1. Medicine 1993 Phillip A. Sharp Autobiography Nobel Lecture Interview Other Resources 1992 1994. The 1993 Prize in Physics Chemistry Physiology or http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

2. Phillip A. Sharp - Autobiography Phillip A. Sharp Autobiography. A sense of place was and remains an important part of my life. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

3. MSN Encarta - Sharp, Phillip A. Interactive Atlas. Magazine Center. Find more about Sharp, Phillip A. from Other Features from Encarta. Search Encarta for Sharp, Phillip A. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. MIT Department Of Biology Phillip A. Sharp Home Faculty and Areas of Research Phillip A. Sharp, 2005 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Phillip A Sharp of Research......Phillip Sharp, Ph.D. RNA interference and splicing. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. MSN Encarta - Search Results - Sharp Phillip A Sharp, Phillip A. ( The Nobel Foundation) MSN Encarta Premium. Get moreresults for sharp phillip a . 86 results on MSN Encarta http://encarta.msn.com/Sharp_Phillip_A.html

fdbkURL="/encnet/refpages/search.aspx?q=Sharp+Phillip+A#bottom"; errmsg1="Please select a rating."; errmsg2="Please select a reason for your rating."; MSN Home My MSN Hotmail Shopping ... Sign In Web Search: Encarta Subscriber Sign In Help Home ... Upgrade your Encarta Experience Search Encarta Exclusively for MSN Encarta Premium Subscribers. Join Now Searched Encarta for ' Sharp Phillip A' Articles Sharp, Phillip A. Sharp, Phillip A. , born in 1944, American chemist and Nobel laureate born in Falmouth, Kentucky. Sharp received a Ph.D. degree from the University of... ... (1738-1814), British naval officer, creator and governor of the first European settlement in the colony of New South Wales,... See all search results in Articles (149) Phillip Sharp Philip II Philip IV (of Spain, Naples, and Sicily) Philip Hench ... Map of Phillip Island See all search results in Maps (12) Books about "Sharp Phillip A" Search for books about your topic, "Sharp Phillip A" Magazines Search for Magazine Articles on " ... Learn more. Go to Magazine Center MSN Encarta Premium Get more results for "Sharp Phillip A" 86 results on MSN Encarta 191 results on MSN Encarta Premium Click here to join today!

7. Sharp Phillip R Md - Doctors Physicians SHARP PHILLIP R MD General and Family Practice 5 SANDHILL CRANE RD FERNANDINA BEACH, FL 32034 Phone (904) 2616727 Research and Compare http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. Philip Dean Sharp Vietnam War The Franklin County Veterans Contact Us. Philip Dean Sharp The Franklin County Veterans Memorial " Another Seaton Family Website " Ottawa Kansas U.S.A. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Forrest Carter Top 10 Bestselling Books Forrest Carter Rennard Bells, The Education of Little Tree, The Mountain Farm (Collector's Library Edition) by Marilyn Sharp, Phillip Rock, Forrest Carter, Ernest http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. DBLP: Phillip A. Sharp Phillip A. Sharp. List of publications from the DBLP Bibliography Server FAQ Rufang Yeh, Paul Goldstein, Matthew Mawson, Phillip A. Sharp, http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/s/Sharp:Phillip_A=.htm

Phillip A. Sharp List of publications from the DBLP Bibliography Server FAQ Coauthor Index - Ask others: ACM DL ACM Guide CiteSeer CSB ... Matthew Mawson , Phillip A. Sharp, Christopher B. Burge : RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Research 32 (Web-Server-Issue): 187-190 (2004) Coauthor Index Christopher B. Burge William G. Fairbrother Paul Goldstein Matthew Mawson ... Gene W. Yeo DBLP: [ Home Author Title Conferences ... Michael Ley (ley@uni-trier.de) Wed Sep 14 20:37:40 2005

11. New York Academy Of Sciences EBriefing Phillip sharp phillip a. Sharp is institute professor and founding director atthe McGovern Institute at MIT, where he studies the control of gene http://www.nyas.org/ebriefreps/main.asp?intSectionID=245

12. The Nobel Prize In Physiology Or Medicine 1993: Phillip Allen Sharp Phillip Allen Sharp *1944 (USA). For their discoveries of split genes ( jointlywith Richard John Roberts ). The Nobel Prize in Physiology or Medicine http://www.nobelpreis.org/english/medizin/sharp.htm

The Nobel Prize in Physiology or Medicine 1993 Next Previous Search Home ... Economics Phillip Allen Sharp (USA) "For their discoveries of split genes" ( jointly with Richard John Roberts External links The Nobel Prize - Phillip Allen Sharp The Nobel Foundation powered by xago.org - The World Heritage Sites Webmaster Services

13. Untitled Document Phillip A. sharp phillip a. Sharp. Wilson Chris Wilson Photo by Gavin Sisk.Michael Berridge Sir Michael J. Berridge. Verrier Edward Verrier. UPASS Reports http://depts.washington.edu/~uweek/archives/1999.03.MAR_11/_Photos.html

Lois Price Spratlen, UW Ombudsman Although rainy weather has bogged down progress on the World War II Memorial at the south end of Memoiral Drive, plans are to have the project completed and dedicated in May. In the meantime, the area around the flagpole is being transformed into a circular pattern of flagstone designed by Seattle artist Jon Gierlich to represent history spiraling from order to chaos, as life did for those who lived before and during World War II. Plantings in the area will include beach grasses to reflect campaigns in the Pacific and at Normandy. The Honorable Richard A. Jones, Maestro Abrahm Kaplan conducts Phillip A. Sharp Chris Wilson Photo by Gavin Sisk Sir Michael J. Berridge Edward Verrier A new outdoor kiln Photos identified by number may be ordered from uphoto@u.washington.edu

14. UWeek Vol.16, No.20 March, 11, 1999 Memorial service for Dodge. RNA splicing is topic for Nobel Laureate Sharp’slecture. Phillip A. sharp phillip a. Sharp http://depts.washington.edu/~uweek/archives/1999.03.MAR_11/article20.html

Wilson named to chair Immunology Sir Michael Berridge to speak on discoveries in calcium signaling Perfusionists to present John Gibbon Award to cardiothoracic chief Poll Scholar to present public lecture on new approaches to a cure for diabetes ... Memorial service for Dodge Phillip A. Sharp Scientists work around the clock trying to understand precisely how RNA segments are spliced in the subregions of our cells. All our hereditary data, including genetic disease, is passed on at this level. What chemical reactions take place? Can the process be regulated? How is the RNA itself formed? In light of recent cloning and gene therapy advances, it may be surprising to hear investigators say that little is known about this process. The fact is that what knowledge there is has come rapidly and dramatically. In the early 1970s, biotechnology companies did not exist. Genetic research was conducted primarily in academic labs. The first biotech company, Genentech Inc., was founded in 1976. Today, there are hundreds of biotech companies around the world. Working independently, Sharp and Roberts were attempting to identify the location of genes on the DNA molecule in the adenovirus nucleus. Using electron microscopy, they found that single RNA segments corresponded to separate segments of DNA in the larger molecule. In other words, they found that genes exist as discontinuous segments on a DNA molecule.

15. Abstract Phillip A. Sharp Phillip A. Sharp. The sequence of vertebrate genome is expressed by RNA splicingproducing mRNA. Interpreting the genome requires understanding the http://bioinf.mpi-sb.mpg.de/conferences/recomb2001/WWW/ABSTRACTS/Sharp.html

RNA Biology and the Genome Phillip A. Sharp

16. BioTIK - Alt Om DNA: Biografi Richard Roberts & Phil Sharp PHILLIP ALLEN SHARP (1944). Billede af Phillip Allen Sharp. Phillip (Phil) Sharpblev født i Kentucky i USA. Sharp læste på “University of Illinois”, http://www.biotik.dk/viden/afsnit2/kap24/biografi/

Forside Viden Alt om DNA Afsnit 2 24. En RNA-besked ka... / Biografi Viden Hvad er bioteknologi Tidslinie Etik Mennesket ... English Alt om DNA Afsnit 2 - 24. En RNA-besked kan ændres Om emnet Biografi Animation Quiz ... Links Biografi Richard Roberts og Phil Sharp delte nobelprisen i 1993 for deres opdagelse af, at gener er adskilt. RICHARD JOHN ROBERTS Richard (Rich) Roberts blev født i Derby i England. Hans far bakkede meget op om sønnens spørgelystne sind, og han hjalp ham med at opbygge et kemilaboratorium i kælderen. Her fremstillede og studerede Rich Roberts fyrværkeri og andre kemikalier. Han tog afgangseksamen fra Sheffield University i 1965 og her gik han videre med forskning inden for organisk kemi. Da han afsluttede sin Ph.D., læste han John Kendrew's book, Thread of Life: An Introduction to Molecular Biology . Han blev fascineret af denne introduktion til krystallografiens tidlige historie, og Roberts besluttede at kaste sig over området molekylærbiologi. Senere tog Roberts til Harvard , hvor han blev fortrolig med biokemiens “jargon”. Han arbejdede bl.a. med at finde sekvensen af det tRNA, som er involveret i at opbygge bakteriers cellevægge. I 1970 tog Roberts til Cambridge for at få Fred Sanger til at lære sig metoden med at bestemme sekvenser ud fra radioaktiv mærkning. Og da han kom tibage til Harvard, lærte han teknikken fra sig til mange andre forskere.

17. Phillip A. Sharp Winner Of The 1993 Nobel Prize In Medicine phillip A. sharp, a Nobel Prize Laureate in Physiology and Medicine, at the NobelPrize Internet Archive. http://almaz.com/nobel/medicine/1993b.html

P HILLIP A S HARP 1993 Nobel Laureate in Medicine for discovery of split genes. Background Born: 1944 Residence: U.S.A. Affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA Featured Internet Links Prize co-recipient Richard J. Roberts Search WWW Search The Nobel Prize Internet Archive Nobel News Links Let Nobelists Inspire, Menino Says Two from Mass. Win Nobel for Medicine Latest Nobel Affirms MIT Leadership in Biology Sharp Jolts MIT, Rejects Top Post (1990) Links added by Nobel Internet Archive visitors Home town reaction Biogen Winner of The Gairdner Foundation Int'l Award Phillip A. Sharp - Autobiography (submitted by Daike) Phillip A. Sharp - Nobel Lecture (submitted by Davis Brown) La rancontre des specialistes de l'ARN a Orford (submitted by alis) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

18. MIT Department Of Biology: Phillip A. Sharp Home Faculty and Areas of Research phillip A. sharp, 2005 Doench, JG, andsharp, PA Specificity of microRNA target selection in translational http://web.mit.edu/biology/www/facultyareas/facresearch/sharp.shtml

Home Faculty and Areas of Research Phillip A. Sharp, 2005 Phillip A. Sharp Institute Professor Ph.D. 1969, University of Illinois Room E17-529B Phone: (617) 253-6421 Fax: (617) 253-3867 Email: sharppa at mit.edu Sharp Lab Website Overview The ability to silence genes in mammalian cells through RNA interference (RNAi) has dramatically expanded the possibilities for genotype/phenotype analysis in cell biology. Investigation into the mechanisms responsible for the activities of short interfering RNAs (siRNAs) are ongoing with the objective of increasing their effectiveness in gene silencing. siRNAs have overlapping functions with microRNAs, endogenous genes in mammalian cells that, when paired by partial complementarity to an mRNA, inhibit accumulation of the corresponding protein. We are studying this translational repression and are also using RNAi technology to identify specific proteins important for the regulation of alternative RNA splicing and transcription. Research Summary RNA Interference: RNAi was first identified as a post-transcriptional response to exogenous double-stranded RNA (dsRNA) introduced into the nematode worm

19. Sharp, Phillip A. phillip A. sharp, 1993. Copyright Brooks Kraft/Sygma. in full phillip ALLEN sharp (b.June 6, 1944, Falmouth, Ky., US), American molecular biologist, http://www.britannica.com/nobel/micro/541_28.html

Sharp, Phillip A., Phillip A. Sharp, 1993 in full PHILLIP ALLEN SHARP (b. June 6, 1944, Falmouth, Ky., U.S.), American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine , along with Richard J. Roberts , for his independent discovery that individual genes are often interrupted by long sections of DNA that do not encode protein structure. Sharp received a doctorate in chemistry from the University of Illinois at Urbana-Champaign in 1969. In that year he began working at the California Institute of Technology, moving to the Cold Spring Harbor Laboratory in New York in 1971. In 1974 he went to the Massachusetts Institute of Technology, where he did his prize-winning research. In 1977 Sharp helped found Biogen Ltd., a biotechnology company. In 1977 Sharp and his team discovered that the messenger RNA (mRNA) of an adenovirus corresponded to four separate, discontinuous segments of DNA. They found that the segments of DNA that coded for proteins, now called exons, were separated by long stretches of DNA, now called introns, that did not contain genetic information. At the same time, a team working independently under Roberts came up with the same finding. Previously biologists had believed that genes were continuous stretches of DNA that served as direct templates for mRNA in the assembly of proteins; this model was based on studies of prokaryotic organisms such as bacteria. Following the discovery of Sharp and Roberts, it was demonstrated that the discontinuous gene structure is the most common one found in eukaryotes, among which are all higher organisms, including human beings.

20. Sharp, Phillip Britannica Student Encyclopedia sharp, phillip (born 1944), American molecular biologist and cowinner (withRichard Roberts) of the 1993 Nobel prize in medicine or physiology, http://www.britannica.com/ebi/article-9313498

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