61. Nobel Prize Winner Puts Trust In Nature - ExpressNews - University Of Alberta Dr. John Vederas (front left) with Dr. K. barry sharpless (. Dr. John Vederas (frontleft) with Dr. K. barry sharpless (front right) on campus Monday http://www.expressnews.ualberta.ca/expressnews/articles/news.cfm?p_ID=2483&s=a

62. Nobel Connection The 2001 Chemistry Nobel Prize winner, Professor K. barry sharpless, with K.barry sharpless (Nobel Prize, asymmetric catalysis, 2001) at MIT. http://www.hkbu.edu.hk/~chem/nobel.htm

The Nobel Connection at HKBU Department of Chemistry Hong Kong Baptist University The 2001 Chemistry Nobel Prize winner, Professor K. Barry Sharpless, was the post-doctoral research supervisor of our chemistry colleague Professor Albert Lee. All together, five scientists at HKBU had worked under the direct supervision, either as Ph.D. students or post-doctoral researchers, of a Chemistry Nobel Laureate. Four of them are from the Chemistry Department. Prof. Rick W. K. Wong , Chemistry Department and Dean of the Science Faculty, with GEOFFREY WILKINSON (Nobel Prize, organometallic chemistry, 1973) at Imperial College. more details... Dr. M. H. Mok (Vice-President of Administration, former Head of the Chemistry Department) and Dr. S. K. So (Physics Department), with JOHN C. POLANYI (Nobel Prize, dynamic of chemical elementary processes, 1986) at the University of Toronto. Dr. Frank S. C. Lee (Retired in 2003), Chemistry Department

63. Sharpless, Former MIT Professor, Wins Nobel In Chemistry - MIT News Office K. barry sharpless, an MIT chemistry professor for 17 years until he joinedScripps Research Institute in 1990, was chosen October 10 to share the 2001 http://web.mit.edu/newsoffice/2001/sharpless.html

Skip to content massachusetts institute of technology news office advanced search news recent research campus by topic ... archives services request images subscribe submit news promote news ... media inquiries about us news office info MIT background contact Sharpless, former MIT professor, wins Nobel in chemistry October 10, 2001 CAMBRIDGE, Mass. K. Barry Sharpless, an MIT chemistry professor for 17 years until he joined Scripps Research Institute in 1990, was chosen October 10 to share the 2001 Nobel Prize in chemistry with two other researchers. Sharpless, 60, received a Ph.D. degree in 1968 from Stanford University. Since 1990, he has been W. M. Keck Professor of Chemistry at the Scripps Research Institute. After starting his career at MIT as an assistant professor, Sharpless moved back to Stanford in 1977. Although he had started his quest for a practical catalyst for asymmetric epoxidation while at MIT, after 10 years of effort, the key breakthrough took place in January 1980 at Stanford. Sharpless decided that he wanted to return to MIT to pursue this important discovery. He and his lab moved back to MIT that summer. It was at MIT that he fully developed the process now known as the Sharpless Asymmetic Epoxidation and it was also here that he and his coworkers discovered the Sharpless Asymmetric Dihydroxylation. Sharpless left MIT in 1990 to join the Scripps Research Institute. "Barry's friends and former colleagues here at MIT are thrilled that his important contributions to chemistry have been recognized with this year's Nobel Prize in chemistry," said Rick L. Danheiser, A. C. Cope Professor and associate department head in chemistry. "Most of the work for which the prize was awarded was carried out here at MIT, where Barry was a valued colleague and a wonderful teacher and mentor for a great many students over the years."

64. Sharpless Endows UROP Fund The creation of the $30000 endowment by K. barry sharpless, Dartmouth Class of1963, and his wife, Jan, honors Professor Thomas A. Spencer, http://web.mit.edu/newsoffice/tt/1991/may29/24754.html

Published by the MIT News Office at the Massachusetts Institute of Technology, Cambridge, Mass. May 29 Tech Talk Search MIT News ... MIT Sharpless Endows UROP Fund May 29 Tech Talk Search MIT News ... MIT

65. Thieme-connect / Synlett / Table Of Contents Wang, ZhiMin; sharpless, K. barry Walsh, Patrick J.; sharpless, K. barryAsymmetric Dihydroxylation (AD) of a,ß-Unsaturated Ketones PDF (182 kb) http://www.thieme-connect.com/ejournals/toc/synlett/1368

Home Subject List Alphabetical List Help ... Deutsche Version Quick Search Advanced Search LogIn Username Password Register Now Free Trial Thieme-connect / Synlett / Table of contents Contact Us Synlett Issue 08 Volume 1993 account McCombie, Stuart W.; Ortiz, Claudio; Cox, Brian; Ganguly, Ashit K.: Controlling Benzylic and Anomeric Functionality and Stereochemistry: Methodology and Syntheses Utilising Intramolecular Ionic Hydrogenation PDF (605 kb) letter Solladie, Guy; Urbano, Antonio; Stone, Guy B.: Stereospecific Synthesis of cis- and trans-Galbanolenes by Na(Hg) Reductive Elimination of Allylic Dibenzoates PDF (222 kb) Heintzelman, Geoffrey R.; Parvez, Masood; Weinreb, Steven M.: A Model Study on the Synthesis of the Marine Hepatotoxin Cylindrospermopsin PDF (109 kb) Hegarty, Philip; Mann, John: A Concise Route to the Tetracyclic Skeleton of Stemodin PDF (155 kb) Koreeda, Masato; Dixon, Lisa A.; Hsi, Jeffrey D.: An Efficient Formal Synthesis of Aflatoxin B by Use of the Kikuchi Rearrangement Reaction PDF (171 kb) Stereoselective Syntheses of Ethyl ( ... PDF (297 kb) Ward, Dale E.; Liu, Yadong; Rhee, Chung K.: Enhancing Stereoselectivity from Reactions with Modest Group Selectivity PDF (233 kb) Bourhim, Abdellatif; Gaud, Oliver; Granet, Robert; Krausz, Pierre; Spiro, Marenglen:

66. International: Italiano: Scienze: Chimica: Chimici E Ricercatori: Sharpless, K. Translate this page Scienze Chimica Chimici e Ricercatori sharpless, K. barry - Open Site. In tutta la Directory, Solo in Chimici_e_Ricercatori/sharpless,_K._barry http://open-site.org/International/Italiano/Scienze/Chimica/Chimici_e_Ricercator

Open Site The Open Encyclopedia Project Pagina principale Aggiungi Contenuti Diventa Editore In tutta la Directory Solo in Chimici_e_Ricercatori/Sharpless,_K._Barry Top International Italiano Scienze ... Chimici e Ricercatori : Sharpless, K. Barry Questa Categoria ha bisogno di un Editore - Richiedila Open Site Code 0.5.3 robot company. Visit our sister sites dmoz.org mozilla.org chefmoz.org musicmoz.org ... modifica

67. Newsletter K. barry sharpless, an research fellow from the Scripps Research Institute, K. barry sharpless has been dedicated to the research on asymmetrical http://www.conference.ac.cn/Newewsletter/html/new37/brief.htm

68. 2001 Benjamin Franklin Medal In Chemistry K. barry sharpless, Ph.D. Keck Professor of Chemistry Professor K. barry sharplesshas pioneered the discovery of three catalytic reactions that add http://www.fi.edu/tfi/exhibits/bower/01chem.html

2001 Benjamin Franklin Medal in Chemistry K. Barry Sharpless, Ph.D. Keck Professor of Chemistry The Scripps Research Institute Citation: A Benjamin Franklin Medal of The Franklin Institute in the field of Chemistry is awarded to K. Barry Sharpless for his innovative contributions to the development of broadly useful and commercially viable catalytic oxidation chemistry for the selective production of bioactive molecules with the proper right or left "handedness," which allow the manufacture of safer and more effective drugs and agricultural chemicals. Summary The manufacture of safer and more effective pharmaceuticals and chemicals for a variety of applications in the life sciences demands the ability to selectively synthesize molecules of left or right "handedness." Handedness refers to the existence of pairs of chemical molecules that differ only by being mirror images of each other. The most effective way to steer a chemical reaction toward the formation of only the product of desired handedness is the use of a handed catalyst. While not being consumed in the reaction, the catalyst speeds up the formation of the desired product. In doing so repeatedly, it transfers its "handedness" to many product molecules and thus multiplies its structural information manifold. Professor K. Barry Sharpless has pioneered the discovery of three catalytic reactions that add oxygen atoms to molecules containing a carbon-carbon double bond, to selectively produce chemical compounds with the desired handedness. These processes are used extensively by academic and industrial chemists.

69. NIH News Release--NIGMS Grantee K. Barry Sharpless Wins Nobel Prize For Advances NIGMS Grantee K. barry sharpless Wins Nobel Prize for Advances in MirrorImage Dr. K. barry sharpless, a long-time grantee of the National Institute of http://www.nih.gov/news/pr/oct2001/nigms-10.htm

NATIONAL INSTITUTES OF HEALTH National Institute of General Medical Sciences FOR IMMEDIATE RELEASE Wednesday, October 10, 2001 Contact: Alison Davis , NIGMS NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry "Dr. Sharpless' creativity has helped the entire field of chemistry produce extremely useful molecules, including many different therapeutics, that continue to improve the health and enhance the lives of all Americans," said Dr. Ruth L. Kirschstein, acting director of NIH. "This year's Nobel Prizes in Chemistry and Physiology or Medicine both beautifully underscore the value of basic biological research in yielding vital medical advances." The Royal Swedish Academy of Sciences in Stockholm announced the chemistry prize winners this morning. Dr. Sharpless, W.M. Keck Professor of Chemistry at The Scripps Research Institute in La Jolla, California, received half of this year's chemistry award for his work on "chirally catalyzed oxidation reactions." Sharing the other half of the prize for their work on "chirally catalyzed hydrogenation reactions," are Dr. William S. Knowles of St. Louis, Missouri (formerly of the Monsanto Company) and Dr. Ryoji Noyori of Nagoya University, Chikusa, Nagoya, Japan. After more than a decade of trying, in 1980 Dr. Sharpless figured out how to force a chemical reaction to go one-handed. The winning combination turned out to be a mixture of two inexpensive commercial chemicals: a relatively simple titanium compound and either the right or left hand of a chemical called "tartrate."

70. Sharpless Epoxidation -- Facts, Info, And Encyclopedia Article (Click link for more info and facts about K. barry sharpless) K. barry sharplessshared the (An annual award for outstanding contributions to chemistry or http://www.absoluteastronomy.com/encyclopedia/s/sh/sharpless_epoxidation.htm

Sharpless epoxidation [Categories: Organic reaction, Organic chemistry] Sharpless epoxidation is a ((chemistry) a process in which one or more substances are changed into others) chemical reaction of an allylic alcohol with t-butylperoxide and titanium tetraisopropylate to form an (Click link for more info and facts about epoxide) epoxide . To form (Click link for more info and facts about chiral) chiral products it is possible to add diethyltartrates. Epoxides can be easily converted into dialcohols, aminoalcohols or (A colorless volatile highly inflammable liquid formerly used as an inhalation anesthetic) ether s, so formation of chiral epoxides is a very important step in the synthesis of natural products. (Click link for more info and facts about K. Barry Sharpless) K. Barry Sharpless shared the (An annual award for outstanding contributions to chemistry or physics or physiology and medicine or literature or economics or peace) Nobel prize in 2001 with William S. Knowles and Ryoji Noyori for his work on asymmetric oxidations. More Subjects form Category Demethylation Decarboxylation Anerobic glycolysis Oxymercuration reaction ... Williamson ether synthesi...

71. Sharpless Bishydroxylation -- Facts, Info, And Encyclopedia Article (Click link for more info and facts about K. barry sharpless) K. barry sharplesswon the 2001 (Click link for more info and facts about Nobel Prize in http://www.absoluteastronomy.com/encyclopedia/s/sh/sharpless_bishydroxylation.ht

Sharpless bishydroxylation [Categories: Organic reaction, Organic chemistry] Sharpless bishydroxylation or asymmetric dihydroxylation (AD) is a ((chemistry) a process in which one or more substances are changed into others) chemical reaction of an (Any unsaturated aliphatic hydrocarbon) alkene with (Click link for more info and facts about osmium tetroxide) osmium tetroxide to form an diol (dialcohol). (Click link for more info and facts about Chiral) Chiral products can be formed by adding (A bitter alkaloid extracted from chinchona bark; used in malaria therapy) quinine derivatives. A more efficient way to perform this reaction is reoxidise the osmate, which is formed in the reaction, with (Click link for more info and facts about potassium ferricyanide) potassium ferricyanide . This reduces the amount of the highly toxic and very expensive osmium tetroxide needed by up to 95%. It is possible to buy these mixtures as (Click link for more info and facts about AD-mix) AD-mix The (Click link for more info and facts about chiral) chiral diols are important for further synthesis. The introduction of

72. Cardinal Chronicle: 10/01 WHEN NEWLY MINTED NOBEL LAUREATE K. barry sharpless lectures in Braun Auditoriumat the Mudd Chemistry Building Thursday afternoon, he ll be just a couple http://www.stanford.edu/news/report/news/october24/column-1024.html

Stanford Report, October 24, 2001 Cardinal Chronicle / weekly campus column BY BARBARA PALMER NEARLY 85 STAFF, FACULTY, STUDENTS AND community members showed up for a "Habitat Restoration Day" at the Dish last Saturday to plant oak trees and butterfly host bushes and learn about the Foothills habitat. The planting of 23 sets of three acorns one valley oak and two coast live oaks to a set capped off the initial phase of the plan to restore 5 acres disturbed by the installation of a storm water drain this summer, said SEAN ANDERSON , a postdoctoral fellow at the Center for Conservation Biology. Anderson helped round up the stars of a natural history exhibit, including a night snake, tree frogs, and blue-bellied and alligator lizards. "I touched a millipede," said a surprised-sounding DEBRA ZUMWALT , the university's general counsel, who came out for the morning with her 11-year-old daughter. Afterward, the exhibit slithered and scuttled back into the hills. WHEN NEWLY MINTED NOBEL LAUREATE K. BARRY SHARPLESS lectures in Braun Auditorium at the Mudd Chemistry Building Thursday afternoon, he'll be just a couple of flights of stairs away from where he made the breakthrough that led to his being awarded the Nobel Prize in chemistry Oct. 10. Sharpless, now at the Scripps Research Institute in La Jolla, was a Stanford chemistry professor in 1980 and working in a third-floor lab at Mudd when he developed a way to catalyze an oxidation reaction so that only one side of a molecule's mirror image is produced. The discovery is used in the synthesis of pharmaceuticals such as antibiotics, anti-inflammatory drugs and heart medicines. Sharpless, who earned a doctorate in chemistry from Stanford in 1968 and was a postdoctoral fellow with chemistry Professor

73. Catalysts All The Way and the other half to K. barry sharpless (60) of Scripps Research Institute, Ryoji Noyori and K. barry sharpless for key research that has been used http://www.frontlineonnet.com/fl1822/18220590.htm

Volume 18 - Issue 22, Oct. 27 - Nov. 09, 2001 India's National Magazine from the publishers of THE HINDU Table of Contents NOBEL PRIZES Catalysts all the way Developers of chiral catalysts for asymmetric synthesis in hydrogenation and oxidation win the Nobel Prize for Chemistry. R. RAMACHANDRAN MANY naturally occurring molecules, particularly biological molecules, are found in two forms that are mirror images of each other, just as human hands mirror each other. Such molecules are chiral or handed, derived from the Greek word cheir, meaning hand. The two forms are called enantiomers. The amino acid alanine, for example, occurs as S-alanine and R-alanine. When the molecule is produced in the laboratory under normal conditions, a mixture containing equal amounts of the two enantiomers is obtained. That is, the synthesis is symmetrical. Asymmetric synthesis concerns the production of one of the enantiomers in excess over the other. In many applications, particularly pharmaceuticals, asymmetric synthesis is very important because, while one form may be beneficial to health, the other may even be harmful, as in the case of thalidomide. One form of this drug was known to prevent nausea in pregnant women while the other was found to cause foetal damage. For many biological molecules, nature seems to prefer one form over the other. In plant and animal systems amino acids, peptides, enzymes and other proteins, nucleic acids such as DNA and RNA and carbohydrates occur as only one kind of enantiomer. Receptors in human cells too are chiral and so they, like the glove to a hand, prefer to bind only to one form. In fact, the two enantiomers can have different effects on the cells. Limonene, for example, is chiral and occurs as S-limonene and R-limonene which produce quite different sensations in our olfactory cells. The former smells of lemons and the latter of oranges. Therefore, it becomes important to be able to produce the two enantiomers in pure and unmixed form. This is particularly important in the case of drugs, the active ingredients in many of which are chiral molecules.

74. Nobel Prize: Chemistry 2001 Laureate (1/2) K. barry sharpless Born 1941 in Philadelphia, PA, USA Acquired a Ph.D.From Stanford University in 1968. He is currently affiliated with the Scripps http://library.thinkquest.org/TQ0313040/ch2001.html

William S. Knowles - Born on June 1, 1917 in Taunton, Massachusetts, U.S.A. Recieved a Ph.D. from Columbia University in 1942. He has just recently retired from working at the Monsato Company in St. Louis, U.S.A. He was part of the group that won the noble chemistry prize for chirally catalysed hydrogenation reactions. Ryoji Noyori - Born September 3, 1938 in Kobe, Japan. Earned a Masters and Ph.D. from Kyoto University in 1963 and 1967. He is currently affiliated with the Research Center for Materials Science at Nagoya University in Nagoya Japan. He was part of the group that won the noble chemistry prize for chirally catalysed hydrogenation reactions. K. Barry Sharpless - Born 1941 in Philadelphia, PA, U.S.A. Acquired a Ph.D. From Stanford University in 1968. He is currently affiliated with the Scripps Research Institute in La Jolla, U.S.A. He won the Nobel prize for chirally catalysed oxidation reactions.

75. Rhodia Pharma Solutions With people like Professors Eric Jacobsen, Andrew Myers, K. barry sharpless andStephen Buchwald, working with our talented chemists, we develop novel http://www.rhodia-pharmasolutions.com/AboutUs/People.htm

About us Our mission Compliance People Facilities Development services Formulation solutions Technologies Catalogue Intermediates ... Analgesics and Bulk API Product Data Sheet - Acetaminophen / Paracétamol - Aspirin / Acetylsalicylic Acid - Guaifenesin - Methyl Salicylate ... Nutraceuticals Product Data Sheet - Calcium Phosphate Granular - Calcium Phosphate Powder - Calcium Phosphate Directly Compressible People Rhodia Pharma Solutions offers you products and services wherever you are in the world, thanks to teamwork involving 1120 people, including highly skilled scientists, pharma-experienced management, industrial development experts and a responsive sales force. Sales and development teams Scientific Advisory Board President Nick Green Nick Green is a graduate of London University and holds an MBA from Huddesfield University. He began his career at Woodnab Chemicals Ltd before moving to Hodgson Specialties Ltd (Great Britain) in 1990. After holding different operational positions in the BTP Group, taken over by Clariant in 2000, he was appointed head of Clariant Life Science Molecules (USA).

76. Modification De K. Barry Sharpless - Modifier - Wikipédia Symposium highlights list of participants for charting chemical K. barry sharpless WM Keck Professor of Chemistry The Scripps Research Institute,La Jolla, California, USA http//www.scripps.edu/chem/sharpless/ http://fr.wikipedia.com/w/index.php?title=K._Barry_Sharpless&action=edit

77. Fiftieth Annual NSTA Convention Underway In San Diego Nobel laureate K. barry sharpless addresses NSTA convention attendees. In a highlypersonal presentation, sharpless described his journey of scientific http://www.nsta.org/main/news/stories/nsta_story.php?news_story_ID=46832

78. College Of Chemistry Facts And Figures 199596 K. barry sharpless 1996-97 Marye Anne Fox 1997-98 Bernd Giese 1998-99Ryoji Noyori 2003-04 K. barry sharpless 2004-05 Kendall Houk http://chemistry.berkeley.edu/editor/COC_facts/coc_prizes.html

Welcome from the Dean College Facts Faculty Awards History ... Online Tours College of Chemistry Prizes and Lectureships Explore the College College Facts Faculty Honors and Awards : College Prizes and Lectureships Bayer Lecturers Berkeley Lectures in Chemical Engineering Melvin Calvin Lecturers Cynthia Ann Chan Memorial Lecturers ... Glenn T. Seaborg Lecture Bayer Lecturers 1996 Gregory Stephanopoulos 1997 E. Terry Papoutsakis 1998 Douglas A. Lauffenburger 1999 George Georgiou 2000 Frances Arnold 2001 Bernhard Palsson 2002 Linda G. Griffith 2005 Michael Betenbaugh (back to the top) Berkeley Lecturers in Chemical Engineering 1994-Sheldon K. Friedlander 2003- Pablo G. DeBenedetti

79. Minerva. Storia Della Chimica. Premi Nobel Per La Chimica: Sharpless Translate this page K. barry sharpless è stato uno dei 110 premi Nobel che hanno sottoscritto K.barry sharpless, d’altro canto, condivide il premio per aver sviluppato http://www.minerva.unito.it/Theatrum Chemicum/NobelChimica/Sharpless.htm

Theatrum Chemicum Personae: K. Barry Sharpless K. Barry Sharpless n. 1941 Premio Nobel per la chimica 2001 con William S. Knowles e con Ryoji Noyori Premio Nobel 2000 Premio Nobel 2002 K. Barry Sharpless è stato uno dei 110 premi Nobel che hanno sottoscritto l' appello promosso da John Polanyi in difesa della pace e dell'ambiente. Nel punto centrale della dichiarazione dei 110 premi Nobel si legge: "La sola speranza per il futuro riposa nella collaborazione internazionale, legittimata dalla democrazia. È tempo di voltare le spalle alla ricerca unilaterale di sicurezza, in cui noi cerchiamo di rifugiarci dietro ai muri. Dobbiamo invece insistere nella ricerca dell'unità d'azione per contrastare sia il surriscaldamento del pianeta che un mondo armato". "per lo sviluppo della sintesi catalitica asimmetrica" , unitamente a William S. Knowles St Louis, Missouri, USA e a Ryoji Noyori , Nagoya University, Chikusa, Nagoya, Giappone, "per il loro lavoro sulle reazioni di idrogenazione attivate da catalisi chirale” , ed a K. Barry Sharpless

80. Search Results For Chiral - Encyclopædia Britannica American chemist who, with Noyori Ryoji and K. barry sharpless, sharpless, K.barry American scientist who, with William S. Knowles and Noyori Ryoji, http://www.britannica.com/search?query=chiral&submit=Find&source=MWTAB

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