Extractions: (advertisement) Synonyms, Key Words, and Related Terms: ALS, Lou Gehrig disease, Lou Gehrig's disease, Charcot disease, Charcot's disease, motor neuron disease Background: Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the anterior horn cells of the spinal cord and the motor cranial nuclei that leads to progressive muscle weakness and atrophy. Although major recent advances have shed light on its etiology, the key mechanisms in both familial and sporadic ALS remain unknown. No cure is known. This article reviews the major breakthroughs in ALS research, the clinical aspects of the disease, and current therapeutic options. An outline of new and promising technology and its application to the understanding of ALS is presented. Pathophysiology: ALS primarily involves anterior horn cells in the spinal cord and cranial motor nerves. Patients may have weakness of bulbar muscles or of single or multiple limb muscle groups. Presentation is not always bilateral or symmetrical. A predominantly bulbar form usually leads to more rapid deterioration and death. Limb weakness is predominantly distal. Weakness and atrophy of the intrinsic hand muscles are prominent. Weakness progresses to involve the forearms and shoulder girdle muscles and the lower extremities. Involvement of both upper and lower motor neurons is characteristic. Patients develop variable hyperreflexia, clonus, spasticity, extensor plantar responses, and limb or tongue fasciculations. Wallerian degeneration of corticospinal and corticobulbar tracts may be demonstrated by MRI (high-intensity T2 lesions in frontal lobes) or in postmortem examination. Extraocular muscles and bladder and anal sphincter muscles typically are spared.
New York Yankees News A long story short, he was diagnosed with ALS, Lou Gehrig s disease. referred to as Lou Gehrig s disease, is a neurodegenerative disease that attacks http://newyork.yankees.mlb.com/NASApp/mlb/nyy/news/nyy_news.jsp?ymd=20030620&con
Encyclopedia Table Of Contents neuromuscular Disorders (eg, ALS/Lou Gehrig s disease) neuroOncology neuro-Ophthalmology Pediatric Ophthalmology Retina diseases. Genetics http://www.pennhealth.com/ency/
Neurology Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig s disease). Aneurysm, Cerebral Myasthenia Gravis. neuroophthalmologic Disorders. Parkinson s disease http://www.westfloridahospital.com/CustomPage.asp?guidCustomContentID={86ADF80D-
Lou Gehrig Disease ALS/Lou Gehrig s disease Nutritional causes, therapies, remedies . also knownas Lou Gehrig s disease, is a progressive neuro degenerative http://www.jogeorgeclinic.co.uk/1041-lougehrigdisease-10138.html
Extractions: Amyotrophic Lateral Sclerosis Definition: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD . Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION , hyperreflexia, DYSARTHRIA , dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
ALS Association - Bay Area Chapter Parkinson s, amyotrophic lateral sclerosis (ALS Lou Gehrig s disease),Multiple Sclerosis (MS), or other neuro-degenerative diseases. http://www.alsabayarea.org/press_releases/pr_09_01_04_natl.php
Extractions: September 1, 2004 -The following news release announces a special Webcast to air Sept. 8 on the involvement of biotechnology and pharmaceutical companies in the quest to find answers to ALS and other neurodegenerative diseases. New Webcast Series Reveals Potential for Neurodegenerative Disease Market Benefits to Patients, Biotech Firms, Pharmaceutical Firms Palo Alto, CA September 1, 2004 (PRIMEZONE) Today, 7 million persons one out of every 40 in the U.S. are afflicted with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS - Lou Gehrig's disease), Multiple Sclerosis (MS), or other neuro-degenerative diseases. It could take 10 or 20 years, or more to find cures for these horrible illnesses. However, there may be a much shorter path to cures that benefit patients and open a multibillion dollar marketplace for innovative biotech and pharmaceutical companies. The potential is described in a new Webcast series, produced by Killen & Associates. The series is titled "The Neurodegenerative Disease Market:
Weill Cornell Department Of Neurology And Neuroscience principally Alzheimer s disease, amyotrophic lateral sclerosis (ALS, LouGehrig s disease), Huntington s disease, Parkinson s disease and progressive http://www.med.cornell.edu/neuro/research/neurodegenerative.html
Extractions: Advanced Search INTRODUCTION The focus of the Neurodegeneration Laboratory is to determine the mechanisms of cell death and cell dysfunction which underlie a number of different disorders of the brain. These include both dementing illnesses and movement disorders, principally Alzheimer's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Huntington's disease, Parkinson's disease and progressive supranuclear palsy (PSP), which are characterized by progressive neuronal degeneration in specific brain regions. In particular, we are interested in the roles that oxidative stress and abnormal energy metabolism in the brain play in all of these disorders, and in turn how these parameters are influenced by genetic mutations and predisposition, as well as extrinsic factors. By characterizing the events leading to neuronal loss in these disorders, the ultimate aim of these studies is to develop therapeutic strategies to both prevent disease onset and halt symptom progression. EXPERIMENTAL APPROACHES The experimental approaches used in the laboratory explore how cerebral function is altered in both affected human tissue and in transgenic mouse models of different neurodegenerative disorders. Techniques employed include HPLC to measure alterations in neurochemical levels ex vivo, notably energy metabolites and markers of free radical-mediated oxidative damage in cells; biochemical assays of metabolic enzyme activities; cell culture and cybrid approaches to measure mitochondrial and cell function in vitro; In vivo autoradiography to measure cerebral glucose metabolism; in vitro autoradiographic techniques to investigate neurotransmitter alterations; excitotoxic and mitochondrial toxin models of cell- and region-specific degeneration.
Neuro Final 2002 BL A615 Neural bases of behavior Final examination - Fall, 2002, - Prof. familial version of amyotropic lateral sclerosis (ALS, Lou Gehrig s disease)? http://starklab.slu.edu/neuro/Final2002.htm
Neuro Final Answers 2002 a neural circuit that reverberates because of excitatory connections the familial version of amyotropic lateral sclerosis (ALS, Lou Gehrig s disease)? http://starklab.slu.edu/neuro/FinalAnswers2002.htm
Neuroblastoma Neurological diseases, Research Young Scholars ALS/Lou Gehrig s disease Diabetes Nerve Trauma Spinal Cord Injury Muscular Dystrophy http://www.med.umich.edu/pfund/neuro.htm
Extractions: Childhood Cancer NEUROBLASTOMA CANCER (NBL) Neuroblastoma is a childhood tumor of the nervous system. If diagnosed over the age of 1 year, patients have a less than 10 % chance of surviving beyond age 5. The spread of neuroblastoma to other parts of the body (metastasis) is the leading cause of death in this disease. Neuroblastoma often metastasizes to bone, which leads to bone destruction, severe pain and fractures. PFUND Inestigators are dedicated to fighting this devastating cancer. The investigation of how neuronal cells survive and can be made to die compliments the neurodegeneration projects well, and has led to remarkable insights into neuron biology. PFUND Investigators are focusing on two areas of neuroblastoma biology: 1) factors that stop tumor growth and 2) factors that prevent metastasis. Tumor cell interactions with their environment provide important insight into how cells move and survive, and may reveal ways to kill these malignant cells. By inestigating these cellular functions, PFUND Investigators hope to identify new ways of treating neuroblastoma cancer. Specifically, the effects of insulin-like growth factor-I (IGF-I) on neuroblastoma cells are under investigation. We have shown that IGF-I allows tumor cells to live, even in the presence of toxic substances. This may underlie the resistance of the tumors to cancer therapy. Gold motility assay; measures cellular mobility in response to growth factors and chemotherapy agents.
SupportPath.com: Amyotropic Lateral Sclerosis Also called ALS, Lou Gehrig s disease, wasting palsy Websitehttp//neuromancer.mgh.harvard.edu/cgi-bin/forumdisplay.cgi?action=topics forum= http://www.supportpath.com/sl_a/amyotropic_lateral_sclerosis.htm
Transcript 122802 terryw Kennedy s disease is a rare, progressive neuromuscular disease terryw The symptoms are similar to ALS/Lou Gehrig s disease but are http://www.kennedysdisease.org/122802transcript.html
University Of Kentucky Department Of Neurology http//www.medtronic.com/neuro/pain/neuropathy/ Medtronics site on Painfulneuropathy This Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig s disease) http://www.mc.uky.edu/neurology/support.asp
Extractions: Medicine Home For Patients News College of Medicine Quick Links Campus Directory Employment Alumni Association Basic Science Departments Clinical Departments Centers Medical Education Integrated Biomedical Sciences Doctoral Programs MD/PhD Program Continuing Medical Education Faculty Resources Postdoctoral Resource Office General Clinical Research Center UK Clinical Research Organization Medical Professions Placement Service UK Health Services Links: About the Department For Patients For Students For Applicants ... Home Neuromuscular Disorders Support Group Information Amyotrophic Lateral Sclerosis Spinal Muscular Atrophy Charcot-Marie Tooth Dejerine-Sottas ... Post Polio Syndrome Neuropathy Links Compiled by Sharman Hammers, PharmD. candidate Spine-Healths website: All about Neuropathy and Back Pain - Has an introduction section which includes Types of Pain and Anatomy of Nerve Pain. Other sections include: Common Causes, Conservative Care, Surgery, Diagnostics, and Anatomy. Canadian Neuropathy Association Focuses on patient knowledge of neuropathy. Has a Forum section where patients can read or post questions and discussion topics. Patient Resources section has a list of other helpful websites.
Brief Records For I\&R, Health 46032 Provides information and referral regarding ALS/Lou Gehrig s disease . Information Link (800) 4214555; neuro Information Link (877) 774-7125. http://www.imcpl.org/cgi-bin/irnget.pl?I&R, health
StevieGuitar.com :: Index concerts to raise awareness of neuromuscular and Environmental disease with The resulting from his recent diagnosiswith ALS - Lou Gehrig s disease, http://www.stevieguitar.com/events.php
Extractions: NOTES ON NORTH WOODS REVUE BENEFIT: Former Sandpoint resident Steve Sparks has returned to North Idaho to convalesce two years into a diagnosis of Lou Gehrigs Disease (ALS - www.alsa.org ) from George Washington University Medical Center in Washington, DC. Area musicians are gathering in celebration of friendship and live music at The Panida Theater (www.panida.org) in Sandpoint, Idaho ( www.sandpoint.com
