61. Therapy May Reverse Symptoms Of Fragile X Syndrome – Clinical Trials For Dr Gül Dölen and Baer (Best Syndication) New research from the Massachusetts Institute of Technology (MIT) may pave way for treatment of fragile x syndrome and http://www.bestsyndication.com/?q=121907_fragile_x_syndrome_cure_therapy_fxs.htm

62. Fragile X Syndrome: Encyclopedia Of Children's Health fragile x syndrome Encyclopedia of Children s Health. http://www.enotes.com/childrens-health-encyclopedia/fragile-x-syndrome

Fragile X Syndrome: Encyclopedia of Children's Health Welcome, guest! Login Join eNotes Entire Site Literature Science History Business Soc. Sciences Health Arts College Journals Literature Science History Business ... Z Search Encyclopedia of Children's Health: Fragile X Syndrome Printable Version Download PDF Cite this Page Definition Fragile X syndrome, a genetic condition involving changes in the long arm of the X chromosome, is the most common form of inherited mental retardation . Individuals with this condition have developmental delay , variable levels of mental retardation, and behavioral and emotional difficulties. They may also have characteristic physical traits. Generally, males are affected with moderate mental retardation (since they only have one X chromosome) and females with mild mental retardation. Description Fragile X syndrome is the most common form of inherited mental retardation in the United States. Fragile X syndrome is... [The entire page is 2252 words long] Join eNotes The above is a free excerpt. Get total access to this content with the: eNotes Pass eNotes Lookup Tip: Lookup any word on eNotes with our dictionary. Simply highlight the word and press SHIFT + D for a definition.

63. Fragile-x Research Foundation OfCanada Scheduled to open in June of 2006, it will serve as a centre to assess and treat patients of all ages who have fragile x syndrome. http://www.fragile-x.ca/default2.htm

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64. The Fragile X Society We are the UK registered charity providing support, information and friendship to families whose children and relatives have fragile x syndrome. http://www.fragilex.org.uk/

Search Home About Fragile X Publications Fragile X Families ... Contact Us The Fragile X Society, Rood End House, 6 Stortford Road, Great Dunmow, Essex CM6 1DA Tel: 00 44 (0)1371 875100, Fax: 00 44 (0)1371 859915, Email: Reg/ Charity No. 1003981 Welcome to The Fragile X Society We are the UK registered charity providing support, information and friendship to families whose children and relatives have fragile X syndrome. We are also here to help the many professionals who are working and caring for children and adults affected by fragile X. Fragile X Syndrome is the most common known cause of inherited learning disabilities Our website provides information about fragile X which we hope you will find helpful. National Support and Information Service Whether you are - please call us on 01371 875100 email us by going to Contact Us Journalists Please contact us for: Call Lynne Zwink, Press Officer on 01245 231941 Fragile X Research The Fragile X Society encourages research into fragile X through the participation of its family members in fragile X studies. To find out more about fragile X research in the UK go to Research.

65. A New Approach To Correcting Autism - TIME Parker Roos (right) and his sister Allison, both of whom have fragile x syndrome, wait for evaluations and checkups at the UC Davis M.I.N.D. Institute. http://www.time.com/time/health/article/0,8599,1696451,00.html

var s_account="timecom"; Time.com CNN.com Search Archive Home U.S. The Page Main ... Pictures of the Week A New Approach to Correcting Autism Wednesday, Dec. 19, 2007 By CLAUDIA WALLIS Parker Roos (right) and his sister Allison, both of whom have fragile X syndrome, wait for evaluations and check-ups at the UC Davis M.I.N.D. Institute. (c) UC Regents Article Tools Print Email Reprints Sphere addthis_url = location.href; addthis_title = document.title; addthis_pub = 'timecom'; RSS Neuron is bound to generate excitement, even though the work was done in rodents. It shows that wide-ranging symptoms of Fragile X, which include epilepsy, impaired mental functioning, aberrant brain structure and other abnormalities, can be reversed. The work, researchers say, holds enormous promise for humans with Fragile X and probably for other forms of autism as well. Related Articles Sphere.Inline.search('sphereSideBar','http://time.com/') tiiQuigoWriteAd(755774, 1290760, 180, 200, -1); Roughly 1 in 3,600 people have Fragile X Syndrome, with boys more severely affected than girls. People with the disorder tend to have elongated faces and prominent ears; about half of them fall somewhere on the autism spectrum and most are mentally retarded or learning disabled as well. Fragile X occurs when the brain fails to produce normal quantities of a chemical known as the Fragile X mental retardation protein, or FMRP. This protein appears to act as a brake on the production of other proteins in the brain, including those associated with learning and memory. Without enough FMRP, protein production spins out of control, like a runaway train. The brain develops an abnormally dense number of connections, resulting in a variety of physical, mental and behavioral problems. "Fragile X is a disorder of excess," explains Mark Bear, lead author of the

66. Special Child: Disorder Zone Archives - Fragile X Syndrome As it turned out, we went to Riley s Hospital in Indianapolis and the diagnosis was made Matt has fragile x syndrome, a full mutation, and he inherited it http://www.specialchild.com/archives/dz-008.html

Disorder Zone Archives Fragile X Syndrome TJ Therrell Eric Therrell Introduction Fragile X is a genetic disorder that is caused by a break or weakness on the long arm of the X chromosome (females have two X chromosomes and males have one X and one Y). The gene where the break or weakness has occurred has been named FMR1 (Fragile X Mental Retardation-1). Because of this defect, the gene cannot manufacture the protein that it normally makes, which causes the features and characteristics of the syndrome. Fragile X is estimated to occur in 1 in 1,200 males and 1 in 2,500 females. It occurs in all racial, ethnic, and socioeconomic groups. It is said to be one of the most common genetic diseases and is the most common inherited cause of learning disabilities and mental retardation known to exist. Features and Characteristics There are several physical and behavioral characteristics that are associated with fragile X, however, not every individual has all the characteristics. The following is a list of the most common traits: Long narrow face Prominent ears, jaw, and forehead

67. Scientists Link Fragile X Tremor/ataxia Syndrome To Binding Protein In RNA fragile x syndrome occurs when a region of the FMR1 gene repeats a particular sequence of three DNA basesÑCGGcausing silencing of the FMRP protein. http://www.biologynews.net/archives/2007/08/15/scientists_link_fragile_x_tremora

Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA August 15, 2007 08:36 PM Previous article: X-ray images help explain limits to insect body size Next article: Bursts of waves drive immune system 'soldiers' toward invaders Add Comment Mail to a Friend Link to this article Print Article Scientists have discovered a key protein in the toxic brain pathway that leads to fragile X tremor/ataxia syndrome (FXTAS), an inherited neurodegenerative disorder. The finding, in a Drosophila (fly) model of FXTAS, could help unravel the complex mechanisms of FXTAS and lead scientists to develop therapies to target the protein. The research will be published in the Aug. 16 issue of the journal Neuron. Fragile X tremor/ataxia syndrome was first recognized several years ago as a neurodegenerative disease caused by a premutation in carriers of the mutated FMR1 gene, the same gene that causes fragile X syndromethe most common inherited cause of mental retardation. Individuals with the FMR1 premutation (a less exaggerated form of the mutation) do not have retardation, but instead are at risk for developing FXTAS, usually after age 50, causing progressive problems with movement (ataxia), tremor, memory loss, loss of sensation in the lower extremities (peripheral neuropathy), and mental and behavioral changes. Fragile X syndrome occurs when a region of the FMR1 gene repeats a particular sequence of three DNA bases‘CGGcausing silencing of the FMRP protein. Called a trinucleotide repeat, this CGG sequence repeats only about 6 to 55 times in normal individuals, but between 200 and 1,000 times in those with fragile X syndrome.

68. Developing Medications For Fragile-X Syndrome - Mental Health Articles A new NIMH grant is enabling scientists to begin testing safety and effectiveness of potential medications for fragileX syndrome, the most common inherited http://www.emaxhealth.com/7/19393.html

SUBMIT FORUM SIGNUP CALENDAR ... Mental Health Articles Developing Medications For Fragile-X Syndrome Fragile-X Syndrome A new NIMH grant is enabling scientists to begin testing safety and effectiveness of potential medications for fragile-X syndrome, the most common inherited form of mental retardation. No effective medications are available for the disorder. The animal studies currently underway are designed to lay the groundwork for the first human clinical trials in subsequent phases of the research. People with other developmental disorders that share some of the same brain mechanisms which lead to fragile-X syndrome, including some cases of autism, also may benefit from this research. The purpose of the study is to advance promising laboratory findings into treatments for patients. The grant will total $3.37 million over three years. Randall Carpenter, M.D., of Seaside Therapeutics (Cambridge, Massachusetts), is the principal investigator. The National Institute of Mental Health (NIMH) is the primary funder of the project, with additional support from two other institutes of the National Institutes of Health: the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Two private organizations, the Fragile X Research Foundation and Cure Autism Now, also contributed funding. What Is Fragile-X Syndrome?

69. Fragile-X Syndrome --  Britannica Online Encyclopedia Britannica online encyclopedia article on fragileX syndrome a chromosomal disorder associated with a fragile site on the end of the X chromosome. http://www.britannica.com/eb/article-9035089/fragile-X-syndrome

var britAdCategory = "other"; Already a member? LOGIN Encyclopædia Britannica - the Online Encyclopedia Home Blog Advocacy Board ... Free Trial Britannica Online Content Related to this Topic This Article's Table of Contents fragile-X syndrome Print this Table of Contents Linked Articles mental retardation Shopping New! Britannica Book of the Year The Ultimate Review of 2007. 2007 Britannica Encyclopedia Set (32-Volume Set) Revised, updated, and still unrivaled. New! Britannica 2008 Ultimate DVD/CD-ROM The world's premier software reference source. fragile-X syndrome Page 1 of 1 a chromosomal disorder associated with a fragile site on the end of the X chromosome. The major symptom of the syndrome is mental retardation fragile-X syndrome... (75 of 117 words) To read the full article, activate your FREE Trial Close Enable free complete viewings of Britannica premium articles when linked from your website or blog-post. Now readers of your website, blog-post, or any other web content can enjoy full access to this article on fragile-X syndrome , or any Britannica premium article for free, even those readers without a premium membership. Just copy the HTML code fragment provided below to create the link and then paste it within your web content. For more details about this feature, visit our Webmaster and Blogger Tools page Copy and paste this code into your page var dc_UnitID = 14; var dc_PublisherID = 15588; var dc_AdLinkColor = '009900'; var dc_adprod='ADL'; var dc_open_new_win = 'yes'; var dc_isBoldActive= 'no';

70. Access : Fragile X Fixed In Mice : Nature News Researchers have reversed almost all symptoms of fragileX syndrome in a mouse model for the disease. In humans, fragile X is the most common form of http://www.nature.com/uidfinder/10.1038/news.2007.386

Jump to main content Jump to navigation nature.com homepage ... Browse by subject Search This site All of nature.com Advanced search E-alert sign up RSS feed Subscribe ... nature journal Access To read this story in full you will need to login or make a payment (see right). Published online 19 December 2007 News Fragile X fixed in mice Animal studies suggest a way to treat the devastating mental retardation disorder. Brendan Maher Tools Send to a Friend RSS Feeds Researchers have reversed almost all symptoms of fragile-X syndrome in a mouse model for the disease. In humans, fragile X is the most common form of heritable mental retardation and one of the leading known causes of autism. To read this story in full you will need to login or make a payment (see right). Comments Reader comments are usually moderated after posting. If you find something offensive or inappropriate, you can speed this process by clicking 'Report this comment' (or, if that doesn't work for you, email redesign@nature.com). For more controversial topics, we reserve the right to moderate before comments are published. Speaking of the causes of autism... New Study: Declining Autism Cases Tied to Removal of Mercury from Vaccines http://www.infowars.com/articles/science_technology/health_medicine/vaccines/new_study_declining_autism_cas.html I keep hearing that autism cases have skyrocketed except in Amish communities and other communities where mercury isn't injected into the body.

71. Fragile-X Syndrome fragile X Research Foundation of Canada (Fondation Canadienne de Rescherche sur le syndrome de Fragilite du Chromosome X), English, French, and Portuguese http://www.kumc.edu/gec/support/fragilex.html

Fragile X Syndrome FRAXA Research Foundation 45 Pleasant St. Newburyport, MA 01950 Phone: (978) 462-1866 Fax: (978) 463-9985 Web site: http://www.fraxa.org E-mail: fraxa@seacoast.com or kclapp@fraxa.org Information in English, Japanese, German, Spanish, French or Hebrew National Fragile X Foundation P.O. Box 190488 San Francisco, California 94119 800-688-8765 or 510-763-6030 Fax 510-763-6223 E-mail: natlfx@sprintmail.com Web site: http://www.nfxf.org or http://fragilex.org/ Fragile X Research Foundation of Canada (Fondation Canadienne de Rescherche sur le Syndrome de Fragilite' du Chromosome X), English, French, and Portuguese (including links to other organizations Also see: National organizations information on genetic conditions or birth defects Fragile X Syndrome: Diagnostic and Carrier Testing , when and how to test for fragile-X syndrome Policy Statement, American College of Medical Genetics Fragile X , Society for Neuroscience Brain Briefings, 1998 Fragile X Association of Germany (Online der Interessengemeinschaft Fragiles-X e.V.)

72. FragileXSyndrome.org | Fragile X Syndrome | Fragile X Syndrome Treatment | Autis Fibromyalgia Awareness Fibromyalgia Food CFS Treatment Options Chronic Leukemia Treat Fibromyalgia Lupus Symptoms Medical Books CFS syndrome http://www.fragilexsyndrome.org/

@import url("/common/premium/premium_lite/default.css"); FragileXSyndrome.org FragileXSyndrome.org See all Domains for Sale Fragile X Syndrome Treatment Autism X Linked Mental Retardation Syndrome ... Symptoms Of Fragile X Related Searches: Fragile X Syndrome Treatment Autism X Linked Mental Retardation Syndrome Fragile X Research Foundation ... Renal Syndrome Sponsored Listings Associated Sites Fragile X Language Delay www.babybumblebee.com/ Heal Fragile X Children Duncan Neuro Research Institute The First of Its Kind In Fragile X www.texaschildrenshospital.org/ Medical Dictionary $48.95 Medical Dictionary/Bibliography on Fragile X Syndrome by ICG Affiliate www.icongrouponline.com/ Fragile X Syndrome Cure Find Low Cost Health Insurance. One Quick Form. Multiple Offers. www.insurancedesk.com/ Down Syndrome blurtit.com/ Buy a Premium Domain for your Business RareSyndrome.com BloomsSyndrome.com BatonsSyndrome.com LupusSyndrome.com ... WastingSyndrome.com document.write(''); FragileXSyndrome.org Search our Catalogue for more Domains

73. Trinucleotide Repeats: Fragile-X Syndrome - Lucile Packard Children's Hospital DNA, the chemical that makes up our genes, contains a. http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/trinucleo.html

Center for Down Syndrome Genetics Clinic Metabolic/Biochemical Genetics Clinic Medical Geneticists ... Packard Children’s Hospital Pediatrician Receives E. Mead Johnson Award For Pediatric Research Medical Genetics Trinucleotide Repeats: Fragile-X Syndrome What are trinucleotide repeats? DNA, the chemical that makes up our genes, contains a "code" of three letter words known as "codons" or "trinucleotide repeats." Many genes normally contain a trinucleotide repeat which is present several times. When the number of trinucleotide repeats increases to a larger than normal number of copies, the DNA is altered, and the gene may not function properly, or may not work at all. It is not well understood what causes a trinucleotide repeat to expand into more than the usual number of copies that should be in a gene. Sometimes, a person may have more than the usual number of copies, but not enough to alter the function of the gene. These individuals are referred to as "premutation carriers." When they pass on these extra copies to a child, however, the extra trinucleotide repeats cause the DNA to become unstable, and the area of DNA expands even more. The result is that the child has a gene that no longer functions, or is not functioning properly and they are said to have the "full mutation." An example of a trinucleotide repeat disease is Fragile-X syndrome. What is Fragile-X syndrome?

74. GeneReviews: FMR1-Related Disorders FMR1Related Disorders GeneReview. GeneReviews are expert-authored, peer-reviewed, current disease descriptions that apply genetic testing to the diagnosis, http://www.geneclinics.org/profiles/fragilex/

FMR1-Related Disorders GeneReview. GeneReviews are expert-authored, peer-reviewed, current disease descriptions that apply genetic testing to the diagnosis, management, and genetic counseling of patients and families with specific inherited conditions.

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