41. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher sharpless, K. barry 1998. Kolb, HC, sharpless, K..Asymmetric Aminogydroxylation (IN PRESS).. Reddy, KL, Dress, KR, sharpless, http://hcr3.isiknowledge.com/formViewCharacteristic.cgi?table=Publication&link1=

42. C&EN: JACS AT 125 - A PRACTICAL REACTION Soc., 102, 5974 (1980) evokes vivid memories for K. barry sharpless. Also calledthe sharpless asymmetric epoxidation (AE), the reaction uses inexpensive http://pubs.acs.org/cen/science/8143/8143jacs125.html

Table of Contents cen-chemjobs.org Today's Headlines Cover Story ... What's That Stuff? Back Issues Safety Letters Chemcyclopedia ACS Members can Join ACS October 27, Volume 81, Number 43 CENEAR 81 43 p. 42 ISSN 0009-2347 JACS AT 125 A PRACTICAL REACTION Titanium-catalyzed asymmetric epoxidation paved the way to a Nobel Prize in Chemistry MAUREEN ROUHI T he paper titled "The First Practical Method for Asymmetric Epoxidation," which reports the discovery of titanium-catalyzed asymmetric epoxidation [ J. Am. Chem. Soc. ] evokes vivid memories for K. Barry Sharpless tert CHEERS Katsuki (left) and Sharpless, in 1980, celebrate the discovery of titanium-catalyzed asymmetric epoxidation. COURTESY OF THE SHARPLESS LAB The paper is one of the 125 most cited papers in the history of the Journal of the American Chemical Society but it might never have been published there. Sharpless, a chemistry professor at Scripps Research Institute and winner of the Nobel Prize in Chemistry in 2001 for his work on asymmetric oxidations, says one reviewer rejected the paper on the grounds that it was merely an incremental improvement over previous work. The paper was published only after Barry M. Trost

43. ACS Journal Archives: About The Journal Archives Hartmuth C. Kolb, Michael S. VanNieuwenhze, K. barry sharpless Chem. Rev. Per HJ Carlsen, Tsutomu Katsuki, Victor S. Martin, K. barry sharpless http://pubs.acs.org/archives/articles2004.html

Don't yet subscribe to ACS Journal Archives? Here's your chance to find out about the low cost of the Archives and enter to win an iPod. Request a quote for your institution and enter the Archives iPod drawing. View a list of the most-accessed articles from ACS Journal Archives in 2004. The ACS Journal Archives now includes 22 total volumes of the Journal of Natural Products , with the recent addition of 17 volumes published under the title Journal of Natural Products Enjoy free access to selected articles from the ACS Journal Archives Timeline Search the Archives Institutional Archives Subscriptions: Librarians and Information Specialists can fill out an online form to receive a quote from their ACS Account Manager Read ACS Journal Archives success stories Non-subscribers can access the abstracts or first page of all articles from ACS journals, including these articles from the Archives. 100 Most-Accessed Articles Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds Norio Miyaura, Akira Suzuki

44. Nobel Prize Winning Chemists Nobel Prize Winning Chemists. 2000 2002. K. barry sharpless. The Nobel PrizeIn Chemistry 2001. No Biography Available. Back To Main Page. http://www.sanbenito.k12.tx.us/district/webpages2002/judymedrano/Nobel Winners/k

Nobel Prize Winning Chemists K. Barry Sharpless The Nobel Prize In Chemistry 2001 No Biography Available Back To Main Page

45. Tricking HD K. barry sharpless, Ph.D. WM Keck Professor of Chemistry It works a lot betterthan we ever anticipated. In a first attempt to test a new general http://hdlighthouse.org/see/research/trojanhorse2.htm

Just as acetylcholinesterase inhibitors such as Aricept and Huperzine A are being investigated for the treatment of HD, professor Sharpless has a clever easy method to make a more powerful inhibitor. The ablilty of HD to cause disease can be turned against itself. When researchers discover a target for HD treatment, this fast easy method will quickly trick the target into submission. I am reminded of Edna St. Vincent Millay's prophetic sonnet . Jerry 22-Mar-02 Inspired by Scripps Research Institute Press Release, 20-Mar-02 Tricking Diseases Into Synthesizing Their Own Worst Enemies K. Barry Sharpless , Ph.D. W. M. Keck Professor of Chemistry "It works a lot better than we ever anticipated." In a first attempt to test a new general strategy for drug discovery, chemists at The Scripps Research Institute (TSRI) and TSRI's Skaggs Institute for Chemical Biology created the most potent blocking agent known against an enzyme implicated in Alzheimer's disease. In the current issue of the journal Angewandte Chemie, 2001 Nobel laureate K. Barry Sharpless, W.M. Keck Professor of Chemistry at TSRI, and colleagues at TSRI and the University of California at San Diego, describe how click chemistry, a modular protocol for organic synthesis that Sharpless developed, was used to make a drug-like molecule that powerfully blocks the neurotransmitter destruction caused by the brain enzyme, acetylcholinesterase. Unlike existing methods, this new drug-discovery strategy—click chemistry—mobilizes the target itself, acetylcholinesterase in this case, to play a decisive role and select the final synthetic step. The acetylcholinesterase enzyme actually catalyzed the click reaction that created that enzyme's own inhibitor, and, remarkably, the result is by far the most potent inhibitor ever discovered for this important, widely studied brain enzyme.

46. HDLighthouse.org 2001 Nobel laureate K. barry sharpless, WM Keck Professor of Chemistry at This is a breakthrough typical of barry sharpless, says TSRI President http://hdlighthouse.org/research/general/updates/0040trickinghd.shtml

New to the Huntington's Disease Lighthouse: Welcome, start here Beginners Search Research ... Tissue HD Lighthouse Editors Comment: Just as acetylcholinesterase inhibitors such as Aricept and Huperzine A are being investigated for the treatment of HD, professor Sharpless has a clever easy method to make a more powerful inhibitor. The ablilty of HD to cause disease can be turned against itself. When researchers discover a target for HD treatment, this fast easy method will quickly trick the target into submission. I am reminded of Edna St. Vincent Millay's prophetic sonnet Posted to HDLighthouse: 20 March 2002 HDL Update: Tricking HD Tricking Diseases Into Synthesizing Their Own Worst Enemies In a first attempt to test a new general strategy for drug discovery, chemists at The Scripps Research Institute (TSRI) and TSRI's Skaggs Institute for Chemical Biology created the most potent blocking agent known against an enzyme implicated in Alzheimer's disease. In the current issue of the journal Angewandte Chemie, 2001 Nobel laureate K. Barry Sharpless, W.M. Keck Professor of Chemistry at TSRI, and colleagues at TSRI and the University of California at San Diego, describe how click chemistry, a modular protocol for organic synthesis that Sharpless developed, was used to make a drug-like molecule that powerfully blocks the neurotransmitter destruction caused by the brain enzyme, acetylcholinesterase.

47. NACS - News K. barry sharpless, on the other hand, is awarded half of the Prize for K.barry sharpless, 60 years, born 1941 Philadelphia, Pennsylvania, USA (US http://www.nacatsoc.org/news.asp?NewsID=8

48. K. Barry Sharpless - Nobelpreis Für Chemie Arbeiten über chiral katalysierende Oxidationsreaktionen http://www.nobelpreis.org/chemie/sharpless.html

vor suchen Home Chemie ... Wirtschaft K. Barry Sharpless * 28. 4. 1941, Philadelphia (Pennsylvania/USA) "Für seine Arbeiten über chiral katalysierende Oxidationsreaktionen" diesen Artikel bearbeiten Webmaster Services

49. K. Barry Sharpless - De Nobelprijs Voor De Scheikunde K. barry sharpless *1941 (Verenigde Staten). Voor zijn werk aangaande chiralemoleculen . K. barry sharpless *1941. http://www.nobelpreis.org/nederlands/chemie/sharpless.html

De Nobelprijs voor de Scheikunde 2001 Volgende pagina Vorige pagina Zoeken Home ... Economie K. Barry Sharpless (Verenigde Staten) "Voor zijn werk aangaande chirale moleculen"

50. Nobel Prize K. barry sharpless, on the other hand, is awarded half of the Prize for K.barry sharpless, 60 years, born 1941 Philadelphia, Pennsylvania, http://www.nagoya-u.ac.jp/noyori/index-e.html

history link Prof. Ryoji Noyori won Nobel Prize in Chemistry. The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2001 for the development of catalytic asymmetric synthesis, with one half jointly to William S. Knowles St Louis, Missouri, USA, and Ryoji Noyori Nagoya University, Chikusa, Nagoya, Japan, "for their work on chirally catalysed hydrogenation reactions" and the other half to K. Barry Sharpless the Scripps Research Institute, La Jolla, California, USA, "for his work on chirally catalysed oxidation reactions". Mirror Image Catalysis Many molecules appear in two forms that mirror each other ? just as our hands mirror each other. Such molecules are called chiral. In nature one of these forms is often dominant, so in our cells one of these mirror images of a molecule fits "like a glove", in contrast to the other one which may even be harmful. Pharmaceutical products often consist of chiral molecules, and the difference between the two forms can be a matter of life and death ? as was the case, for example, in the thalidomide disaster in the 1960s. That is why it is vital to be able to produce the two chiral forms separately.

51. Danforth Lecturer 2002- Sharpless K. barry sharpless, 2002 Danforth Lecturer at Grinnell Colleg An AsymmetricOdyssey Leading Back to Its Port of Origin The Danforth Lecture on October 3, http://www.grinnell.edu/academic/chemistry/danforth/sharplessvisit/

Search Back to Danforth Lectureship Danforth Lecturer 2002 - K. Barry Sharpless "An Asymmetric Odyssey Leading Back to Its Port of Origin" The Danforth Lecture on October 3, 2002 Unlike most academics engaged in basic research, Nobel Laureate K. Barry Sharpless has always been exclusively interested in useful chemistry. Since he regards the oxidation of olefins as the single most versatile, powerful and reliable class of transformations in organic synthesis, Sharpless concentrates on expanding the scope of existing oxidative reactions and discovering new ones. Sharpless is best known for discovering three "name" reactions, general methods for catalytic asymmetric epoxidation, dihydroxlylation, and aminohydroxylation. His Nobel Prize citation says, "many scientists have identified Sharpless's epoxidation [discovered in 1980 with Tsutomu Katsuki] as the most important discovery in the field of synthesis during the past few decades." In 2001 Barry Sharpless received not only the Nobel Prize in Chemistry, but Israel's Wolf Prize, the Benjamin Franklin Medal and the John Scott Medal Award. Also in 2001, Sharpless turned 60, an event celebrated with a three-day symposium during the American Chemical Society's annual meeting; all of the symposium's 33 speakers were former members of Sharpless's research group. Sharpless is W.M. Keck Professor of Chemistry at the Scripps Research Institute.

52. SignOnSanDiego > News > Science -- Research Is Breakthrough K. barry sharpless, a San Diego chemist whose research led to new methods for News conference at Scripps; K. barry sharpless tells reporters that, http://www.uniontrib.com/news/science/20011011-9999_7m11sharp.html

Advertising Info About Us Contact SignOn Membership ... AP Wire Research is breakthrough Scripps scientist shares award; work led to new manufacturing techniques By Bruce V. Bigelow UNION-TRIBUNE STAFF WRITER October 11, 2001 K. Barry Sharpless, a San Diego chemist whose research led to new methods for making drugs and other compounds shared the Nobel Prize in chemistry yesterday. Sharpless, a scientist at The Scripps Research Institute, shared the prestigious award with William S. Knowles of St. Louis and Ryoji Noyori of Japan's Nagoya University. The three were honored for discovering new types of chemical reactions that could be used to duplicate the highly specific way that nature makes molecules. Nobel winner's enthusiasm is intoxicating Nobel is awesome, but also carries a price Their research led to manufacturing techniques that didn't exist before the 1970s, enabling scientists to produce new types of medicine such as L-dopa, a now-standard treatment for Parkinson's disease. Their work, which dates to the 1960s, also allowed other industries to create purer, more-effective compounds from perfumes and pheromone-based pesticides to flavorings and sweeteners. From the archives: Scripps scientist cited for molecular work Scripps, UCSD top influence list in chemistry

53. ChIN S Summary Page K. Barry Sharpless Research Group, The This is the summary page for K. barry sharpless research group, The ScrippsResearch Institute, USA on CSDLChIN. http://chemport.ipe.ac.cn/cgi-bin/chemport/getfiler.cgi?ID=CWpONpIw6vupj9iDYtd19

54. ChIN?K. Barry Sharpless(2001? http://chemport.ipe.ac.cn/cgi-bin/chemport/getfiler.cgi?ID=CWpONpIw6vupj9iDYtd19

55. 65th Anniversary Fax 23649932. Professors Ryoji Noyori (Japan), K. barry sharpless (USA) andWilliam S. Knowles (USA) shared the Nobel Prize in Chemistry 2001. http://www.polyu.edu.hk/cpa/anniversary/event_core_07.htm

Core 65th Anniversary Celebratory Activities «Ø®Õ¤»¤Q¤­©P¦~¬ö©À­«ÂI¼y¯¬¬¡°Ê Date ¤é´Á Event ¬¡°Ê Enquiries ¸Ô±¡¬d¸ß Nobel Laureate Lectures ¿Õ¨©º¸±o¼úªÌÁ¿®y Department of Applied Biology and Chemical Technology À³¥Î¥Íª«¤Î¤Æ¾Ç¬ì§Þ¾Ç¨t Prof. Albert Chan Tel: 2766-5607 Fax: 2364-9932 Professors Ryoji Noyori (Japan), K. Barry Sharpless (USA) and William S. Knowles (USA) shared the Nobel Prize in Chemistry 2001. The Royal Swedish Academy of Sciences has awarded the Prize for their development of catalytic asymmetric synthesis. The achievements of these three chemists are of great importance for academic research, and for the development of new drugs and materials which are being used in many industrial syntheses of pharmaceutical products and other biologically active substances. Professors Ryoji Noyori and K. Barry Sharpless will deliver lectures at 3:00p.m. on 29 April 2002 at Chiang Chen Studio Theatre, PolyU.

56. 65th Anniversary K. barry sharpless (right). Dr Sir Gordon Wu presented the Certificate of Appointment K. barry sharpless, WM Keck Professor of Chemistry at the Scripps http://www.polyu.edu.hk/cpa/anniversary/news_04.htm

Event Highlight Lectures by Nobel Laureates Dr Sir Gordon Wu presented the Certificate of Appointment to Prof. K. Barry Sharpless (right). Dr Sir Gordon Wu presented the Certificate of Appointment to Prof. Ryoji Noyori (left) Interviewing Dr William Knowles (left) by Prof. Albert Chan Sun-chi. PolyU conferred the title of Distinguished Honorary Professorship, the highest academic honour of the University, to the winners of the 2001 Nobel Prize in Chemistry at a special ceremony held on campus on 29 April. The association with the three top scholars will be a strong boost to the further development of the University's Area of Excellence "The Hong Kong Institute of Molecular Technology for Drug Discovery and Synthesis". The esteemed academic honour was conferred by Council Chairman Dr Sir Gordon Wu upon the three Nobel Laureates. They are Prof. Ryoji Noyori, Director of the Research Centre for Materials Science of Nagoya University in Japan; Prof. K. Barry Sharpless, W.M. Keck Professor of Chemistry at the Scripps Research Institute in the US; and Dr William Knowles, previously with Monsanto Company in the US.

57. K. Barry Sharpless Translate this page K. barry sharpless nació en Filadelfia, Pensylvania (EE.UU) en 1941. Doctor enQuímica en 1968 por la Universidad de Stanford. Desde 1990 es profesor de http://www.guajara.com/wiki/es/wikipedia/k/k_/k__barry_sharpless.html

K. Barry Sharpless K. Barry Sharpless nació en Filadelfia, Pensylvania (EE.UU) en . Doctor en Química en 1968 por la Universidad de Stanford. Desde 1990 es profesor de química en el Scripps Research Institute de La Jolla (EE.UU.). Recibió el Nobel de Química en 2001, por haber logrado catalizar moléculas quirales mediante oxidación . El premio fue compartido con otros dos investigadores William S. Knowles y Ryoji Noyori por idéntico logro mediante hidrogenación. Tagoror.com CineBSO Radioaficionados.net Tacoronte Guia ... Deranet El contenido de Wikipedia se publica bajo la Datos de Contacto

58. SunSITE India : 2001 Nobel Chemistry Prize K. barry sharpless the Scripps Research Institute, La Jolla, California, USA, K. barry sharpless, on the other hand, is awarded half of the Prize for http://sunsite.iisc.ernet.in/nobel2001/che2001_rel.html

2001 Nobel Prize 2001 Nobel Prize in Chemistry Press Release The 2001 Nobel Prize in Chemistry 10 October 2001 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2001 for the development of catalytic asymmetric synthesis, with one half jointly to William S. Knowles St Louis, Missouri, USA, and Ryoji Noyori Nagoya University, Chikusa, Nagoya, Japan, "for their work on chirally catalysed hydrogenation reactions" and the other half to K. Barry Sharpless the Scripps Research Institute, La Jolla, California, USA, "for his work on chirally catalysed oxidation reactions". Mirror Image Catalysis Many molecules appear in two forms that mirror each other - just as our hands mirror each other. Such molecules are called chiral. In nature one of these forms is often dominant, so in our cells one of these mirror images of a molecule fits "like a glove", in contrast to the other one which may even be harmful. Pharmaceutical products often consist of chiral molecules, and the difference between the two forms can be a matter of life and death - as was the case, for example, in the thalidomide disaster in the 1960s. That is why it is vital to be able to produce the two chiral forms separately. This year's Nobel Laureates in Chemistry have developed molecules that can catalyse important reactions so that only one of the two mirror image forms is produced. The catalyst molecule, which itself is chiral, speeds up the reaction without being consumed. Just one of these molecules can produce millions of molecules of the desired mirror image form.

59. SunSITE India : 2001 Nobel Chemistry Prize William S.Knowles Ryoji Noyori K.barry sharpless K. barry sharpless, 60 years,born 1941 Philadelphia, Pennsylvania, USA (US citizen). http://sunsite.iisc.ernet.in/nobel2001/che2001_bio.html

2001 Nobel Prize 2001 Nobel Prize in Chemistry William S.Knowles Ryoji Noyori K.Barry Sharpless Biography William S. Knowles , 84 years, born 1917 (US citizen). PhD 1942 at Columbia University. Previously at Monsanto Company, St Louis, USA. Retired since 1986. Ryoji Noyori , 63 years, born 1938 Kobe, Japan (Japanese citizen). PhD 1967 at Kyoto University. Since 1972 Professor of Chemistry at Nagoya University and since 2000 Director of the Research Center for Materials Science, Nagoya University, Nagoya, Japan. http://www-noyori.os.chem.nagoya-u.ac.jp K. Barry Sharpless , 60 years, born 1941 Philadelphia, Pennsylvania, USA (US citizen). PhD 1968 at Stanford University. Since 1990 W.M. Keck Professor of Chemistry at the Scripps Research Institute, La Jolla, USA. http://www.scripps.edu/chem/sharpless/kbs.html Comments/Suggestions to Webmaster, SunSITE

60. Encyclopedia: K. Barry Sharpless Other descriptions of K. barry sharpless. Karl barry sharpless (born April 28, Click chemistry is a concept introduced by K. barry sharpless in 2001 and http://www.nationmaster.com/encyclopedia/K.-Barry-Sharpless

Supporter Benefits Signup Login Sources ... Pies Related Articles People who viewed "K. Barry Sharpless" also viewed: Ryoji Noyori Sharpless epoxidation Scripps Research Institute Sharpless bishydroxylation ... Nobel Prize in Chemistry What's new? Our next offering Latest newsletter Student area Lesson plans Recent Updates File Transfer Protocol Fertilizer Faustus (I) Cornelius Sulla Fall of the Ming Dynasty ... More Recent Articles Top Graphs Richest Most Murderous Most Taxed Most Populous ... More Stats Encyclopedia: K. Barry Sharpless Updated 31 days 8 hours 48 minutes ago. Other descriptions of K. Barry Sharpless Karl Barry Sharpless (born April 28 ) is a chemist renowned for his work on organometallic chemistry April 28 is the 118th day of the year (119th in leap years) in the Gregorian Calendar, with 247 days remaining. ... 1941 was a common year starting on Wednesday (link will take you to calendar). ... This is a list of famous chemists: Contents: Top - 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A Emil Abderhalden, (1877-1950), German chemist Richard Abegg, (1869-1910), German chemist... In he won the Nobel Prize in Chemistry for his work on stereoselective oxidation reactions ( Sharpless epoxidation Sharpless bishydroxylation , Sharpless aminohydroxylation). This prize was shared with

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