61. Roles Of Tumour Localization, Second Signals And Cross Priming In Cytotoxic T-ce Correspondence to rolf M. zinkernagel1 Correspondence and requests for materialshould be addressed to RMZ (email Email rolf.zinkernagel@pty.usz.ch) or http://www.nature.com/doifinder/10.1038/35082583

nature.com homepage Jump to main content Jump to navigation ... Browse by subject Search This journal All of Nature.com Advanced search Journal home Archive Letters to Nature Abstract Letters to Nature Nature doi Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction Adrian F. Ochsenbein , Sophie Sierro , Bernhard Odermatt , Marcus Pericin , Urs Karrer , Jan Hermans , Silvio Hemmi , Hans Hengartner and Rolf M. Zinkernagel Top of page The vertebrate immune system has evolved to protect against infections that threaten survival before reproduction. Clinically manifest tumours mostly arise after the reproductive years and somatic mutations allow even otherwise antigenic tumours to evade the attention of the immune system . Moreover, the lack of immunological co-stimulatory molecules on solid tumours could result in T-cell tolerance ; that is, the failure of T cells to respond. However, this may not generally apply Top of page Institute of Experimental Immunology, University Hospital, CH-8091 Zurich, Switzerland Malaghan Institute of Medical Research, Wellington South, New Zealand

62. Virus Persistence In Acutely Infected Immunocompetent Mice By Exhaustion Of Anti Demetrius Moskophidis, Franziska Lechner, Hanspeter Pircher rolf M. zinkernagel Odermatt, B., Eppler, M., Leist, TP, Hengartner, H. zinkernagel, http://www.nature.com/doifinder/10.1038/362758a0

nature.com about npg news@nature.com naturejobs ... register SEARCH JOURNAL Journal Home Current Issue AOP Archive THIS ARTICLE Download PDF References Export citation Export references ... Table of Contents Nature , 758 - 761 (22 April 1993); doi:10.1038/362758a0 Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells Demetrius Moskophidis , Franziska Lechner , Hanspeter Pircher VIRUSES that are non- or poorly cytopathic have developed various strategies to avoid elimination by the immune system and to persist in the host . Acute infection of adult mice with the noncytopathic lymphocytic choriomeningitis virus (LCMV) normally induces a protective cytotoxic T-cell response that also causes immunopathology . But some LCMV strains (such as DOCILE (LCMV-D) or Cl-13 Armstrong (Cl-13) ) derived from virus carrier mice tend to persist after acute infection of adult mice without causing lethal immunopathological disease . Tendency to persist correlates with tropism , rapidity of virus spread and virus mutations . We report here that these LCMV isolates may persist because they induce most of the specific antiviral CD8 cytotoxic T cells so completely that they all disappear within a few days and therefore neither eliminate the virus nor cause lethal immunopathology. The results illustrate that partially and sequen-tially induced (protective) immunity or complete exhaustion of T-cell immunity (high zone tolerance) are quantitatively different points on the scale of immunity; some viruses exploit the latter possibility to persist in an immunocompetent host.

63. 20th Century Year By Year 1995 1940; and zinkernagel, rolf M., Switzerland, University of Zurich, UniversityHospital, Zurich, Switzerland, b. 1944 for their discoveries concering the http://www.historycentral.com/20th/1996.html

Major Event/ Sports Nobel Prizes Pulitz er Prizes ... Popular Book s / Popular Television Shows Popular Music/ Grammy Awards/ Tony Awards Major Events of 1996 Elections in Bosnia Taliban capture Afghanistan Nigerian unrest Suicide bombers hit Israel ... TWA Flight 800 explodes Sports NBA: Chicago Bulls vs. Seattle Supersonics Series: 4-2 NCAA Football: Florida Record: 12-1-0 Heisman Trophy: Danny Wuerffel, florida, QB points: 1,3 Stanley Cup: Colorado Avalanche vs. Florida Panthers Series: 4-0 Super Bowl XXX: Dallas Cowboys vs. Pittsburgh Steelers Score: 27-17 US Open Golf: Steve Jones Score: 278 Course: Oakland Hills CC Location: Bloomfield Hills, MI World Series: New York Yankees vs. Atlanta Braves Series: 4-2 Best Record: "Change the World" ... Eric Clapton Best Song: "Change the World" ... Gordon Kennedy Best Album: "Falling Into You" ... Celine Dion Male Vocalist: Eric Clapton ... "Change the World" Female Vocalist: Toni Braxton ... "Un-break My Heart" 1."Because You Loved Me" ... Celine Dion

64. Directions Of Vaccine Research Interview with Nobel Laureate rolf zinkernagel. Dr. rolf M. zinkernagel, alongwith Dr. Peter C. Doherty, was awarded the Nobel Prize for Medicine in 1996 http://www.frontlineonnet.com/fl1810/18100840.htm

Volume 18 - Issue 10, May 12 - 25, 2001 India's National Magazine from the publishers of THE HINDU Table of Contents MEDICINE Directions of vaccine research Interview with Nobel Laureate Rolf Zinkernagel. Dr. Rolf M. Zinkernagel , along with Dr. Peter C. Doherty, was awarded the Nobel Prize for Medicine in 1996 for his discovery relating to the "specificity of the cell-mediated immune defence". They discovered, on the basis of their work done at the John Curtin School of Medical Research (Australian National University, Canberra), how the immune system recognises virus-infected cells. This laid the foundation for an understanding of the mechanisms used by the cell immune system to recognise foreign micro-organisms as also its own molecules. K. GAJENDRAN The discovery revolutionised clinical medicine as it helped strengthen the immune response against invading organisms and cancers, apart from diminishing the effects of auto-immune reactions in inflammatory conditions such as rheumatic situations, multiple sclerosis and diabetes. This opened up a whole new area of research in vaccine development. A specialist in immunology, Zinkernagel (57) is Professor at the Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland. Since 1981, his work has won him at least one award every year from reputed international institutions.

65. EMBO - Promoting Molecular Biology In Europe. Alain Peyraube (FR) Jens R. RostrupNielsen (DK) Salvatore Settis (IT) rolf M.zinkernagel* (CH) *EMBO member **EMBO young investigator http://www.embo.org/organisation/ERC_selection.htm

66. Korea University rolf M. zinkernagel Friday, 200 PM, July 15, 2550 Inchon Memorial Hall, TheKorea University, Seoul Nobel Laureate in Medicine, 1996. http://www.korea.ac.kr/english04/2005/aboutus/bbs_notice-view.jsp?idx=2713&page=

67. Dr. Peter Doherty, St. Jude Hospital Immunologist, Wins Nobel Prize Peter C. Doherty, Ph.D., and rolf M. zinkernagel, MD, immunologists whoseexperiments revolutionized the field by explaining the mechanism of Tcell http://www.stjude.org/media/0,2561,453_2143_4605,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_News); In order for our site to display correctly you will need a newer version of your web browser. The following browsers support numerous web standards including CSS, XHTML, and the DOM (a universal means of controlling the behavior of web pages): v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project. Opera v7 or higher (Windows, Linux) Apple's Safari (Mac OS X) Konqueror (Linux KDE Desktop) Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh) St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help 1996 Archived News Home News Home Media News Releases ... 1996 Archived News Dr. Peter Doherty, St. Jude Hospital Immunologist, wins Nobel Prize (Memphis, Tennessee, October 7, 1996)

68. Enciclopedia :: 100cia.com Translate this page rolf M zinkernagel. (En este momento no hay texto en esta p¡gina. Para iniciarel art­culo, click editar esta p¡gina (http//es.wikipedia. http://100cia.com/enciclopedia/Rolf_M_Zinkernagel

Portada Artículos favoritos Vea sus documentos y artículos favoritos pulsando aquí No hay artículos favoritos todavía. documentos sin leer: Siguiente doc sin leer Borrar los docs leídos Borrar todos los docs ¡Webmaster! ¿Quieres tener los contenidos de 100cia.com en tu página? Pulsa aquí Buscar: en Google en noticias en Enciclopedia Estás en: 100cia.com > Enciclopedia Rolf M Zinkernagel (En este momento no hay texto en esta p¡gina. Para iniciar el art­culo, click editar esta p¡gina http://es.wikipedia.orgRolf_M_Zinkernagel Información de Wikipedia (Licencia de uso GFDL) e Internet ¿Sabías que Aristóteles dijo...? Las ciencias tienen las raíces amargas, pero muy dulces los frutos. Traducciones Acerca de Sync.es Webs amigas: AstroRED CanalGame DVDenlared

69. Kurt A Bienz Johannes Eckert U A Von Fritz H Kayser Rolf M Zinkernagel Medizinis Translate this page Kurt A Bienz Johannes Eckert ua Von Fritz H Kayser rolf M zinkernagel MedizinischeMikrobiologie. http://www.wm-verlag.de/Medizinische-Mikrobiologie-000000385027.html

Kurt A Bienz Johannes Eckert u a Von Fritz H Kayser Rolf M Zinkernagel Medizinische Mikrobiologie Medizinische Mikrobiologie Von Fritz H Kayser Kurt A Bienz Johannes Eckert u a Rolf M Zinkernagel Kurt A. Bienz Johannes Eckert u. a. Von Fritz H. Kayser Rolf M. Zinkernagel Verstehen, Lernen, Nachschlagen Mikrobiologie; Hand-/Lehrbücher / [Mathematik / Naturwissenschaften / Technik / Medizin] [Medizin / Pharmazie] Allgemeinmedizin / Diagnostik / Therapie / Grundlagen Zehnsprachig/Medizinischer Spr Medizinisches Wörterbuch, Deutsch-Französisch, Medizinisches Wörterbuch, Deutsch-Englisch, Englisch-Deutsch Medizintechnik in der Intensivstation ... Plasma Astrophysics

70. Transplant Pioneer Dr. Thomas Starzl To Be Honored By Colleagues At Two-day Acad Then 1996 Nobel Laureate rolf M. zinkernagel, MD, Ph.D., in recent years a closecollaborator with Dr. Starzl, will receive the inaugural Starzl Prize in http://www.scienceblog.com/community/older/2001/E/200115494.html

April 2001 From University of Pittsburgh Medical Center Transplant pioneer Dr. Thomas Starzl to be honored by colleagues at two-day academic event PITTSBURGH, April 18 Thomas E. Starzl, M.D., Ph.D., played a paramount role in bringing organ transplantation from concept to reality. And his numerous contributions over the span of more than 40 years have continued to advance the field. One measure of his place in medical history is the vast number of surgeons and scientists who trained under his tutelage and still more whose daily practice continues to be influenced by his work and vision. Many of these former students and colleagues a who's who in the transplant world from six continents will pay tribute to Dr. Starzl at a Festschrift in his honor April 27-28 at the University of Pittsburgh. More than 300 are expected to attend the Festschrift, which in academic circles can be both a celebration and subsequent publication of selected scholarly writings in honor of an esteemed scholar late in his or her career. This event also serves as a belated celebration of Dr. Starzl’s 75th birthday, which was March 11. The first day consists of a program of some 27 oral and 50 poster scientific presentations of novel work or very recent findings, many in areas of study of keen interest to Dr. Starzl. The following morning Dr. Starzl's portrait will be unveiled in the School of Medicine's main lecture room, where it will hang among the 28 portraits of the school's former deans and most distinguished faculty, including polio vaccine discoverer Jonas Salk, M.D.

71. FUTURO-SIDA Translate this page El Dr. rolf M. zinkernagel destacó en la Universidad de Navarra la dificultad deconseguir una respuesta inmunitaria para prevenir la infección por este http://www.universia.es/html_estatico/portada/actualidad/noticia_actualidad/para

Jueves, 15 de Septiembre de 2005 Estudiantes Internacionales Cultura Internet ... El Tiempo Por un futuro sin sida Un Nobel de Medicina anuncia que en el futuro se desarrollarán vacunas que ralenticen la evolución del sida. El Dr. Rolf M. Zinkernagel destacó en la Universidad de Navarra la dificultad de conseguir una respuesta inmunitaria para prevenir la infección por este virus. "Va a ser prácticamente imposible, dadas las evidencias experimentales, tener una vacuna totalmente esterilizante y protectiva contra el virus del sida, pero se desarrollarán vacunas o inmunógenos que consigan ralentizar la evolución de la enfermedad". Avances en investigaciones Así lo afirmó en la Universidad de Navarra Rolf M. Zinkernagel, Premio Nobel de Medicina y Fisiología en 1996. Este científico intervino en una rueda de prensa celebrada con motivo de la VI Lección Conmemorativa Eduardo Ortiz de Landázuri, organizada por la Clínica Universitaria y la Facultad de Medicina. Para el experto suizo, que valoró el esfuerzo que se está haciendo para conseguir fármacos que rebajen el nivel de infección, si esto se consigue "va a cambiar radicalmente la epidemiología y el patrón de transmisión del VIH". Inmunizar el sida Por otro lado, el Dr. Rolf M. Zinkernagel se refirió a las investigaciones sobre la inmunoterapia del cáncer. Según explicó, "actualmente el objetivo consiste en acelerar el sistema inmunitario para que consiga destruir ese tumor sin dañar los tejidos normales del organismo". Sin embargo, se mostró reticente ante esta práctica: "Al inducir unas respuestas inmunitarias muy intensas las consecuencias pueden ser muy desagradables".

72. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher zinkernagel, rolf Martin Andre, P., Groettrup,M., Klenerman, P., De Giuli, R., Booth, BL, Cerundolo, V., Bonneville, M., http://hcr3.isiknowledge.com/formViewCharacteristic.cgi?table=Publication&link1=

73. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher zinkernagel, rolf Martin Battegay, M., Fiedler,P., Kalinke, U., Brombacher, F., zinkernagel, RM, Peter, HH, Kohler, G., Eibel, http://hcr3.isiknowledge.com/formViewCharacteristic.cgi?table=Publication&link1=

74. Eesti Geenikeskus rolf M. zinkernagel ja Prof. Andres Metspalu Nobeli preemia pälvinud Professorzinkernagel tutvustas immunoloogilise mälu tekkemehhanisme ja sellest http://www.genomics.ee/index.php?lang=est&show=2&sub=93

75. Universidad De Navarra: Asociación De Amigos, Presentación, Translate this page El profesor rolf M. zinkernagel en su comparecencia durante la celebración de lasexta edición de la Lección Conmemorativa Eduardo Ortiz de Landázuri. http://www.unav.es/amigos/RevistaAbril2005/portada/zinkernagel/default.html

Asociación de Amigos Presentación Portada Asociación de Amigos Presentación Presentación VI LECCION CONMEMORATIVA EDUARDO ORTIZ DE LANDAZURI ROLF M. ZINKERNAGEL, UN NOBEL EN LAS AULAS El profesor Rolf M. Zinkernagel en su comparecencia durante la celebración de la sexta edición de la Lección Conmemorativa Eduardo Ortiz de Landázuri. Los universitarios tuvieron un profesor excepcional. En octubre de 2004, en el marco de la sexta edición de la Lección Conmemorativa Eduardo Ortiz de Landázuri, organizada por la Clínica Universitaria y la Facultad de Medicina, intervino Rolf M. Zinkernagel, Premio Nobel de Medicina y Fisiología en 1996. Mujeres y afecciones autoinmunes ASOCIACIÓN DE AMIGOS

76. Compredia.de » Medizinische Mikrobiologie Von Kayser, Fritz H. | Bienz, Kurt A. Translate this page Johannes zinkernagel, rolf M. - Hardcover - Thieme Georg Verlag Fritz H. Bienz, Kurt A. Eckert, Johannes zinkernagel, rolf M. http://www.compredia.de/product_info.php/cPath/20000_20253_20321_20323/products_

Home Alle Bücher Preiswerte-Tinte.de Kauf-Akkus.de ... POPULäRSTE BüCHER Suche: in: Allen Kategorien Alle Bücher Preiswerte-Tinte.de Kauf-Akkus.de DVDs 0 Artikel - Zwischensumme: Startseite Bücher Medizin und Pharmazie Medizinische Mikrobiologie Untertitel: Verstehen - Lernen - Nachschlagen Compredia - Preis: Dieses Produkt ist bei uns zur Zeit nicht lieferbar, Versandkosten -> siehe Warenkorb Kurzbeschreibung: [Produktspezifisches] ISBN: EAN: Verlag: Thieme Georg Verlag Co-Verlag: Lucius + Lucius Erscheinungsjahr: Auflage: 10. Auflage von 2001 Ausgabe: Studienausgabe.. Sprache: Deutsch Abbildungsinfo: 177 farbig Abbildungen, 97 Tabellen [Dimensionen] Länge: 190 mm Breite: 131 mm Höhe: 37 mm Gewicht: 787 gr [Kontributoren / Mitwirkende] Autoren: Compredia - Preis: (inkl. 7.00% MwSt.) Dieses Produkt ist bei uns zur Zeit nicht lieferbar Suche: in: Allen Kategorien Alle Bücher Preiswerte-Tinte.de Kauf-Akkus.de DVDs 0 Artikel - Zwischensumme: AGB Impressum Rücksendungen Widerrufsrecht ... Über Compredia.de

77. Glossar ROLF Translate this page Fischer Verlag 2000 Kayser Fritz H Bienz Kurt A Eckert Johannes zinkernagel RolfM Medizinische Mikrobiologie verstehen lernen nachschlagen 9 Auflage . http://www.orthopedia-shop.de/glossar/glossar_wort-ROLF/rolf.html

Glossar ROLF ... Glossar ROLF ... Handball Volleyball Tennis Laufsport ... WWW Schnellsuche Home Oberschenkel Kniegelenk Unterschenkel ... Impressum document.write('VitaAktiv'); info document.write('VitaAktiv ist ein rein pflanzliches und hoch-ergiebiges Nahrungs-ergänzungs-mittel aus 21 Obst-und G'); mehr Webdesign Frankfurt neu neu A B C D ... W Gr./Kleinschreibung beachten ignorieren Ja Nein Die Glossar Suche von " ROLF " Röteln ... Fischer Verlag 2000 Kayser Fritz H Bienz Kurt A Eckert Johannes Zinkernagel Rolf M Medizinische Mikrobiologie verstehen lernen nachschlagen 9 Auflage ... Physiologie ... August Universität Göttingen Somatoviszerale Sensorik und Schmerz Prof Dr Rolf Detlef TreedeInstitut für Physiologie und Pathophysiologie Johannes Gutenberg... Pharao ... Liste der Pyramiden Liste der römischen Kaiser Pyramide Bauwerk Literatur Rolf Gundlach Der Pharao und sein Staat Die Grundlegung der ägyptischen Kö... Nobelpreis für Medizin ... einem neuen biologischen Prinzip der Infektion 1996 Peter C Doherty AU und

78. 13 Nye æresdoktorer Ved UiO rolf M. zinkernagel Avslører immunforsvaret. Professor rolf M. zinkernagelsforskning handler om kroppens immunforsvar og smittsomme sykdommer. http://www.admin.uio.no/ia/uniforum/1997/uniforum12-97/06.htm

Uniforum nr. 12 1997 AV MARTIN TOFT Professor Rolf M. Zinkernagels forskning handler om kroppens immunforsvar og smittsomme sykdommer. I 1996 delte han nobelprisen i medisin med en annen forsker. Moderniteten og Holocaust Theodore W. Anderson: Matematisk statistikk An Introduction to Multivariate Statistical Analysis Inga-Stina Ewbank: Kulturell brobygger , Purity and Danger James Wertsch: Fortolker av Vygotsky Uniforum nr. 12 1997

79. Zinkernagel To Give Dyer Lecture, April 13, 2004 NIH Record - National Institute Swiss immunologist and Nobel Prize winner Dr. rolf M. zinkernagel will presentthe RE Dyer lecture on Wednesday, Apr. 14, at 3 pm in the Clinical Center s http://www.nih.gov/news/NIH-Record/04_13_2004/story03.htm

Front Page Previous Story Next Story Zinkernagel To Give Dyer Lecture By Anne A. Oplinger Swiss immunologist and Nobel Prize winner Dr. Rolf M. Zinkernagel will present the R.E. Dyer lecture on Wednesday, Apr. 14, at 3 p.m. in the Clinical Center's Masur Auditorium. His talk, titled "Antiviral Immunity and Vaccines," will explore a wide range of immunological topics, including why vaccines against persistent infections such as HIV or tuberculosis have been difficult to achieve, while vaccines that maintain or induce high levels of neutralizing antibodies have been much more effective at preventing disease. A native of Basel, Zinkernagel was awarded an M.D. from the University of Basel in 1968. Deciding not to pursue a career as a surgeon, he undertook postgraduate education in experimental medicine at the University of Zurich and in immunology at the University of Lausanne. In 1973, he began a second postdoctoral course in immunology at the Australian National University, Canberra. Between 1973 and 1975, Zinkernagel and Dr. Peter C. Doherty collaborated in work that led to the 1996 Nobel Prize in Physiology or Medicine, which the two shared. Dr. Rolf M. Zinkernagel

80. Biografia De Rolf M. Zinkernagel Translate this page rolf M. zinkernagel. (1944- ) Biólogo suizo, n. en Basilea. Trabajaba en elInstituto de Inmunología Experimental de la Universidad de Zürich cuando en 1996 http://www.biografiasyvidas.com/biografia/z/zinkernagel.htm

Inicio Buscador Las figuras clave de la historia Reportajes Los protagonistas de la actualidad Rolf M. Zinkernagel (1944- ) Biólogo suizo, n. en Basilea. Trabajaba en el Instituto de Inmunología Experimental de la Universidad de Zürich cuando en 1996 compartió el premio Nobel de Fisiología y Medicina con el australiano Peter C. Doherty por sus trabajos sobre inmunología. Junto con éste había investigado en la escuela médica John Curtin de Canberra sobre la vulnerabilidad de las células a ciertos linfocitos portadores de antígenos histocompatibles, trabajos de gran utilidad en el tratamiento del reumatismo, la diabetes y la esclerosis múltiple. Inicio Buscador Recomendar sitio

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