor's T-lymphocytes (a type of immune cell) see the patient's cells as foreign and mount an immune response to reject them. The attack can cause skin rash, mouth sores, liver or lung inflammation, lack of appetite, and muscle stiffness. Chronic GvHD can cause serious illness, and even death, from the long-term effects of immune dysfunction and from toxic effects of medications (such as cyclosporine and prednisone) used to treat it. ECP is an experimental treatment designed to stop the lymphocytes from attacking the body. It involves collecting some of the cells that cause GvHD, treating them with a combination of drug and light therapy and returning them to the body. Sixty to 80 percent of patients with chronic GvHD improve with ECP treatment, and some patients can stop treatment with prednisone or cyclosporine, or reduce the drug dosages.

14. Graft Vs Host Disease graft vs host disease Medical.WebEnds.com. graft vs host disease. GraftVersus-Host Disease; Homologous Wasting Disease; Runt Disease; Graft-vs-Host http://medical.webends.com/kw/Graft vs Host Disease

Medical.WebEnds.com - Medical Terminology Dictionary A B C D ... Z WWW Medical.WebEnds.com Graft vs Host Disease Graft-Versus-Host Disease; Homologous Wasting Disease; Runt Disease; Graft-vs-Host Disease; Disease, Graft-Versus-Host; Disease, Graft-vs-Host; Disease, Homologous Wasting; Disease, Runt; Diseases, Graft-Versus-Host The clinical entity characterized by anorexia diarrhea , loss of hair , leukopenia, thrombocytopenia , growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION Google links Processing time was 0.017534971237183 seconds.

15. Genomics|HuGENet|e-Journal|Graft Vs Host Disease The mission of the Office of Genomics and Disease Prevention is to integrate advances in human genetics into public health research, policy, and programs. http://www.cdc.gov/genomics/hugenet/ejournal/GraftVsHost.htm

home e-journal graft-versus-host disease Archived: 5/6/2004 Relation of an Interleukin-10 Promoter Polymorphism to Graft-versus-Host Disease and Survival after Hematopoietic-Cell Transplantation ejournal abstract template on Lin M, et al. May 6, 2004 Access past issues Reviewed by: Jennifer Kuzara Emory University Department of Anthropology; Rollins School of Public Health Department of Epidemiology The Health Outcome Graft versus Host Disease (GVHD) is a condition that can result from hematopoietic cell transplant (HCT). It affects a large percentage of individuals who receive HCT; the chronic form occurs in 50% of HLA-matched sibling transplants, and in 64% of patients whose donors were HLA-unmatched. Frequency of the acute form varies widely according to other risk factors such as age and underlying illness: from 19% to 66% in HLA-matched transplant patients, and 70% to 90% of HLA-unmatched transplants patients ( The effects of donor-T-cell alloresponse can take both acute and chronic forms. The acute form occurs within 30 days of transplant. The symptoms are characteristic of systemic cytokine overload. The chronic form usually follows the acute form, though it can also occur de novo. It resembles an autoimmune syndrome and is generally expressed in epidermal tissues. Lin et al. propose that single-nucleotide polymorphisms in various cytokines may affect the outcome of GVHD by reducing or enhancing the inflammatory response of the recipient. Only

16. Genomics|HuGENet|e-Journal|Abstract|Graft Vs Host Disease The mission of the Office of Genomics and Disease Prevention is to integrate advances in human genetics into public health research, policy, and programs. http://www.cdc.gov/genomics/hugenet/ejournal/GraftVsHostabst.htm

home e-journal graft-versus-host disease abstract Archived: 5/6/2004 Relation of an Interleukin-10 Promoter Polymorphism to Graft-versus-Host Disease and Survival after Hematopoietic-Cell Transplantation back to report May 6, 2004 Abstraction Template Article Reference Complete the bibliographic reference for the article according to AJE format. Lin M, et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. NEJM. 2003;349:2201-2210. Category of HuGE information Specify the types of information (from the list below) available in the article: Prevalence of gene variant Gene-disease association Gene-environment interaction Gene-gene interaction Genetic test evaluation/monitoring 2. Gene-disease associations Study hypotheses or purpose The authors study hypotheses or main purpose for conducting the study Hypothesis: Polymorphisms in cytokine promoter regions that enhance or suppress cytokine expression may affect the severity of the inflammatory response involved in GVHD and associated survival. This study is meant to replicate the findings of other studies showing associations between a variety of cytokine promoter-region single-nucleotide polymorphisms and GVHD outcomes Gene(s) Identification of the following: Gene name Chromosome location Gene product/function Alleles OMIM # Gene name Chromosome location Gene product/function : Interleukin 10; anti-inflammatory cytokine, influences Th2 differentiation

17. HighWire -- Browse Journals - Graft Vs Host Disease Journals focusing on graft vs host disease (in order by highest focus). Stem Cells info free ISSUES Archives of Dermatology info http://highwire.stanford.edu/lists/topic_dir/608683/618131/626532/626708/focus.d

WELCOME TO THE NEW VERSION OF OUR SITE details About Us Contact Us Help ... Sign in for more free features or create a free account Key words: any all phrase more options... Authors: e.g. Smith, JS; Jones, D Citation: Year Vol Page Articles: HighWire-hosted only From My Favorite Journals only sign in All (including PubMed) Browse Journals publishing on Graft vs Host Disease: (return to Topic List page) Graft vs Host Disease Sort by: Alphabet Frequency of articles in Graft vs Host Disease Focus of journal on Graft vs Host Disease What's this? Journals focusing on Graft vs Host Disease (in order by highest focus) Stem Cells info free ISSUES Archives of Dermatology ... help HighWire Press is a registered trademark.

18. Pharmalicensing.com: Graft Vs Host Disease Therapeutic These blocking agents may prevent the development of graft vs host disease in addition to other autoimmune disorders. An in press publication is available http://pharmalicensing.com/licensing/displicopp/3369

Navigation Partnering Opportunities Needs Companies ... Corporate Opportunities Graft vs Host disease therapeutic King's College London - KCL Enterprises Ltd Use of a peptide to block CD40:CD154(CD40L) interactions Licensing contact Ian Hill Senior Technology Transfer Manager Request more information Development status Early Stage Mechanism of action blockade of CD40:CD154(CD40L) Industry sectors Biotechnology: Human therapeutics Pharmaceutical: Prescription Therapeutic targets Immunomodulation: Organ transplant rejection Immunomodulation: Transplant rejection Immunomodulation: Xenotransplantation Immunomodulation: Immune thrombocytopenic purpura ... Hospital and Surgery: Tissue grafting Full description Administration of blocking antibodies directed against the CD154(CD40L) molecule leads to long-term graft survival in a nonhuman primate model. Clinical trials with two humanized mouse anti-human CD154 monoclonal antibodies, hu5c8 (Biogen) and IDEC-131 (IDEC) have been suspended after the occurrence of rare thrombotic events. A problem thought to be a class effect of anti-CD154 mAbs, unrelated to their epitope specificity. Professor Lehner has demonstrated that it is possible to block the critical costimulatory pathways in monocytes or dendritic cells between CD40 and CD154(CD40L) or HSP70 by the use of a peptide blocking agents. These blocking agents may prevent the development of graft vs host disease in addition to other autoimmune disorders.

19. Penn State Faculty Research Expertise Database (FRED) , The clinical entity characterized by Graft Versus Host Disease, GraftVersus-Host Diseases. Graft-vs-Host Diseases......graft vs host disease. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D006086

20. The DAVE Project - Gastroenterology Video Capsule Endoscopy graft vs host disease, Small Intestine Prior EGD, colon, and CT suggested graft vs. host disease or GVH, and this capsule http://dave1.mgh.harvard.edu/ViewFilms.cfm?Film_id=102&View=Pathology

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