Genotype And Phenotype Database (GPDB) genotype and phenotype Management System (GPDB). Efficient management of genotypeand phenotype data is necessary in genetic and genomic studies for complex http://apps.sbri.org/gpdb/
Extractions: Genotype and Phenotype Management System (GPDB) Efficient management of genotype and phenotype data is necessary in genetic and genomic studies for complex human diseases. Previous software for large-scale management of genotype data has its limitations, i.e., operation system (OS) dependency, limited database capacity and lacks of functions for management of phenotype data. To overcome these limitations, a web based Java application for genotype and phenotype database management system (GPDB) is developed. To try demo version of the program, you may freely register as a demo user with the system; however, the data entered by demo users are not guaranteed available in the future and are subjected loss, deletion or change without further notice. Only the users created through authority have the privilege to keep the data in a permanent database which is maintained daily and backup regularly. User Sign in User Name: Password: Last modified: 06-29-04
Extractions: This Article Abstract Full Text (PDF) Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Borm, P.J.A. Articles by Schins, R.P.F. Eur Respir J 2001; 18:127S-133S
ERJ -- Sign In Page The genotypephenotype correlation is not known for many rare mutations. Mickle J, Cutting G. genotype-phenotype relationships in cystic fibrosis. http://erj.ersjournals.com/cgi/content/full/23/5/679
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Extractions: URL: http://parallel.acsu.unsw.edu.au/rks Ecolab ] is a model system of an ecology that attempts to understand evolutionary processes. It makes a particular assumption about the embryology or genotype-phenotype map in order to generate the novel ecological interaction coefficients from the novel genotypes as they arise through mutation. The Eco-Tierra project [ ] examines this assumption using Tierra ] as a model ecosystem, which has an implicitly defined embryology. Ecolab ] is a model system of an ecology that attempts to understand evolutionary processes. Ecolab's dynamics is taken to be a generalised form of the Lotka-Volterra equation which is, in fact, the most general analytic two-term interaction model. Here n is the population density, the component being the number of individuals of species i r is the difference between reproduction and death
Embryology In Tierra: A Study Of A Genotype To Phenotype Map Embryology in Tierra A study of a genotype to phenotype map It makes aparticular assumption about the embryology or genotypephenotype map in order to http://journal-ci.csse.monash.edu.au/ci/vol04/eco-tierra/
Extractions: Embryology in Tierra: A study of a genotype to phenotype map Abstract Ecolab [9, 7] is a model system of an ecology that attempts to understand evolutionary processes. It makes a particular assumption about the embryology or genotype-phenotype map in order to generate the novel ecological interaction coefficients from the novel genotypes as they arise through mutation. The Eco-Tierra project [7] examines this assumption using Tierra [2] as a model ecosystem, which has an implicitly defined embryology.
Extractions: This Article Full Text Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Koch, R. Related Collections PEDIATRICS Vol. 104 No. 2 August 1999, pp. 258-262 Received Jul 27, 1998; accepted Dec 21, 1998. Colleen Azen Per Guldberg Anne Romstad William B. Hanley Harvey L. Levy Reuben Matalon Bobbye M. Rouse Friedrich Trefz Felix de la Cruz and Richard Koch From the John F. Kennedy Institute, Glostrup, Denmark; Children's Hospital, Division of Medical Genetics and the University of Southern California, Los Angeles, California; Hospital for Sick Children, Toronto, Canada; Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;
Extractions: This Article Abstract Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Koch, R. Related Collections PEDIATRICS Vol. 104 No. 2 August 1999, pp. 258-262 Colleen Azen, MS Per Guldberg, PhD Anne Romstad, MS William B. Hanley, MD Harvey L. Levy, MD Reuben Matalon, MD, PhD Bobbye M. Rouse, MD Friedrich Trefz, MD Felix de la Cruz, MD and Richard Koch, MD From the John F. Kennedy Institute, Glostrup, Denmark; Children's Hospital, Division of Medical Genetics and the University of Southern California, Los Angeles, California; Hospital for Sick Children, Toronto, Canada; Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;
Extractions: Search for: Limit by: All Topics Original Reports Review Articles Special Articles Biology of Neoplasia Editorials Comments and Controversies Diagnosis in Oncology Art of Oncology Correspondence All Years Browse by Topic or Issue Home Search/Browse Subscriptions ... Customer Service This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Bertario, L. Articles by Radice, P. Journal of Clinical Oncology , Vol 21, Issue 9 (May), 2003: 1698-1707 American Society for Clinical Oncology L. Bertario A. Russo P. Sala L. Varesco M. Giarola P. Mondini M. Pierotti P. Spinelli P. Radice for the Hereditary Colorectal Tumor Registry From the Division of Predictive and Preventive Medicine, Department of Experimental Oncology, and Endoscopy Division, National Cancer Institute; Epidemiology Unit, Local Health Authority of Milan, Milan; and Division of Experimental Oncology, National Cancer Institute, Genoa, Italy. Address reprint requests to Lucio Bertario, MD, National Cancer Institute, Via Venezian 1 20133 Milan, Italy; email:
Extractions: Vol. 61 No. 5, May 2004 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Larner AJ ISI Web of Science (1) Contact me when this article is cited Topic Collections Alzheimer Disease Neurogenetics Topic Collection Alerts Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. The recent description by Rippon et al of 2 brothers with early-onset Alzheimer disease associated with the M139V mutation in the presenilin 1 ( PSEN-1 ) gene raises some interesting points about genotype-phenotype correlations in this disease. Their findings concur with other recent analyses of M139V, which have noted
Extractions: Vol. 58 No. 6, June 2001 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Wu ZY Yu L Articles that cite this article ISI Web of Science (5) ... Contact me when this article is cited Topic Collections Genetic Counseling/ Testing/ Therapy Genetics, Other Neurogenetics Topic Collection Alerts
Brazilian Journal Of Medical And Biological Research - We observed a good correlation between genotype and phenotype. Discordance betweengenotype and phenotype was found in one SV patient with a mild mutation http://www.scielo.br/scielo.php?pid=S0100-879X2003001000006&script=sci_arttext
Extractions: Genotype and Phenotype (DIGEST) PI: Johanna Lampe PhD DIGEST website: http://www.fhcrc.org/phs/digest Research has shown that certain fruits and vegetables can increase the activity of a group of enzymes (called glucuronosyltransferases or UGT for short) that help our body get rid of potentially harmful substances, including carcinogens. Genetic differences among individuals can play a role in how effectively these cancer-fighting enzymes work. The DIGEST study will look at how the interplay of genes and diet in particular, a diet rich in certain fruits and vegetables may affect the function of the bodys cancer-fighting enzymes. The results of this study, funded by the National Cancer Institute, could be important in making recommendations about diets that prevent cancer. About 300 people, ages 20 to 40, are sought for the first half of this two-part study. They will be asked detailed questions about diet and health. DNA from a sample of blood will be analyzed to determine genetic patterns of enzymes. Activity of these cancer-fighting enzymes will be measured by looking at the rate that the body breaks down aspirin and Tylenol. Of those initially enrolled, 60 will be asked to participate in the second part, two 14-day feeding studies during which the Hutchinson Center will provide all food and beverages. Eligibility will depend on genetic patterns of the enzymes.
Extractions: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Dolz;an, V Articles by Battelino, T CLINICAL STUDY V Dol ;an G Fekete V Rakosnikova F Votava J Lebl Z Pribilincova SM Baumgartner-Parzer S Riedl F Waldhauser H Frisch M Stopar-Obreza C Kr ;i nik and T Battelino Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary, Department of Paediatrics, University of Szeged, Szeged, Hungary
Extractions: Click here to start The Predictive Quality of Genotype and Phenotype Data on Virological Response to Salvage Therapy in HIV-1 Infected Patients (CNAA2007)Resistance Collaborative Group Reanalysis Background Information Methods Baseline Characteristics of Study Population ... Phenotypic Multivariate Analysis:Odds Ratio of Virological FailureClass Phenotypic Sensitivities Author: Jeff Booker, VisCom Inc.
Drug Discovery@nature.com From genotype to phenotype a shortcut through the library A new methodprovides a shortcut on this path from genotype to phenotype it uses a http://www.nature.com/drugdisc/res_high/articles/nrg1650.html
Extractions: From genotype to phenotype: a shortcut through the library from Nature Reviews Genetics 10 June 2005 Louisa Flintoft In the new study, this annotation stage was avoided by directly linking species with phenotypic information already available in the published literature. The authors linked 92 completely sequenced prokaryotic species with 172,967 nouns in MEDLINE abstracts (from the database compiled by the US National Library of Medicine). The nouns were grouped according to the species they matched up with, assuming that words that relate more frequently to a particular set of species are likely to be specific to a shared trait. For the same species, 11,026 orthologous gene sets were identified from the STRING (search tool for the retrieval of interacting genes/proteins) database, defining shared sets of genes. Many of the other associations made in this study also linked genes to disease-related phenotypes, which could provide a valuable source of new drug targets. This skew towards clinically relevant phenotypes reflects the fact that pathogens are highly represented among fully sequenced prokaryotes, but as more sequences and more MEDLINE entries become available, this method should provide a way to link genes to a wide range of biological processes.
Accessing Article The phenotype and genotype of converted blackpigmented clones was stable.These results demonstrate a permanent and stable gene correction by the RNA-DNA http://www.nature.com/nbt/journal/v16/n13/full/nbt1298_1343.html
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Test Information - Genotype-Phenotype Discordances The central dogma of biology can be restated to mean genotype determines phenotype. Yet physicians who order both genotype and phenotype tests often get http://www.hivresistanceweb.com/protected/testinfo/02sep/rws-02sep23-ti-genophen
Extractions: published on HIVresistanceWeb: September 27, 2002 Drug resistance can be measured using either genotypic or phenotypic assays. Genotypic assays detect mutations that cause drug resistance. Phenotypic assays are drug susceptibility assays in which a fixed inoculum of HIV-1 is cultured in the presence of serial dilutions of an inhibitory drug. The central dogma of biology can be restated to mean "genotype determines phenotype." Yet physicians who order both genotype and phenotype tests often get back interpretations that appear to be discordant. In this article, I will review the six causes for these discordances: (i) genotypic mixtures; (ii) transitional mutations; (iii) antagonistic mutations; (iv) the effect of thymidine analog mutations on ddI, d4T, and tenofovir susceptibility; (v) atypical mutations; and (vi) complex patterns of mutations. Genotypic mixtures
Extractions: As we reported in May, the results of six prospective, randomized studies that evaluated short-term virologic responses in subjects receiving a genotypic or phenotypic resistance test - compared to those who did not receive a resistance test - have been published ( see related article ). Initial studies compared one technology (genotype or phenotype) with no test in order to assess the clinical utility of resistance testing in general. The second round of studies compared the two testing strategies with each other. The contribution of expert advise to improved virologic outcomes has also been evaluated. Ongoing studies are comparing different interpretation approaches for genotype testing, including different rules-based algorithms and comparative database systems (e.g., Virtual Phenotype TM ); results of these studies have yet to be published. Five studies presented at the XIV International AIDS Conference in Barcelona address similar or related questions - questions that are important for understanding the utility and limitations of resistance testing in clinical practice. In addition to determining the clinical utility of these tests with regard to short-term virologic responses, it is important to address the longer-term clinical utility of resistance testing, and how well different interpretation systems work. New findings regarding this latter issue are discussed in a separate article, entitled "