61. Division Of Environmental Quality A small mouth bass being processed to determine if endocrine disruptors have U.S. Fish and Wildlife Service Pacific Region endocrine disruptors http://www.fws.gov/contaminants/Issues/EndocrineDisruptors.cfm

The Environmental Quality Program Environmental Quality Home News and Activities Electronic Library About Us ... Contact Us Endocrine (Hormone) Disruptors There is mounting concern in the scientific, environmental, private, and governmental sectors on a wide range of substances, known as endocrine disruptors, that may interfere with the normal functioning of a living organism's hormone system. Endocrine disruption has the potential to cause: A small mouth bass being processed to determine if endocrine disruptors have affected sex tissue. Credit: USFWS Research shows that endocrine disruptors may pose the greatest risk to offspring during prenatal and early postnatal development when organ and neural systems are developing. However, adverse consequences may not be apparent until much later in life. In addition, endocrine disruptors may affect not just the offspring of mothers exposed to endocrine disruptors during pregnancy, but future offspring as well.

62. New Evidence That Endocrine Disruptors Block Sperm Function A new study shows that adult sperm, when exposed to hormone disrupting chemicals (often called endocrine disruptors), mature too quickly and fail to reach http://ipm.osu.edu/trans/082_021.htm

New Evidence That Endocrine Disruptors Block Sperm Function August 2, 2002 The link between male fertility and hormone disrupting chemicals is now more fully understood. A new study shows that adult sperm, when exposed to hormone disrupting chemicals (often called endocrine disruptors), mature too quickly and fail to reach and fertilize the egg. Dozens of pesticides are known or suspected endocrine disruptors. The list includes widely used carbamates such as aldicarb and carbaryl, common organophosphates (e.g., malathion and chlopyrifos), and persistent chlorinated pesticides such as endosulfan, lindane and DDT. Individuals face potential exposure to endocrine disrupting pesticides through food residues, home pesticide use, and soil, water and air contaminated by agricultural pesticide use. The study, released in early July 2002 at Europe's annual human reproduction conference by scientists from King's College in London, provides the first direct evidence that endocrine disruptors affect sperm function. For many years, the debate over male fertility has focused on the effects of prenatal exposure to such compounds on development of testicles in infants and evidence of declining sperm counts worldwide. In the past ten years, dozens of studies have linked endocrine disrupting chemicals to a number of reproductive and other health effects. The chemicals closely mimic naturally occurring hormones and can disrupt the functioning of hormone systems in humans and other animals at very low levels of exposure. Dr. Theo Colburn's research more than a decade ago linking reproductive failure in alligators with chemical exposure led researchers to further explore the reproductive and other effects of this class of chemicals.

63. Reproductive Health Effects Exposure to endocrine disruptors at critical developmental periods in utero may derail the normal path of reproductive development. http://www.cape.ca/children/repro6.html

Summary Reproductive Development Exposures of Concern Preconception Effects ... Congenital Malformations Endocrine Disruption Clinical Practice Prevention Resources Notes Endocrine disruptors act by binding to the receptor sites, eliciting abnormal biochemical responses. Science is now appreciating that a number of other hormonal systems may be altered by such contaminants, including thyroid hormones, progesterone, glucocorticoids and retinoids. Exposure to endocrine disruptors at critical developmental periods in utero may derail the normal path of reproductive development. Studies show marked trends to increased incidence of hypospadias and cryptorchidism, decreasing age at menarche and increased infertility occurring over the last several decades in industrialized western nations. Increases in reproductive cancers (e.g., testicular cancer and breast cancer) may be caused by exposure to hormonally active agents in utero.

64. Strategic Programs On Environmental Endocrine Disruptors '98 (SPEED '98)[MOE] 67 chemicals suspected to be endocrine disruptors (2), Monitoring of environmental pollution by potential endocrine disruptors http://www.env.go.jp/en/chemi/ed/speed98/sp98.html

It appears that your browser does not support JavaScript, or you have it disabled. This site is best viewed with JavaScript enabled.If JavaScript is disabled in your browser, please turn it back on then reload this page. Link to main body Search Help Sitemap ... Category menu main body MOE Strategic Programs on Environmental Endocrine Disruptors '98 (SPEED '98) Strategic Programs on Environmental Endocrine Disruptors '98 (SPEED '98) May 1998 Japan Environment Agency Preface I. The problem of Exogenous Endocrine Disrupting Chemicals What are exogenous endocrine disrupting chemicals? (1) Problems associated with exogenous endocrine disrupting chemicals (2) Estrogenic substances Hormones (1) Roles of hormones (2) How hormones work Mechanisms for the chemical disruption of hormone function (1) Mechanisms of endocrine disruption (2) Phytoestrogens Reports of adverse effects of endocrine disruptors on humans and wildlife Reports of adverse effects on humans and wildlife Uncertainties and gaps in scientific knowledge Specific issues to be taken into consideration in tackling the problem of endocrine disruptors 67 chemicals suspected to be endocrine disruptors Environmental laws and regulations concerning potential endocrine disruptors Monitoring of environmental pollution by potential endocrine disruptors International approaches to the problem (1) Approaches in other countries (2) The approach of international organizations II. The Environment Agency's Basic Policy on Environmental Endocrine Disruptors

65. Endocrine Disruptors: Characteristics Any substance that alters the function of this system is termed an endocrine disruptor. endocrine disruptors, commonly referred to as “Endocrine Disrupting http://enhs.umn.edu/5103/endocrine/character.html

Endocrine Disruptors Characteristics Fate and Transport in the Environment Methods for Monitoring in the Environment Methods for Measuring Human ... 5103/5104 Home What are endocrine disruptors? The endocrine system is a complex communication system between chemical signals and their targets responsible for regulating internal functions of the body (for more info see http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookENDOCR.html). 1. By mimicking the sex steroid hormones estrogen and androgen by binding to their natural receptors either as agonists or antagonists. 2. By altering the synthesis and breakdown of natural hormones. 3. By modifying the production and functioning of hormone receptors. In general, compounds that mimic estrogens are termed environmental estrogens whereas compounds that block hormone action are termed anti-estrogens or anti-androgens (male sex hormone). Environmental estrogens have been the focus of the majority of research on endocrine disruptors. This includes, but is not limited to chemicals that mimic the female sex hormone estradiol-17b. Chemical structures of EDCs Interestingly, the chemical structures of natural hormones and environmental hormones are most often very different. It is not possible to determine whether a chemical is an endocrine disruptor or not by merely looking at its chemical structure. Because the structures of endocrine disruptors are so variable and unpredictable, they are sometimes synthesized unintentionally. A couple examples include the pesticide DDT and polychlorinated biphenyls (PCBs), both of which have estrogenic activity, but were originally synthesized for a completely unrelated purpose. The figure below demonstrates the structural diversity of chemicals in the environment reported to be estrogenic (1).

66. WWF Endocrine Disruptor Information Papers and speeches on how hormone disruptors interfere with biochemical processes, and a suspected list of hormone disruptors. http://www.pmac.net/theos.htm

Pesticides as Endocrine Disruptors WWF Endocrine Disruptor Information Dr. Theo Colborn, a leading scientist and expert on endocrine disruptors, has co-authored Our Stolen Future with Dianne Dumanoski and John Peterson Myers. STATE OF THE WORLD FORUM Dr. Theo Colborn, November 6, 1997, San Francisco CA. Evolutionary differences between natural and synthetic estrogens are discussed in a fascinating November 16, 1997 post to the Sanet discussion group by Dr. Ann Clark, University of Guelph. Dr. Clark reflects upon information in Our Stolen Future and offers examples cropping-livestock systems of how animals respond differently to plant estrogenic compounds they have evovled with, in contrast to those introduced into their environment from an exogenous source. WWF - Hormone Disruptor site with information on how hormone disruptors interfere with bio-chemical processes, the wildlife- human connection, a known and suspected list of hormone disruptors and an audio clip from Dr. Theo Colburn as she explains endocrine disruption and it's hazards "Acceptance Speech" , Dr. Theo Colborn, delivered June 19, 1997, upon receipt of the

67. Hormone Disruptors - Endocrine Disrupting Chemicals And Endocrine System Disorde Article about hormone disruptors (endocrine disrupting chemicals) and endocrine system disorders. http://www.grinningplanet.com/2005/03-01/endocrine-disruptors-hormone-imbalance-

Get GP free via email ! SEARCH Home GP Issues Index Jokes-Cartoons ... Contact endocrine disruptors (endocrine disrupting chemicals (EDCs)) and hormone imbalance effects "ENGAGE THE GLOBAL TOXIFICATION WEAPON!" SCREAMED THE KLINGON COMMANDER Today we get an overview of how the problem of hormone disruptors arose and where the issue stands. Our article on these endocrine disrupting chemicals comes from Joseph K. Sheldon, Professor of Biology and Environmental Science at Messiah College in Pennsylvania, and David K. Foster, Associate Professor of Biology and Environmental Science, also at Messiah College. It has been excerpted from an article they previously published in Christian Scholars' Review by Joseph K. Sheldon and David K. Foster smog event, as they did in Donora, Pennsylvania in October of 1948, and rivers don't catch on fire, as the Cuyahoga River of Cleveland, Ohio did in 1936, 1952, and most famously in 1969. Even sewage treatment has advanced so that every American city has at least secondary treatment, and many plants can remove most of the excess phosphorous and nitrogen before the water is returned to nature's ecosystems. Chemicals that were directly toxic to humans, such as arsenic and nicotine pesticides, and even some chemicals that are known carcinogens, are now largely removed from our food supply.

68. Endocrine Disruptor Screening Program | US EPA This site provides information about the endocrine Disruptor Screening Program (EDSP) and EPA s approach and progress for screening and testing chemicals http://www.epa.gov/endo/

@import 'http://www.epa.gov/epafiles/s/epa.css'; Jump to main content. Endocrine Disruptor Screening Program (EDSP) Recent Additions Contact Us Search: All EPA This Area You are here: EPA Home Office of Prevention, Pesticides, and Toxic Substances Office of Science Coordination and Policy Endocrine Disruptors This site provides information about the Endocrine Disruptor Screening Program (EDSP) and EPA's approach and progress for screening and testing chemicals for potential endocrine effects. If you are new to the topic of endocrine disruption you might want to read the EDSP Overview and EDSP Primer for more detailed information on the endocrine system and the EDSP. In recent years, some scientists have proposed that certain chemicals might be disrupting the endocrine system of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and compelling evidence shows that endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems. Based on this and other evidence, Congress passed the Food Quality Protection Act in 1996, requiring that EPA initiate EDSP to screen pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife. Highlights Peer Review Results for the AR Binding Assay (PDF) (77 pp, 311K)

69. Endocrine Disrupters Information from the Why Files about the endocrine system, effects of pesticides/PCBs/dioxins on wildlife and people, and prospects for action to resolve http://whyfiles.org/045env_hormone/

In July, an EPA committee met in Chicago. Their problem: are synthetic chemicals causing hormonal chaos? [Posted August 7, 1997] Wildlife woes : Pesticides don't discriminate Human woes : DES, DDT, PCB's, dioxin 'n more Hormone basics Hormone confusion : How disrupters do their work History : DDT and eagles' eggs The EPA's action plan Prospects for success There are documents. Bibliography Credits Search

70. The Endocrine Disruption Exchange Creates a banner frame on the top, menu frame on the left, and main frame on the right. Hyperlinks in the banner frame are targeted to the menu frame. http://www.endocrinedisruption.com/

You need a browser that supports frame to view this page.

71. Endocrine Disruptor Knowledge Base Home Page The endocrine Disruptor Knowledge Base (EDKB) website consists of a biological activity database, relevant literature citations, computational models, http://edkb.fda.gov/

Health and Human Services Food and Drug Administration NCTR EDKB Home ... Publications Welcome to the Endocrine Disruptor Knowledge Base Go straight to the Database page The Endocrine Disruptor Knowledge Base (EDKB) website consists of a biological activity database, relevant literature citations, computational models, and ultimately, models for risk assessment. It is designed to help research and regulatory scientists, and other interested parties set priorities for testing of endocrine disrupting compounds, make use of the existing body of knowledge, and reduce dependency upon slow and expensive animal experiments. Legislation requiring the development and implementation of a strategy for screening and testing chemicals for estrogen, androgen and thyroid endpoints [ EDSTAC, #545 ] led to the definition of a two-tiered, multiple-endpoint strategy by EPA's Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) of which FDA is a participating member. This strategy incorporates more than 20 different in vitro and in vivo assays [ Gray, 1998 #250]

72. Our Stolen Future: Home Provides updates about endocrine disruption created by manmade chemical contaminants that interfere with hormones in humans and wildlife. http://www.ourstolenfuture.org/

Navigate the site Newest developments Book Basics New Science Consensus Statements Commentary Myths vs. Reality Useful links Important Events Other Sources Other Languages About the Authors The book Our Stolen Future brought world-wide attention to scientific discoveries about endocrine disruption and the fact that common contaminants can interfere with the natural signals controlling development of the fetus. This website tracks the most recent developments. Does the ' dose make the poison Want some good news , for a change? About Our Stolen Future About this web site Latest news about endocrine disruption: More news about endocrine disruption Read about the latest scientific results and what they mean: New CDC data show ubiquitous exposure to BPA at significant levels Scientists warn policymakers about bisphenol A BPA linked to middle-aged uterine defects DDT linked to breast cancer ... Cancer and EDCs: are we asking the wrong question in human studies? Shortcut to a list of recent, important studies , and links thereto... Daily news about endocrine disruption available via RSS syndication courtesy of EnvironmentalHealthNews.org

73. WWF | Toxic Chemicals | Conservation Results | Endocrine Disrupting Chemicals Wildlife researchers over the last several years have unearthed a variety of endocrine disruptorrelated effects interrupted sexual development; http://www.worldwildlife.org/toxics/results/results2.cfm

Join WWF Member Login Take Action Donate Now Search DISCOVER Endangered Species Where We Work Global Forces Conservation Science ... Jobs EXPLORE WildFinder Camera Traps Marketing Partners Shop WWF Gear ... Photo Galleries DONATE Donate to WWF Gift Center Adoption Center Monthly Supporter ... Toxic Chemicals Toxics > Conservation Results Catalyzing Action on Endocrine Disrupting Chemicals Thanks to the pioneering work of WWF Senior Fellow Dr. Theo Colborn, the science of endocrine disrupting chemicals has gained worldwide attention. Colborn and her book, Our Stolen Future , have triggered public concern regarding endocrine disrupting chemicals, and prompted enactment of new laws and redirection of research by governments, the private sector, and academics. Bald eagles are one of many animals that have been threatened by toxics in the past - and continue to face problems from them today. photo: WWF-Canon / Chris Martin Bahr Our Stolen Future , published in 1996, chronicles the voluminous scientific evidence that common synthetic chemicals can block, mimic or otherwise interfere with naturally produced hormones and cause developmental and reproductive abnormalities. Wildlife and humans are exposed daily to these pervasive chemicals, most of which were developed during the past 50 years. Wildlife researchers over the last several years have unearthed a variety of endocrine disruptor-related effects: interrupted sexual development; thyroid system disorders; inability to breed; reduced immune response; and abnormal mating and parenting behavior. Species such as terns, gulls, harbor seals, bald eagles, beluga whales, lake trout, panthers, alligators, turtles, and others, have suffered more than one of these effects. WWF has been at the forefront of endocrine disruption debate, pushing for increased scientific research and improved protections from these hazardous chemicals.

74. Americanchemistry.com : Endocrine Disruption ACC is engaged with the scientific community and government agencies in a broad effort to understand the potential of chemicals to interact with the http://www.americanchemistry.com/s_acc/sec_policyissues.asp?CID=318&DID=1144

75. Theo Colborn But then look at the scientists who are trying to demonstrate that endocrine disruption is real. Where do they get their money? Follow the money. http://www.motherjones.com/news/qa/1998/03/snell.html

HOME RECENT POLITICS BLOGS ... RSS MOTHER JONES BY E-MAIL Theo Colborn News: A controversial scientist speaks on plastics, IQ, and the womb By Marilyn Berlin Snell March/April 1998 Issue TOOLS E-mail article Print article document.write("Digg") document.write("del.icio.us") document.write("Reddit") document.write("Yahoo MyWeb") BACKTALK E-mail the editor document.write("StumbleUpon") document.write("Newsvine") document.write("Google") Michelle vs. Bill: In the Democratic Race, the Spouses Go at It Happy 2008! Your Prius' Fuel Efficiency Just Dropped 16% "The Man's" Morse Code and the Continuing Blight of White Racism Giuliani Foreign Policy Advisor Says 'Bomb 'Em' ... New 'Manifesto' Suggests Preemptive Nuclear Strikes For her groundbreaking work on the effect everyday chemicals have on children, Theodora "Theo" Colborn has been called "the Rachel Carson of the '90s." Just as Carson was pilloried for her 1962 book Silent Spring, which warned of the dangers of the pesticide DDT, Colborn has been in the hot seat for her 1996 book Our Stolen Future (co-authored with Dianne Dumanoski and John Peterson Myers). Colborn's controversial message is that even low-dose exposures to many of the man-made chemicals found in common plastics, cleaning compounds, and cosmetics can affect newborn babies and developing fetuses, and can cause a range of problems, including low IQs, genital malformations, low sperm counts, and infertility.

76. E.hormone | Hormones And The Environment E.Hormone is sponsored and designed by the Center for Bioenvironmental Research at Tulane and Xavier Universities as a gateway to the environment and http://e.hormone.tulane.edu/

e.hormone annual symposium on the environment and hormones Society for Integrated and Comparative Biology Annual Meeting (SICB) American Association for the Advancement of Science (AAAS) Annual Meeting ... Center for Bioenvironmental Research at Tulane and Xavier Universities

77. News Brief: Index Of Endocrine Disruptor Resources RiskWorld has compiled the index below of major endocrine disruptor resources available on line from a variety of sources including government agencies, http://www.riskworld.com/news/99q1/nw9aa081.htm

Index Of On-line Endocrine Disruptor Resources Compiled by RiskWorld senior editor Amy Charlene Reed (e-mail reed@tec-com.com RiskWorld has compiled the index below of major endocrine disruptor resources available on line from a variety of sources including government agencies, universities, international groups, and environmental organizations. Editor's Note: RiskWorld is not responsible for the content of external Internet sites U.S. EPA Universities U.S. Department of the Interior Other Organizations ... International U .S. Environmental Protection Agency Endocrine Disruptor Resources Endocrine Disruptor Research Initiative: U.S. Federal Research Project Inventory http://www.epa.gov/endocrine/Project.html http://www.epa.gov/opptintr/opptendo/index.htm http://www.epa.gov/opptintr/opptendo/finalrpt.htm U.S. EPA’s Science Policy Council, May 1997: "Interim Position on Environmental Endocrine Disruption" http://www.epa.gov/ordntrnt/ORD/spc/endcrdis.htm U.S. EPA's Risk Assessment Forum, February 1997: Abstract of "Special Report on Environmental Endocrine Disruption: An Effects Assessment and Analysis" http://www.epa.gov/ORD/WebPubs/endocrine/

78. Ask TreeHugger: What Is An Endocrine Disruptor? : TreeHugger My particular concern is of endocrine disruptor s and their effects on developing kids. I know for conventional produce there is a dirty dozen list to avoid http://www.treehugger.com/files/2007/11/ask_treehugger_26.php

Ask TreeHugger: What is an Endocrine Disruptor? "Cutting-edge Environmental Website." -The Independent. Advertise About Tips TV ... ask treehugger featured: Edmund Hillary, Hero featured: Plants Save Us featured: UK Deploys Robot Armada Indoor Air Pollution Organic Food Compact Fluorescent Lightbulbs ... Bicycle DD said: "It's Tucson not Tuscon...." [ read Doug said: "It's good to see churches being turned into something useful...." [ read Michael Barger said: "I've gotta say that I love my country and I hope we can become better than we have been lately, but the truly sad thing about this event is that th..." [ read Timmy G. said: "Well, let's name the names of the evil doers: PepsiCo - Aquafina and "Poland" bottled water Nestle - "Pure Life" bottled water ..." [ read Timmy G. said: "That woman should have her license revoked and be hanged in public. Tucson is another armpit of suburbia. Screw car drivers, all of them! B..." [ read Green Stats Happy Trails TreeHugger Picks ... UnTreeHugger Latest TH Radio The TH Interview: David Orr (Part Three) Where Hope and O... The TH Interview: David Orr (Part Two) The Carbon Connect... The TH Interview: The Preacher's Son, David Orr (Part One... Latest THTV Convenient Truths - Servin' Save CO2...

79. Ija_832 1..6 Your browser may not have a PDF reader available. Google recommends visiting our text version of this document. http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1365-2605.2007.00832.x

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