1. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser aplastic anemia MDS (Myelodysplastic Syndromes) International Foundation, Inc. providing patient assistance and emotional support, educational materials http://www.aamds.org/

In The News Updates on diseases and treatments. Frequently Asked Questions Want to Talk? Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Support Congressional Resolution 179 P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation Rare Diseases Clinical Research Network This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by Vansant Creations Web Development Interactive Masterminds This site is hosted by Toad.net

2. MEdIC - Aplastic Anemia Answer Book Patient information about this disease and all aspects of bone marrow. Diagnoses, treatment and some helpful hints are offered. http://medic.med.uth.tmc.edu/ptnt/00001038.htm

Aplastic Anemia Answer Book Aplastic Anemia - The Disease Aplastic anemia is a rare but extremely serious disorder that results from the unexplained failure of the bone marrow to produce blood cells. In all probability you had never heard of this disease until the time of diagnosis. We hope that this pamphlet helps you deal with your situation by providing basic information about aplastic anemia and the various treatment options. This pamphlet is not intended as a substitute for the advice of a physician. It is important that you ask questions and learn as much as you can about this disease. By contacting the Aplastic Anemia Foundation of America, you can be connected with others in your same situation and receive information free of charge. There are AAFA chapters around the country. You do not need to be alone in dealing with aplastic anemia. Normal Bone Marrow Function The central portion of bones is filled with a spongy red tissue called bone marrow. The bone marrow is essentially a factory producing the cells of the blood: red cells that carry oxygen from the lungs to all areas of the body, white cells that fight infection by attacking and destroying germs, and platelets that control bleeding by forming blood clots in areas of injury. Continuous production of blood cells is necessary all through life because each cell has a finite life span once it leaves the bone marrow and enters the blood: red cells120 days, platelets6 days, and white cellsone day or less!

3. MEdIC - Aplastic Anemia - Introduction For The General Physician MEdIC An explanation of aplastic anemia, followed by a look at the diagnosing, treatment and prognosis. http://medic.med.uth.tmc.edu/ptnt/00001040.htm

Aplastic Anemia: Introduction for the General Physician Aplastic anemia is a hematologic disorder characterized by a decrease in the cellular elements of the peripheral blood. This results from underproduction of peripheral blood elements due to bone marrow failure. Aplastic anemia develops before age 30-40 in patients who are predisposed due to a congenital chromosomal abnormality such as Fanconi's anemia or dyskeratosis congenita. Acquired aplastic anemia may be caused by toxic chemicals, radiation, or by idiosyncratic reactions to medications or infections. However, in over 50% of cases there is no identifiable cause and the condition is then referred to as idiopathic aplastic anemia. Making the Diagnosis Patients with aplastic anemia generally present with symptoms of bleeding or bruising due to the thrombocytopenia (low platelets), tiredness or pallor due to the anemia (low hemoglobin), or infection due to the neutropenia (low white blood cell count). A complete blood count and reticulocyte count usually show depression of all blood elements (pancytopenia). The peripheral blood smear shows no abnormal cells. The diagnosis is confirmed by a bone marrow biopsy with an assessment of cellularity. The bone marrow is also evaluated for the degree of maturation of all cell lines. Aplastic anemia is usually categorized as severe if, in addition to a hypocellular bone marrow for age, two of the three following criteria are present: a platelet count of less than 20,000/mm3, a corrected reticulocyte count of less than 1%, and a granulocyte or absolute neutrophil count [ANC = total white count x (segs + bands)] of less than 500/mm3. Patients With pancytopenia, but not severe enough to meet the above criteria, have mild or moderate aplastic anemia. Very severe aplastic anemia exists if the ANC or granulocyte count is less than 200/mm3.

4. Aplastic Anemia (Severe) This page provides a basic overview of the symptoms, diagnosis, possible treatment options for severe aplastic anemia. http://www.marrow.org/PATIENT/aplastic_anemia.html

HOME CONTACT US CAREERS MEDIA ... PHYSICIAN RESOURCES switchIt("patient" ,"main_nav_sel"); Home Patient Resources Learning More about Your Disease > Aplastic Anemia (Severe) E-mail a Friend Print this Page Aplastic Anemia (Severe) On this page: Symptoms/Diagnosis Treatment Transfusions Drug Therapies ... Marrow or Blood Cell Transplantation Aplastic anemia is not a single disease, but a group of closely related disorders characterized by the failure of the bone marrow to produce all three types of blood cells: red blood cells, white blood cells and platelets. Aplastic anemia is rare, affecting fewer than 1,000 people each year in the United States. The exact cause of aplastic anemia is unknown, although it has been linked to exposure to chemicals and radiation. It is also believed that some cases of aplastic anemia are inherited and that some cases are due to a viral infection. Symptoms/Diagnosis In aplastic anemia, the quantity of each of the three blood cell types is much lower than normal, which leads to the symptoms that cause a physician to suspect the disease. These symptoms are unexplained infections (due to fewer white blood cells), unexpected bleeding (due to fewer platelets) and fatigue (due to fewer red blood cells). To confirm a diagnosis of aplastic anemia, a physician examines a blood sample and determines the number of each type of blood cell circulating in the blood. Aplastic anemia is strongly suspected when two or three of the cell counts are extremely low. A definitive diagnosis is made if a marrow sample (a biopsy) shows a great reduction in the number of cells in the marrow itself.

5. Katelyn Rose Hubbell Beats Aplastic Anemia Personal page of this young resident that won her battle against Severe aplastic anemia. http://www.katyhubbell.com/

Click a flag above to translate this page into the language of your choice! To Katelyn Rose Hubbell's Aplastic Anemia Website! For more pictures of me and my family.. CLICK HERE! Katy's Story Katelyn Rose Hubbell turned four years old on June 26th 1997, and had a big party at her home in Fisher, Illinois. She was a happy, healthy little girl, until July 11, 1997 when she was diagnosed with a life threatening bone marrow failure disease called Severe Aplastic Anemia. In case you didn't know, bone marrow is the soft spongy material inside your bones that is home to stem cells. Stem Cells are the little factories that produce the three types of blood cells, that along with a liquid called plasma, makes up your blood. In people with Aplastic Anemia, the workers in the "factory" go on strike. They do not produce enough blood cells to keep the patient alive. There are three main types of blood cells. White blood cells fight infection by "eating" bacteria and viruses that enter the body. Red blood cells are responsible for carrying oxygen to organs and tissues throughout the body.

6. Catherine's Page Catherine is a currently undergoing a bone marrow transplant. Her page is for those interested in aplastic anemia, myelodysplasia, and bone marrow transplant issues. Includes links to BMT resources. http://www.geocities.com/catmac1991/

7. MEdIC - Aplastic Anemia Answer Book aplastic anemia is a rare but extremely serious disorder that results from the unexplained failure of the bone marrow to produce blood cells. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser Fighting aplastic anemia, Myelodysplastic Syndromes, and other bone marrow failure. http://www.aplastic.org/

In The News Updates on diseases and treatments. Frequently Asked Questions Want to Talk? Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Support Congressional Resolution 179 P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation Rare Diseases Clinical Research Network This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by Vansant Creations Web Development Interactive Masterminds This site is hosted by Toad.net

9. Pathology - Table Of Contents Announcements http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Aplastic Anemia Myelodysplastic Syndromes International Fighting aplastic anemia, Myelodysplastic Syndromes, and other bone marrow failure. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Aplastic Anemia (Severe) - Redirect The aplastic anemia (Severe) page has moved. If you are not automatically redirected in five seconds, please click here. http://www.marrow.org/MEDICAL/aplastic_anemia_basic.html

HOME CONTACT US CAREERS MEDIA ... PHYSICIAN RESOURCES switchIt("medical" ,"main_nav_sel"); Home Aplastic Anemia (Severe) - Redirect The Aplastic Anemia (Severe) page has moved. If you are not automatically redirected in five seconds, please click here SITE MAP GLOSSARY EDITORIAL BOARD ... PRIVACY STATEMENT Last Revised 01/27/05

12. National Marrow Donor Program Provides marrow transplants from volunteer unrelated donors to patients with leukemia, aplastic anemia and other potentially lifethreatening blood diseases. http://www.marrow.org/

HOME CONTACT US CAREERS MEDIA ... RESOURCES Information for our committed community of volunteer donors and those thinking of joining How To Join Update Your Address ABCs of Donation PATIENT ... RESOURCES Connecting patients and their families with support and advocacy services Learn about Your Disease NMDP Patient Services Financial Resources Get ... RESOURCES Information and resources on transplantation for medical professionals Medical Education Subscriptions Transplant Consultation Guidelines Education Programs NMDP ... NEWS The latest on NMDP partnerships and initiatives Help for Katrina Transplant Patients Dec. 2 Symposium 2005 NMDP Council Info NMDP Studies Transplant Methods ... PRIVACY STATEMENT

13. Aplastic Anemia-Blood Diseases Disorders Overview of aplastic anemia http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. National Marrow Donor Program Provides marrow transplants from volunteer unrelated donors to patients with leukemia, aplastic anemia and other potentially lifethreatening blood http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. EMedicine - Aplastic Anemia : Article By Sameer Bakhshi, MD aplastic anemia aplastic anemia is a bone marrow failure syndrome characterized by peripheral pancytopenia and marrow hypoplasia. http://www.emedicine.com/med/topic162.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Aplastic Anemia Last Updated: September 29, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: progressive hypocythemia, aregeneratory anemia, aleukia hemorrhagica, panmyelophthisis, hypoplastic anemia, toxic paralytic anemia, bone marrow failure syndrome, peripheral pancytopenia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Sameer Bakhshi, MD , Assistant Professor of Pediatric Oncology, Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences Coauthor(s): Roy Baynes, MB, BCh, PhD, FACP , Charles Martin Professor of Cancer Research, Department of Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University; Esteban Abella, MD

16. Fanconi Anemia Research Fund To find effective treatments and a cure for this disease, and to provide education and support services to affected families worldwide. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. Aplastic Anemia-Blood Diseases & Disorders Overview of aplastic anemia. aplastic anemia occurs when the bone marrow produces too few of all three types of blood cells red blood cells, http://www.umm.edu/blood/aneaplas.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Donations / Banking Blood Diseases Blood Disorders... Anemias... ... Site Map Related Resources Within UMM Hematology Pediatric Oncology Translate using Google to Spanish German French Italian Portuguese Blood Diseases Aplastic Anemia What is aplastic anemia? Aplastic anemia occurs when the bone marrow produces too few of all three types of blood cells: red blood cells, white blood cells, and platelets. A reduced number of red blood cells causes hemoglobin to drop. A reduced number of white blood cells makes the patient susceptible to infection. And, a reduced number of platelets causes the blood not to clot as easily. What causes aplastic anemia? Aplastic anemia has multiple causes. Some of these causes are idiopathic, meaning they occur sporadically for no known reason. Other causes are secondary, resulting from a previous illness or disorder. Acquired causes, however, may include the following: history of specific infectious diseases such as infectious hepatitis history of taking certain medications, such as antibiotics and anticonvulsants

18. Aplastic Anemia And Myelodysplasia Association Of Canada . Causes. Treatments. How can I help?......Understanding aplastic anemia and Myelodysplasia. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. ► Idiopathic Aplastic Anemia A medical encycopedia article on the topic Idiopathic aplastic anemia. http://www.umm.edu/ency/article/000554.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Z Maryland Medical Center Programs Department of Orthopaedics Home Medical Reference Encyclopedia (English) Toggle English Spanish Idiopathic aplastic anemia Overview Symptoms Treatment Prevention Definition: Idiopathic aplastic anemia is a failure of the bone marrow to properly form all types of blood cells. Alternative Names: Anemia - idiopathic aplastic Causes, incidence, and risk factors: Idiopathic aplastic anemia is a condition that results from injury to the stem cell, a cell that gives rise to other cell types after it divides. Consequently, there is a reduction in all cell types red blood cells, white blood cells and platelets with this type of anemia , which is called pancytopenia. The cause of idiopathic aplastic anemia is unknown, but is thought to be an autoimmune process (the body reacting against its own cells). Causes of other types of aplastic anemia may be chemotherapy radiation therapy toxins , drugs, pregnancy , congenital disorder, or systemic lupus erythematosus Symptoms arise as the consequence of bone marrow failure. Anemia (low

20. The Aplastic Anaemia Trust Charity dedicated to research into aplastic anaemia or bone marrow failure. Information on the disease and support group. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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