Extractions: @import "/stylesheet-site.css"; Search The guide, Understanding cancer genetics , is aimed at anyone who is worried they may have inherited an increased risk of cancer, and dispels popular myths about cancer and genes. Understanding cancer genetics answers the questions many people worry about: The guide looks at the role of genetic counselling and explores genetic testing, explaining its limitations as well as the implications for people who are found to have a cancer gene. Dr Charlotte Augst, CancerBACUPs genetic information project manager and author of the guide, says: Some people think they are at greater risk because one or two elderly relatives have had cancer. This is not true. Cancer is a common illness, which one in three people will develop in their lifetime usually over the age of 65. Only people who have at least two blood relatives under 60 on the same side of the family with the same cancer are at a significantly increased risk. All those who are at high risk should have access to evidence-based screening programmes or clinical trials.
Colorectal Cancer And Genetics Geneticists have been studying genetic linkages to colorectal cancer since There are several kinds of hereditary colon cancers. Genetic researchers have http://www.csu.edu.au/learning/ncgr/gpi/odyssey/colon/
Extractions: In the past few years, reports about possible genetic elements of colon and colorectal cancers have made headlines. Over 500,000 people throughout the world are diagnosed with colon cancers every year. So, when news spreads about discoveries related to colon cancer, people pay attention. It has long been observed that colon cancer runs in some families. Medical researchers suspected that a portion of colon and rectal cancer cases might have a genetic basis. Geneticists have been studying genetic linkages to colorectal cancer since the mid-1980s. It is important to understand that only about 5 to 10 percent of all colon cancer cases are directly linked to hereditary, or genetic, factors. The other 95 percent are considered sporadic. Just because a disorder such as colon cancer tends to concentrate in some families does not necessarily mean that a predisposition to the disease is passed on genetically. Family members also share similar environments, lifestyles, and diets that are risk factors for cancer. Colon cancer is a multifactorial condition. That means there may be many things that have acted together to cause the cancer in any given case, including DNA. There are several kinds of hereditary colon cancers. Genetic researchers have uncovered evidence that genetics does play a role in two types of familial conditions that can lead to colon cancer. Researchers have undertaken studies of families where these conditions can be traced through family members over several generations.
Latest Research On Breast Cancer And Genetics WEB LINKS INFORMATION ABOUT BREAST cancer. MEDICAL SCIENCE AND genetics Support for genetic research related to breast cancer is included in the plan. http://www.csu.edu.au/learning/ncgr/gpi/odyssey/BCAN2/
Extractions: Compiled by Lauren McCain and Clay Dillingham INTRODUCTION WEB LINKS: INFORMATION ABOUT BREAST CANCER MEDICAL SCIENCE AND GENETICS SOCIAL AND ETHICAL ISSUES LEGAL AND POLICY ISSUES RECENT NEWS STORIES OTHER RESOURCES Introduction Geneticists have been working to locate genes that may play a role in causing breast cancer. The 1994 discovery of the gene mutation for breast cancer made headlines around the world. Studies seeking to discover other relationships between genetic mutations and breast cancer are under way. Following lung cancer, breast cancer is the second leading cause of cancer deaths among women (heart disease is the leading cause of death in women). One out of eight women is expected to develop breast cancer by the age of 80. Men can develop breast cancer, too. About 1% of breast cancers develop in males. In 1996 the Centers for Disease Control and Prevention reported 184,300 new cases of breast cancer. An estimated 44,200 deaths from breast cancer are expected in 1997, and the U.S. government will spend more than $550 million on breast cancer research in 1997 ("In Research, the Sincerest Form of Concern is Money,"
News Articles PE03257A.gif (4096 bytes) News, genetics /cancer Information amidea.wmf (1622bytes) cancer and genetics Information cancer Information from the http://texas.cgnweb.org/NewsInfo.htm
Extractions: Texas Cancer Genetics Consortium Dr. Louise C. Strong holds a primary appointment as Professor of Cancer Genetics, tenured, in the Department of Molecular Genetics. In addition to her current appointment, she also holds a joint appointment as Professor in the Department of Breast Medical Oncology, Division of Cancer Medicine, effective March 1, 2002 with clinical privileges. Dr. Strong holds the Sue and Radcliffe Killam Chair as Professor of Cancer Genetics and in November of 2002 was appointed Chief of the Clinical Cancer Genetics Section and directs the Clinical Cancer Genetics program. She is the 1997 Ashbel Smith Distinguished Alumna of the University of Texas Medical Branch at Galveston, and was also awarded the Distinguished Texas Geneticist Award from the Texas Genetics Society for 1997. She has served on many review groups and policy-making committees of the National Cancer Institute, including the National Cancer Advisory Board, as well as serving as President of the American Association of Cancer Research. In 1999 she was honored with the Charles A. LeMaistre Outstanding Achievement Award in Cancer at The University of Texas M.D. Anderson Cancer Center and the Faculty Achievement Commendation from the University of Texas Graduate School of Biomedical Sciences in 2000.
Genetics In Aging The future of breast cancer and genetics. Further discoveries about breast cancergenes will allow doctors to develop personalized prevention, diagnosis, http://www.agingresearch.org/geneticsinaging/brc_1_5.html
Extractions: The future of breast cancer and genetics Further discoveries about breast cancer genes will allow doctors to develop personalized prevention, diagnosis, treatment, and prognosis based upon the effects of mutations and variants in a person's genes and their interaction with hormonal and other factors. Treatment better use of existing treatments Scientists already know that gene mutations that develop in a malignant breast tumor (different than mutations that are inherited, as discussed above) determine how the tumor responds to treatment. Learning about these treatment-response genes will allow oncologists to pick the best treatment to use in each individual person. (This is a complicated problem. Mutations in these genes only occur in the tumor, so the tumor tissue itself must be tested. They are not found in the blood like BRCA1 or BRCA2 mutations.)
Genetics In Aging The future of prostate cancer and genetics Discoveries about the underlyinggenetic contribution to prostate cancer can have an enormous impact. http://www.agingresearch.org/geneticsinaging/pro_1_5.html
Extractions: The future of prostate cancer and genetics Further discoveries about prostate cancer genes will allow doctors to develop personalized prevention, diagnosis, treatment, and prognosis based upon information found in a person's genes. Treatment better use of existing treatments Specific genes may influence the responses to different treatments. Better genetic information could explain why some drugs work better in some people than others. This will make choosing treatments less hit-and-miss than in the past. Prevention, Diagnosis, Prognosis Prevention, diagnosis, and prognosis all improve when our ability to calculate risk improves. Scientists believe genes will tell us a lot about the risk of developing prostate cancer and the progression of prostate cancer. Discoveries about the underlying genetic contribution to prostate cancer can have an enormous impact. Knowing which genes are involved allows doctors to screen individuals and identify those more likely to develop prostate cancer. If prostate disease is detected early, it is much easier to cure. Discovering the genes provides insights into how the disease begins and how to cure it. Scientists also can begin to discover drugs that reverse the effects of those genes. The areas below provide more information on the exciting and promising research in this cutting edge area of science as well as links to more information.
Turner Construction Company University of Florida, cancer genetics Center Gainesville, FL. Turner, in ajoint venture with PPI, will provide construction management services for a http://www.turnerconstruction.com/pharmaceutical/content.asp?d=3523
Collection Of Recent MEDLINE Abstracts On Genetics What s new concerning prostate cancer and genetics? Genetic and EnvironmentalFactors in Prostate cancer Genesis Identifying HighRisk Cohorts http://www.cancer.prostate-help.org/caabsge.htm
Genetics & IVF Institute The genetics IVF Institute is the world s largest, fully integrated, ovarian cryopreservation for patients with cancer; genetics IVF discovered a http://www.givf.com/
Extractions: Available Through December 31, 2005 Through this new program, GIVF will be able to provide free Gonadotropin drugs to most Donor Egg, Shared Risk and self-pay IVF patients who begin their cycle(s) by December 31, 2005. The per cycle savings for these drugs is approximately $900. By providing these drugs to our patients at no cost, the cost of prescription drugs for a typical IVF cycle will be reduced by approximately one-third. GIVF is pleased to offer this program to benefit both new and current patients. IVF ICSI (intracytoplasmic sperm injection) non-surgical sperm aspiration for improved treatment of male infertility ovarian cryopreservation for patients with cancer
Extractions: (PDFs free after 6 months) Figures/Tables List Related articles in Annals Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Chung, D. C. Rustgi, A. K. Related Articles in PubMed PubMed Citation ... PubMed What is the problem and what is known about it so far? Cancer is fundamentally a genetic disorder. A defect, or mutation in a specific gene can increase cancer risk. Before most mutations fixes them in a fashion similar to a computer spell checker. The DNA mismatch repair system recognizes one type of mutation and corrects it by substituting the right chemical structures in the gene. However, when gene mutations occur in the genes for the repair system itself, it may not be able to do its job. Mutated genes in the DNA mismatch repair system may cause a disorder called hereditary nonpolyposis colorectal cancer (HNPCC)
Extractions: (PDFs free after 6 months) Summary for Patients Figures/Tables List Related articles in Annals Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Chung, D. C. Rustgi, A. K. Related Articles in PubMed PubMed Citation ... PubMed Daniel C. Chung, MD and Anil K. Rustgi, MD Basic studies of DNA replication and repair have provided surprising and pivotal insights into a novel pathway of tumorigenesis. Defects in the DNA mismatch repair process dramatically increase the risk for specific types of cancer because of instability in microsatellite DNA sequences. A germline mutation in either the or mismatch repair gene results in the hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch, syndrome.
Elsevier.com - Molecular Genetics Of Cancer Molecular genetics of cancer, 2E is an essential book for anyone MOLECULARgenetics OF LUNG cancer Introduction. Histologic types of lung cancer. http://www.elsevier.com/wps/product/cws_home/700038
Extractions: Home Site map Regional Sites Advanced Product Search ... Molecular Genetics of Cancer Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view MOLECULAR GENETICS OF CANCER Since the first volume was published, there has been significant success in isolating genes responsible for particular cancers as well as a major improvement in our understanding of the molecular events leading to tumors. This book explores possible genetic treatments that can suppress cancer cells that have formed tumors and it presents the details of the isolation and characterization of new human cancer genes that have recently been identified. Molecular Genetics of Cancer, 2E
Elsevier.com - The Genetics Of Cancer The genetics of cancer will be useful to all graduate students, clinicians, andresearchers working in the fields of cancer biology, genetics, and molecular http://www.elsevier.com/wps/product/cws_home/701071
Extractions: Home Site map Regional Sites Advanced Product Search ... The Genetics of Cancer Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view THE GENETICS OF CANCER Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.
Extractions: ASCO Guidelines Introduction to Cancer Cancer is a common disease. One out of every 3 people in the United States will develop some form of cancer in their lifetime, and 1 out of 4 Americans will die from cancer, making it the second leading cause of death in the US. Because cancer is so common, having several family members with cancer does not automatically mean that a family has an inherited (familial) form of cancer. In 80-85% of cancer cases, it occurs due to sporadic and environmental causes and does not have an inherited genetic basis. In order to determine whether the type of cancer occurring in a family is based on an inherited genetic susceptibility or if it is sporadic, careful collection and analysis of an individual's and his or her family's medical histories must be done. To learn important questions to ask and how to record your family history, access the National Society of Genetic Counselors' family history tool at http://www.nsgc.org/consumer/familytree/index.asp
The Genetics And Genomics Of Cancer - Nature Genetics Nature genetics 33, 238 244 (2003) doi10.1038/ng1107. The genetics and genomicsof cancer. Allan Balmain1, Joe Gray2 Bruce Ponder3 http://www.nature.com/ng/journal/v33/n3s/abs/ng1107.html
Extractions: doi:10.1038/ng1107 Allan Balmain , Joe Gray UCSF Comprehensive Cancer Center and Department of Biochemistry and Biophysics, San Francisco, California 94143, USA. Correspondence should be addressed to Allan Balmain abalmain@cc.ucsf.edu UCSF Comprehensive Cancer Center and Dept. of Laboratory Medicine, San Francisco, California 94143, USA. jgray@cc.ucsf.edu Cancer Research UK Department of Oncology, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK. bajp@mole.bio.cam.ac.uk MORE ARTICLES LIKE THIS
Extractions: doi:10.1038/ng1038 Christine H. Chung , Philip S. Bernard Department of Pathology, University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, Utah 84112-5550, USA. Correspondence should be addressed to Charles M. Perou cperou@med.unc.edu The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide expression patterns in complex biological systems. Although the potential of microarrays is yet to be fully realized, these tools have shown great promise in deciphering complex diseases such as cancer. The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns. MORE ARTICLES LIKE THIS
Cancer: Databases - Genetics cancer genetics Services Directory (Website). This National cancer Institutedirectory lists professionals who provide services related to cancer genetics http://www.library.ucsf.edu/collres/reflinks/cancer/db_genetics.html
Extractions: Other subject guides print-friendly version GALEN Home Cancer Resources Databases - Genetics Breast Cancer Gene Database (Website) This database allows you to search for breast cancer genes by name or for facts about breast cancer genes by topic. The retrieval provides citations which are linked to Pubmed. Cancer Genetics Services Directory (Website) This National Cancer Institute directory lists professionals who provide services related to cancer genetics (cancer risk assessment, genetic counseling, genetic susceptibility testing, and others). Familial Cancer Database (Website) This database provides software to assist with differential diagnosis in familial cancer. It is free but requires registration, downloading and installation of the software and data. (Website) A new human gene map from the International RH Mapping Consortium. Each chromosome is displayed with RH Map GB3 and GB4, the genetic map, gene density and a cytogenetic ideogram.
Breast Cancer Care : Genetics Only 5% of breast cancers are genetic, although they are expecting to find morefaulty genes in the future. I have pasted some information from the Royal http://www.breastcancercare.org.uk/Chat/Forums/Diagnosis/634649
Extractions: When I was diagnosed, it was revealed to me that my great grandmother had... died of bc in her early 40s. She had two sons - both of which had prostate cancer. My mum and her sister are fine and my sister is fine and cousins and so on are all well. But I have ended up with BC. Do you think I should be tested? Are my boys going to be getting prostate cancer? I'm a bit freaked by this since I had dismissed family history as a fluke since mum and aunt and sister and so on are fine.
Breast Cancer Care : Genetics Also if you go to breakthrough breast cancer website they have quite a lot onthere about the genetics of breast ovarian cancer. Best of luck Justine http://www.breastcancercare.org.uk/Chat/Forums/Youngerwomen/908544
