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81. Autoimmunity FAQS Appendix II: Glossary Of Diseases
A simple look at the many common autoimmune diseases, with a basic In moresevere forms, connective tissue can build up in the kidneys, lungs, heart,
http://womenshealth.about.com/library/bl_autoimmune12.htm
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Search Women's Health Autoimmunity FAQS Appendix II: Glossary of Diseases Adapted by Tracee Cornforth Autoimmunity plays a role in more than 80 diseases. Following are brief descriptions of some of the many diseases in which autoimmunity may be involved. Note: Because the specific causes of many diseases are unknown, there is debate among scientists about whether some of these are truly autoimmune diseases. Your own doctor may classify some of these diseases differently. Alopecia areata A disorder in which the immune system attacks the hair follicles, causing loss of hair on the scalp, face, and other parts of the body. Ankylosing spondylitis A rheumatic disease that causes inflamed joints in the spine and sacroiliac (the joints that connect the spine and the pelvis) and, in some people, inflamed eyes and heart valves. Arthritis A general term for more than 100 different diseases that affect the joints. Many forms of arthritis and related conditions are believed to have an autoimmune component.

82. THE MERCK MANUAL--SECOND HOME EDITION, Mixed Connective Tissue Disease In Ch. 68
autoimmune Disorders of connective tissue Mixed connective tissue disease isa term used by some experts to describe a collection of symptoms similar to
http://www.merck.com/mmhe/sec05/ch068/ch068f.html
var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Bone, Joint, and Muscle Disorders Chapter Autoimmune Disorders of Connective Tissue Topics Introduction Eosinophilic Fasciitis Mixed Connective Tissue Disease Polymyositis and Dermatomyositis Relapsing Polychondritis Scleroderma Sj¶gren's Syndrome ... Systemic Lupus Erythematosus Mixed Connective Tissue Disease Buy The Book Print This Topic Email This Topic Pronunciations arthritis corticosteroid dermatomyositis eosinophil ... systemic lupus erythematosus Mixed connective tissue disease is a term used by some experts to describe a collection of symptoms similar to those of systemic lupus erythematosus, scleroderma, polymyositis, and dermatomyositis. About 80% of people who have this disease are women. Mixed connective tissue disease affects people from ages 5 to 80. Its cause is unknown, but it appears to be an autoimmune disorder.

83. THE MERCK MANUAL--SECOND HOME EDITION, Sjögren's Syndrome In Ch. 68, Autoimmune
autoimmune Disorders of connective tissue. Topics. Introduction· EosinophilicFasciitis· Mixed connective tissue Disease· Polymyositis and Dermatomyositis·
http://www.merck.com/mmhe/sec05/ch068/ch068d.html
var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Bone, Joint, and Muscle Disorders Chapter Autoimmune Disorders of Connective Tissue Topics Introduction Eosinophilic Fasciitis Mixed Connective Tissue Disease Polymyositis and Dermatomyositis ... Scleroderma Sj¶gren's Syndrome Systemic Lupus Erythematosus Buy The Book Print This Topic Email This Topic Pronunciations arthritis corticosteroid dermatomyositis eosinophil ... trachea Symptoms In some people, only the mouth or eyes are dry (a condition called sicca complex or sicca syndrome). Dryness of the eyes may severely damage the cornea, resulting in a scratchy or irritated sensation, and a lack of tears can cause permanent eye damage. Insufficient saliva in the mouth can dull taste and smell, make eating and swallowing painful, and cause cavities. The salivary glands in the cheeks (parotids) become enlarged and slightly tender in about one third of people. The mouth may also burn, which may sometimes indicate a complicating yeast infection.

84. Caring Medical - Symptoms - Mixed Connective Tissue Disease
mixed connective tissue disease (MCTD) is an autoimmune disease that Because mixed connective tissue disease is up to 15 times more common among
http://www.caringmedical.com/conditions/Mixed_Connective_Tissue_Disease.htm

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CONDITION: Mixed Connective Tissue Disease
DESCRIPTION:
First described in 1972, mixed connective tissue disease (MCTD) is an autoimmune disease that encompasses symptoms of three other rheumatoid autoimmune diseases: systemic lupus erythematosus, scleroderma and polymyositis. Patients with this pattern illness have features of each of these three diseases. MCTD can occur at any age, with the average age of onset between the teens to the 30s. Eight out of ten patients are women. How does mixed connective tissue disease develop?
The connective tissues are the structural elements that hold the cells of the body together. These tissues form a framework or matrix for the body. The connective tissues are composed of two major structural molecules: collagen and elastin. Connective tissue diseases feature abnormalities involving the collagen and elastin and are often characterized by a variety of immune abnormalities. Lab tests show that most patients diagnosed with MCTD have high levels of anti-nuclear antibodies as well as antibodies to ribonucleoprotein (anti-RNP). Because mixed connective tissue disease is up to 15 times more common among women than men, some theorize that the condition is related to hormones. What are the symptoms of mixed connective tissue disease?

85. Caring Medical - Symptoms - Autoimmune Diseases
Many different autoimmune diseases exist, each affecting the body in A specificautoimmune disease may result in the destruction of an organ or tissue,
http://www.caringmedical.com/conditions/Autoimmune_Diseases.htm

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Phone
708.848.7763 Fax
CONDITION: Autoimmune Diseases
DESCRIPTION:
The immune system is a complex network of cells and cell components that normally work to defend the body and eliminate infections caused by bacteria, viruses and other invading microbes. Normally, the immune system is capable of differentiating "self" from "non-self" tissue. However, if an individual has an autoimmune disease, the immune system mistakenly turns on the self, targeting the cells, tissues and organs of the individual's own body. Many different autoimmune diseases exist, each affecting the body in different ways. For example, in multiple sclerosis, the autoimmune reaction is directed against the brain, while in Crohn's disease it’s the large intestine. Although many of the individual autoimmune diseases are rare, as a group they afflict millions of Americans. Most autoimmune diseases tend to strike women more often than men, and they particularly affect working-age women as well as women during their childbearing years. How does an autoimmune disease develop?

86. UpToDate Patient Information: Antinuclear Antibodies (ANA)
Symptoms of autoimmune and connective tissue disorders vary from patient to Physicians often use the ANA test when an autoimmune disease is suspected.
http://patients.uptodate.com/topic.asp?file=arth_rhe/8855

87. UpToDate Thyroid Disorders And Connective Tissue Disease
Given the high frequency of chronic autoimmune thyroiditis and hypothyroidism in Furthermore, even if thyroid disease and connective tissue disease are
http://patients.uptodate.com/topic.asp?file=thyroid/21226&title=Polymyalgia rheu

88. EMedicine - Mixed Connective Tissue Disease : Article By Marisa S Klein-Gitelman
Mixed connective tissue Disease In 1972, Sharp and colleagues first proposedmixed connective tissue disease (MCTD) as a separate autoimmune disorder.
http://www.emedicine.com/ped/topic1466.htm
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Mixed Connective Tissue Disease
Last Updated: July 20, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: MCTD AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography
Author: Marisa S Klein-Gitelman, MD, MPH, MS , Assistant Professor, Department of Pediatrics, Section of Immunology-Rheumatology, Northwestern University and Children's Memorial Hospital Marisa S Klein-Gitelman, MD, MPH, MS, is a member of the following medical societies: American College of Rheumatology Editor(s): Barry L Myones, MD Robert Konop, PharmD , Director of Drug Programs and Utilization; David D Sherry, MD , Professor of Pediatrics, University of Pennsylvania; Director of Clinical Rheumatology, Division of Rheumatology, Children's Hospital of Philadelphia; Daniel Rauch, MD

89. EMedicine - Graves Disease : Article By Sai-Ching Jim Yeung, MD, PhD, FACP
However, they are markers of autoimmune disease against the thyroid. peptic ulcer disease; hepatic dysfunction; connective tissue infections;
http://www.emedicine.com/med/topic929.htm
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Graves Disease
Last Updated: July 28, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: diffuse toxic goiter thyrotoxicosis hyperthyroidism Basedow's disease ... systemic lupus erythematosus , thyroid antigens, thyroglobulin , thyroperoxidase, sodium-iodide symporter, TSH receptor, life-threatening thyrotoxic crisis thyroid storm Graves ophthalmopathy , thyroid acropachy, severe weight loss, osteoporosis apathetic hyperthyroidism cardiac hypertrophy , CTLA-4, pretibial myxedema , palpitation, nervousness, tremor, heat intolerance, hyperdefecation, inability to concentrate, proximal muscle weakness, easy fatigability with physical activity, proptosis , lid retraction, lacrimation, gritty sensation in the eye, photophobia, eye pain, diplopia hyperhidrosis increased sweating , restlessness, anxiety , irritability, insomnia thyrotoxic periodic paralysis onycholysis alopecia , hyperactive deep-tendon reflexes, brisk deep-tendon reflexes, hypokalemic periodic paralysis atrial fibrillation cardiomyopathy , elevated transaminases, lid lag , irregular menstrual periods, gynecomastia impotence decreased parathyroid hormone levels , decreased total cholesterol, decreased triglycerides, hand tremor, thyroid bruits, conjunctival injection, conjunctival chemosis

90. Autoimmune Disease
autoimmune disease, any of a number of abnormal conditions caused when the body eg, scleroderma and dermatomyositis, affect collagen (connective tissue)
http://www.infoplease.com/ce6/sci/A0805404.html
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91. OMNI: The UK's Gateway To High Quality Internet Resources In Health And Medicine
bmj.com collected resources connective tissue disease. Collected resources onconnective tissue disease from the online British Medical Journal.
http://omni.ac.uk/text/browse/subject-listing/WD300.html
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Immunologic and collagen diseases, hypersensitivity
Adverse food reactions This patient-orientated information leaflet is made available on the BBCi Health Web site, as part of their Allergy Guide resource. The leaflet explains the causes and symptoms of food allergy and food intolerance; discusses food toxicity and food aversion; and includes information about the diagnosis and prevention of food allergies. Patient Education Handout [Publication Type] Food Hypersensitivity Adverse reaction to foods : peanut allergy This document is one in a series of fact sheets produced by the British Nutrition Foundation on the topic of adverse reactions to food, which aim to "clarify the terminology used by experts in the field and the actual prevalence of various types of adverse reaction." This fact sheet focuses on peanut allergy and covers: prevalence and symptoms; sensitisation and at-risk groups; diagnosis; management of peanut allergy; and prevention of peanut allergy/anaphylaxis. Peanut Hypersensitivity Patient Education Handout [Publication Type] Adverse reactions to food This document is the first in a series of fact sheets produced by the British Nutrition Foundation on the topic of adverse reactions to food, which aim to "clarify the terminology used by experts in the field and the actual prevalence of various types of adverse reaction." This fact sheet focuses on food intolerance, and provides information about allergic reactions (IgE mediated and non-IgE mediated) and non-allergic food intolerances (including those with an enzymic cause, those with a pharmacological cause, and toxic substances).

92. FindLaw For Legal Professionals - Case Law, Federal And State Resources, Forms,
The IOM Report was based on a general review of past and ongoing research onsilicone With regard to connective tissue disease, including scleroderma,
http://caselaw.lp.findlaw.com/cgi-bin/getcase.pl?court=DC&navby=case&no=007241A

93. The Arthritis Society Routinely Receives Frequently Asked
connective tissue disease is not a specific disease per se, but a general termthat is used to encompass a number of disease processes.
http://www.arthritis.ca/toolbox/qa database/browse/default.asp?s=1&page=7

94. Forum On Opportunistic Infections: Lymphoma And Autoimmune Disease
Mixed connective tissue disease (MCTD) and other related autoimmune disorderscan be associated with the subsequent devlopment of lymphoma.
http://www.thebody.com/Forums/AIDS/Infections/Archive/Cancers/Q13563.html
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Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered. Ask the Experts about Opportunistic Infections
Lymphoma and Autoimmune disease
Feb 25, 2001 I have had a high ANA for 4 years and systemic symptoms. I was told I have MCTD. I have had a terrible rash on the scalp, pubic area and in areas over the body for 7 months. Diagnosis was folliculitus. No medication has helped as yet. Last week I noticed an enlarged lymph node. My DR found many nodes on each side of my neck. Both he and the ENT DR suspect lymphoma and I will have a node biopsy in one week. Can you tell me if there is a connection to MCTD and lymphoma. My DR said he thinks this node condition is the basis for all of my symptoms. I wonder if it is both conditions or if one thing lead to another. Your answer will be greatly appreciated. Response from Dr. Feinberg

95. Additional Reading (from Connective Tissue Disease) --  Encyclopædia Britannic
connective tissue disease Detailed accounts of the connective tissue diseasesand of the rheumatic disorders in general may be found in e ty = s WSC
http://www.britannica.com/eb/article?tocId=41940

96. Health Library -
Disorder Subdivisions general Discussion resources For a Complete Report Anemia, autoimmune Hemolytic; Cold Agglutinin Disease; Cold Antibody Disease
http://yalenewhavenhealth.org/library/healthguide/en-us/illnessconditions/topic.

97. NEJM -- Sign In
We defined connectivetissue disease as a group of disorders that Autoimmunedisease developing after augmentation mammoplasty report of 3 cases.
http://content.nejm.org/cgi/content/full/330/24/1697
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98. Scleroderma
Scleroderma is categorized as an autoimmune disease. Systemic sclerosis mayaffect connective tissue in various parts of your body (such as skin,
http://www.healthywomen.org/content.cfm?L1=3&L2=69

99. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Musculoskeletal_Di
Mixed connective tissue Disorder An autoimmune process with symptoms of connective tissue Disease - A definition from the Merriam-Webster s Medical
http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Musculoskel
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100. Research Symposium On Integrating Discovery Platforms In Autoimmune Diseases - C
Recent Advances and Underlying Themes in autoimmune Disease Research Mixed connective tissue disease Multiple sclerosis Myasthenia gravis Myocarditis
http://www.cihr-irsc.gc.ca/e/25890.html
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Institute of Infection and Immunity (III)
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Research Symposium on Integrating Discovery Platforms in Autoimmune Diseases
Appendix V
Background Document
Foreword Introduction: Immune Dysfunction and Autoimmunity The Burden of Autoimmune Diseases Recent Advances and Underlying Themes in Autoimmune Disease Research ... Appendix V-B: Glossary
Foreword
Autoimmunity results from a dysfunction of the immune system in which the body attacks its own organs, tissues, and cells. Immune-mediated diseases such as rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and systemic lupus erythematosus, cause much human suffering and place a major burden on the health care system. Millions of Canadians are affected and increasing numbers urge amelioration in clinical research and health care. The Canadian Institutes of Health Research ( CIHR ) Institute of Infection and Immunity ( III ) supports research to enhance immune-mediated health and to reduce the burden of disease through prevention plans, diagnosis, treatment strategies, support systems, and palliation. To facilitate discoveries and broaden current understanding, the III encourages cross-disciplinary collaborations. As such, a committee has been formed and the research workshop "Integrating Discovery Platforms in Autoimmune Diseases" organized, in order to develop a Canadian health research agenda in autoimmune diseases.

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