61. Forums - Detecting Mad Cow Disease By Stanley B. Prusiner July 2004 SCIENTIFIC A This is a forum for discussion of the public relations industry, propaganda and media spin. To find out more, go to http//www.prwatch.org. http://www.prwatch.org/forum/archive/index.php/t-4415.html

Forums Books by PR Watch Staff Mad Cow USA PDA View Full Version : Detecting Mad Cow Disease By Stanley B. Prusiner July 2004 SCIENTIFIC AMERICAN Terry June 24th, 2004, 01:36 PM Detecting Mad Cow Disease By Stanley B. Prusiner July 2004 SCIENTIFIC AMERICAN [too long to post here, go to url below for full text] http://www.vegsource.com/talk/madcow/messages/92734.html TSS

62. Forums - Detecting Mad Cow Disease By Stanley B. Prusiner July 2004 SCIENTIFIC A This is a forum for discussion of the public relations industry, propaganda and media spin. To find out more, go to http//www.prwatch.org. http://www.prwatch.org/forum/showthread.php?t=4415

63. Nobel Prize: Medicine 1997 Laureate stanley B. prusiner Born in Des Moines, Iowa, he received his medical degree in biochemistry from the University of Pennsylvania. http://library.thinkquest.org/TQ0313040/med1997.html

Stanley B. Prusiner - Born in Des Moines, Iowa, he received his medical degree in biochemistry from the University of Pennsylvania. After he earned his medical degree he set out to find the cause of the rare brain disorder called Creutzfeldt-Jakob. Through his research he discovered and named the a new kind of protein making particle called a prion (proteinaceous infectious particle). A prion is has no DNA so it cannot be called a protein. Prions are suspected to cause Creutzfeldt-Jakob disease, mad cow disease, scrapie (fatal sheep disease), Alzheimer's disease, Parkinson disease, and amyotrophic lateral sclerosis (ALS).

64. Prusiner - Stanley B. Translate this page prusiner - stanley B. dieses Keyword ist leider offline. Jetzt informieren! von Benutzern eingegebene Ergänzungen zu diesem Thema. Autor http://www.unister.de/Unister/wissen/sf_lexikon/ausgabe_stichwort25794_328.html

Startseite zu meinem Account Anmeldung Unister - Intro ... Studium - Startseite Prof / Uni-Voting UniGuide Veranstaltungs - Kalender Stipendium ... Karriere - Startseite Bewerbung schreiben Bewerberhomepage Unternehmensprofile Jobs ... Wissen - Startseite Fach-Lexikon Hausarbeiten Diplomarbeiten Skripte ... Community - Startseite Uni - Flirt Uni - Chat Uni - Parties Alumni ... Reise - Rubrik Startseite Studium Karriere Wissen Community Uni-Reisen Hinweis zum Lexikon: unser Buch - Tipp Skript zusammenstellen Beachte auch unseren Buchtipp ! Handbuch Ethik von Marcus Düwell. Das Handbuch bietet allen, die in den unterschiedlichen Kontexten mit ethischen Fragen befasst sind, fundiertes Hintergrundwissen. Prusiner - Stanley B. dieses Keyword ist leider offline von Benutzern eingegebene zu diesem Thema Autor zu diesem Stichwort wurden noch keine Ergänzungen gemacht Die Beiträge geben ausschließlich die Ansicht des jeweiligen Verfassers wieder. Alle Angaben, auch im Lexikon, ohne Gewähr.

65. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher prusiner, stanley B. ISI Assigned Category, Molecular Biology Genetics. ISI Indexed Name, prusiner SB prusiner. ISI Notes http://hcr3.isiknowledge.com/author.cgi?&link1=Browse&link2=Results&id=4084

66. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher prusiner, stanley B. prusiner, SB, Scott, MR, Dearmond, SJ, Cohen, FE Prion protein biology. Cell 93 337 348, 1998. http://hcr3.isiknowledge.com/formViewCharacteristic.cgi?table=Publication&link1=

67. The Lasker Foundation | Former Award Winners, Basic Medical Research 1994 stanley B. prusiner For landmark, revolutionary work that established the existence of an entirely new class of infectious agents, and which opened new http://www.laskerfoundation.org/awards/library/1994basic.shtml

Lasker Awards Jury Members This Year's Winners Former Winners Library of Laureates Browse the Library for former winners of the Albert Lasker Basic Medical Research Award select Clinical Research Award select Public Service Award select Special Achievement Award select Nominations Open call to... Nominate a Scientist 1994 Winner Albert Lasker Award for Basic Medical Research Stanley B. Prusiner For landmark, revolutionary work that established the existence of an entirely new class of infectious agents, and which opened new understanding of the pathogenesis of several baffling neurodegenerative diseases.

68. Prions Backgrounder on stanley B. prusiner, MD, UCSF discoverer of the prion stanley B. prusiner, MD, 55, is Professor of Neurology and Biochemistry and http://www.mad-cow.org/Nobel.html

Mad Cow Home or Best Links Nobel Prize to Prusiner! Full text of the Award Nobel Prize winner sits on FDA panel ... Curriculum vitae Off-Site: Karolinska Institutet award page ... featuring a third-rate 2.7 meg shockwave animation Nobel Prize to Prusiner! STOCKHOLM, Sweden (Reuter) - Stanley Prusiner, a U.S. biochemist whose discovery provided key insights into dementia-related diseases, won the 1997 Nobel Medicine Prize, Sweden's Karolinska Institute said on Monday. The institute said Prusiner's work helped the world to understand more about Alzheimer's and Mad Cow disease through his discovery of the prion, a disease-causing agent like bacteria or viruses. The prion protein can manifest itself as two proteins, one an innocent ``Dr. Jekyll'' character, while the other, dangerous ``Mr Hyde'' protein causes disease and death. The institute said Prusiner solved the riddle of the prion's properties. Prusiner, 55, is professor of biochemistry at the University of California in San Francisco (UCSF). ``Prusiner's discovery provides important insights that may furnish the basis to understand the biological mechanisms underlying other types of dementia-related diseases, for example Alzheimer's disease, and establishes a foundation for drug development and new types of medical treatment strategies,'' it added.

69. Especiales Diario Médico Translate this page stanley B. prusiner nació en Estados Unidos en 1942. Cursó los estudios de Medicina en la Universidad de Pensilvania y en la Universidad de California, http://www.diariomedico.com/medicinasiglo/nobel1997.html

Mapa Web Contacto Publicidad Servicios Internet Sanitario Archivo Asesor Legal Congresos Deportes Dossieres Especiales DM Foros Imprescindibles DM Impuestos Informes Web Medline Multimedia Newsletters Ocio en DM Ofertas de trabajo Ondasalud.com Tienda de libros Especialidades Aparato Digestivo Enfermedades raras Ginec./Obstet. Infecciosas/Sida Med. Deportiva Med. Familiar Medicina Intensiva Med. Interna Medicina Legal Med. Nuclear Med. Preventiva Med. Trabajo Med. Urgencias Otorrinolaring. Trasplantes Form. continuada Telemedicina Secciones Sanidad Normativa Medicina Gestion Entorno Inicio Comentarios y sugerencias dminternet@recoletos.es Portada Stanley B. Prusiner Stanley B. Prusiner © Recoletos Medios Digitales S.L. Aviso Legal

70. Diario Médico Premio Nobel de Fisiología o Medicina de 1997 a stanley B. prusiner, americano, http://www.diariomedico.com/grandeshist/prusiner.html

Premio Nobel 1997 Stanley B. Prusiner "La Asamblea del Nobel del Instituto Karolinska ha decidido distinguir con el Premio Nobel de Fisiología o Medicina de 1997 a Stanley B. Prusiner, americano, profesor de Bioquímica de la Universidad de San Francisco, (Estados Unidos), por su descubrimiento de los priones como un nuevo principio biológico causante de infecciones". http:www.nobel.se/announcement-97/med-cv.html Otros premiados con el Nobel de Medicina Sobre los priones Otras enfermedades causadas por los priones ... Grandes Historias

71. NIH Press Release - Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize - LongTime NIH Grantee stanley B. prusiner Wins Nobel Prize. stanley B. prusiner, MD, a long-time grantee of the National Institutes of Health (NIH), http://www.nih.gov/news/pr/oct97/ninds-06.htm

NATIONAL INSTITUTES OF HEALTH National Institute of Neurological Disorders and Stroke FOR IMMEDIATE RELEASE Monday, October 6, 1997 Marian Emr Natalie Larsen Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel Prize Stanley B. Prusiner, M.D., a long-time grantee of the National Institutes of Health (NIH), is the recipient of the 1997 Nobel Prize in physiology or medicine for his discovery of an unusual class of infectious particles called prions. Prions are believed to be responsible for a group of diseases that include "mad cow" disease. Prusiner, who is professor of neurology, virology, and biochemistry at the University of California, San Francisco (UCSF), has received more than 56 million dollars in research grant support from NIH during the last three decades. "Dr. Prusiner is a pioneer in science and medicine. He introduced a truly new idea to the biology of disease... the idea that a protein can be an infectious agent," says Zach W. Hall, Ph.D., Director of the National Institute of Neurological Disorders and Stroke (NINDS), which has supported Dr. Prusiner since 1975. "His work has turned a once obscure corner of medicine into an important source of new ideas about fundamental biological mechanisms." Dr. Prusiner has received additional funding from the National Institute on Aging, the National Center for Research Resources, and the National Institute of General Medical Sciences, all of which are components of NIH. Dr. Prusiner led the work that uncovered the nature of prions (a term he coined from "

72. CNN - American Wins Nobel Prize For Medicine - Oct 6, 1997 stanley B. prusiner, a professor at the University of California at San Francisco, Physiology or Medicine 1997 awarded to stanley B. prusiner for his http://www.cnn.com/WORLD/9710/06/nobel/

American scientist wins Nobel Prize for medicine His work provides insight into brain diseases October 6, 1997 Web posted at: 8:51 a.m. EDT (1251 GMT) STOCKHOLM, Sweden (CNN) An American biologist won the 1997 Nobel prize for medicine Monday for his discovery of a new class of germ believed responsible for brain-wasting conditions such as "mad cow" disease. Stanley B. Prusiner, a professor at the University of California at San Francisco, discovered prions, "an entirely new genre of disease-causing agents," the Nobel citation from Sweden's Karolinska Institute said. "Prusiner has added prions to the list of well-known infectious agents, including bacteria, viruses, fungi and parasites." Prusiner began his search for prions in 1972, after one of his patients died from dementia resulting from Creutzfeldt-Jakob disease, the human equivalent of "mad cow" disease. After 10 years, he and his team produced a preparation derived from diseased hamsters' brains that contained a single agent he called a prion. His work was greeted with skepticism at first: Unlike known infectious agents, prions contain no genetic material, and are simply proteins. Furthermore, the gene encoding for prions is found in all mammals, including humans.

73. Health Report - 16/08/1999: Prions stanley B. prusiner, Prion biology and diseases . Paper presented at the XIth International Congress of Virology, Sydney, August 1999. Guests http://www.abc.net.au/rn/talks/8.30/helthrpt/stories/s44356.htm

Radio National with Rae Fry Prions Monday 16 August 1999 Summary: Rae Fry talks to the discoverer of prions (which cause Creutzfeldt-Jakob disease), Dr. Stanley Prusiner who won the Nobel Prize for his discovery. Rae Fry: There's lots scientists don't know about viruses, but even more of a mystery are things called prions. It's prions that cause Creutzfeld-Jakob Disease, or CJD, the brain disease that people in Britain seem to have caught from cows with mad cow disease. A prion is a protein, not an organism. At first the idea that a protein could be infectious was considered outrageous. For something to be infectious it has to be able to reproduce itself, and organisms do that using genetic material, DNA or RNA. So how can a protein possibly be infectious? Who better to tell us than Dr Stanley Prusiner, who discovered prions, and won a Nobel Prize for it. He's from the University of California, San Francisco, and he's in Australia at the moment. Stanley Prusiner: They're infectious because the protein which we call PrP prion protein, can exist in two states: the normal state and the abnormal state. And the reason that it's infectious is that the abnormal protein is capable of recruiting the normal one into more of the abnormal form. Rae Fry: You make it sound quite sinister.

74. Detecting Mad Cow Disease stanley B. prusiner. 1997 Nobel Prize lecture. Available from the Nobel Edited by stanley B. prusiner. Cold Spring Harbor Laboratory Press, 2004. http://www.maddeer.org/saved/070104prusiner.html

Detecting MAD COW Disease By Stanley B. Prusiner Contents Identifying the Cause Tracing the Mad Cow Epidemic Overview/Rooting Out Prions Designing Diagnostics Some New Insights Novel Therapies MORE TO EXPLORE A WORLDVIEW A BAD INFLUENCE TESTING FOR MAD COW BIOASSAY IMMUNOHISTOCHEMISTRY IMMUNOASSAY CONFORMATION-DEPENDENT IMMUNOASSAY [CDI] New tests can rapidly identify the presence of dangerous prions-the agents responsible for the maladyand several compounds offer hope for treatment Last December mad cow disease made its U.S. debut when federal officials announced that a holstein from Mabton, Wash., had been stricken with what is formally known as bovine spongiform encephalopathy (BSE). The news kept scientists, government officials, the cattle industry and the media scrambling for information well past New Year's. Yet the discovery of the sick animal came as no surprise to many of us who study mad cow disease and related fatal disorders that devastate the brain. The strange nature of the prionthe pathogen at the root of these conditionsmade us realize long ago that controlling these illnesses and ensuring the safety of the food supply would be difficult. As researchers learn more about the challenges posed by prionswhich can incubate without symptoms for years, even decadesthey uncover strategies that could better forestall epidemics. Key among these tools are highly sensitive tests, some available and some under development, that can detect prions even in asymptomatic individuals; currently BSE is diagnosed only after an animal has died naturally or been slaughtered. Researchers have also made some headway in treating a human prion disorder called Creutzfeldt-Jakob disease (CJD), which today is uniformly fatal.

75. Med.E.Mail Volume 2 stanley B. prusiner Main Auditorium, The Toronto Hospital (Western Division) stanley B. prusiner, University of California, San Francisco http://www.library.utoronto.ca/medicine/medemail/vol2/2number03.html

Faculty of Medicine News Med.E.Mail Volume 2 September 20, 1993. Volume 2, Number 3 Return to: [ FAXulty OF MEDICINE Index APPOINTMENTS Beata Fitzpatrick, previously Assistant Vice-Provost, Health Sciences has been appointed Assistant Provost, effective July 1, 1993. Donna Crossan has been appointed Assistant Vice-Provost, Health Sciences, for a one-year term, effective July 1, 1993. Donna is on a leave of absence from her position as Assistant Dean (Administration) in the Faculty of Dentistry. MRC AWARDS GROUP GRANT TO AIDS RESEARCH By providing an initial first-stage grant of $575,000, plus promise of support of almost $1 million per year over the next five years, the MRC has made it possible for our Faculty to create a network of scientists to conduct research into prevention and treatment of AIDS. A core group of scientists, scheduled to begin in the spring of 1994 and be fully in place by 1995-96, will be at the centre of the AIDS Research Network. The core group's leader will direct the Network, co-ordinating and stimulating research collaboration on campus and in the affiliated teaching hospitals and research institutes. Collaboration will also involve industrial partners and the HIV laboratory of the Ontario Ministry of Health's Public Health Laboratory. In addition to the core research group, who will be appointed, as appropriate, to the Departments of Microbiology, Immunology or Molecular and Medical Genetics, the Faculty will recruit other investigators to the AIDS Research Network, primarily through the Department of Medicine. The ultimate goal is to create a team of investigators spanning the full spectrum of AIDS-related research, from prevention to treatment, from laboratory bench to bedside. These individuals will not only be in a position to develop new treatments, but also to interact with the pharmaceutical industry to test new therapeutic agents.

76. Science -- Sign In It was led by stanley prusiner of the University of California, San Francisco, Fred E. Cohen, Stephen J. DeArmond, and stanley B. prusiner http://www.sciencemag.org/cgi/content/full/305/5684/589a

You do not have access to this item: Full Text : Couzin, BIOMEDICINE: An End to the Prion Debate? Don't Count on It, Science You are on the site via Free Public Access. What content can I view with Free Public Access If you have a personal user name and password, please login below. SCIENCE Online Sign In Options For Viewing This Content User Name Password this computer. Help with Sign In If you don't use cookies, sign in here Join AAAS and subscribe to Science for free full access. Sign Up More Info Register for Free Partial Access including abstracts, summaries and special registered free full text content. Register More Info Pay per Article 24 hours for US $10.00 from your current computer Regain Access to a recent Pay per Article purchase Need More Help? Can't get past this page? Forgotten your user name or password? AAAS Members activate your FREE Subscription

77. NDSU Library: /research/subjects/ag/Scrapie Books.php Title Prion biology and diseases / edited by stanley B. prusiner. Author prusiner, stanley B. Title Prion Diseases of humans and animals http://www.lib.ndsu.nodak.edu/research/subjects/ag/Scrapie Books.php

Home Research Subjects Ag Scrapie and Prion Diseases: Books For more books available in libraries, search the NDSU online catalog . For an extensive database of library catalogs, search WorldCat (NDSU staff and students only) Scrapie Prion Diseases Scrapie Title: Diseases of sheep / edited by W.B. Martin and I.D. Aitken. Edition: 3rd ed. Publisher: Oxford [England] ; Malden, MA, USA : Blackwell Science, 2000. Part VI: Diseases of the nervous system. Scrapie in sheep and goats, and related diseases. NDSU call number: SF968 .D465 2000 Title: Prion diseases / edited by Harry F. Baker and Rosalind M. Ridley ; with a foreword by Stanley B. Prusiner. Publisher: Totowa, N.J. : Humana Press, c1996. NDSU call number: QR201.P737 P74 1996 Title: Prion biology and diseases / edited by Stanley B. Prusiner. Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c1999. Part IV. Prion diseases in animals.

78. Re: How Does The Structural Transformation Occur In Prion Protein? The term prion was 1st coined by stanley B. prusiner of University of The Prion diseases stanley B. prusiner, Scientific American, Jan 1995. 3. http://www.madsci.org/posts/archives/may2001/990738574.Bc.r.html

MadSci Network : Biochemistry Re: How does the structural transformation occur in prion protein? Date: Wed Apr 11 07:39:25 2001 Posted By: shashank HARITHSA, Grad student, Research fellow in Microbiology department, National Institute of Oceanography Area of science: Biochemistry ID: 985392812.Bc Message: Current Queue Current Queue for Biochemistry Biochemistry archives Try the links in the MadSci Library for more information on Biochemistry MadSci Home Information Search ... Join Us! MadSci Network, webadmin@www.madsci.org

79. Journal Club Presentations, Spring Of 2000 Scott, Michael R.; Will, Robert; Ironside, James; Nguyen, Hoang Oahn B. Tremblay, Patrick; DeArmond, Stephen J.; and prusiner, stanley B. 1999. http://www.foodscience.cornell.edu/wiedmann/jnlspring2000.htm

Back to Main Links Contact Us Spring 2000 Date: Presenter: Paper: May 10, 2000 Adriana Ferreira Cotter, Paul D.; Emerson, Nathan; Gahan, Cormac G.M.; and Hill, Colin. 1999. Identification and disruption of lisRK , a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes Journal of Bacteriology , Nov. 6840-6843. May 3, 2000 Belgin Dogan Sperandio, Vanessa; Mellies, Jay L.; Nguyen, William; Shin, Sooane; and Kaper, James B. 1999. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli Proc. Natl. Acad. Sci. April 26, 2000 Céline Nadon Scott, Michael R.; Will, Robert; Ironside, James; Nguyen, Hoang- Oahn B. Tremblay, Patrick; DeArmond, Stephen J.; and Prusiner, Stanley B. 1999. Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. PNAS . Vol. 96. No. 26. 15137-15142. April 19, 2000

80. Untitled Document stanley B. prusiner (see photo) was awarded a Nobel Prize in 1997 for his discovery of prions. In a recent article (see article) prusiner established the http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/WilsonE/home.p

This page was produced as an assignment for an undergraduate course at Davidson College WHAT ARE PRIONS? Prions are small, simple proteins. They are infective, and interesting because they are the only known infective agents that do not contain genetic material. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of modified protein PrP Sc (Prusiner, 2003). Prion is an acronym for, proteinaceous infective particle PAST PRIONS Prions are important because when they change conformation, they cause problems. Normal versions of cellular prion proteins are abundant on the surface of brain nerve cells and are said to be involved in synaptic function. These wild type prion proteins, PrP C , were discovered upon investigation of the diseased version that causes neurodegenerative diseases, PrP Sc . Transmissible spongiform encephalopathies (TSE's) are degenerative brain diseases that occur in many mammals. The brain degrades gradually, developing holes as it does so and evetually looks like a sponge. The three most notably afflicted animal species affected by the disease causing form of prion proteins, PrP Sc , are

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