41. Alan Ebringer: Research ankylosing spondylitis (AS) affects approximately 1/2 million people in the UK It is proposed that BSE is a neurological, autoimmune reactive disease, http://www.kcl.ac.uk/kis/schools/life_sciences/life_sci/ebringerR.html

Department of Life Sciences Alan Ebringer Research ANKYLOSING SPONDYLITIS Related References: Ebringer Ebringer and Wilson (1996) The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. Clin Rheumatol Vol.15. Suppl.2. Pg:62-66. Tani et al. (1997) Antibodies to Klebsiella, Proteus and HLA-B27 peptides in Japanese patients with ankylosing spondylitis and rheumatoid arthritis. Journal of Rheumatol Vol 24. Pg:109-114. CROHN'S DISEASE Related References: Tiwana et al. (1997) Antibody responses to gut bacteria in AS, RA, Crohn's disease and ulcerative colitis. Rheum Internat Vol.17. Pg:11-16. RHEUMATOID ARTHRITIS Biochemical studies demonstrated that RA patients had antibodies to both EQRRAA/ESRRAL sequences. Further molecular studies identified a second similarity sequence IRRET, present in Proteus urease which showed molecular mimicry with the LRREI sequence found in type XI collagen, a common component of hyaline cartilage. Since erosions of hyaline cartilage are frequently found in RA patients, especially in the small joints of the hands and feet, this could explain the localization of the pathological lesions in this disease to these sites. These results are consistent with the hypothesis that RA is an autoimmune reactive arthritis following infection of the upper urinary tract by Proteus mirabilis microbes.

42. Dr. Schilling's Net Health Book - Treatment Of Ankylosing Spondylitis And Spondy The purpose of treating spondylitis, ankylosing spondylitis and It is animmunomodulator that addresses the autoimmune reaction that is behind the joint http://www.nethealthbook.com/treatmentofankylosingspondylitisandspondyloarthropa

Last Modified: June 22, 2004 webmaster@nethealthbook.com We subscribe to the HONcode principles. Verify here Dr. Ray's Health Newsletter / table of contents The latest Health Newsletter Treatment Of Ankylosing Spondylitis And Spondyloarthropathies The principles of treatment of anylosing spondylitis are to control the inflammation so that scarring and calcification with subsequent stiffening of the spine and of joints is minimized as much as possible. The usual anti-inflammatories that are used for other forms of arthritis are utilized here as well, such as NSAIDs and COX-2 inhibitors. Corticosteroids, which play a larger role in rheumatoid arthritis, play less of a role for ankylosing spondylitis. However, for single joints that are affected, these may be injected by the physician or rheumatologist for easier rehabilitation. Treatment of spondyloarthopathies Name of disease: ankylosing spondylitis psoriatic arthritis Reactive arthritis Reiter's syndrome ... Crohns disease Acute iritis is treated by the ophthalmologist utilizing topical corticosteroid drops as well. Systemic corticosteroids are avoided because of the danger of osteoporosis that would develop much easier in these patients and the danger of septicemia with life threatening infections as a result of the immunosuppressive side effect of corticosteroids.

43. Genetic Test For Ankylosing Spondylitis - Isis Innovation Licensing Opportunity A clinical diagnostic has been developed for ankylosing spondylitis, of geneticvariations associated with the autoimmune disease ankylosing spondylitis http://www.isis-innovation.com/licensing/1326.html

Introduction New Technologies Agricultural Chemistry (Industrial) ... Technology Search Project Number Genetic Test For Ankylosing Spondylitis Researchers at Oxford University's Institue of Musculoskeletal Sciences have identified a number of genetic variations associated with the autoimmune disease Ankylosing Spondylitis which constitute an accurate diagnostic for the disease. Background Oxford Invention Oxford researchers have identified polymorphisms within particular genes in the interleukin-1 gene region of chromosome 2 associated with AS. The discovery is based upon 227 sibling-pair families and 317 parent case trios, all Caucasian. These genes can be used for detecting whether a subject has or is genetically predisposed to a seronegative spondyloarthropathy. Such a test would also assist in diagnosis of a patient showing seronegative spondyloarthropathy symptoms. Commercialisation Opportunity Isis Innovation Ltd is interested in partnering with a company to develop this technology into a clinical diagnostic test.

44. CCHS Clinical Digital Library Miscellaneous ankylosing spondylitis Patients/Family Resources Additionalankylosing spondylitis resources (These sites have not been reviewed. http://cchs-dl.slis.ua.edu/patientinfo/rheumatology/autoimmune/spondyloarthropat

Patient/Family Resources by Topic: Rheumatology Ankylosing Spondylitis Patient/Family Resources Pediatrics Spanish Miscellaneous See also: General Rheumatology Patient/Family Resources Ankylosing Spondylitis Clinical Resources MD Consult: Homepage Health Sciences Library subscription INFO Patient Handouts Table of content Ankylosing Spondylitis: Access document Low and Sciatica Back Pain (Comprehensive Version): Access document Arthritis Foundation: Homepage Disease Center: List of documents Ankylosing Spondylitis Access document American College of Rheumatology: Homepage Patient Information: List of documents Ankylosing Spondylitis: Access document American Academy of Family Physicians (familydoctor.org): Homepage Self Care Flowcharts: List of documents Lower Back Pain: Access document University of Birmingham (U.K.) Dept of Rheumatology: Homepage Patient Information: List of documents Arthritis Help: A Primer on Rheumatic Diseases: Table of contents A Few Definitions Access document General Features of Inflammatory Arthritis Access document Treatments Access document American Pain Foundation: Homepage Consumer Health Information: List of documents Arthritis: Modern Treatments: Access document Arthritis and Exercise: Access document MedlinePlus Medical Encyclopedia: Table of contents Ankylosing Spondylitis: English Spanish Arthritis: English Spanish Joint Pain: English Spanish InteliHealth Disease and Condition Guide Table of contents Ankylosing Spondylitis: Access document Merck Manual - Second Home Edition Table of contents Section 5. Bone, Joint, and Muscle Disorders:

45. Welcome To Southern Cross ankylosing spondylitis (AS) is a chronic (longterm) inflammatory disease It is thought to be an autoimmune disease - where the body’s own immune system http://www.southerncross.co.nz/index.cfm?6C75C834-5E96-486F-AA16-380FDC991372

46. Juvenile Ankylosing Spondylitis - Mountain View Bay Area Sunnyvale Cupertino Pal Juvenile ankylosing spondylitis El Camino Hospital is located in the heart ofSilicon Some of these disorders, such as JAS, are autoimmune related and http://www.elcaminohospital.org/15464.cfm

@import url(default.css); @import url(module.css); Home Hospital News Find A Doctor Health Information A-Z ... Back to Search Juvenile Ankylosing Spondylitis What is juvenile ankylosing spondylitis? Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse. JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.

47. Abbott Laboratories Press Releases (774) Psoriatic arthritis may stem from an autoimmune disorder in which a human protein, HUMIRA Improved Symptoms of Active ankylosing spondylitis http://abbott.com/news/releaseonly.cfm?id=774

48. AI - News(200577411:55:49) HUMIRA Improved Symptoms of Active ankylosing spondylitis Clinical trialsare currently underway in autoimmune diseases. Important Safety Information http://abbott.com/ai/news/news.cfm?id=774

49. BBC - Radio 4 - Case Notes - Autoimmune Diseases ankylosing spondylitis affects 1 in 200 men and 1 in 500 women in Britain Join Dr Mark Porter for Case Notes on Autoimmune Diseases on Tuesday 24th http://www.bbc.co.uk/radio4/science/casenotes_20040824.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index 18 September 2005 Text only BBC Homepage BBC Radio Radio 4 PROGRAMME FINDER: A-Z Directory Listen Again What's On Listings Presenters PROGRAMME GENRES: Arts and Drama Science History Factual TOP PROGRAMMES THIS WEEK: The Archers In Our Time Today Programme Woman's Hour ... Help Like this page? Send it to a friend! CASE NOTES MISSED A PROGRAMME? Go to the Listen Again page PROGRAMME INFO Tuesday 21:00-21:30 Repeat Wednesday 16:30 Dr Mark Porter gives listeners the low-down on what the medical profession does and doesn't know. Each week an expert in the studio tackles a particular topic and there are reports from around the UK on the health of the nation - and the NHS. Contact Case Notes LISTEN AGAIN 30 min Listen to 24 August PRESENTER DR MARK PORTER "I spend half my week practising medicine - as an NHS GP in Gloucestershire - and the rest writing and talking about it. I always listened to Case Notes and I was over the moon when I was asked to present it." Mark Porter PROGRAMME DETAILS Tuesday 24 August 2004 Full programme transcript >> Auto-Immune Diseases These are conditions where the body's own immune system is fighting other cells in the body which might not be diseased, causing inflammation and pain and most are often chronic conditions.Â

50. Juvenile Ankylosing Spondylitis Spinal Column with Vertebrae Juvenile ankylosing spondylitis (JAS) is a type of Some of these disorders, such as JAS, are autoimmune related and http://www.chw.org/display/PPF/DocID/1651/router.asp

Juvenile Rheumatoid Arthritis Juvenile Ankylosing Spondylitis Psoriatic Arthritis Systemic Lupus Erythematosus (SLE, or Lupus) ... Common Types of Juvenile Arthritis and Other Rheumatic Diseases : Juvenile Ankylosing Spondylitis E-mail this page Print this page Juvenile Ankylosing Spondylitis What is juvenile ankylosing spondylitis? Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse. JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. Individuals may have antigen and no disease. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.

51. UK Wellness: Medical Conditions: Bio-medical: Ankylosing Spondylitis ankylosing spondylitis. Risk Click here for risk definitions DEFINITIONankylosing spondylitis is an autoimmune disease that causes inflamation of the http://www.ukwellness.com/medical-conditions/biomechanical/ankylosing-spondyliti

Ankylosing Spondylitis Risk Click here for risk definitions Click here to find a qualified fitness trainer Click here to order the Self Help Guide 'Exercise and Back Pain' ... by Dr Allinson SNAPSHOT EXERCISE SUMMARY: Swimming is preferred, as it avoids jarring impact of the spine. Breaststroke is good for spinal extension. Running, tennis, golf, and athletics, but avoid contact sports. Daily stretching. DEFINITION: Ankylosing spondylitis is an autoimmune disease that causes inflamation of the spine and sacroiliac joints and can cause inflammation of the eyes, lungs, and heart valves. It varies from intermittent episodes of back pain that occur throughout life to a severe chronic disease that attacks the spine, peripheral joints and other body organs, resulting in severe joint and back stiffness, loss of motion and deformity as life progresses. A dramatic loss of flexibility in the lumbar spine is an early sign of AS. Although most symptoms begin in the lumbar and sacroiliac areas, they may involve the neck and upper back as well. Arthritis may also occur in the shoulder, hips and feet. As with many of the autoimmune diseases, many body systems can be effected in extreme cases. AT RISK: Ankylosing spondylitis typically starts as an insidious onset of back pain in the late teens or early twenties, and seems to effect men more than women. It is a genetically determined disease, susceptability to which is related to the presence of the HLA-B27 antigen in the patients' cells.

52. JCR: Journal Of Clinical Rheumatology - UserLogin ankylosing spondylitis an autoimmune disease? Ann Rheum Dis 1991; 50 7781.Context Link. 4. Montenegro V, Monteiro RC. Elevation of serum IgA in http://www.jclinrheum.com/pt/re/jcr/fulltext.00124743-200206000-00015.htm

LWWOnline LOGIN eALERTS REGISTER ... Archive You are attempting to access protected content. To access this content please login using an established account or create/activate an account. If you have already created/ activated an online account, please login below: User Name: Password: Note: passwords are CASE SENSITIVE If you are a new user or guest visiting an LWWonline site for the first time, please complete the new account setup process to view or purchase content. Forgot your password? Subscribe Renewal Information Subscribe to RSS feed utrdc-pt02 Release 4.0

53. Hep C And Autoimmune Diseases Topic Hepatitis C Subject Hep C and autoimmune Diseases Because I havejuvenile rheumatoid arthritis and ankylosing spondylitis my doctor recommended http://www.medhelp.org/forums/Hepatitis/messages/30222.html

Questions in the Hepatitis Forum have been answered by doctors from Henry Ford Health System. Hep C and Autoimmune Diseases Forum: The Hepatitis Forum Topic: Hepatitis C Subject: Hep C and Autoimmune Diseases From To Post Nancy I was diagnosed with Hep C about 2 years ago, and genotyped 1b. Because I have juvenile rheumatoid arthritis and ankylosing spondylitis my doctor recommended I do not have Interferon treatment. Are there any other options at this point or do I just wait until another treatment becomes available? Are there any other drugs in clinical studies at this time? My ALT and AST's are in the 70's. HFHSM.D.-D.M. Nancy Dear Nancy: I appreciate your question and I also imagine you are a little frustrated. I understand that you have hepatitis C and you are not an ideal candidate for interferon based therapies because of your juvenile rheumatoid arthritis and ankylosing spondylitis. The first question, I have for you is: do you know what your liver biopsy shows. If you have a benign liver biopsy with little scarring or fibrosis, you might not want to do anything right now. Hepatitis C typically causes liver disease over decades and doesn’t even cause cirrhosis in half of infected individuals. Typically women who do not drink alcohol are likely to have relatively slow progressing disease. One drug that is being used in clinical trials is a drug called interleukin-10 (IL-10). This is a drug that does not get rid of the virus but has anti-inflammatory activity that some liver specialist feel can slow the level of fibrosis in individuals with hepatitis C. Because it is anti-inflammatory or even immune-suppressing it might be safe in individuals with juvenile rheumatoid arthritis and ankylosing spondylitis. However, I think most of the studies looking at IL-10 in hepatitis C require a liver biopsy.

54. Townsend Letter For Doctors And Patients: Phytotherapy For Ankylosing Spondyliti Full text of the article, Phytotherapy for ankylosing spondylitis and Bone K.Phytotherapy for autoimmune disease A focus on multiple sclerosis. http://www.findarticles.com/p/articles/mi_m0ISW/is_251/ai_n6112657/pg_4

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Home Advanced Search IN free articles only all articles this publication Automotive Sports FindArticles Townsend Letter for Doctors and Patients June 2004 Content provided in partnership with 10,000,000 articles Not found on any other search engine. Related Searches Inflammatory bowel diseases / Care and treatment Ankylosing spondylitis / Care and treatment Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Phytotherapy for ankylosing spondylitis and inflammatory bowel disease Townsend Letter for Doctors and Patients June, 2004 by Kerry Bone Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. Continued from page 3. The safety and efficacy of a Boswellia extract was compared against mesalazine for the treatment of 102 patients with active Crohn's disease in an eight-week randomized, double-blind study. (2) The primary clinical outcome measured was the change in Crohn's Disease Activity Index (CDAI). After therapy with Boswellia extract (3.6 g per day) the average CDAI was reduced by 90, compared to a reduction of 53 for the mesalazine group (4.5 g per day). The authors concluded that the Boswellia extract was as effective as mesalazine, which is the state-of-the-art treatment for this disorder. Considering the observed fewer side effects and better safety profile of Boswellia, they suggested that this novel herbal treatment appears to be superior to mesalazine in terms of a risk-benefit evaluation.

55. The Pathogenesis Of Rheumatoid Arthritis, Psoriatic Arthritis, And and ankylosing spondylitis are chronic inflammatory autoimmune disorders. ankylosing spondylitis is a chronic, systemic, inflammatory disorder http://www.enbrel.com/rheumatology/enbrel-rhcpscience-pathogenesis.jsp

56. ENBREL Rheumatology HCP The Role Of TNF In Rheumatoid Arthritis Role of TNF in ankylosing spondylitis (AS). In autoimmune disease, TNF (yellow)produced by cells of the immune system (grey) binds to TNF receptors (blue) http://www.enbrel.com/rheumatology/enbrel-rhcpscience-TNF.jsp

57. Autoimmune Diseases / Family Village Dedicated to the eradication of autoimmune diseases and the alleviation of Alopecia Areata,ankylosing spondylitis,Behcet s Disease, Chronic Fatigue http://www.familyvillage.wisc.edu/lib_auto.htm

Autoimmune Diseases Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Autoimmune" Who to Contact American Autoimmune Related Diseases Association, Inc. (AARDA) 22100 Gratiot Ave. Eastpointe E. Detroit, MI 48021 800-598-4668 (Literature Requests) Website: http://www.aarda.org/ Dedicated to the eradication of autoimmune diseases and the alleviation of suffering and the socioeconomic impact of autoimmunity through fostering and facilitating collaboration in the areas of education, research, and patient services in an effective, ethical and efficient manner. Where to Go to Chat with Others Autoimmunity The Autoimmune Conditions Group Most of these conditions are fairly rare. Seeking help and support is NOT easy, but it is available. Living with Autoimmune Diseases This group is for people with autoimmune diseases like Lupus, Fibromyalgia, Arthritis, MS, Raynaud's Phenomenon, Narcotizing Vasulitis, Celiac Diseas(SPRUE)Peroarteritis nodosa,progressive systemic sclerosis, Alopecia Areata,Ankylosing Spondylitis,Behcet's Disease, Chronic Fatigue Syndrome, Crohn's Disease, Myasthenia Gravis, Psoriasis, Scleroderma, Juvinile Dermatomyosistis, Granulomatous Angiitis of the Central Nervous System(GACNS), Hashimoto's Disease, etc. Teens Autoimmune This is a group for teens suffering from different autoimmune disorders/disease. Please feel free to join. It is open to anyone from ages 10-25.

58. Juvenile Rheumatoid Arthritis And Ankylosing Spondylitis Juvenile Rheumatoid Arthritis and ankylosing spondylitis An autoimmune disordercan cause the body to rebel against itself. How does the disease start? http://www.spineuniverse.com/displayarticle.php/article2236.html

search kidsplanet>back pain for kids> Juvenile Rheumatoid Arthritis and Ankylosing Spondylitis Lawrence G. Lenke, M.D. The Jerome J. Gilden Professor of Orthopaedic Surgery St. Louis, MO, USA Juvenile Rheumatoid Arthritis (JRA) (Juvenile Rue-ma-toyed Arthritis) Ankylosing Spondylitis (AS) (Ankle-oo-sing Spondie-lie-tiss) When most people hear the word Arthritis they think of elderly folks - Grandma and Grandpa. Although many adults and older people will develop arthritis, it is not very common in children. Juvenile Arthritis (JA) is a term used to categorize the different types of arthritis affecting children. The most common type of JA is Juvenile Rheumatoid Arthritis (JRA). The type of JRA that affects the spine is called Ankylosing Spondylitis (AS). JRA is diagnosed in children less than 16 years of age whose arthritis has persisted for longer than six weeks. What causes JRA or AS? The exact cause or causes are not understood. Sometimes it is triggered by a bacterial infection or an autoimmune problem. An autoimmune disorder can cause the body to rebel against itself. How does the disease start?

59. Ankylosing Spondylitis ankylosing spondylitis an autoimmune disease affecting the spine ankylosingspondylitis (AS) is an inflammatory arthritis that affects the spine. http://www.arthritis-treatment-and-relief.com/ankylosing-spondylitis.html

Ankylosing spondylitis...an autoimmune disease affecting the spine... Ankylosing spondylitis (AS) is an inflammatory arthritis that affects the spine. Usually the sacroiliac joints (joints joining the pelvis to the sacrum of the spine) are involved first with gradual involvement of the rest of the spine following. AS falls into the category of diseases designated as the “spondyloarthropathies.” Other members of this group include psoriatic arthritis and reactive arthritis. The term spondyloarthropathy refers to the propensity for spinal involvement. There is a strong genetic predilection with 90 per cent of Caucasian patients showing the presence of the HLA Br27 genetic marker. Many AS patients will have a positive family history for the disease. Spondyloarthropathies, in general, cause early erosion and damage. As the disease progresses, there is gradual destruction of joints with bony bridging leading to marked deformity and loss of function. Like the other spondyloarthropathies, AS is an enthesopathy causing inflammation at the site where the tendon inserts into bone. AS occurs in about 0.5 per cent of the population. It is more common in men than women in a ratio of about 5:1. It should be mentioned that AS is probably under diagnosed in women. When AS does affect women, it tends to happen a bit later, have less hip involvement, have more symphysis pubis involvement, and definitely more cervical spine (neck) involvement.

60. Ankylose This!: October 2004 Blogging about life with ankylosing spondylitis. About ankylosing Spondlyitis.It s a painful, debilitating autoimmune disease with a funny name. http://www.mcwetboy.net/ankylose_this/archives/2004_10_01_as.html

@import url("http://www.blogger.com/css/blog_controls.css"); @import url("http://www.blogger.com/dyn-css/authorization.css?blogID=8338776"); Ankylose This! Thursday, October 28, 2004 Travelling with ankylosing spondylitis I've always enjoyed travelling, but since I came down with ankylosing spondylitis it's gotten a lot harder for me. A recent trip to Winnipeg brought this home for me: I now expect elevated pain every time I travel, and this trip was, as I had predicted, no exception. But at least I'm at the point where I can analyse it a little bit. From what I've observed, pain and inflammation due to AS are higher when I travel for three reasons: 1. Stress. Stress exacerbates autoimmune disease (about which see Gabor Mat©'s When the Body Says No ). Travel is stressful. And travel is especially stressful for me: I plan out itineraries to each pee break, and rehearse every possible (and several impossible) worst-case scenarios in my head before I get under way. It's so bad that even on weekend excursions I have to leave the packing to my significant other I'm just too wound up to be useful. Once on the road (or at the airport or the train station), I'm fine in fact I'm more than fine: I'm an excellent long-distance driver, and my only problem with air turbulence is nausea, not terror. But getting to that point is sometimes only just short of traumatic. The end result is usually that my joints are screaming by the following morning. 2. Seating.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 3     41-60 of 103    Back | 1  | 2  | 3  | 4  | 5  | 6  | Next 20