Extractions: Spondyloarthropathy Now we get really complicated! We are in fact criss-crossing "families". Spondyloarthropathy is defined as a group of rheumatic diseases that share similar clinical features of axial arthritis, peripheral inflammatory arthritis and extra-articular symptoms such as conjunctivitis, skin rashes (eg., psoriasis), inflammation of mucosal surfaces and inflammation in the tendinous attachments to bone (enthesitis). Fine! sounds complicated but OK lets go along with that but then we learn that the family includes: Psoriatic arthritis - Which we have already covered as a separate section Ankylosing spondylitis - Which we have covered as one of the Psoriatic arthritis conditions Reiters syndrome and Enteropathic arthritis neither of which we have come across before! So here goes: Is a combination of arthritis, conjunctivitis and urethritis (or dysentery), which is called a "reactive arthritis" because joint inflammation that occurs in Reiters appears to be a reaction to an infection that originates in areas of the body other than the joints. The most common pathogens known to induce Reiters syndrome are Shigella, Salmonella, Yersinia, Campylobacter or urogenital/post venereal pathogens such as Chlamydia or Ureaplasma.
Extractions: Signs, symptoms and indicators Conditions that suggest it Contributing risk factors Other conditions that may be present ... Recommendations Ankylosing spondylitis (AS) is an autoimmune disease which affects collagen structures, specifically the joints between the vertebrae of the spine. The joints and ligaments that normally permit the spine to move become inflamed and stiff. The bones of the spine may grow together, causing the spine to become rigid and inflexible. Other joints such as the hips, shoulders, knees, or ankles also may become involved. Symptoms of ankylosing spondylitis appear most frequently in young men between the ages of 16 and 35. It is less common in women, whose symptoms are often milder and more difficult to diagnose. About 5% of ankylosing spondylitis cases begin in childhood; boys are more likely to have it than girls. When children develop ankylosing spondylitis, it usually begins in the hips, knees, bottoms of the heels or big toes and may later progress to involve the spine.
Extractions: Prepared by: Reva C. Lawrence, M.P.H. The conference, Ankylosing Spondylitis Research: HLA-B27 and Beyond, was held at Lister Hill Auditorium on the NIH campus in Bethesda, Maryland on Sept 1-2, 1998. The purpose of the conference was to review current work in ankylosing spondylitis (AS) and related fields; to get critical input from experts in current work; to promote new ideas and approaches to the study of AS; and to provide an opportunity to foster new collaborations and sharing of resources and information. One of the major goals of the conference was to have a highly interactive meeting. The conference was divided into four half-day sessions, each devoted to one of four main themes pertinent to AS: (i) clinical, genetic, epidemiologic and radiographic features of AS; (ii) HLA-B27 and immunopathogenesis of AS; (iii) bone, cartilage, and the problems of ankylosis and osteoporosis; and (iv) the association between inflammatory bowel disease and AS, and the potential role of bacteria.
Extractions: Bovine Spongiform Encephalopathy: Is It An Autoimmune Disease Due to Bacteria Showing Molecular Mimicry With Brain Antigens? Alan Ebringer, John Pirt, Clyde Wilson, Phil Cunningham, Carlos Thorpe, and Camille Ettelaie Division of Life Sciences, Infection and Immunity Group and Department of Computing, King's College, Campden Hill Road, London, United Kingdom Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (
Extractions: Vol Page [Advanced] This Article Extract Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Add article to my folders ... Download to citation manager PubMed PubMed Citation Articles by Leech, S. Related Collections Other immunology
UK NEWS These are both very widespread diseases; ankylosing spondylitis affects about aquarter There may well be difficulties in the autoimmune theory of BSE, http://www.mad-cow.org/~tom/bob_colo.html
Extractions: A confidential report from the World Trade Organisation has backed US and Canadian complaints that the European Union ban was illegal and unjustified. The ban was imposed in 1989 because of fears that hormones widely used in North America to promote animal growth could cause cancer and other abnormalities in humans.
Extractions: Ankylosing Spondylitis as an Auto-immune Disease Caused by Intestinal Klebsiella Infection: Prospects for a New Therapeutic Approach A. Ebringer , T. Rashid , and C. Wilson 'Division of Life Sciences, Infection and Immunity Group, Waterloo Campus, King's College London; ? Department of Rheumatology, Middlesex Hospital, UCL School of Medicine, London, Correspondence to: Professor Alan Ebringer Division of Life Sciences, Infection and Immunity Group, King's College London, Stamford Strecl, London SE1 Tel: 020-78484302 Fax: 020-7848 4500 Email: alan.ebringer@kcl.ac.uk Key words: Ankylosing spondylitis, AS and Klebsiella reactive arthritis, Klebsiella, HLA-B27 Ankylosing spondylitis (AS) is the most prominent component of a group of inflammatory arthritides, collectively named as "spondyloarthropathies (SpAs)", It is a chronic disease of insidious onset starting usually in males between ages of 10 and 40 years. It commonly involves the sacroiliac and lower spinal joints and less frequently other large joints such as the hips, knees and ankles as well as the entheses. Non-articular manifestations may also be associated with the disease, such as acute anterior uveitis or iritis, which occurs in 25 percent of patients with AS [1]. The true prevalence of AS appears to be in the region of 0.25 to l% with a peak of 2% in Northern Norway [2], The role of genetic and environmental factors in AS The association between AS and HLA-B27 was not the first HLA association to be defined but it remains to this day, the most prominent example linking susceptibility to a rheumatic disease with genes in the major histocompatibility complex. This remarkable association which was reported over 28 years ago [3, 4] has been shown to be universal in world populations. The frequency of HLA-B27 in patients with AS ranges from 81 to 96% with control frequencies ranging between 4 and 12%. Rats transgenic for B27 spontaneously develop a chronic inflammatory disease that resembles, both clinically and histologically, the human SpA, while control rats transgenic for HLA-A2 do not develop such an illness [5]. These observations would signify the importance of this particular HLA gene in the development of AS.
Hardin MD : Ankylosing Spondylitis ADAM / National Library of Medicine; ankylosing spondylitis Ken Crocker, UnivNewfoundland, Canada; ankylosing spondylitis Vincent Keiser, Mark Robbin, http://www.lib.uiowa.edu/hardin/md/spondylitis.html
Extractions: Ankylosing spondylitis is a form of chronic inflammationof the spine and the sacroiliac joints. The sacroiliac jointsare located in the low back where the sacrum (the bone directlyabove the tailbone) meets the iliac bones (bones on either sideof the upper buttocks). Chronic inflammation in these areas causespain and stiffness in and around the spine. Over time, chronicspinal inflammation (spondylitis) can lead to a complete cementingtogether (fusion) of the vertebrae, a process called ankylosis.Ankylosis causes total loss of mobility of the spine. Ankylosing spondylitis is also a systemic rheumatic disease. Therefore, itcan cause inflammation in other joints away from the spine, aswell as other organs, such as the eyes, heart, lungs, and kidneys.Ankylosing spondylitis shares many features with several other arthritis conditions, such as
What Is Ankylosing Spondylitis ankylosing spondylitis is a form of chronic inflammation of the spine and thesacroiliac What is in the future for patients with ankylosing spondylitis? http://www.myfibrosite.com/users/dwaynebright/products.html
Extractions: Ankylosing spondylitis is a form of chronic inflammation of the spine and the sacroiliac joints. The sacroiliac joints are located in the low back where the sacrum (the bone directly above the tailbone) meets the iliac bones (bones on either side of the upper buttocks). Chronic inflammation in these areas causes pain and stiffness in and around the spine. Over time, chronic spinal inflammation (spondylitis) can lead to a complete cementing together (fusion) of the vertebrae, a process called ankylosis. Ankylosis causes total loss of mobility of the spine. Ankylosing spondylitis is also a systemic rheumatic disease. Therefore, it can cause inflammation in other joints away from the spine, as well as other organs, such as the eyes, heart, lungs, and kidneys. Ankylosing spondylitis shares many features with several other arthritis conditions, such as psoriatic arthritis, reactive arthritis, and arthritis associated with Crohn's disease and ulcerative colitis. Each of these arthritic conditions can cause disease and inflammation in the spine, other joints, eyes, skin, mouth, and various organs. In view of their similarities and tendency to cause inflammation of the spine, these conditions are collectively referred to as "spondyloarthropathies." For more information, please read the following articles; Psoriatic Arthritis, Reactive Arthritis, Crohn's Disease and Ulcerative Colitis.
Extractions: Feedback Thesaurus Legend: Synonyms Related Words Antonyms Noun ankylosing spondylitis - a chronic form of spondylitis primarily in males and marked by impaired mobility of the spine; sometimes leads to ankylosis Marie-Strumpell disease rheumatoid spondylitis autoimmune disease autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues spondylitis - inflammation of a spinal joint; characterized by pain and stiffness
Extractions: Home Health Information Health Topics A to Z Health Topics A to Z Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse. JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.
Anklylosing Spondylitis Information From MedicineNet.com Explains ankylosing spondylitis (a form of chronic inflammation of the spine andthe sacroiliac joints) includes causes, symptoms, diagnosis, and treatment http://www.medicinenet.com/ankylosing_spondylitis/page2.htm
Extractions: How inflammation occurs and persists in different organs in ankylosing spondylitis is a subject of active research. The initial inflammation may be a result of an activation of body's immune system by a bacterial infection. Once activated, the body's immune system becomes unable to turn itself off, even though the initial bacterial infection may have long subsided. Chronic tissue inflammation resulting from the continued activation of the body's own immune system in the absence of active infection is the hallmark of an inflammatory autoimmune disease. What are the symptoms of ankylosing spondylitis?
Ankylosing Spondylitis - Wikipedia, The Free Encyclopedia ankylosing spondylitis (AS) is a chronic, progressive inflammatory arthritisprimarily ankylosing spondylitis The facts. Oxford University Press. http://en.wikipedia.org/wiki/Ankylosing_spondylitis
Extractions: Ankylosing spondylitis (AS) is a chronic, progressive inflammatory arthritis primarily affecting spine and sacroiliac joints , causing eventual fusion of the spine; it is a member of the group of the spondylarthropathies . Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine Treatment is with physiotherapy and medication . Some cases remain mild, while other result in marked disability. edit The typical patient is a young man of 15-30 years old (although women are also affected) with pain and stiffness in the spine. It is also associated with iridocyclitis (anterior uveitis), ulcerative colitis psoriasis and Reiter's disease , through HLA-B27 (see below). Osteopenia or osteoporosis of AP spine, causing eventual compression fractures and a back "hump" if untreated. Organs affected by AS, other than the axial spine , are the hips heart heels , and other areas (peripheral).
EMJA: The Anti-TNF Revolution In Ankylosing Spondylitis ankylosing spondylitis affects about 0.5%1.0% of the population and typically To date, the treatment of ankylosing spondylitis has been unsatisfactory. http://www.mja.com.au/public/issues/181_10_151104/sch10544_fm.html
Extractions: Home Issues Email alerts Classifieds ... Pdf version of this article Editorials The anti-TNF revolution in ankylosing spondylitis Lionel Schachna MJA Patients with severe disease now have access to promising new drugs To have lived through a revolution, to have seen a new birth of science, a new dispensation of health . . . is not given to every generation. William Osler (1913) D riven by evidence from well designed clinical trials, infliximab, a monoclonal antibody that targets tumour necrosis factor alpha (TNF- ), was recently listed on the Pharmaceutical Benefits Scheme (PBS) for treatment of ankylosing spondylitis. This is welcome news for patients with a disorder for which, until now, there have been few effective therapeutic options. To date, the treatment of ankylosing spondylitis has been unsatisfactory. Rheumatologists have combined physiotherapy and non-steroidal anti-inflammatory drugs, with the modest goal of relieving pain and stiffness, but such therapies do not alter the underlying disease process. Drugs that modify the disease process and prevent joint damage in rheumatoid arthritis (eg, corticosteroids, methotrexate and leflunomide) are of marginal benefit in ankylosing spondylitis. Randomised controlled trials have shown that sulfasalazine is of some benefit in ankylosing spondylitis, but only for peripheral joint involvement. Clearly, novel approaches for treating ankylosing spondylitis have been long overdue.
Introduction: Ankylosing Spondylitis - CureResearch.com Introduction to ankylosing spondylitis as a medical condition including symptoms,diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.cureresearch.com/a/ankylosing_spondylitis/intro.htm
Extractions: Ankylosing Spondylitis: This type of arthritis primarily affects the spine, but may also cause arthritis in the hips, shoulders, and knees. The tendons and ligaments around the bones and joints in the spine become inflamed, resulting in pain and stiffness, especially in the lower back. Ankylosing spondylitis tends to affect people in late adolescence or early adulthood. Researching symptoms of Ankylosing Spondylitis: Further information about the symptoms of Ankylosing Spondylitis is available including a list of symptoms of Ankylosing Spondylitis , other diseases that might have similar symptoms in differential diagnosis of Ankylosing Spondylitis , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Ankylosing Spondylitis: Research more detailed information about misdiagnosis of Ankylosing Spondylitis underlying causes of Ankylosing Spondylitis (possibly misdiagnosed), or research
Ankylosing Spondylitis - Enpsychlopedia ankylosing spondylitis (AS) is a chronic, progressive inflammatory arthritis It uses material from the Wikipedia article ankylosing spondylitis . http://psychcentral.com/psypsych/Ankylosing_spondylitis
Extractions: home resource directory disorders quizzes ... support forums Advertisement ( Ankylosing spondylitis (AS) is a chronic, progressive inflammatory arthritis primarily affecting spine and sacroiliac joints , causing eventual fusion of the spine; it is a member of the group of the spondylarthropathies . Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine Treatment is with physiotherapy and medication . Some cases remain mild, while other result in marked disability. Contents showTocToggle("show","hide") 1 Signs and symptoms 2 Diagnosis 3 Pathophysiology 4 Epidemiology ... edit The typical patient is a young man of 15-30 years old (although women are also affected) with pain and stiffness in the spine. It is also associated with iridocyclitis (anterior uveitis), ulcerative colitis psoriasis and Reiter's disease , through HLA-B27 (see below). Organs affected by AS, other than the axial spine , are the hips heart heels , and other areas (peripheral). edit The diagnosis is by X-ray studies of the spine, which show characteristic spinal changes and
Extractions: PLACEBO VERSUS COMBINATION ANTIMICROBIAL CHEMOTHERAPY BSR reported by Andrei Calin , Bath, UK published 14 April, 2003 Leirisalo-Repo and colleagues (Finland) reported a randomised 3-month study of placebo versus combination antimicrobial chemotherapy in patients with acute reactive arthritis. They concluded that this mixture of a quinolone and a macrolide antibiotic (presumably the best available) did not influence outcome. Calin Comment: At last we have "proof" that antibiotics are useless, as many of us have taught over the last decades. Thus, we are dealing with "reactive" arthropathy rather than active infective chronic arthritis! Hopefully this will be the last of antibiotic studies in reactive arthritis. HIGH PREVALENCE OF THE RHEUMATOLOGIC COMPLAINTS IN HCV DISEASE Elbeialy and colleagues (Egypt) described the high prevalence of the rheumatologic complaints in hepatitis C virus (HCV) disease. After screeneing 100 patients with HCV and controls, they found 25% with polyarthropathy in the infected group. By contrast, only 4% of 100 patients with rheumatoid disease were HCV positive. All HCV-positive patients with arthropathy were Rheumatoid Factor positive, in contrast to 69% of those without arthropathy. Calin Comment: Clearly, we should have a high threshold for considering HCV infection in patients presenting with unexplained joint pains and should appreciate that management of such individuals would be different for those with HCV compared to those without.
