61. Genotype And Phenotype Database (GPDB) genotype and phenotype Management System (GPDB). Efficient management of genotypeand phenotype data is necessary in genetic and genomic studies for complex http://apps.sbri.org/gpdb/

Genotype and Phenotype Management System (GPDB) Efficient management of genotype and phenotype data is necessary in genetic and genomic studies for complex human diseases. Previous software for large-scale management of genotype data has its limitations, i.e., operation system (OS) dependency, limited database capacity and lacks of functions for management of phenotype data. To overcome these limitations, a web based Java application for genotype and phenotype database management system (GPDB) is developed. To try demo version of the program, you may freely register as a demo user with the system; however, the data entered by demo users are not guaranteed available in the future and are subjected loss, deletion or change without further notice. Only the users created through authority have the privilege to keep the data in a permanent database which is maintained daily and backup regularly. User Sign in User Name: Password: Last modified: 06-29-04

62. Genotype And Phenotype In Susceptibility To Coal Workers' Pneumoconiosis. The Us genotype and phenotype in susceptibility to coal workers pneumoconiosis. The useof cytokines in perspective. PJA Borm and RPF Schins http://erj.ersjournals.com/cgi/content/full/18/32_suppl/127S

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Borm, P.J.A. Articles by Schins, R.P.F. Eur Respir J 2001; 18:127S-133S ERS Journals Ltd Genotype and phenotype in susceptibility to coal workers' pneumoconiosis. The use of cytokines in perspective P.J.A. Borm and R.P.F. Schins Keywords: biomarkers, coal workers' pneumoconiosis, cytokines, genotype, phenotype Received: March 8, 2001 This work was supported by several grants including ECSC grant 7263/03. Abstract TOP Abstract Susceptibility studies: genotype Susceptibility to coal workers'... Validation of tumour necrosis... Multiple marker approach: the... Acknowledgements References The readily available technique of screening for gene polymorphisms could be used to explain inter-individual variability in a classic occupational interstitial lung disease, such as coal workers'

63. ERJ -- Sign In Page The genotypephenotype correlation is not known for many rare mutations. Mickle J, Cutting G. genotype-phenotype relationships in cystic fibrosis. http://erj.ersjournals.com/cgi/content/full/23/5/679

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a subscription to European Respiratory Journal Online. Members: Your User Name has been set to your Membership Number and your Password has been set to your last name. Have you forgotten your Membership Number Full Text Genotype/phenotype correlation of the G85E mutation in a large cohort of cystic... Decaestecker et al. Eur Respir J. This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Download to citation manager Search for citing articles in: ISI Web of Science (1) PubMed PubMed Citation Articles by Decaestecker, K. Articles by De Boeck, K. To view this item, select one of the options below: Sign In: Members: Your User Name has been set to your Customer Number and your Password has been set to your last name. Remove any zeros that precede your membership number e.g. 000123 becomes 123 User Name Sign in without cookies.

64. Embryology In Tierra: A Study Of A Genotype To Phenotype Map Embryology in Tierra A study of a genotype to phenotype map. http://journal-ci.csse.monash.edu.au/ci/vol04/eco-tierra/eco-tierra.html

ISSN 1320-0682 Volume 4 Embryology in Tierra: A study of a genotype to phenotype map Russell K. Standish ACSU, Division of Information Services The University of New South Wales Sydney 2052, Australia Email: R.Standish@unsw.edu.au URL: http://parallel.acsu.unsw.edu.au/rks Abstract: Ecolab ] is a model system of an ecology that attempts to understand evolutionary processes. It makes a particular assumption about the embryology or genotype-phenotype map in order to generate the novel ecological interaction coefficients from the novel genotypes as they arise through mutation. The Eco-Tierra project [ ] examines this assumption using Tierra ] as a model ecosystem, which has an implicitly defined embryology. Ecolab's Embryology Ecolab ] is a model system of an ecology that attempts to understand evolutionary processes. Ecolab's dynamics is taken to be a generalised form of the Lotka-Volterra equation which is, in fact, the most general analytic two-term interaction model. Here n is the population density, the component being the number of individuals of species i r is the difference between reproduction and death

65. Embryology In Tierra: A Study Of A Genotype To Phenotype Map Embryology in Tierra A study of a genotype to phenotype map It makes aparticular assumption about the embryology or genotypephenotype map in order to http://journal-ci.csse.monash.edu.au/ci/vol04/eco-tierra/

/vol04/eco-tierra/ Volume 01 Received: Accepted: Embryology in Tierra: A study of a genotype to phenotype map Russell K. Standish Abstract Ecolab [9, 7] is a model system of an ecology that attempts to understand evolutionary processes. It makes a particular assumption about the embryology or genotype-phenotype map in order to generate the novel ecological interaction coefficients from the novel genotypes as they arise through mutation. The Eco-Tierra project [7] examines this assumption using Tierra [2] as a model ecosystem, which has an implicitly defined embryology. Full Text Multimedia Links (none) Reference Links (none) Citation Reference Get viewers [CI Editor] [Site Manager]

66. Relationship Among Genotype, Biochemical Phenotype, And Cognitive Performance In The biochemical phenotype predicted from the genotype in functionally hemizygouspatients was related significantly to the assigned phenylalanine level. http://pediatrics.aappublications.org/cgi/content/abstract/104/2/258

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Koch, R. Related Collections PEDIATRICS Vol. 104 No. 2 August 1999, pp. 258-262 Relationship Among Genotype, Biochemical Phenotype, and Cognitive Performance in Females With Phenylalanine Hydroxylase Deficiency: Report From the Maternal Phenylketonuria Collaborative Study Received Jul 27, 1998; accepted Dec 21, 1998. Colleen Azen Per Guldberg Anne Romstad William B. Hanley Harvey L. Levy Reuben Matalon Bobbye M. Rouse Friedrich Trefz Felix de la Cruz and Richard Koch From the John F. Kennedy Institute, Glostrup, Denmark; Children's Hospital, Division of Medical Genetics and the University of Southern California, Los Angeles, California; Hospital for Sick Children, Toronto, Canada; Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;

67. Relationship Among Genotype, Biochemical Phenotype, And Cognitive Performance In The biochemical phenotype predicted from the genotype in functionally Two previous studies have compared genotype with biochemical phenotype and http://pediatrics.aappublications.org/cgi/content/full/104/2/258

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Koch, R. Related Collections PEDIATRICS Vol. 104 No. 2 August 1999, pp. 258-262 Relationship Among Genotype, Biochemical Phenotype, and Cognitive Performance in Females With Phenylalanine Hydroxylase Deficiency: Report From the Maternal Phenylketonuria Collaborative Study Colleen Azen, MS Per Guldberg, PhD Anne Romstad, MS William B. Hanley, MD Harvey L. Levy, MD Reuben Matalon, MD, PhD Bobbye M. Rouse, MD Friedrich Trefz, MD Felix de la Cruz, MD and Richard Koch, MD From the John F. Kennedy Institute, Glostrup, Denmark; Children's Hospital, Division of Medical Genetics and the University of Southern California, Los Angeles, California; Hospital for Sick Children, Toronto, Canada; Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;

68. Multiple Approach To The Exploration Of Genotype-Phenotype Correlations In Famil genotypephenotype Correlations in 953 Familial Adenomatous Polyposis (FAP) genotype and phenotype factors as determinants of desmoid tumours in http://www.jco.org/cgi/content/full/21/9/1698

Search for: Limit by: All Topics Original Reports Review Articles Special Articles Biology of Neoplasia Editorials Comments and Controversies Diagnosis in Oncology Art of Oncology Correspondence All Years Browse by Topic or Issue Home Search/Browse Subscriptions ... Customer Service This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Bertario, L. Articles by Radice, P. Journal of Clinical Oncology , Vol 21, Issue 9 (May), 2003: 1698-1707 American Society for Clinical Oncology Multiple Approach to the Exploration of Genotype-Phenotype Correlations in Familial Adenomatous Polyposis L. Bertario A. Russo P. Sala L. Varesco M. Giarola P. Mondini M. Pierotti P. Spinelli P. Radice for the Hereditary Colorectal Tumor Registry From the Division of Predictive and Preventive Medicine, Department of Experimental Oncology, and Endoscopy Division, National Cancer Institute; Epidemiology Unit, Local Health Authority of Milan, Milan; and Division of Experimental Oncology, National Cancer Institute, Genoa, Italy. Address reprint requests to Lucio Bertario, MD, National Cancer Institute, Via Venezian 1 20133 Milan, Italy; email:

69. Arch Neurol -- Genotype-Phenotype Correlation In Early-onset Alzheimer Disease W Neurogenetics. •, Collection Email Alerts. genotype–phenotype Correlation inEarly-onset Alzheimer Disease With Presenilin 1 Gene Mutations http://archneur.ama-assn.org/cgi/content/extract/61/5/801

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 61 No. 5, May 2004 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Larner AJ ISI Web of Science (1) Contact me when this article is cited Topic Collections Alzheimer Disease Neurogenetics Topic Collection Alerts Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. The recent description by Rippon et al of 2 brothers with early-onset Alzheimer disease associated with the M139V mutation in the presenilin 1 ( PSEN-1 ) gene raises some interesting points about genotype-phenotype correlations in this disease. Their findings concur with other recent analyses of M139V, which have noted

70. Arch Neurol -- Abstract: Mutation Analysis And The Correlation Between Genotype Mutation Analysis and the Correlation Between genotype and phenotype of Arg778LeuMutation in Chinese Patients With Wilson Disease http://archneur.ama-assn.org/cgi/content/abstract/58/6/971

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 58 No. 6, June 2001 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Wu ZY Yu L Articles that cite this article ISI Web of Science (5) ... Contact me when this article is cited Topic Collections Genetic Counseling/ Testing/ Therapy Genetics, Other Neurogenetics Topic Collection Alerts Mutation Analysis and the Correlation Between Genotype and Phenotype of Arg778Leu Mutation in Chinese Patients With Wilson Disease Zhi-Ying Wu, MD, PhD Ning Wang, MD, PhD Min-Ting Lin, MD Ling Fang, MD, PhD Shen-Xing Murong, MD Long Yu, MD, PhD Arch Neurol.

71. Artificial Life - Von Neumann's Quintessential Message: Genotype + Ribotype = Ph Von Neumann s Quintessential Message genotype + Ribotype = phenotype. Daniel Mangeand Moshe Sipper pp. 225 227 Requires Adobe Acrobat Reader Download At http://mitpress.mit.edu/catalog/item/default.asp?ttype=6&tid=101

72. Artificial Life - Radical Epistasis And The Genotype-Phenotype Relationship - Th The MIT Press online catalog contains descriptions of inprint and out-of-printbooks, current and past journals, online ordering/subscription options, http://mitpress.mit.edu/catalog/item/default.asp?ttype=6&tid=52

73. Brazilian Journal Of Medical And Biological Research - We observed a good correlation between genotype and phenotype. Discordance betweengenotype and phenotype was found in one SV patient with a mild mutation http://www.scielo.br/scielo.php?pid=S0100-879X2003001000006&script=sci_arttext

74. Cancer Prevention Projects: Glucuronidation In Humans: Genotype And Phenotype (D genotype and phenotype (DIGEST). PI Johanna Lampe PhD. DIGEST websitehttp//www.fhcrc.org/phs/digest. Research has shown that certain fruits and http://www.fhcrc.org/science/phs/cprp/projects/digest.html

@import "/wrapper/global.css"; @import "/wrapper/wrapper.css"; Glucuronidation in Humans: Genotype and Phenotype (DIGEST) PI: Johanna Lampe PhD DIGEST website: http://www.fhcrc.org/phs/digest Research has shown that certain fruits and vegetables can increase the activity of a group of enzymes (called glucuronosyltransferases or UGT for short) that help our body get rid of potentially harmful substances, including carcinogens. Genetic differences among individuals can play a role in how effectively these cancer-fighting enzymes work. The DIGEST study will look at how the interplay of genes and diet – in particular, a diet rich in certain fruits and vegetables – may affect the function of the body’s cancer-fighting enzymes. The results of this study, funded by the National Cancer Institute, could be important in making recommendations about diets that prevent cancer. About 300 people, ages 20 to 40, are sought for the first half of this two-part study. They will be asked detailed questions about diet and health. DNA from a sample of blood will be analyzed to determine genetic patterns of enzymes. Activity of these cancer-fighting enzymes will be measured by looking at the rate that the body breaks down aspirin and Tylenol. Of those initially enrolled, 60 will be asked to participate in the second part, two 14-day feeding studies during which the Hutchinson Center will provide all food and beverages. Eligibility will depend on genetic patterns of the enzymes.

75. Mutational Spectrum Of Steroid 21-hydroxylase And The Genotype-phenotype Associa A good genotype–phenotype correlation was observed, with the exception of Ile172Asnand Pro30Leu mutations. In 37% of patients low resolution genotyping http://www.eje-online.org/cgi/content/abstract/153/1/99

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: DOI: 10.1530/eje.1.01944 European Journal of Endocrinology, Vol 153, Issue 1, 99-106 This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Dolz;an, V Articles by Battelino, T CLINICAL STUDY Mutational spectrum of steroid 21-hydroxylase and the genotype-phenotype association in Middle European patients with congenital adrenal hyperplasia V Dol ;an G Fekete V Rakosnikova F Votava J Lebl Z Pribilincova SM Baumgartner-Parzer S Riedl F Waldhauser H Frisch M Stopar-Obreza C Kr ;i nik and T Battelino Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary, Department of Paediatrics, University of Szeged, Szeged, Hungary

76. The Predictive Quality Of Genotype And Phenotype Data On Virological Response To The Predictive Quality of genotype and phenotype Data on Virological Response toSalvage Therapy in HIV1 Infected Patients (CNAA2007) Resistance http://www.fda.gov/ohrms/dockets/ac/99/slides/3541s1l/

The Predictive Quality of Genotype and Phenotype Data on Virological Response to Salvage Therapy in HIV-1 Infected Patients (CNAA2007)Resistance Collaborative Group Reanalysis Click here to start Table of Contents The Predictive Quality of Genotype and Phenotype Data on Virological Response to Salvage Therapy in HIV-1 Infected Patients (CNAA2007)Resistance Collaborative Group Reanalysis Background Information Methods Baseline Characteristics of Study Population ... Phenotypic Multivariate Analysis:Odds Ratio of Virological FailureClass Phenotypic Sensitivities Author: Jeff Booker, VisCom Inc.

77. Drug Discovery@nature.com From genotype to phenotype a shortcut through the library A new methodprovides a shortcut on this path from genotype to phenotype — it uses a http://www.nature.com/drugdisc/res_high/articles/nrg1650.html

nature.com about npg news@nature.com naturejobs ... register SEARCH Wednesday 21 September 2005 Home News Archive Research highlights ... About this site Resources Nature Reviews Drug Discovery Nature Nature Biotechnology Nature Chemical Biology ... Molecular Psychiatry Bioinformatics: From genotype to phenotype: a shortcut through the library from Nature Reviews Genetics 10 June 2005 Louisa Flintoft In the new study, this annotation stage was avoided by directly linking species with phenotypic information already available in the published literature. The authors linked 92 completely sequenced prokaryotic species with 172,967 nouns in MEDLINE abstracts (from the database compiled by the US National Library of Medicine). The nouns were grouped according to the species they matched up with, assuming that words that relate more frequently to a particular set of species are likely to be specific to a shared trait. For the same species, 11,026 orthologous gene sets were identified from the STRING (search tool for the retrieval of interacting genes/proteins) database, defining shared sets of genes. Many of the other associations made in this study also linked genes to disease-related phenotypes, which could provide a valuable source of new drug targets. This skew towards clinically relevant phenotypes reflects the fact that pathogens are highly represented among fully sequenced prokaryotes, but as more sequences and more MEDLINE entries become available, this method should provide a way to link genes to a wide range of biological processes.

78. Accessing Article The phenotype and genotype of converted blackpigmented clones was stable.These results demonstrate a permanent and stable gene correction by the RNA-DNA http://www.nature.com/nbt/journal/v16/n13/full/nbt1298_1343.html

NATURE.COM NEWS@NATURE.COM NATUREJOBS NATUREEVENTS ... Help E-MAIL: PASSWORD: Save password Forgotten password? Most users gain access to full text articles through a site license. This is available to institutional customers only. For further information visit the Librarian Gateway. Full-text articles are also available through a number of other options: I want to purchase this article Select this option to view this article immediately and access it for seven days. Price: US$30* In order to purchase this article you must be a registered user. Click here to register or log in above. I want to subscribe to Nature Biotechnology Select this option to purchase a personal subscription. I am already a personal subscriber to Nature Biotechnology Personal subscribers to Nature Biotechnology can view this article. To do this you need to associate your subscription with your registration via the My Account page. If you already have an active online subscription, log in via the login box in the top right-hand corner of this page. You can request the document from a number of document delivery services: British Library Document Supply Centre CISTI Canadian Institute for Scientific and Technical Information Infotrieve Thomson ISI Document Delivery You can also request the document from your local library through interlibrary loan services.

79. Test Information - Genotype-Phenotype Discordances The central dogma of biology can be restated to mean genotype determines phenotype. Yet physicians who order both genotype and phenotype tests often get http://www.hivresistanceweb.com/protected/testinfo/02sep/rws-02sep23-ti-genophen

Up-to-date information concerning HIV drug resistance assay development and access, regulatory status, reimbursement and related issues Genotype-Phenotype Discordances Written by Robert W. Shafer, M.D. published on HIVresistanceWeb: September 27, 2002 Drug resistance can be measured using either genotypic or phenotypic assays. Genotypic assays detect mutations that cause drug resistance. Phenotypic assays are drug susceptibility assays in which a fixed inoculum of HIV-1 is cultured in the presence of serial dilutions of an inhibitory drug. The central dogma of biology can be restated to mean "genotype determines phenotype." Yet physicians who order both genotype and phenotype tests often get back interpretations that appear to be discordant. In this article, I will review the six causes for these discordances: (i) genotypic mixtures; (ii) transitional mutations; (iii) antagonistic mutations; (iv) the effect of thymidine analog mutations on ddI, d4T, and tenofovir susceptibility; (v) atypical mutations; and (vi) complex patterns of mutations. Genotypic mixtures HIV-1 is a quasispecies containing innumerable variants related to the original infecting strain. About 1% of all nucleotide positions in the RT and protease isolates from persons receiving antiretroviral therapy have detectable mixtures by population-based sequencing [

80. HIVresistanceWeb – From The Podium – Update From Barcelona On The Utility Of R Initial studies compared one technology (genotype or phenotype) with no test At 24 weeks, the proportions of subjects in the genotype and phenotype arms http://www.hivresistanceweb.com/protected/podium/02aug/mr-02aug-ftp-assays1.shtm

Update From Barcelona on the Utility of Resistance Testing in Clinical Practice Written by Michelle E. Roland, M.D. Published on HIVresistanceWeb: August 1, 2002 As we reported in May, the results of six prospective, randomized studies that evaluated short-term virologic responses in subjects receiving a genotypic or phenotypic resistance test - compared to those who did not receive a resistance test - have been published ( see related article ). Initial studies compared one technology (genotype or phenotype) with no test in order to assess the clinical utility of resistance testing in general. The second round of studies compared the two testing strategies with each other. The contribution of expert advise to improved virologic outcomes has also been evaluated. Ongoing studies are comparing different interpretation approaches for genotype testing, including different rules-based algorithms and comparative database systems (e.g., Virtual Phenotype TM ); results of these studies have yet to be published. Five studies presented at the XIV International AIDS Conference in Barcelona address similar or related questions - questions that are important for understanding the utility and limitations of resistance testing in clinical practice. In addition to determining the clinical utility of these tests with regard to short-term virologic responses, it is important to address the longer-term clinical utility of resistance testing, and how well different interpretation systems work. New findings regarding this latter issue are discussed in a separate article, entitled "

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