61. Mathematical Finance David epstein, paul Wilmott. 1999MF-20. Pricing and Hedging Convertible Bonds Under Non-probabilistic Interest Rates David epstein, Richard Haber, http://www.finance.ox.ac.uk/mathematical_finance.htm

Powered by Mathematical Finance Papers Click on the title of a paper to view the abstract. From there you may download the full text of the paper in Adobe Acrobat (.pdf) format. Working Paper Series MF A matched asymptotic expansions approach to continuity corrections for discretely sampled options. Part 2: Bermudan options Sam Howison -MF-0 A matched asymptotic expansions approach to continuity corrections for discretely sampled options. Part 1: barrier options Sam Howison , Mario Steinberg -MF-01 Matched asymptotic expansions in financial engineering Sam Howison 2004 Working Paper Series 2004-MF-0 An Asymptotic Analysis of an American Call Option with Small Volatility N. P. Firth J. N. Dewynne S. J. Chapman 2004-MF-0 High Dimensional Radial Barrier Options N.P. Firth and J.N. Dewynne 2004-MF-01 Option Pricing with Levy-Stable Processes Alvaro Cartea, Sam Howison 2003 Working Paper Series 2003-MF-08 Purely discontinuous Levy processes and power variation: inference for integrated volatility and the scale parameter Jeannette Woerner 2003-MF-07 An Option Pricing Formula for the GARCH diffusion model Giovanni Barone-Adesi, Henrik Rasmussen and Claudia Ravanelli

62. Biography Of Paul M. Kaplan - Epstein Becker & Green, P.C. epstein Becker Green, PC, founded in 1973, is a fullservice law firm with more than 375 attorneys practicing in eleven offices throughout the US http://www.ebglaw.com/atty_bio_97.htm

document.write(time); Attorneys : Paul M. Kaplan Paul M. Kaplan Member of the Firm, New York E-Mail Address: pkaplan@ebglaw.com PAUL M. KAPLAN is a member of the firm and heads the Financial Practice Groups in the New York office. He represents domestic and foreign financial institutions, and corporations on transactional, regulatory, antitrust, and international matters. Mr. Kaplan: Represents both domestic and international financial institutions in a broad range of transactions and regulatory matters, including government enforcement proceedings Advises clients on the antitrust aspects of mergers and acquisitions Counsels corporations on the antitrust ramifications of business transactions to avoid or minimize exposure. Mr. Kaplan has taught an advanced seminar in antitrust law since 1991 as an Adjunct Professor of Law at Fordham Law School. He is listed in Who’s Who in American Law. Newsstand Items for Paul M. Kaplan: Category Topic Title Alerts antitrust Conducting an Antitrust Audit: In Preparation for a Merger, Acquisition or the Formation of a Joint Venture or Other Corporation TEXT Articles Microsoft The Unfolding Microsoft Drama: Shattered Windows TEXT Articles antitrust An Antitrust Primer: Pre-Merger Exchanges of Information TEXT Articles Microsoft's Conclusions of Law – Act 3, Scene 1:

63. Biography Of Paul C. Burkholder - Epstein Becker & Green, P.C. epstein Becker Green, PC, founded in 1973, is a fullservice law firm with more than 375 attorneys practicing in eleven offices throughout the US http://www.ebglaw.com/atty_bio_14.htm

document.write(time); Attorneys : Paul C. Burkholder Paul C. Burkholder Senior Attorney, Los Angeles E-Mail Address: pburkholder@ebglaw.com PAUL C. BURKHOLDER is a senior attorney in the firm's Los Angeles office concentrating in the areas of government contracts and commercial litigation. He has more than 20 years of government contracts experience as a government attorney, corporate counsel and attorney in private practice. Mr. Burkholder: Counsels clients in all aspects of government contract litigation Represents companies in the prosecution and defense of bid protests, as well as in complex equipment litigation Drafts and negotiates licensing, web site linking, sponsorship, and other internet related agreements Advises clients regarding sweepstakes, contests and game promotions. Prior to joining EBG, Mr. Burkholder served on active duty for four years with the Air Force Judge Advocate General's Department and is currently a Lieutenant Colonel in the Air Force Reserve. He served as a Senior Counsel with the Northrop Grumman Corporation, where he was involved in all aspects of government contract litigation, including claims at both the prime and subcontract level and the prosecution and defense of bid protests. Practice Areas: Government Contracts and Technology National Litigation Areas of Focus: Government Contracts Commercial Litigation Internet and E-Commerce Education: J.D., University of Wisconsin Law School, 1982,

64. U.S. Global Change Research Information Office By paul R. epstein. Epidemics are like signposts from which the statesman of stature can read that a disturbance has occurred in the development of his http://www.gcrio.org/CONSEQUENCES/vol3no2/climhealth.html

New Library About Ask Dr. Global Change ... Vol. 3, No. 2, 1997 Climate, Ecology, and Human Health Search Updated 15 November 2004 Consequences Vol. 3, No. 2, 1997 See also: summary Climate, Ecology, and Human Health By Paul R. Epstein Epidemics are like sign-posts from which the statesman of stature can read that a disturbance has occurred in the development of his nationthat not even careless politics can overlook. Dr. Rudolf Virchow, 1848 There are many determinants of health and well-being, and they can all interact with one another. Human biological and psychological factors come into play on a personal level, but ecological and global systems are also involved, as are economics and access to health care, which determine the social vulnerabilities to disease. Recently, our chief means of controlling infectionsantibiotics and insecticides have themselves become a source of new, resistant microbes and disease carriers, and the growing number of people with malnutrition or depressed immune systems have helped select and disseminate these emerging organisms. Environmental conditions, interacting with the biology of disease agents, can exert profound effects. Changes in how land is used affect the distribution of disease carriers, such as rodents or insects, while climate influences their range, and affects the timing and intensity of outbreaks. In this review we examine how our health is influenced by the interplay of social conditions, local environmental factors, and global changes. The discussion focuses primarily on the environment, forgiven its scale and pace of changethis sometimes forgotten determinant seems destined to play an ever-increasing role in determining disease patterns in the future.

65. American Scientist Online paul R. epstein. paul R. epstein is associate director of the Center for Health and the Global Environment at Harvard Medical School. http://www.americanscientist.org/template/AuthorDetail/authorid/731

Home Current Issue Archives Bookshelf ... Subscribe In This Section Search Book Reviews by Issue Issue Index Topical Index ... Classics Site Search Advanced Search Visitor Login Username Password Help with login Forgot your password? Change your username Paul R. Epstein Paul R. Epstein is associate director of the Center for Health and the Global Environment at Harvard Medical School. By this author Coming: Calamity and Chaos Book Review March-April 2001 ADVERTISEMENTS About American Scientist Site Map Text Archive ... Contact Us

66. Gold Teleproductions DP List Daniel epstein, DP. Epitaph Records 10AM Automatic for The Black Keys from paul Koestner, DP. Comedy Central s Tough Crowd with Colin Quinn and http://www.goldtele.com/dps.htm

Who Makes Up Gold Teleproductions? ...selected credits Daniel Epstein, DP: Epitaph Records "10AM Automatic" for The Black Keys from the CD Rubber Factory PBS + WGBH "Antique Roadshow" selected New York remotes. SunTV Cybernetworks : On PAL Digibeta format for multi-camera location interviews. The program, “Yang Lan One on One” based in Shanghai, China, a "Barbara Walters interview style" series, took us to NYC, New Haven, Washington DC, and Cambridge, Massachusetts. Most recently: February, March 2002. Bravo : "Page to Screen," Working title for a currently in-production interview series focusing on accomplished books turned into feature films. Turner Sports : NBA Coverage including NBA Draft, All-Star Game, and Championship Playoffs in NYC and various games in Philadelphia and Detroit (since 1995). Biography CBS Syndication : Camera/Producer for ‘The Wild, Wild Web Show’ produced by Parallax Productions. Lifetime Television : ‘Intimate Portraits’ interviews in NYC produced by Ken Ehrlich Productions. Fox Sports : Camera/Lighting Designer including Opens for the World Series and Stanley Cup Finals ’95-96.

67. : Consortium For Conservation Medicine paul epstein Executive+ CommitteeConsortium for Conservation Medicine. paul epstein Dr. epstein is a widely published public health physician and http://www.conservationmedicine.org/paul_epstein.htm

Paul Epstein, M.D., M.P.H. Associate Director, Center for Health and the Global Environment, Harvard Medical School and Instructor in Medicine, Harvard Medical School, Massachusetts E-mail: paul_epstein@hms.harvard.edu Telephone: 617-384-8530 Fax: 617-384-8530 Website: www.med.harvard.edu/chge Dr. Epstein is a widely published public health physician and medical educator with expertise in the areas of marine ecosystems, infectious diseases, and global climate change. He is a member of the Harvard Working Group on New and Resurgent Infectious Diseases and an author of both the Health Section of the IPCC 2nd Assessment Report and the WHO/WMO/UNEP report Climate Change and Human Health . He was the recipient of a National Oceanic Atmospheric Administration's Office of Global Programs and NASA grant to study the health, ecological, and economic dimensions of global change in marine environments. Dr. Epstein is a member of the Harvard University Committee on the Environment. Selected Publications Epstein PR. Is Global Warming Harmful to Health?

68. Unfogged If you don t know of Joseph epstein, or have never read one of his books of paul Simon, former Senator from Illinois, and one of the real good guys in http://www.unfogged.com/archives/week_2003_12_07.html

Go To Main Page About Unfogged About Unf About Ogged ... About Alameida Email to blogger name at domain dot com Site design gratefully adapted from Fewer cock jokes at the Unfogged Reading Group Latest Comments eb comments on Suburban Bliss Gary Farber comments on The Slack Chopper comments on The Slack Camera Obscura comments on Vote or Die! Becks comments on The Slack Matt Weiner comments on The Slack text comments on The Joy Of Chores Gary Farber comments on But You're Not Gary Farber comments on The Slack andrew comments on Weenie Links Agenda Bender Amygdala Apostropher Billmon ... Veiled Conceit Search Blog Archives State Secrets? Posted by Ogged on 12.13.03 Sometimes it really is simple: this administration is full of bad people The Bush administration has removed from the public domain millions of pages of information on health, safety, and environmental matters, lowering a shroud of secrecy over many critical operations of the federal government. The Bush administration is denying access to auto and tire safety information, for instance, that manufacturers are required to provide under a new "early-warning system" created following the Ford-Firestone tire scandal four years ago. The U.S. Consumer Product Safety Commission, meanwhile, is more frequently withholding information that would allow the public to scrutinize its product safety findings and product recall actions. New administrative initiatives have effectively placed off limits critical health and safety information potentially affecting millions of Americans. The information includes data on quality and vulnerability of drinking-water supplies, potential chemical hazards in communities, and safety of airline travel and others forms of transportation.

69. NHS Equal Pay - Robin Allen QC - Paul Epstein - 1500 Women Employed By Cumberlan Robin Allen QC, joint head of chambers, and paul epstein, both of Cloisters, have today settled the biggest ever equal pay case for 1500 women employed by http://www.legalday.co.uk/lexnex/cloister05/nhs-equal-pay-cloister-140305.htm

NHS Equal Pay NHS Equal Pay - Robin Allen QC - Paul Epstein - 1500 women employed by Cumberland Infirmary and West Cumbria Hospital - Wilson v North Cumbria Acute NHS Trust LegalDay Home Cases Commentary CurrentIssues ... SiteMap QuickService Accountancy Company Formation CPD/Conferences Credit Rating ... Click here for a job in UK Law! Search This Page Ctrl + F Index of CurrentIssues LegalDay Today's News and Links Search LegalDay on LegalCommentary Resources 15 March 2005 NHS Equal Pay Wilson v North Cumbria Acute NHS Trust Robin Allen QC, joint head of chambers, and Paul Epstein, both of Cloisters, have today settled the biggest ever equal pay case for 1500 women employed by Cumberland Infirmary and West Cumbria Hospital. The case, Wilson v North Cumbria Acute NHS Trust, has lasted for eight years. The women involved, who range from clerical officers to nurses, lodged claims in 1997 and in some cases will be awarded up to fourteen years back pay. Further information can be found at www.cloisters.com and www.unison.org.uk

70. Wisconsin Vascular Plants: Photographers paul Drobot, Plants To Grow and Franklin High School, Franklin Wis. Eric J. epstein, Wisconsin Dept. of Natural Resources http://www.botany.wisc.edu/wisflora/photographers.asp

W ISCONSIN B OTANICAL I NFORMATION S YSTEM Wisconsin State Herbarium Wisflora - Vascular Plant Species University of Wisconsin - Madison Menu: Herbarium Home WISFLORA: Vascular Plant Species Vascular Plant Taxon Search Search Specimen Database Photographs mawetter@wisc.edu List of Photographers Dennis Albert Ecology Program Manager at Michigan Natural Features Inventory William S. Alverson Wisconsin Dept. of Natural Resources Derek Anderson University of Wisconsin - Superior Dan Aussem Donated to University of Wisconsin-Madison for "Orchids of Wisconsin" website Harvey Ballard Ohio University, Athens Rob Baller Beloit, Wisconsin Richard Bauer Donated to Wisconsin Dept. of Natural Resources John H. Beaman Donated to University of Wisconsin-Madison for Botany website Jessie Bennett Driftless Land Stewardship Paul E. Berry University of Wisconsin-Madison Robert Bierman West Allis, Wisconsin Merel R. Black University of Wisconsin-Madison Richard Barloga Hales Corners, WI Charles R. Bomar University of Wisconsin - Stout Kathie and Tom Brock Madison, Wisconsin

71. Paul Epstein [#41] At 2004 National SCRABBLE® Championship On this page, you will find information about paul epstein, epstein played 2 Tim Adamson (Saint paul, MN) and lost 399 to 407 (a spread of 8) . http://www.scrabble-assoc.com/tourneys/2004/nsc/build/player/1/041.html

Jul. 31 - Aug. 5 LIVE COVERAGE Registered Players Player Information ... History Go to: Commentary Games Players Photos ... Merchandise Back to Congratulations to the new National Champion, Trey Wright, who defeated David Gibson in three straight games, 365-328, 355-344 and 429-328. Please tune in to ESPN to watch the final games at 1 P.M. ET on Sunday, October 3rd, 2004. We welcome your e-mailed corrections to our web site. ] Lower on this page, you can find brief self-reported biographical details of the player, statistics on the player's past several years of rated tournament play in North America, a graphic showing the player's ups and downs at this tournament, and a round-by-round report on the player's opponents and games. Background Information Given name(s): Paul Surname(s): Epstein Home: Ann Arbor, MI, United States Age: Awards: Hobbies: Music, Writing Occupation: Social Worker WSC 1999 Rank: Career History 5-year record against other players at this event Past 1-12 months WW LLL W L W LL WWW L W LL WW L WWW LLLL Past 13-24 months WW L W LLLLL WW L W L WWW L W LL WW LLLLLLLL WWW LLLLLLL WWW L W LL WWWW L WW LL WW L W LL W LLLL WW LLL WWWW L Past 25-36 months LL W LLL WTWWW LL W LLLLLL W LLL W LLLLL WWW LL W L WWW L W L W LL WWWWWWW L WW L WWWW LL W L WWW Past 37-48 months WWW L WWW L W LL WWW L WW L WW LLL WW LLL W L W L WWWWW LL WWWW L WW LL W LLL WWWWW LLLL WWWWW Past 49-60 months W LL W LL WW L WWW LLLL WW L WW LLL W LL W L WWWW L W L WW LLL WWW LL Rank Diagram See legend Round-by-Round High score Average for

72. NSC 2000: J Paul Epstein J paul epstein (MI) is player 023, ranked 49 of 98 in Division 1 and was rated 1854 2 1 (+291) epstein, J paul 24. 2- 1 (+254) Tiekert, Ronald B 25. http://www.scrabble-assoc.com/tourneys/2000/nsc/players/1/023.html

Back to NSC 2000 Players NSC 2000: J Paul Epstein J Paul Epstein (MI) is player #023, ranked 49 of 98 in Division 1 and was rated 1854 in the NSA's July 1st ratings list (listed as EPSTEIN PAUL). This web page will be updated with information about how this player is doing throughout the NSC Round 1 vs. Trip Payne 9. 1- (+156) Hahn, Albert 10. 1- (+147) Logan, Adam 11. 1- (+136) Okosagah, Sammy 12. 1- (+136) Moss, Avi 13. 1- (+131) Wright, Trey 14. 1- (+128) Epstein, J Paul 15. 1- (+126) Mead, Jere 16. 1- (+114) Tiekert, Ronald B 17. 1- (+109) Lerman, Jerry 18. 1- ( +97) Weinike, Joseph 19. 1- ( +95) Erbprasartsook, Akegapun Round 2 vs. Lynn Cushman 1. 2- (+392) Sherman, Joel 2. 2- (+360) Hersom, Randy 3. 2- (+343) Onyeonwe, Iffy 4. 2- (+340) Kramer, James J 5. 2- (+296) Epstein, J Paul 6. 2- (+232) Logan, Adam 7. 2- (+228) Okosagah, Sammy 8. 2- (+227) Ellickson, Robert 9. 2- (+226) Alexander, Steven 10. 2- (+222) Lerman, Jerry 11. 2- (+203) Cappelletto, Brian Round 3 vs. Steven Alexander

73. Closer To Truth . Participants | PBS Robert epstein, Ph.D., is University Research Professor at the California School of Robert epstein. paul Ewald. Robert Freeman. Murray GellMann http://www.pbs.org/kcet/closertotruth/participants/index2.html

EXPLORE ALL EPISODES ASK THE EXPERTS JOIN THE DISCUSSION PARTICIPANTS ... Closer to Truth : Participants Participants Meet our show participants. Dr. Eric Courchesne Neuroscientist/Neurologist Eric Courchesne, Ph.D., is a professor of neuroscience at UC San Diego and director of the Center for Autism Research at the San Diego Children's Hospital. He is a leading researcher in the study of the neural basis of autism. Autism is a developmental brain disorder that affects the ability to communicate, form relationships, and respond appropriately to the environment. Autism can vary greatly in its severity, from mild social impairments to extreme retardation, bizarre behavior, and total withdrawal from the world. Some autistics develop "savant" abilities such as prodigious talents for mental arithmetic. Courchesne studies the brain wiring and genetic basis of autism, hoping to discover the causes of this mysterious disorder that afflicts one in 500 people. Michael Crichton Author, Filmmaker Michael Crichton, began his career in medicine in the early 1970's, and soon switched tracks to become a writer and filmmaker. Most of Crichton's books are set in the present or near future, and some of his most successful stories are cautionary tales about the potential pitfalls of science and technology. Known as "the father of the techno-thriller," his fiction novels include The Andromeda Strain Congo Jurassic Park Timeline , and Prey . He has also penned four non-fiction books, including

74. Paul Chapman - Author/Editor - Joyce L Epstein Joyce L epstein. Affiliations. Johns Hopkins University Baltimore, USA. No results found for your search of . Site best viewed with Microsoft Internet http://www.paulchapmanpublishing.co.uk/author.aspx?aid=356847

75. The Paul-Bunnell Heterophile Antibody Determinant In Epstein-Barr Virus-Associat The paulBunnell Heterophile Antibody Determinant in epstein-Barr Virus-Associated Disease. http://www.cfsresearch.org/cfs/jcfs/13.htm

Articles and Abstracts from The Journal of Chronic Fatigue Syndrome CFSResearch.org Chronic Fatigue Syndrome The Journal of Chronic Fatigue Syndrome Journal of Chronic Fatigue Syndrome: Multidisciplinary Innovations in Research, Theory, and Clinical Practice Volume Issue ISSN Pub Date The Paul-Bunnell Heterophile Antibody Determinant in Epstein-Barr Virus-Associated Disease Roberto Patarca-Montero MD,PhD, Miami Beach,FL,33160,USA,rpatarca@pol.net, Mary Ann Fletcher PhD, University of Miami School of Medicine Reprinted with Expressed Permission of The Haworth Press, Inc Abstract: Reactivation of latent herpes viruses (notably EpsteinBarr virus, human herpesvirus-6) is commonly seen in chronic fatigue syndrome and it is believed to contribute to symptom perpetuation. EpsteinBarr virus (EBV), which was first isolated by Epstein, Barr and Achong (1964) from a cultured Burkitt's lymphoma lymphoblast cell line, is the etiological agent for infectious mononucleosis (IM), polyclonal and oligoclonal lymphomas associated with primary and acquired immunodeficiencies, and the complications of X-linked lymphoproliferative syndrome (XLP) (Cantani and Mastrantoni, 1989; Englund, 1988; Ernberg et al., 1990; Jones and Straus, 1987; Okano et al., 1988; Purtilo, 1987; Purtilo et al., 1981; Rowe et al., 1986; Saemundsen et al., 1981) and nasopharyngeal cancer (Pearson et al., 1984). Furthermore, people who have had IM have higher rates of subsequent development of malignant lymphoproliferative disorders (Abo et al., 1982; Snydman et al., 1982) and Hodgkin's disease (Green et al., 1979; Mueller, 1987; Poppema et al., 1985; Weiss et al., 1989), while patients with XLP have a higher incidence of non-Hodgkin's malignant lymphoma (Harrington et al., 1987).

76. EReader.com: Author: Paul R. Epstein Looking for eBooks? eReader.com is the World s largest eBook store, providing eBook downloads for fiction, nonfiction and reference books, http://www.ereader.com/author/detail/9705

View Cart Home Wish List Account ... Sign in or create an account SHOP Software Special Offers Recently Reduced New Releases ... Under Five Dollars CATEGORIES View all Romance Science Fiction Travel ... View by author Browse by category... Action/Adventure Anthologies Back To School Biography/Memoir Careers Children's Books Classics Contemporary Fiction Entertainment Fantasy Historical Fiction History Horror Humor Law Literature Magazines New Age Nonfiction Poetry Recently Reduced Reference Religion Romance Science Fiction Self-Help Special Offers Staff Picks Star Trek Books Study Guides Summer Reading Teen Travel True Crime Under Five Dollars Western Paul R. Epstein Home Authors Paul R. Epstein Paul R. Epstein, an M.D. trained in tropical public health, is associate director of the Center for Health and the Global Environment at Harvard Medical School. He has served in medical, teaching and research capacities in Africa, Asia and Latin America and has worked with the Intergovernmental Panel on Climate Change, the National Oceanic and Atmospheric Administration, and the National Aeronautics and Space Administration to assess the health effects of climate change and to develop health applications for climate forecasting and remote-sensing technologies. Notify me when new books by Paul R. Epstein

77. Center For Health And The Global Environment-The Center paul R. epstein, MD, MPH is Associate Director of the Center for Health and the Global Environment at Harvard Medical School http://www.med.harvard.edu/chge/epstein.html

Faculty Staff Advisory Board Corporate Council Paul R. Epstein M.D., M.P.H Associate Director Instructor in Medicine, Harvard Medical School paul_epstein@hms.harvard.edu Paul R. Epstein, MD, MPH is Associate Director of the Center for Health and the Global Environment at Harvard Medical School ( http://www.med.harvard.edu/chge ), and is a medical doctor trained in tropical public health. Paul has worked in medical, teaching and research capacities in Africa, Asia and Latin America and, in 1993, coordinated an eight-part series on Health and Climate Change for the British medical journal, Lancet. He has worked with the Intergovernmental Panel on Climate Change (IPCC), the National Academy of Sciences, the National Oceanic and Atmospheric Administration (NOAA) and the National Aeronautics and Space Administration (NASA) to assess the health impacts of climate change and develop health applications of climate forecasting and remote sensing. Visit the Center's media page for appearances of Dr. Epstein and other Center staff in the news. Selected journal articles are below.

78. Brian Epstein - Wikipedia, The Free Encyclopedia epstein s father owned a furniture store where paul McCartney s family bought a piano. epstein s father put him in charge of the ground floor of the newly http://en.wikipedia.org/wiki/Brian_Epstein

Wikimedia needs your help in its 21-day fund drive. See our fundraising page Over US$150,000 has been donated since the drive began on 19 August. Thank you for your generosity! Brian Epstein From Wikipedia, the free encyclopedia. Brian Epstein, The Beatles Manager and a force behind the group's early success. Brian Samuel Epstein September 19 August 27 ) was a British businessman, best known as the manager of the Beatles Epstein's family owned a furniture store in Liverpool (where Paul McCartney 's family had bought a piano). When Epstein dropped out of the Royal Academy of Dramatic Art (RADA) in London (his classmates included actors Susannah York and Peter O'Toole ) after his third term, his father put him in charge of the record department of the newly-opened North East Music Stores (NEMS) on Great Charlotte Street. Eventually, a second location was opened at 12-14 Whitechapel, and Epstein was put in charge of the entire operation. On August 3 Epstein began writing a regular music column in Mersey Beat Epstein first noticed the Beatles' name on a concert bill, thinking it sounded silly. When several customers began asking for a single they made with Tony Sheridan in Germany, he couldn't find it through any of his

79. US Senate Committee On Commerce, Science, & Transportation The Testimony of Dr. paul epstein Associate Director, Center for Health and the Global Environment, Harvard Medical School http://commerce.senate.gov/hearings/testimony.cfm?id=1176&wit_id=3367

80. Paulgroup - Ludwig epsteinBarr Virus Laboratory. paul FARRELL, Director and Professor of Tumour Virology LINDSAY SPENDER, Assistant Investigator http://www.med.ic.ac.uk/ludwig/paulgroup.htm

Epstein-Barr Virus Laboratory PAUL FARRELL, Director and Professor of Tumour Virology LINDSAY SPENDER, Assistant Investigator HELEN BRYANT, Postdoctoral fellow HANNAH WHITEMAN, PhD student WOLFGANG AMON, PhD student SAMUEL PATTLE, PhD student MAHA AL-MOZAINI, PhD student CLAUDIO ELGUETA, Technician p53 and cancer molecular biology TIM CROOK, Associate Investigator MARLENE ATTARD, Technician ALEX SULLIVAN, Technician NELOFER SYED, Technician Epstein-Barr virus is a human herpesvirus that infects most people in the world early in life and then persists life-long. Primary EBV infection that is delayed until adolescence or adulthood frequently causes infectious mononucleosis (glandular fever). Most carriers of EBV show no symptoms or pathology but in some circumstances EBV is associated with human cancers, the virus normally being present in all of the tumor cells of an EBV associated case. These cancers include lymphomas in immunosuppressed people (either as a result of medication after transplant surgery or AIDS), Hodgkin's disease, Burkitt's lymphoma in central Africa, nasopharyngeal carcinoma in South-East Asia and some gastric carcinomas. EBV infects human B lymphocytes and certain epithelial cells; infection of lymphocytes is readily accomplished in the laboratory and EBV drives the cells into a state of permanent proliferation. We are studying the mechanisms by which EBV causes human cells to grow, the role of the virus in human cancers and the regulation of the switch between latent persistence and virus replication. The virus proteins EBNA-1, EBNA-2, EBNA-3A, EBNA-3C, EBNA-LP and LMP-1 are required for EBV to cause permanent growth of human B lymphocytes and expression of the virus proten BZLF1 is the key switch from latency to the replicative cycle. The functions and mechanisms of action of these viral proteins comprise much of the EBV research at the Branch.

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