21. Health Effects From Endocrine Disruptors EMCOM is a website about endocrine disruptors and environmental estrogens and their effects on human health. http://www.emcom.ca/

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22. Environment And Health: 6. Endocrine Disruption And Potential Human Health Impli The public health implications of these socalled endocrine disruptors have been the subject of scientific debate, media interest and policy attention over http://www.cmaj.ca/cgi/content/full/163/11/1471

ADVANCED SEARCH This Article Full Text (PDF) Submit a response Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Solomon, G. M. Articles by Schettler, T. Search for Related Content PubMed PubMed Citation Articles by Solomon, G. M. Articles by Schettler, T. Related Collections Other endocrinology Environment and Health Series Maternal-fetal medicine Canadian Medical Association or its licensors Review Environment and health: 6. Endocrine disruption and potential human health implications Gina M. Solomon and Ted Schettler Dr. Solomon is with the Natural Resources Defense Council and the Department of Medicine, University of California at San Francisco, San Francisco, Calif. Dr. Schettler is with the Science and Environmental Health Network and the Department of Medicine, Boston Medical Center, Boston, Mass. Series editor: Dr. Michael McCally

23. Endocrine Disruptors endocrine disruptors to be Monitored by the EU. EU Directive 2000/60/EC, Annex X Regulation (EEC) No. New US EPA Endocrine Disruptor Screening Program http://www.accustandard.com/asi/np_endocrine_disruptors.php3

if(document.all) document.write(''); else document.write(''); Endocrine Disruptors to be Monitored by the EU EU Directive 2000/60/EC New US EPA Endocrine Disruptor Screening Program Draft List of 73 Chemicals , for Initial Tier 1 Screening. June 2007 Chemical Name Cat. No. Chemical Name Cat. No. Carbendazim P-278S 4-Chloro-3-methylphenol APP-9-041 Aldrin P-002S Hexachlorobenzene APP-9-112 Trans-Nonachlor P-184S 4-tert-Butylphenol ALR-030S-ET-10X Chlordane P-017S bis(2-Ethylhexyl)adipate P-233S Chlordene P-136S Benzyl butyl phthalate APP-9-034 Dieldrin P-037S Di-2-ethylhexyl phthalate APP-9-029 Endosulfan, mixed isomers P-435S Dicyclohexyl phthalate ALR-099S alpha-Endosulfan P-091S Diethyl phthalate APP-9-081 beta-Endosulfan P-092S Diisodecyl phthalate ALR-101S Endrin P-045S Dibutyl phthalate APP-9-063 Kepone P-152S Biphenyl H-133S Mirex P-066S o-Phenylphenol P-460S Oxychlordane Isomer P-331S 2,2',3,3',4,4'-Hexachlorobiphenyl C-128S Toxaphene P-093S 2,2',3,3',6,6'-Hexachlorobiphenyl C-136S 2,4-D butyl ester P-712S 2,2',4,4',5,5'-Hexachlorobiphenyl C-153S 2,4-D butoxyethyl ester

24. Endocrine Disruptors endocrine disruptors are chemicals that interfere with the normal function of hormones and the way hormones control growth, metabolism and body functions. http://www.ens-lyon.fr/LBMC/laudet/nurebase/endocrine_disruptor/endocrine_disrup

LIST OF WEB SITES DEVOTED TO ENDOCRINE DISRUPTORS What are Endocrine Disruptors? Nuclear receptors regulate critical cellular processes such as cell growth and differentiation, metabolic processes, reproduction, development. Nuclear hormone receptors function as ligand activated transcription factors, thus providing a direct link between signalling molecules that control these processes and transcriptional responses. Endocrine disrupting agents, acting through nuclear receptors, are thus involved in many different pathological situations such as tumor development, metabolic desease and obesity, coronary heart problem. Endocrine disruptors are chemicals that interfere with the normal function of hormones and the way hormones control growth, metabolism and body functions. There are different ways that chemicals can interfere with or disrupt hormones, and there are different kinds of chemicals that disrupt. There are more than 70,000 chemicals in commerce, few of which have been tested for carcinogenicity, much less their capacity to disrupt endocrine systems. Websites Other websites on Endocrine Disruptors Report about endocrine disruptors Hormone disrupting compounds Websites: CASCADE Network of Excellence The CASCADE Network of Excellence, launched in February 2004 within EU's sixth framework programme, aims to provide Europeans with a durable, comprehensive and independent network of excellence in research, risk assessment, and education on health risks that are associated with exposure to chemical residues in food. Focus lies on chemicals that act via and/or interfere with cellular regulation by hormone receptors.

25. Impact Of Endocrine Disruptor Chemicals In Gynaecology -- Caserta Et Al. 14 (1): endocrine disruptors (EDCs) are chemicals that have the capacity to interfere with normal signalling systems. EDCs may mimic, block or modulate the http://humupd.oxfordjournals.org/cgi/content/abstract/14/1/59

@import "/resource/css/hw.css"; @import "/resource/css/humupd.css"; Skip Navigation Oxford Journals Contact Us My Basket ... Volume 14, Number 1 Pp. 59-72 Human Reproduction Update Advance Access originally published online on December 10, 2007 Human Reproduction Update 2008 14(1):59-72; doi:10.1093/humupd/dmm025 This Article Full Text FREE Full Text (PDF) O A All Versions of this Article: most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager Google Scholar Articles by Caserta, D. Articles by Moscarini, M. PubMed PubMed Citation Articles by Caserta, D. Articles by Moscarini, M. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org Impact of endocrine disruptor chemicals in gynaecology

26. ExpectMore.gov: Endocrine Disruptors The program provides the scientific information necessary to reduce or prevent unreasonable risks from exposures to endocrine disrupting chemicals. http://www.whitehouse.gov/omb/expectmore/summary/10002280.2004.html

Skip to main content Home About Us Contact ... What's New Show Me Programs Show me the programs that are performing Show me the programs that are not performing Show me the programs by name or keyword Show me the programs by topic Select a Topic Agriculture Business and Commerce Community and Regional Development Disaster Relief Education Energy Foreign Affairs Government Administration Health and Well-Being Housing Law Enforcement National Security Natural Resources and the Environment Science and Space Training and Employment Transportation Veterans Benefits Show me the programs by agency Program Assessment Program View Assessment Details Endocrine Disruptors The program provides the scientific information necessary to reduce or prevent unreasonable risks from exposures to endocrine disrupting chemicals. The research program provides the information and tools which enable the endocrine disruptor screening program to fulfill its purpose. Rating What This Rating Means PERFORMING Adequate This rating describes a program that needs to set more ambitious goals, achieve better results, improve accountability or strengthen its management practices. The endocrine disruptor program is free of major design flaws, has a clear purpose, and is reasonably well-managed.

27. Science And The Environment Bulletin: Endocrine Disruptors And Hog Manure endocrine disruptors and Hog Manure. endocrine disruptors and Hog Manure. Hog farming is a significant agricultural activity in Canada, with the size of http://www.ec.gc.ca/science/sandenov/article3_e.html

Endocrine Disruptors and Hog Manure Hog farming is a significant agricultural activity in Canada, with the size of operations expected to increase substantially in the near future. This will not only mean more pork, but also more hog-generated organic waste, which is traditionally disposed of as manure for field crops. Source: Statistics Canada, Historical Overview of Canadian Agriculture, 1997 The concern, according to Environment Canada scientists, is that pig manure can contain high concentrations of endocrine-disrupting chemicals, including natural estrogens. These chemicals have been proven through various studies to have long-term adverse effects on the growth, development and reproduction of fish and wildlife. Runoff from fields treated with pig manure can enter adjacent streams or other bodies of water, resulting in eutrophication or even acute toxicity. Scientists from Environment Canada's National Water Research Institute (NWRI) and Agriculture and Agri-Food Canada in Ontario joined forces earlier this year to determine the persistence of endocrine-disrupting chemicals in soil after manure application and to establish the identity, exposure and effects of chemicals entering adjacent aquatic environments. Studies completed this spring confirmed the presence of high concentrations of these chemicals in hog manure, and showed that they begin to enter nearby waterways soon after manure has been applied to fields. Studies are currently under way to isolate and identify several unknown compounds that were detected to determine if they also pose a threat to aquatic environments.

28. Endocrine Disruptors endocrine disruptors are chemicals that stop the production or block the transmission of hormones in the body, often interfering with bodily processes and http://www.mcsuk.org/mcsaction/pollution/endocrine disruptors

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29. Poynter Online - Al's Morning Meeting From baby bottles to shampoo to the carpet in your house, you are surrounded by products every day that contain chemicals known as endocrine disruptors. http://www.poynter.org/column.asp?id=2&aid=133400

30. Chemicals What are endocrine disruptors ? Paul Goettlich 27mar01 endocrine disruptors are manmade synthetic chemicals and natural phytoestrogens (naturally http://www.thimmakka.org/Articles/Chemicals/chemicals.html

Enocrine Disruptors Paul Goettlich What are Endocrine Disruptors ? Paul Goettlich 27mar01 http://www.mindfully.org/Pesticide/What-Are-EDs-PWG.htm Index What are Endocrine Disruptors? What is the Endocrine System? What are Hormones? What could be the possible Human Effects? ... Contact Info What are Endocrine Disruptors? Endocrine disruptors are man-made synthetic chemicals and natural phytoestrogens (naturally occurring plant-derived estrogen, a hormone) that interfere with the endocrine systems of humans and animals by mimicking, blocking and/or interfering in some manner with the natural instructions of hormones to cells. The resulting disruption creates many problems with physical development, sex, reproduction, brain development, behavior, temperature regulation and more. Other names for endocrine disruptors (EDs) are hormone mimics and hormone copycats. The bodies of animals and humans depend upon a complexly integrated and timed series of events, of which the delivery of hormones to various organs is vital. When the delivery timing and/or amount of a hormone is upset the results can be devastating and permanent. The most insidious of the EDs are man-made synthetic chemicals. We are routinely exposed to them in most areas of our daily lives at home, work and play. Known and suspected EDs come in things we have been led to believe have been thoroughly tested for the safety of our health and environment. These types of products include cosmetics, sunscreens, perfumes, soaps, detergents, solvents, dental sealants, pharmaceuticals such as birth control pills, clear plastic baby bottles, and some water bottles. The list of goes on to include many chemicals in plastics (PVC, polystyrene aka Styrofoam, and others) and pesticides (Monsanto's

31. Endocrine Disruptors Endocrine Disruptor Worries Here to Stay, by Dr. Allan Felsot, Washington Statue University. This article appeared in the September 1997 Agrichemical and http://www.ecologic-ipm.com/endocrin.html

EPA Actions and Position s Endocrine Disruptors and the FQPA EPA's Endocrine Disruptor Screening and Testing Advisory Committee Home Page (EDSTAC) Press Advisory (1/24/97) on Endocrine Disruptors Screening and Testing Advisory Committee (EDSTAC) Meeting. Other Views Dioxin Study is a Political Hot Potato for EPA Dioxin has gone from being a 'possible' to a 'known' human carcinogen , San Francisco Chronicle, March 12, 2001 Genes may solve hormone-disrupter debate , Robert Triendl, Toyko, Nature, Volume 409, January 18, 2001 Pesticides as Endocrine Disruptors Acceptance Speech , by Dr. Theo Colborn, World Wildlife Fund scientist, upon receipt of the Rachel Carson Leadership Award from Chatham College. WWF-Canada Hormone Disruptor Site The Weybridge Report , by Peter Montague, RACHEL'S ENVIRONMENT AND HEALTH WEEKLY #547, May 22, 1997. Evolutionary differences between natural and synthetic estrogens , November 16, 1997 SANET Post by Dr. Ann Clark. "Endocrine Disruptor Worries Here to Stay," by Dr. Allan Felsot, Washington Statue University. This article appeared in the September 1997 Agrichemical and Environmental News and includes the passage: "I've wondered a lot lately whether industry realizes what a potential mess it has gotten itself, and by association our farmers, into by its passive support of the FQPA last year."

32. Endocrine Disruptors Research | Science Topics | NCER | ORD | US EPA ORD strives to improve our knowledge and understanding of endocrine disruptors in the environment so that we can improve our methods of assessment and risk http://es.epa.gov/ncer/science/endocrine/

@import 'http://www.epa.gov/epafiles/s/epa.css'; Jump to main content. National Center For Environmental Research Contact Us Search: All EPA This Area You are here: EPA Home National Center for Environmental Research Science Topics Endocrine Disruptors Research Endocrine Disruptors Research Searches National Center For Environmental Research (NCER) Research Projects: Advanced Search Frequently Asked Questions (FAQs) Why does ORD have an Endocrine Disruptors Research Program? What are Endocrine Disruptors? Why does ORD have an Endocrine Disruptors Research Program? Evidence suggests that environmental exposure to EDCs may cause adverse health effects in human and wildlife populations. Considerable uncertainty exists regarding the relationship(s) between adverse health outcomes and exposure to environmental contaminants. In 1996, through the enactment of the Food Quality Protection Act (FQPA), the U.S. Congress directed EPA to screen pesticides for estrogenic activity in humans using validated studies or other scientifically relevant information and gave the Agency discretionary authority to screen for other endocrine effects as well. The Safe Drinking Water Act Amendments (SWDA) of 1996, authorized EPA to screen drinking water contaminants for similar activities.

33. Endocrine Disruptors State Activity Page endocrine disruptors or EDCs (endocrine disrupting chemicals) are external agents that interfere in some way with the role of natural hormones in the body. http://www.serconline.org/endoDisrupt.html

Home State Info Innovative Legislation ISSUE: ENDOCRINE DISRUPTORS Center for Bioenvironmental Research at Tulane and Xavier Universities: e.hormone Medical Research Council: Institute for Environment and Health: REDIPED (Relational Database of Information on Potential Endocrine Disrupters) Atrazine One known endocrine disruptor, atrazine, has been the subject of numerous studies documenting its effects on wildlife and humans. According to a press release issued on August 20, 2003 by the Natural Resources Defense Council (NRDC): Even though atrazine has been banned in several European countries, the EPA has been reluctant to determine the full danger it presents. In another press release study file suit against the EPA in August 2003 for failing to consider the implications of atrazine on endangered wildlife. Background Decline in sperm quality Male reproductive abnormalities Early puberty Decline in neurological functions Cancers, including breast, endometrial, testicular, prostate, and thyroid

34. Endocrine Disruptors An endocrine disruptor is any substance that can interfere with normal hormone function. Most are synthetic, fat soluble compounds that are either http://www.ccaej.org/projects/endocrine.htm

Endocrine Disruptors Our Stolen Future: Are We Threatening Our Fertility, Intelligence ad Survival? by Theo Colborn, Diane Dumanoski and John Peterson Myers. The Endocrine System The endocrine system acts as the chemical messenger system for communication throughout our body. The main purpose of the endocrine system is to control and regulate body functions especially growth and development. This is accomplished through hormones, potent, biologically-active chemical messengers that in very small amounts can produce significant biological effects. Hormones are released from the brain, thyroid, ovaries, testes and other endocrine glands and then carries them through the bloodstream to the target cells and organs where they activate and regulate various functions. The system is made up of the pituitary gland which acts as a control center telling the ovaries or the thyroid when to send their signals and how much hormone to send. The pituitary gets its cues from another gland, the hypothalamus, which acts as a thermostat telling the pituitary to increase production, slow down or shut off. These messages travel back and forth continuously to keep all parts of the organism operating as one coordinated being. Hormones also guide the growth of a baby’s nervous system and immune system and "programs" organs and tissues such as the liver, blood, kidneys and muscles so they will function properly. During early development this regulation of growth and development is critical for a child. The thyroid hormone, for example, is essential for normal neurological function and development. Deficiencies of thyroid hormones during fetal development or during early infancy can lead to mental retardation, hearing loss and speech problems. Children with thyroid deficiencies, even those with normal IQ’s, can have language comprehension problems, impaired learning and memory and hyperactive behavior.

35. GreenBiz | Essentials | Endocrine Disruptors Voluntary businessbased efforts to address endocrine disruptors include the development of alternative practices, such as integrated pest management, http://www.greenbiz.com/toolbox/essentials_third.cfm?LinkAdvID=4160

36. PEHSU endocrine disruptors (EDs) are environmental chemicals that affect the function The theory of endocrine disruptors gained credibility from a number of http://www.sph.emory.edu/PEHSU/html/exposures/endocrine.htm

Endocrine Disruptors What are endocrine disruptors? How can my family be exposed to EDs? What are the health effects of endocrine disruptors? Are there medical tests to see if my family has been exposed to endocrine disruptors? ... Back to PEHSU What are endocrine disruptors? Endocrine disruptors (EDs) are environmental chemicals that affect the function of the endocrine system, the system involving the glands and hormones of the body. The endocrine system coordinates the functions of various organs and systems in the body. EDs may disrupt the endocrine system in several ways: they may act as "imposters" of naturally occurring hormones they may block the action of hormones they may alter the chemical message sent by hormones they may disrupt the production of hormones or hormone receptors (proteins used to receive information from hormones) Most EDs act like naturally occurring estrogens in the body. However, some EDs block androgens (male sex hormones such as testosterone). The theory of endocrine disruptors gained credibility from a number of studies demonstrating reproductive problems in wildlife exposed to certain environmental chemicals. For example, alligators exposed to an organochlorine pesticide, diclofol experienced various reproductive abnormalities. [3] Also, certain birds exposed to the organochlorine pesticide DDT failed to reproduce. [4] EDs are a diverse class of chemicals. They include:

37. Endocrine Disruptors In Potomac River Fish | Sprol In 2006, researchers found that many large and smallmouth bass caught in the Potomac River and its tributaries in the Washington DC ( ) http://www.sprol.com/?p=363

38. BASIN: Endocrine Disruption In Boulder Creek Endocrine disruption WWW sites. Overview of the issue Tulane Center for Bioenvironmental research NRDC endocrine disruptors WWW site http://bcn.boulder.co.us/basin/topical/haa.html

Current Theme: Selected Topics Hormonally Active Agents in Boulder Creek Research overview - Jim Waterman - BASIN Reseach into wastewater treatment effluent impact on Boulder Creek fish sexual development In the Fall of 2004 several media reports on observations of abnormal fish gender distributions and development in Boulder Creek received considerable attention. Motivated by reports in the scientific literature regarding the impacts of elevated concentrations of hormonally active agents (HAA) on sexual development in various aquatic organisms a team of University of Colorado biologists lead by Dr's Woodling and Norris of CU's Integrative Physiology Department studied the gender distribution of the white sucker fish species above and below municipal waste water treatment plants on Boulder Creek, the South Platte River and Fountain Creek. Researchers also examined reproductive tissue in the fish samples and found evidence of abnormal development. This CU research has identified a local impact from wastewater treatment plant effluent that reflects a relatively new concern in the scientific community; the extent to which natural and anthropogenic compounds in sewage effluent impact the complex biological systems of chemical signaling agents (aka hormones) know as the endocrine system. BASIN has meet with the CU research team and assembled a summary of their results along with other research on these agents and their impacts on natural environments and its potential for human effects. While CU and USGS researchers have provided input for this review the information presented here is solely the responsibility of BASIN. Please

39. Endocrine Disruptor Vinclozolin Induced Epigenetic Transgenerational Adult-Onset Perspectives The Possible Influence of Assisted Reproductive Technologies on Transgenerational Reproductive Effects of Environmental endocrine disruptors http://endo.endojournals.org/cgi/content/abstract/147/12/5515

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Endocrinology, doi:10.1210/en.2006-0640 This Article Full Text Full Text (PDF) All Versions of this Article: most recent Author Manuscript (PDF) Purchase Article View Shopping Cart Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Anway, M. D. Articles by Skinner, M. K. Search for Related Content PubMed PubMed Citation Articles by Anway, M. D. Articles by Skinner, M. K. Endocrinology Vol. 147, No. 12 5515-5523 Endocrine Disruptor Vinclozolin Induced Epigenetic Transgenerational Adult-Onset Disease Matthew D. Anway Charles Leathers and Michael K. Skinner Center for Reproductive Biology, School of Molecular Biosciences (M.D.A., M.K.S.), Veterinary Microbiology and Pathology (C.L.), Washington State University, Pullman, Washington 99164-4231 Address all correspondence and requests for reprints to: Michael K. Skinner, Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231. E-mail:

40. Earthbeat - 15/12/2001: Endocrine Disruptors A look at the endorine disrupting chemicals that build up in our bodies and affect the development of children in subtle but disturning ways Dr Theo Colborn http://www.abc.net.au/rn/science/earth/stories/s446109.htm

Love that Planet All in the Mind The Buzz Health Report ... Environ News Endocrine Disruptors Broadcast on Saturday 15/12/2001 Summary: A look at the endorine disrupting chemicals that build up in our bodies and affect the development of children in subtle but disturning ways. Dr Theo Colborn first described the theory of endocrine disruption in a book she co-authored with John Peterson Meyers and Dianne Dumanoski "our Stolen Future". Transcript: Alexandra de Blas: Endocrine disruptors are chemicals that affect the body’s natural hormones. The mechanism behind endocrine disruption was first discovered in 1987, in a study of predators affected by pollution in the Great Lakes of North America. While the adults were healthy, disturbing things were happening to the young. Dr Theo Colborn did the literature search that led to the discovery. She is now Director of the Wildlife and Contaminants Program at the World Wildlife Fund in Washington, D.C. And she says even an infinitesimal amount of chemical can affect a developing foetus. Theo Colborn: Alexandra de Blas: So what are the chemicals that are actually causing this endocrine disruption?

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