21. Breast Cancer Genetics Network Of Michigan Book/CD-ROM Understanding cancer genetics CDROM (English only) $50.00 US. Understandingcancer genetics Book and CD-ROM Package (English only) $100.00 US http://www.mi-cancergenetics.org/purchase.html

Book (English or Spanish) $75.00 US CD-ROM (English only) $50.00 US Book and CD-ROM Package (English only) $100.00 US Download the Understanding Cancer and Genetics Order Form (12K Adobe PDF) Need Help? Download orderform.pdf by clicking the link above. Open orderform.pdf using Acrobat Reader ( free from Adobe Print the order form by selecting F P rint... from the Acrobat Reader menu. Fill out all applicable information on the order form. Mail your completed order form with payment (check payable to The Regents of the University of Michigan) to: Sofia D. Merajver, MD, PhD 1500 E. Medical Center Drive 7217 CCGC, 0948 Ann Arbor MI 48109-0948 Still having problems? Print the HTML order form using your Web browser, and follow steps 4 and 5 above. BREAST CANCER GENETICS NETWORK OF MICHIGAN 7217 CCGC, Box 0948 1500 East Medical Center Drive Ann Arbor MI 48109-0948 CONTACT INFORMATION

22. AGI Dermatics - Welcome A private biopharmaceutical company focusing on DNA repair technology, dermatology, liposome diagnosis, skin cancer research and early cancer diagnosis and the lifestyle enhancement market. http://www.agiderm.com/

AGI Dermatics has been recognized as the world leader in DNA repair technology for more than 20 years. AGI Dermatics is at the forefront of dynamic biomolecular research in dermatology and skin care products. We are developing a topical skin lotion for repair of sun damage to skin. Phase III clinical trials have demonstrated that this drug significantly reduces the incidence of pre-malignancies and skin cancer. We supply ingredients for cosmetic products that are found in countless brands around the globe. "The goal is the treatment of patients in the US and around the world with pre-cancerous actinic keratosis and skin cancer." Daniel B. Yarosh, PhD President and Chairman, AGI Dermatics (Aug 29, 2005) AGI Dermatics Featured in Newsweek: "Fighting Crow's Feet and Cancer" (Jun 27, 2005) FOX 5 News (NYC): Dimericine Featured on "Healthline" (May 10, 2005) Dimericine Featured on CBS Early Show "Beauty Breakthoughs" (Feb 28, 2005) ABC World News Tonight: Experimental Lotion Repairs Sun Damage, May Prevent Skin Cancer (May 23, 2003)

23. Breast Cancer Genetics Overview Elements of cancer genetics Risk Assessment and Counseling (part of PDQ ® Ford D and Easton DF (1995) The genetics of breast and ovarian cancer. http://www.geneclinics.org/profiles/brca/details.html

Breast Cancer Genetics Overview Authors: Mary B Daly, MD, PhD Julie O Bars Culver, MS Judith L Hull, MS Ephrat Levy-Lahad, MD About the Authors / Author History Initial Posting: 4 March 2000 Last Update 11 September 2003 Summary Disease characteristics. Breast cancer is a malignant tumor of breast tissue suspected in individuals with clinical findings such as a breast lump, breast thickening, skin change, or changes on mammography. Breast cancer is staged from (earliest) to IV (most advanced), with survival dependent upon the stage at diagnosis. Diagnosis/testing. The diagnosis of breast cancer is established by histological examination of biopsied tissue. Inherited disorders in which breast cancer occurs can be recognized by the associated clinical findings (e.g., Cowden syndrome, Bloom syndrome, Peutz-Jeghers syndrome, Werner syndrome, and xeroderma pigmentosum) or cancer history (e.g., Li-Fraumeni syndrome). Inherited susceptibility to breast cancer may be identified through mutation analysis of the gene or gene . A or cancer-predisposing mutation is more likely to be present if the family history includes Ashkenazi Jewish ancestry, breast cancer diagnosed before age 50 years, bilateral breast cancer, ovarian cancer, or the occurrence of both breast cancer and ovarian cancer in the same person. Software is available for this risk calculation.

24. National Cancer Institute - Malignant Mesothelioma Home Page Array of information resources for lay and professional viewers. Includes causes, prevention, genetics, treatment options and clinical trials. http://www.nci.nih.gov/cancerinfo/types/malignantmesothelioma

var bSearchBoxBool=false; Quick Links Director's Corner Dictionary of Cancer Terms NCI Drug Dictionary Funding Opportunities ... NIH Calendar of Events NCI Highlights Digital Mammography Trial Results Announced NCI Offers Support for Those in Need After Katrina NCI Announces Plan to Fight Lung Cancer National Prostate Cancer Awareness Month ... Past Highlights Malignant Mesothelioma Related Pages What You Need To Know About Cancer - An Overview An overview of cancer detection, symptoms, diagnosis, and treatment. NIH Publication No. Mesothelioma: Questions and Answers A fact sheet that describes the risk factors, symptoms, diagnosis, and treatment of mesothelioma. Full description of the NCI PDQ database. General Cancer Resources Coping with Cancer Managing side effects and complications caused by cancer and its treatment. Support and Resources Information about cancer support organizations, finances, insurance, home care, and hospice care. Learning About Clinical Trials Types of trials, how they work, risks and benefits of taking part. Finding Clinical Trials Ways to look for specific cancer clinical trials.

25. Cancer GeneticsWeb - Home Page cancer geneticsWeb www.cancergenetics.org. Navigate genetics UniversityHospital, Poitiers, France. CGAP, cancer Genome Anatomy Project http://www.cancerindex.org/geneweb/

Cancer Genetics Web www.cancer genetics.org This site includes pages for 606 cancer related genes and entries for chromosome abnormalities. Search: Welcome If you are a first time visitor please read the introduction The site is primarily intended for health professionals and researchers. The aim of the site is to provide comprehensive links to reliable information about genes, their associated proteins, and genetic mutations associated with cancer and related disorders. Each gene page includes links to major genetic databases and where possible links to other related web sites, abstracts references, external searches, and summary information. The site is integrated with Guide to Internet Resources for Cancer to provide links to related clinical and research information sources. Please note: the site includes putative oncogenes / tumour supressor genes and proto-oncogenes implicated in cancer but for which the association with cancer is not necessarily proven. Links to other databases and research abstracts and pre-configured searches of PubMed are included to provide a gateway to available evidence and the latest research relating to specific genes and their role in cancer.

26. Cell Online Biweekly publication of exceptional research articles in areas including molecular biology, biochemistry, cancer research, cell biology, developmental biology, genetics, immunology, microbiology, neurobiology, plant biology, structural biology and virology. http://www.cell.com/

Home Search Archive Subscribe ... Register or Login: Password: Auto-Login Reminder Current Issue Volume 122 Issue 5: September 8, 2005 Next issue: September 22, 2005 In This Issue of Cell: Circadian controls in bone formation Long-sought heme transporter identified Nuclear receptor overlap and the anti-inflammatory response Rethinking the detection of biologically-relevant hormone levels Reconstitution of mismatch repair in vitro Operations of a DNA packaging motor at the single molecule level Tumor suppressors encourage color vision in Drosophila Differences in protein recycling can contribute to asymmetric cell fate decisions Switch in Rabs marks the progress from early to late endosome Balance between methylation and phosphorylation controls protein function Immediate Early Publication CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis Mailand and Diffley Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells Boyer et al.

27. Family Cancer Genetics Network The FCGN is a new resource to help answer important questions about inheritedrisks for cancer. http://www.fcgn.org/

You can participate by clicking here and following the instructions to register and provide us information about your family cancer history. If you have questions about participating in the FCGN, please contact JoAnn Runk at (800) 456-3434, ext. 4990. Welcome to the Family Cancer Genetics Network (FCGN) Website! The FCGN is a new resource to help answer important questions about inherited risks for cancer. Through this site you may find out more about the Family Cancer Genetics Network, how to enroll in the network, or learn more about hereditary cancer. For more information about the Family Cancer Genetics Network, please call the FCGN line at: 1-800-456-3434, extension 4990. Click on a link below to learn more about the FCGN: What is the Mission of the FCGN? What is the the History of the FCGN? What is the FCGN registry? What are some benefits of being included in the FCGN registry? ... How can I participate in FCGN? The FCGN Mission The Family Cancer Genetics Network (FCGN) is a national program of cancer genetics centers, providing clinical care, education and research. FCGN consists of physicians, genetic counselors, nurses, social workers, researchers, and cancer patients and their families.

28. Breast Cancer - Genetics Information about gene mutations and chromosomal abnormalities in this condition. http://www.cancerindex.org/geneweb/X0401.htm

Cancer Genetics Web www.cancer genetics.org Breast Cancer Mutated Genes and Abnormal Protein Expression Recurrent Chromosome Abnormalities Overview of the Molecular Biology of Breast Cancer Hereditary Breast and Ovarian Cancer Genetic Polymorphisms and Breast Cancer Risk Anti-estrogen resistance in Breast Cancer del(1p32-pter) in Breast Cancer Breast Cancer: Clinical and Epidemiological Resources Mutated Genes and Abnormal Protein Expression Gene Location Topics HSPCA HSPCA and Breast Cancer BCAR2 and Breast Cancer BCAR3 and Breast Cancer ( GST1 , MU ) GSTM1 and Breast Cancer ARHC ( RhoC ) RhoC Overexpression in Inflammatory Breast Cancer ( PUM , PEM ) MUC1 and Breast Cancer ( MTS1 , P9KA , metastasin ) S100A4 and Breast Cancer ( KiSS-1 ) KISS1 and Breast Cancer CYP1B1 Polymorphisms in Breast Cancer SRD5A2 and Breast Cancer ( AMPHL , SH3P9 ) BIN1 and Breast Cancer ARHA ( ARH12 , RhoA ) RhoA Overexpression in Breast Cancer TGFBR2 in EHLA and Risk of Breast Cancer RARB ( NR1B2 , HAP ) RARB Expression in Breast Cancer ( EIF-4E ) EIF4E in Breast Cancer HSPCB HSPCB and Breast Cancer TFAP2B Expression in Breast cancer ... LIBC ( ESRA ) ESR1 and Breast Cancer AMPH AMPH Expression in Breast Cancer IL-6 Expression in Breast Cancer ... MYC ( CMYC , C-MYC )

29. Family Cancer Genetics Network The FCGN is a new resource to help answer important questions about inheritedrisks for cancer. http://www.fcgn.org/faqs.htm

Help us understand more about inherited cancer risk by participating in the FCGN registry... What is the FCGN registry? The FCGN registry is a new resource to help answer important questions about inherited risks for cancer. Information provided by people in the registry from across Florida is combined to create a registry that scientists can use for research on cancer. What are some benefits of being included in the FCGN? You can help researchers and society learn more about genetics and cancer. You will receive regular updates on cancer and genetics research. You will be informed about special research studies for which you may be eligible. “Who can participate in the FCGN registry?” Individuals with the following background are welcome to participate in the FCGN registry: Have a personal or family history of cancer.

30. The Sanger Institute: Cancer Genome Project An initiative dedicated to using the human genome sequence and high throughput mutationdetection techniques to identify genes critical in the development of human cancers. http://www.sanger.ac.uk/genetics/CGP/

Sanger Home Acedb YourGenome Ensembl ... News CGP Home Publications Conditions of use Search WWW Site ... FTP Site The Cancer Genome Project Summary All cancers occur due to abnormalities in DNA sequence. Throughout life, the genome within cells of the human body is exposed to mutagens and suffers mistakes in replication. These corrosive influences result in progressive, subtle divergence of the DNA sequence in each cell from that originally constituted in the fertilised egg. Occasionally, one of these somatic mutations alters the function of a critical gene, providing growth advantage to the cell in which it has occurred and resulting in the emergence of an expanded clone derived from this cell. Acquisition of additional mutations, and consequent waves of clonal expansion result in the evolution of the mutinous cells that invade surrounding tissues and metastasise. One in three people in the Western world develop cancer and one in five die of the disease. Cancer is therefore the commonest genetic disease. The identification of genes that are mutated and hence drive oncogenesis has been a central aim of cancer research since the advent of recombinant DNA technology. The Cancer Genome Project is using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers. This initiative will ultimately provide the paradigm for the detection of germline mutations in non-neoplastic human genetic diseases through genome-wide mutation detection approaches.

31. Sloan-Kettering - Hereditary Cancer & Genetics: Colon Cancer & Heredity Questions and answers about hereditary colon cancer. http://www.mskcc.org/mskcc/html/8624.cfm

if(!window.tabs) var tabs = []; var tab = tabs[tabs.length] = []; tab.id = 13; var TAB_WWWROOT = "/mskcc/"; var tabDarkColor = "#336699"; var tabMediumColor = "#99BBCC"; if(window.createHeaderImageCache) createHeaderImageCache(44,512,5626,1072,5664,638,8228); if(window.formatTabs) formatTabs(tabs); Cancer Information Select a Herediatry Cancer Topic - Clinical Research Updates 2005-2006 - Overview - Breast/Ovarian Cancer: - Our Clinical Trials - Clinical Genetics at Memorial Sloan-Kettering - Psychological Services for Families with Cancer - Genetic Discrimination Legislation Information - Clinical Genetics Staff - Contact Us Click on a question to jump to the answer. Important Information for Individuals Who Had Colon Cancer Testing Prior to November 2004 How common is colorectal cancer? How often is colorectal cancer hereditary? What is hereditary nonpolyposis colorectal cancer (HNPCC)? ... What other forms of screening are available for colon cancer? 1. Important Information for Individuals Who Had Colon Cancer Testing Prior to November 2004 For individuals who have tested negative for , or AP C gene mutations, new genetic testing for these genes, called Southern blot, has become available. This test looks for gene changes where large portions of the gene may be missing or rearranged. These changes may be missed or undetectable on more traditional gene sequencing. Genetic testing for mutations in the

32. National Cancer Institute - Anal Cancer Home Page Resource from the U.S. National cancer Institute including causes, genetics, prevention, statistics, treatment and clinical trials. http://www.cancer.gov/cancer_information/cancer_type/anal

var bSearchBoxBool=false; Quick Links Director's Corner Dictionary of Cancer Terms NCI Drug Dictionary Funding Opportunities ... NIH Calendar of Events NCI Highlights Digital Mammography Trial Results Announced NCI Offers Support for Those in Need After Katrina NCI Announces Plan to Fight Lung Cancer National Prostate Cancer Awareness Month ... Past Highlights Anal Cancer Related Pages What You Need To Know About Cancer - An Overview An overview of cancer detection, symptoms, diagnosis, and treatment. NIH Publication No. Full description of the NCI PDQ database. General Cancer Resources Coping with Cancer Managing side effects and complications caused by cancer and its treatment. Support and Resources Information about cancer support organizations, finances, insurance, home care, and hospice care. Learning About Clinical Trials Types of trials, how they work, risks and benefits of taking part. Finding Clinical Trials Ways to look for specific cancer clinical trials. Complementary and Alternative Medicine Healing philosophies, approaches, and therapies used in addition to, or instead of, conventional treatments. Treatment Information about treatment, including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy

33. Sloan-Kettering - Hereditary Cancer & Genetics Here you will find an overview of hereditary cancer and genetic counseling andtesting information; questions answers about hereditary cancers, http://www.mskcc.org/mskcc/html/603.cfm

if(!window.tabs) var tabs = []; var tab = tabs[tabs.length] = []; tab.id = 13; var TAB_WWWROOT = "/mskcc/"; var tabDarkColor = "#336699"; var tabMediumColor = "#99BBCC"; if(window.createHeaderImageCache) createHeaderImageCache(44,512,5626,1072,5664,638,8228); if(window.formatTabs) formatTabs(tabs); Cancer Information Select a Herediatry Cancer Topic - Overview - Colon Cancer, Hereditary - Prostate Cancer, Hereditary - Recent Research Findings - Genetic Discrimination Legislation Information - Clinical Genetics at Memorial Sloan-Kettering - Our Clinical Trials - Psychological Services for Families with Cancer - Clinical Genetics Staff - Contact Us Over the past decade, scientists have discovered specific inherited factors, or genes, that can contribute to the development of some forms of breast, ovarian, colorectal, and other types of cancer. The Clinical Genetics Service at Memorial Sloan-Kettering offers hereditary cancer risk assessment, genetic counseling, and genetic testing by specially trained genetic counselors and physicians to people who are concerned about their personal and/or family history of cancer. This information may be helpful in making medical decisions about how to manage your risk for cancer. Overview An introduction to hereditary cancer, genetic counseling, and genetic testing.

34. UVa Cancer Home Provides information about prevention, diagnosis, support, community outreach, genetics, nutrition, research, clinical trials and news, as well as an introduction to the institution. Located in Charlottesville, Virginia. http://www.healthsystem.virginia.edu/internet/cancer/

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... About Us University of Virginia Cancer Center Welcome to the website of the University of Virginia Cancer Center. Here you'll find complete information on the clinical services, research and physicians available at UVa's National Cancer Institute Clinical Cancer Center. You'll also find a comprehensive library of information about cancer, treatment, diagnosis, nutrition, genetics and more. News and Events Find a Physician UVa Cancer Center has more than 100 physicians specializing in cancer care. If you would like to locate a physician in a particular cancer specialty, call (434) 924-9333 or (800) 223-9173 or you can find a UVa physician online, use the drop down menu below. Select by Cancer Specialty Bladder Cancer Bone Cancers Brain Tumors Brain Cancer: Medical Oncology Breast Cancer Cervical Cancer Colorectal Cancer: Assessment Colorectal Cancer: Surgery Colorectal Cancer: Medical Oncology Esophageal Cancer Kidney Cancer Laryngeal Cancer Leukemia Liver Cancer Liver Cancer: Surgery Lymphoma Lung Cancer: Medical Oncology Lung Cancer: Surgery Lung Cancer: Radiation Oncology Melanoma Ovarian Cancer Pancreatic Cancer Prostate Cancer: Medical Oncology Prostate Cancer: Surgery Prostate Cancer: Radiation Oncology Uterine Cancer Skin Cancer: Assessment Skin Cancer: Surgery Skin Cancer: Radiation Oncology

35. Cancer And Genetics cancer and genetics The Primary Care Physician’s Role in Counseling and Testing The Age of genetics Is Upon Us; Rating the Risks; The National cancer http://www.cancernetwork.com/genetics/contents.htm

Cancer and Genetics A Manual for Clinicians and Their Patients From the American Cancer Society and PRR, Inc. BY Randi Londer Gould IN CONSULTATION WITH Henry T. Lynch, MD Creighton University School of Medicine Robert A. Smith, PhD American Cancer Society James F. McCarthy PRR, Inc. ILLUSTRATIONS BY JEANNE KELLY, AARDVARK DESIGN CONTENTS Acknowledgements A Complicated Question Henry T. Greely, JD, Professor of Law, Stanford University The Age of Genetics Is Upon Us Rating the Risks The National Cancer Genetics Network Cancer Genetics: A Quick Course The Genetic Code DNA Tumor-Suppressor Gene Oncogenes Genetic Mapping DNA Sequencing The Genetics of Breast;and Ovarian Cancer Risk Factors The Genetics of Colon Cancer Genes FAP HNPCC The Rare Cancers Retinoblastoma Von Hippel-Lindau Disease Thyroid Cancer Doctor, Do I Need Genetic Testing? Assessing Risk Sample Questionnaire for Family History Listing of Hereditary Cancer Syndromes Follow-up Case Examples Genetic Tests Available How Useful Are the Tests?

36. Library & Archives CSHL is a research and educational institution with research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics, and a broad educational mission, including the recently established Watson School of Biological Sciences. http://nucleus.cshl.org/CSHLlib/

Please visit our new address: http://library.cshl.edu

37. Cancer And Genetics (Overview) cancer and genetics Answering Your Patients Questions, written by Randi LonderGould in collaboration with Henry T. Lynch, MD, Robert A. Smith, MD, http://www.cancernetwork.com/library/cangenet.htm

Cancer and Genetics: Answering Your Patients' Questions , written by Randi Londer Gould in collaboration with Henry T. Lynch, MD, Robert A. Smith, MD, and James F. McCarthy, is a joint venture of PRR, Inc., and the American Cancer Society. Intended as a manual for clinicians and their patients, Cancer and Genetics covers such topics as the physician's role in genetic counseling and testing; the genetics of breast, ovarian, colon, and other cancers; assessing risk in families with a history of cancer; and dealing with discrimination in the workplace and privacy issues. Also included are glossary of terms, a state-by-state directory of genetic counselors, and regional and national resources for further information. Table of Contents Other Books Other Publications

38. Welcome To Ramesh Kumar Ramalingam's Home Page PhD thesis on epidermal growth factor receptor in relation to monoclonal antibody culture and breast cancer. Includes molecular genetics glossary, and CV of researcher in Hyderabad, India. http://www.geocities.com/rgklink/

Ramesh Kumar Ramalingam Welcomes you to his web page. Science has never been easy. But with the advent of Internet, information can be dessiminated free of cost, to all the needy persons with only a small input. This is an small effort made by me to include Scientific related data's in an free web server. Since my recent interest has been in Molecular Biology, especially in Molecular Genetics, I am in the process of making pages related to these topics. More is yet to come, so keep coming back. I hope these pages are of some help to you. Check out my MY CURRICULAM VITAE My Ph.D Thesis: Generation of Anti-Epidermal Growth factor Receptor Monoclonal Antibody and its Clinical Applications. Glossaries: Functional but still under construction Glossary of Molecular biology and Biochemistry Glossary of Pathology Oncological tearms Search My Web Page For: Match: Any Word All Words Exact Phrase Sound-alike matching Within: Anywhere Title Description Keywords Body Alternate text URL Show: results with without summaries Sort By: score

39. People Living With Cancer - Cancer Genetics - The Genetics Of Cancer People Living With cancer (www.plwc.org) accurate, reliable and oncologistapproved cancer information from the world s leading organization representing http://www.plwc.org/plwc/MainConstructor/1,1744,_12-001038-00_14-00About Cancer

Home About Us Contact Us Message Boards Cancer Type: Select a Cancer Type Adenoid Cystic Carcinoma Adrenal Gland Tumor Amyloidosis Anal Bile Duct Bladder Bone Brain Tumor Breast Breast, Inflammatory Breast, Male Breast, Metaplastic Carcinoid Tumors Cervical Childhood Central Nervous System Astrocytoma Brain Stem Glioma Ependymoma Medulloblastoma Desmoplastic Infantile Ganglioma Ewing's Sarcoma Germ Cell Tumors Leukemia, Acute Lymphoblastic (ALL) Leukemia, Acute Myeloid (AML) Lymphoma, Hodgkin Lymphoma, Non-Hodgkin Neuroblastoma Osteosarcoma Retinoblastoma Rhabdomyosarcoma Wilms Tumor Colorectal Endocrine Tumor Esophageal Eye Eyelid Fallopian Tube Gallbladder Gastrointestinal Stromal Tumor (GIST) Gestational Trophoblastic Tumor Head and Neck Laryngeal and Hypopharyngeal Nasal Cavity and Paranasal Sinus Nasopharyngeal Oral and Oropharyngeal Salivary Gland HIV/AIDS-Related Islet Cell Tumors Kidney Lacrimal Gland Tumor Leukemia, Acute Lymphocytic (ALL) Leukemia, Acute Myeloid (AML) Leukemia, B-Cell Leukemia, Chronic Lymphocytic (CLL) Leukemia, Chronic Myeloid (CML) Leukemia, Eosinophilic

40. Brenner Laboratory Research on the function of histidine triad hydrolases, and members of the nitrilase superfamily using enzymology, yeast genetics and Xray crystallography. Located in the departments of genetics, Biochemistry and the Norris Cotton cancer Center at Dartmouth Medical School, Hanover, NH. http://www.dartmouth.edu/~brenner/

Brenner Group Home Page We are a research group in the Dartmouth Medical School Departments of Genetics Biochemistry and the Norris Cotton Cancer Center Dartmouth's NCI-designated comprehensive cancer center. The Brenner laboratory has three research interests. First, we study the function of histidine triad hydrolases including Hint Aprataxin , and Fhit , their homologs, and their signaling partners. This work has led us into fascinating areas of biology including sex determination in birds ataxia-oculomotor apraxia , and a frequently inactivated proapoptotic tumor suppressor pathway Second, we are interested in unsolved problems of NAD+ metabolism , especially as they relate to aging. We recently described a pathway to NAD+ in fungi and humans involving nicotinamide riboside and conserved NRK genes and we are engaged in discovery and validation of additional NAD+ metabolic genes as well. Finally, we are interested in a pathway for translational and post-translational control of the cell cycle at the G1-S and G2-M transitions that we call the Cdc123/D123-Chfr-eIF2gamma axis of cell division control.

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