Alan Ebringer: Research ankylosing spondylitis (AS) affects approximately 1/2 million people in the UK It is proposed that BSE is a neurological, autoimmune reactive disease, http://www.kcl.ac.uk/kis/schools/life_sciences/life_sci/ebringerR.html
Extractions: Further molecular studies identified a second similarity sequence IRRET, present in Proteus urease which showed molecular mimicry with the LRREI sequence found in type XI collagen, a common component of hyaline cartilage. Since erosions of hyaline cartilage are frequently found in RA patients, especially in the small joints of the hands and feet, this could explain the localization of the pathological lesions in this disease to these sites.
Extractions: Verify here Dr. Ray's Health Newsletter / table of contents The latest Health Newsletter Treatment Of Ankylosing Spondylitis And Spondyloarthropathies The principles of treatment of anylosing spondylitis are to control the inflammation so that scarring and calcification with subsequent stiffening of the spine and of joints is minimized as much as possible. The usual anti-inflammatories that are used for other forms of arthritis are utilized here as well, such as NSAIDs and COX-2 inhibitors. Corticosteroids, which play a larger role in rheumatoid arthritis, play less of a role for ankylosing spondylitis. However, for single joints that are affected, these may be injected by the physician or rheumatologist for easier rehabilitation. Treatment of spondyloarthopathies Name of disease: ankylosing spondylitis psoriatic arthritis Reactive arthritis Reiter's syndrome ... Crohns disease Acute iritis is treated by the ophthalmologist utilizing topical corticosteroid drops as well. Systemic corticosteroids are avoided because of the danger of osteoporosis that would develop much easier in these patients and the danger of septicemia with life threatening infections as a result of the immunosuppressive side effect of corticosteroids.
Extractions: Introduction New Technologies Agricultural Chemistry (Industrial) ... Technology Search Researchers at Oxford University's Institue of Musculoskeletal Sciences have identified a number of genetic variations associated with the autoimmune disease Ankylosing Spondylitis which constitute an accurate diagnostic for the disease. Oxford researchers have identified polymorphisms within particular genes in the interleukin-1 gene region of chromosome 2 associated with AS. The discovery is based upon 227 sibling-pair families and 317 parent case trios, all Caucasian. These genes can be used for detecting whether a subject has or is genetically predisposed to a seronegative spondyloarthropathy. Such a test would also assist in diagnosis of a patient showing seronegative spondyloarthropathy symptoms. Isis Innovation Ltd is interested in partnering with a company to develop this technology into a clinical diagnostic test.
CCHS Clinical Digital Library Miscellaneous ankylosing spondylitis Patients/Family Resources Additionalankylosing spondylitis resources (These sites have not been reviewed. http://cchs-dl.slis.ua.edu/patientinfo/rheumatology/autoimmune/spondyloarthropat
Extractions: Patient/Family Resources by Topic: Rheumatology Ankylosing Spondylitis Patient/Family Resources Pediatrics Spanish Miscellaneous See also: Arthritis Foundation: Homepage American College of Rheumatology: Homepage American Academy of Family Physicians (familydoctor.org): Homepage University of Birmingham (U.K.) Dept of Rheumatology: Homepage American Pain Foundation: Homepage MedlinePlus Medical Encyclopedia: Table of contents InteliHealth Disease and Condition Guide Table of contents Merck Manual - Second Home Edition Table of contents Section 5. Bone, Joint, and Muscle Disorders:
Welcome To Southern Cross ankylosing spondylitis (AS) is a chronic (longterm) inflammatory disease It is thought to be an autoimmune disease - where the bodys own immune system http://www.southerncross.co.nz/index.cfm?6C75C834-5E96-486F-AA16-380FDC991372
Extractions: Back to Search Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse. JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.
Abbott Laboratories Press Releases (774) Psoriatic arthritis may stem from an autoimmune disorder in which a human protein, HUMIRA Improved Symptoms of Active ankylosing spondylitis http://abbott.com/news/releaseonly.cfm?id=774
AI - News(200577411:55:49) HUMIRA Improved Symptoms of Active ankylosing spondylitis Clinical trialsare currently underway in autoimmune diseases. Important Safety Information http://abbott.com/ai/news/news.cfm?id=774
BBC - Radio 4 - Case Notes - Autoimmune Diseases ankylosing spondylitis affects 1 in 200 men and 1 in 500 women in Britain Join Dr Mark Porter for Case Notes on Autoimmune Diseases on Tuesday 24th http://www.bbc.co.uk/radio4/science/casenotes_20040824.shtml
Juvenile Ankylosing Spondylitis Spinal Column with Vertebrae Juvenile ankylosing spondylitis (JAS) is a type of Some of these disorders, such as JAS, are autoimmune related and http://www.chw.org/display/PPF/DocID/1651/router.asp
Extractions: What is juvenile ankylosing spondylitis? Juvenile ankylosing spondylitis (JAS) is a type of arthritis that affects the spine and the sites where the muscles, tendons, and ligaments are attached to bone. "Ankylosing" means stiff or rigid, "spondyl" means spine, and "itis" refers to inflammation. The disease causes inflammation of the spine and large joints, resulting in stiffness and pain. The disease may result in erosion at the joint between the spine and the hip bone (the sacroiliac joint), and the formation of bony bridges between vertebrae in the spine, fusing those bones. In addition, bones in the chest may fuse. JAS is considered to be a multifactorial condition. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Often one gender (either males or females) is affected more frequently than the other in multifactorial traits. Multifactorial traits do recur in families because they are partly caused by genes. A group of genes on chromosome 6 code for HLA antigens play a major role in susceptibility and resistance to disease. Specific HLA antigens influence the development of many common disorders. Some of these disorders, such as JAS, are autoimmune related and inherited in a multifactorial manner. When a child has a specific HLA antigen type associated with the disease, he/she is thought to have an increased chance to develop the disorder. The HLA antigen associated with JAS is called B27. Children with the B27 HLA antigen are thought to have an increased chance (or "genetic susceptibility") to develop JAS; however, it is important to understand that a child without this antigen may also develop JAS. Individuals may have antigen and no disease. This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Males are affected with JAS three times more often than females.
UK Wellness: Medical Conditions: Bio-medical: Ankylosing Spondylitis ankylosing spondylitis. Risk Click here for risk definitions DEFINITIONankylosing spondylitis is an autoimmune disease that causes inflamation of the http://www.ukwellness.com/medical-conditions/biomechanical/ankylosing-spondyliti
Extractions: DEFINITION: Ankylosing spondylitis is an autoimmune disease that causes inflamation of the spine and sacroiliac joints and can cause inflammation of the eyes, lungs, and heart valves. It varies from intermittent episodes of back pain that occur throughout life to a severe chronic disease that attacks the spine, peripheral joints and other body organs, resulting in severe joint and back stiffness, loss of motion and deformity as life progresses. A dramatic loss of flexibility in the lumbar spine is an early sign of AS. Although most symptoms begin in the lumbar and sacroiliac areas, they may involve the neck and upper back as well. Arthritis may also occur in the shoulder, hips and feet. As with many of the autoimmune diseases, many body systems can be effected in extreme cases.
JCR: Journal Of Clinical Rheumatology - UserLogin ankylosing spondylitis an autoimmune disease? Ann Rheum Dis 1991; 50 7781.Context Link. 4. Montenegro V, Monteiro RC. Elevation of serum IgA in http://www.jclinrheum.com/pt/re/jcr/fulltext.00124743-200206000-00015.htm
Hep C And Autoimmune Diseases Topic Hepatitis C Subject Hep C and autoimmune Diseases Because I havejuvenile rheumatoid arthritis and ankylosing spondylitis my doctor recommended http://www.medhelp.org/forums/Hepatitis/messages/30222.html
Extractions: I was diagnosed with Hep C about 2 years ago, and genotyped 1b. Because I have juvenile rheumatoid arthritis and ankylosing spondylitis my doctor recommended I do not have Interferon treatment. Are there any other options at this point or do I just wait until another treatment becomes available? Are there any other drugs in clinical studies at this time? My ALT and AST's are in the 70's. HFHSM.D.-D.M. The first question, I have for you is: do you know what your liver biopsy shows. If you have a benign liver biopsy with little scarring or fibrosis, you might not want to do anything right now. Hepatitis C typically causes liver disease over decades and doesnt even cause cirrhosis in half of infected individuals. Typically women who do not drink alcohol are likely to have relatively slow progressing disease. One drug that is being used in clinical trials is a drug called interleukin-10 (IL-10). This is a drug that does not get rid of the virus but has anti-inflammatory activity that some liver specialist feel can slow the level of fibrosis in individuals with hepatitis C. Because it is anti-inflammatory or even immune-suppressing it might be safe in individuals with juvenile rheumatoid arthritis and ankylosing spondylitis. However, I think most of the studies looking at IL-10 in hepatitis C require a liver biopsy.
Extractions: AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Phytotherapy for ankylosing spondylitis and inflammatory bowel disease Townsend Letter for Doctors and Patients June, 2004 by Kerry Bone The safety and efficacy of a Boswellia extract was compared against mesalazine for the treatment of 102 patients with active Crohn's disease in an eight-week randomized, double-blind study. (2) The primary clinical outcome measured was the change in Crohn's Disease Activity Index (CDAI). After therapy with Boswellia extract (3.6 g per day) the average CDAI was reduced by 90, compared to a reduction of 53 for the mesalazine group (4.5 g per day). The authors concluded that the Boswellia extract was as effective as mesalazine, which is the state-of-the-art treatment for this disorder. Considering the observed fewer side effects and better safety profile of Boswellia, they suggested that this novel herbal treatment appears to be superior to mesalazine in terms of a risk-benefit evaluation.
The Pathogenesis Of Rheumatoid Arthritis, Psoriatic Arthritis, And and ankylosing spondylitis are chronic inflammatory autoimmune disorders. ankylosing spondylitis is a chronic, systemic, inflammatory disorder http://www.enbrel.com/rheumatology/enbrel-rhcpscience-pathogenesis.jsp
ENBREL Rheumatology HCP The Role Of TNF In Rheumatoid Arthritis Role of TNF in ankylosing spondylitis (AS). In autoimmune disease, TNF (yellow)produced by cells of the immune system (grey) binds to TNF receptors (blue) http://www.enbrel.com/rheumatology/enbrel-rhcpscience-TNF.jsp
Autoimmune Diseases / Family Village Dedicated to the eradication of autoimmune diseases and the alleviation of Alopecia Areata,ankylosing spondylitis,Behcet s Disease, Chronic Fatigue http://www.familyvillage.wisc.edu/lib_auto.htm
Extractions: Website: http://www.aarda.org/ Dedicated to the eradication of autoimmune diseases and the alleviation of suffering and the socioeconomic impact of autoimmunity through fostering and facilitating collaboration in the areas of education, research, and patient services in an effective, ethical and efficient manner. Autoimmunity This group is for people with autoimmune diseases like Lupus, Fibromyalgia, Arthritis, MS, Raynaud's Phenomenon, Narcotizing Vasulitis, Celiac Diseas(SPRUE)Peroarteritis nodosa,progressive systemic sclerosis, Alopecia Areata,Ankylosing Spondylitis,Behcet's Disease, Chronic Fatigue Syndrome, Crohn's Disease, Myasthenia Gravis, Psoriasis, Scleroderma, Juvinile Dermatomyosistis, Granulomatous Angiitis of the Central Nervous System(GACNS), Hashimoto's Disease, etc. Teens Autoimmune
Juvenile Rheumatoid Arthritis And Ankylosing Spondylitis Juvenile Rheumatoid Arthritis and ankylosing spondylitis An autoimmune disordercan cause the body to rebel against itself. How does the disease start? http://www.spineuniverse.com/displayarticle.php/article2236.html
Extractions: (Ankle-oo-sing Spondie-lie-tiss) When most people hear the word Arthritis they think of elderly folks - Grandma and Grandpa. Although many adults and older people will develop arthritis, it is not very common in children. Juvenile Arthritis (JA) is a term used to categorize the different types of arthritis affecting children. The most common type of JA is Juvenile Rheumatoid Arthritis (JRA). The type of JRA that affects the spine is called Ankylosing Spondylitis (AS). JRA is diagnosed in children less than 16 years of age whose arthritis has persisted for longer than six weeks. What causes JRA or AS?
Ankylosing Spondylitis ankylosing spondylitis an autoimmune disease affecting the spine ankylosingspondylitis (AS) is an inflammatory arthritis that affects the spine. http://www.arthritis-treatment-and-relief.com/ankylosing-spondylitis.html
Extractions: Ankylosing spondylitis...an autoimmune disease affecting the spine... Ankylosing spondylitis (AS) is an inflammatory arthritis that affects the spine. Usually the sacroiliac joints (joints joining the pelvis to the sacrum of the spine) are involved first with gradual involvement of the rest of the spine following. AS falls into the category of diseases designated as the spondyloarthropathies. Other members of this group include psoriatic arthritis and reactive arthritis. The term spondyloarthropathy refers to the propensity for spinal involvement. There is a strong genetic predilection with 90 per cent of Caucasian patients showing the presence of the HLA Br27 genetic marker. Many AS patients will have a positive family history for the disease. Spondyloarthropathies, in general, cause early erosion and damage. As the disease progresses, there is gradual destruction of joints with bony bridging leading to marked deformity and loss of function. Like the other spondyloarthropathies, AS is an enthesopathy causing inflammation at the site where the tendon inserts into bone. AS occurs in about 0.5 per cent of the population. It is more common in men than women in a ratio of about 5:1. It should be mentioned that AS is probably under diagnosed in women. When AS does affect women, it tends to happen a bit later, have less hip involvement, have more symphysis pubis involvement, and definitely more cervical spine (neck) involvement.
Ankylose This!: October 2004 Blogging about life with ankylosing spondylitis. About ankylosing Spondlyitis.It s a painful, debilitating autoimmune disease with a funny name. http://www.mcwetboy.net/ankylose_this/archives/2004_10_01_as.html
