61. [ISI Highly Cited Researchers Version 1.1] Highly Cited Researcher milstein, César. Home Browse Results Biography milstein, César portrait. Contact Information. Telephone. Fax Number http://hcr3.isiknowledge.com/author.cgi?&link1=Browse&link2=Results&id=1997

62. César Milstein Translate this page Apellido y Nombres, milstein, César. Nacimiento, 8 de octubre de 1927, Bahía Blanca.Nacionalidad, Argentino - Británico http://www.universia.com.ar/multimedia/minisites/premios_nobel/milstein_ficha.ht

Inicio Ficha Cargos Publicaciones ... Recomendados Apellido y Nombres Nacimiento Nacionalidad Estudios Secundarios Estudios Universitarios Fallecimiento 24 de marzo de 2002, Cambridge

63. César Milstein Translate this page en Cambridge a los 75 años ya raíz de una enfermedad cardíaca. Ver en UniversiaLa ciencia de luto falleció César milstein, el último Nobel argentino http://www.universia.com.ar/multimedia/minisites/premios_nobel/milstein_biografi

Inicio Ficha Cargos Publicaciones ... Recomendados Obtuvo el Premio Nobel de Medicina y Farmacología en 1984 por sus teorías relacionadas con la "especificidad en el desarrollo y control del sistema inmunológico", y el descubrimiento de la técnica para producir anticuerpos monoclonales en gran escala. Se graduó de Químico en la Facultad de Ciencias Exactas de la UBA, a los 25 años de edad. Cinco años más tarde, fue nombrado por concurso en el Instituto Nacional de Microbiología "Carlos Malbrán", que gozaba de prestigio mundial. Al poco tiempo, partió hacia Cambridge, Inglaterra, becado por el laboratorio que dirigía otro Premio Nobel, el Dr. Frederick Sanger, en el Medical Center Research. honoris causa de la Universidad Nacional del Sur.

64. César Milstein, The Father Of Modern Immunology - Nature Immunology In memoriam César milstein, who with the late Georges Köhler invented Celia and César milstein, with Tim and Noah Springer, in front of the Fogg Art http://www.nature.com/ni/journal/v3/n6/full/ni0602-501.html

@import "/ni/style.css"; nature.com homepage Login My account ... Browse by subject Search This journal All of nature.com Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology ... Browse all publications Commentary Nature Immunology doi:10.1038/ni0602-501 Timothy A. Springer Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA. springeroffice@cbr.med.harvard.edu Photo credit: Tim Springer The generation of antibody diversity Milstein first approached this problem by determining the sequence of disulfide-bonded peptides in Bence-Jones light chains and obtained evidence for both variable and constant sequences. Milstein also defined the inter-heavy chain disulfide bridges that characterize each immunoglobulin (Ig) subclass. Milstein became an advocate of somatic mutation and, with Sydney Brenner, published a paper on this topic in 1966. As is often the case, the advocates of the opposing schools of germline diversity and somatic mutation both turned out to be right, with a combined mechanism far more complex than imagined by anyone. From myelomas to hybridomas in vitro . RNA sequencing required huge amounts of cells and With David Secher and Richard Cotton, Milstein searched for somatic mutations in the cultured cells. This required both prolonged culture to allow mutations to accumulate and the screening of thousands of clones. The first examples of mutations in somatic cells were identified, but the mutations were not in the variable region and thus were not the type sought.

65. César Milstein, The Father Of Modern Immunology - Nature Immunology In memoriam César milstein, who with the late Georges Köhler invented monoclonalantibodies, died on 24 March 2002. Their invention sprang from basic http://www.nature.com/ni/journal/v3/n6/abs/ni0602-501.html

@import "/ni/style.css"; nature.com homepage Login My account ... Browse by subject Search This journal All of nature.com Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology ... Browse all publications Commentary Nature Immunology doi:10.1038/ni0602-501 Timothy A. Springer Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA. springeroffice@cbr.med.harvard.edu Top Abstract Table of contents Full text Download PDF Send to a friend ... More science jobs Search buyers guide: ADVERTISEMENT ISSN: 1529-2908 EISSN: 1529-2916 Journal home Advance online publication Current issue Archive ... For librarians

66. César Milstein (1926-2002) Translate this page César nació en Bahía Blanca, Argentina, en el hogar del emigrante ucraniano El Dr milstein, fue honrado con múltiples distinciones en todo el mundo, http://www.compumedicina.com/historia/hm_010802.htm

César Milstein (1926-2002) (para Compumedicina.com) Las agencias de noticias han traído hace un tiempo la luctuosa noticia de la muerte de uno de los más ilustres científicos del mundo quien desarolló los Anticuerpos Monoclonales y recibió el Premio Nobel en 1984. César nació en Bahía Blanca, Argentina, en el hogar del emigrante ucraniano Lázaro Milstein y de su esposa Máxima, una maestra hija también de inmigrantes. César fue uno de tres hijos, comenzó sus estudios en su ciudad natal y al terminar el bachillerato viajó a la Capital en donde se matriculó en 1945 en la Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires. En 1956 presentó su tesis sobre estudios cinéticos con la enzima aldehído dehidrogenasa, recibió su doctorado en Quimica y ganó el concurso para trabajar en el Instituto Nacional de Microbiologia Malbrán. Al año siguiente recibió una beca y viajó a Cambridge para perfeccionar sus estudios. Regresó a Buenos Aires en 1961 y fue nombrado Jefe del Departamento de Biología Molecular del Instituto Malbrán. Debido a factores políticos, regresó a Cambridge en donde modificó sus investigaciones de enzimología a inmunología y empezó sus trabajos para desarrollar los anticuerpos monoclonales, uno de los factores inmunológicos mas importantes en la investigación de muchas enfermedades. En 1964 ascendió a Jefe de la División de Quimica de las proteínas del centro de investigaciones médicas de la Universidad de Cambridge en donde prosiguió su labor investigativa que culminó con el reconocimiento del Premio Nobel de Medicina en 1984.

67. Sociedad Española De Inmunología Translate this page César milstein and the spanish science a close relationship César milsteinExtracts from an interview with David Secher in 1999 http://www.inmunologia.org/congresos/ver_congreso.htm?id=16

68. Argentina: Como Somos Translate this page El Sur del Sur WEB SITE Como Somos. LOS ARGENTINOS EN EL EXTERIOR Fuga de CerebrosBiografía de César milstein César milstein nació en Bahía Blanca, http://www.surdelsur.com/somos/fuga/f_milste.htm

El Sur del Sur WEB SITE Como Somos LOS ARGENTINOS EN EL EXTERIOR Fuga de Cerebros: , provincia de Buenos Aires , el 8 de octubre de 1927 Universidad de Buenos Aires Medical Center Research de Cambridge Frederick Sanger , en 1984 por el desarrollo de los anticuerpos monoclonales Doctor Honoris Causa de la Universidad Nacional del Sur Precedente Bernardo Houssay Facultad de Medicina , miembro del Concejo Superior de la UBA , Presidente de la academia Nacional de Medicina Conicet . Obtuvo el Nobel en 1947 por su ciencia argentina Como Somos Tabla de contenidos Navegando el Sur - Todos los derechos reservados. webmaster@surdelsur.com

69. César Milstein Translate this page NAME=milstein, César ALTERNATIVNAMEN= KURZBESCHREIBUNG=argentischerMolekularbiologe GEBURTSDATUM=8. Oktober 1927 GEBURTSORT=Bah a Blanca, http://senioren-check.de/index.php/César_Milstein

C©sar Milstein C©sar Milstein 8. Oktober in Bah­a Blanca Argentinien 24. M¤rz in Cambridge England ) war ein argentischer Molekularbiologe. erhielt er zusammen mit Niels K. Jerne und Georges J. F. K¶hler den Nobelpreis in Physiologie oder Medizin Milstein, Cesar Milstein, Cesar Milstein, Cesar ... Milstein, Cesar NAME=Milstein, C©sar 8. Oktober Bah a Blanca Argentinien 24. M¤rz ... England Geriatrie Die Geriatrie oder Altersheilkunde ist die Lehre von den Krankheiten des alten Menschen. Dies betrifft v.a. Probleme aus den Bereichen der Inneren Medizin , der Orthop¤die Neurologie und Psychiatrie (Gerontopsychiatrie). Als Gerontologie oder Altersforschung wird andererseits die Wissenschaft bezeichnet, die sich mit Alterungsvorg¤ngen in allen ihren Aspekten befasst. Geriatrie ist keinesfalls mit der Palliativmedizin zu verwechseln, die sich das Ziel setzt, dem Menschen im letzten Stadium einer unheilbaren Krankheit ein menschenw¼rdiges Sterben zu erm¶glichen. Die Geriatrie tritt an, dem alten, aber v. A. dem sehr alten Menschen zu einem besseren Leben zu verhelfen. Dabei ist der Geriater haupts¤chlich dann gefordert, wenn Mehrfacherkrankungen ( Multimorbidit¤t ) vorliegen, die den einzelnen Arzt der jeweiligen medizinischen F¤cher aufgrund vielf¤ltiger Verflechtungen ¼berfordern. Die Geriatrie ist somit als eine fach¼bergreifende Disziplin zu verstehen. „rzte k¶nnen nach der Facharztausbildung (z.B. Fach¤rzte f¼r Innere Medizin, Allgemeinmedizin) in Deutschland die Zusatzbezeichnung "Geriatrie" erwerben.

70. César Milstein (1927-), Molecular Biologist National Portrait Gallery, list of portraits for César milstein including Césarmilstein by Nick Sinclair, http://www.npg.org.uk/live/search/person.asp?LinkID=mp06521

71. César Milstein 1927-2002 Nobel Scientist Dr César Milstein, Who Dr César milstein was born in Bahia Blanca, Argentina, in 1927. In a 1975paper in Nature, César milstein and Georges Köhler described how they had http://www.mrc.ac.uk/index/public-interest/public-cesar_milstein.htm

Professor Sir George Radda, Chief Executive of the Medical Research Council (MRC), said: "The discovery of monoclonal antibodies revolutionised biomedical research and sparked an international billion-pound biotechnology industry. No other MRC scientist has made such an outstanding contribution to Britain's science, health and wealth creation. "MRC awarded its first Millennium Medal to César in 2000 in recognition of his ground-breaking work. He was an inspiration to many young scientists and will be sorely missed by friends and colleagues at the MRC Laboratory of Molecular Biology and throughout the scientific world." He returned to Argentina for two years, but political persecution of liberal intellectuals and scientists, and a vendetta against the director of the institute where he was working, forced him to resign. He returned to Cambridge and rejoined Sanger, who was now Head of the Division of Protein Chemistry in the MRC Laboratory of Molecular Biology. He followed Sanger's advice and changed his field of study from enzymes to antibodies. Antibodies recognise and bind to foreign molecules, for example the surface proteins of invading viruses or bacteria, singling them out for elimination by the body's immune defences. In a 1975 paper in

72. OB-GYN-L Messages For March, 2002: César Milstein, 74, Winner Of Nobel Prize César milstein, 74, Winner of Nobel Prize in Medicine, Dies. By KENNETH CHANG.Dr. César milstein, who shared the 1984 Nobel Prize in Medicine for a http://forums.obgyn.net/ob-gyn-l/OBGYNL.0203/0440.html

-VISIT OUR OTHER FORUMS- OB-GYN-L Ultrasound Ultrasound History Physicians-in-Training Tech Talk OBSTET-L (portuguese) OBGIN-L (spanish) Nursing From: Dean Huffman dean@thehuffpeople.net Fri Mar 29 16:38:27 2002 Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] Next message: Marilyn Ringst: "Lawyers are from Mars, doctors are from Venus" Previous message: Strahimir Banovic: "Re: FRI Swollen Vagina" His work has influenced OB/GYN http://www.nytimes.com/2002/03/26/obituaries/26MILS.html March 26, 2002 César Milstein, 74, Winner of Nobel Prize in Medicine, Dies By KENNETH CHANG Dr. César Milstein, who shared the 1984 Nobel Prize in Medicine for a revolutionary technique to produce antibodies that latch onto specific proteins, died on Sunday in Cambridge, England. He was 74. The cause was a heart ailment, according to the laboratory at Cambridge University where he spent most of his career. In 1975, Dr. Milstein and Dr. Georges Köhler, a postdoctoral fellow of his at Cambridge, invented a method of forcing immune system cells to produce one particular type of antibody. Usually, the body's defense system generates a profusion of different antibodies to kill invading bacteria and viruses. Dr. Milstein and Dr. Köhler's research on pure antibodies, known as monoclonal antibodies, provided an important cornerstone in molecular biology research.

73. OB-GYN-L Messages For March, 2002: Re: César Milstein, 74, Winner Of Nobel Priz Re César milstein, 74, Winner of Nobel Prize in M. From Hugo D. Ribot Jr.(hribot@mindspring.com) Sat Mar 30 152447 2002 http://forums.obgyn.net/ob-gyn-l/OBGYNL.0203/0443.html

-VISIT OUR OTHER FORUMS- OB-GYN-L Ultrasound Ultrasound History Physicians-in-Training Tech Talk OBSTET-L (portuguese) OBGIN-L (spanish) Nursing From: Hugo D. Ribot Jr. hribot@mindspring.com Sat Mar 30 15:24:47 2002 Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] Next message: Michael E. Donnellan: "Prematurity" Previous message: Joanne Bulley, MD: "Re: Lawyers are from Mars, doctors are from Venus" As a fellow Argentinian Jewish doctor, I am proud of Dr. Milstein and mourn his passing. Hugo D. Ribot M.D., FACOG Cartersville, GA Private Practice since 1990 2 MDs/3 CNMs Next message: Michael E. Donnellan: "Prematurity" Previous message: Joanne Bulley, MD: "Re: Lawyers are from Mars, doctors are from Venus" use when must restrict search to only the ob-gyn-l forum... Enter search keywords: Returns per screen: Require all keywords: Return to Mail a New Message to the Forum: ob-gyn-l@obgyn.net Forum Administrator: geffrey.klein@obgyn.net Report Technical Problems: webmaster@obgyn.net Last Updated: Fri Sep 2 05:08:49 2005 The American Medical Association is no longer designating CME hours for AMA Category II CME credit. However, physicians themselves may self designate learning activities as Category II CME credit hours if they feel it is of sufficient educational merit and meets the formal definitions of continuing medical education. OBGYN.net believes these interaction in this forum meets these criteria. For further information

74. Lexikon César Milstein César milstein aus der freien EnzyklopädieWikipedia und steht unter der GNU Lizenz. Die Liste der Autoren ist http://lexikon.freenet.de/César_Milstein

E-Mail Mitglieder Community Suche ... Hilfe document.write(''); im Web in freenet.de in Shopping Branchen Lexikon Artikel nach Themen alphabetischer Index Artikel in Kategorien Weitere Themen Sarah und Marc: Erbkrankheit bedroht junges Familiengl¼ck Sexy Werbung f¼r neuen Duft: Shania Twain als Cowgirl IAA-Hingucker: AC Schnitzer motzt den BMW M6 auf Photoshow Elite: So bringt Nero Ord- nung in Ihre Fotos ... Filesharing: Jetzt wird im groŸen Stil zu Kasse gebeten! Sie sind hier: Startseite Lexikon C©sar Milstein C©sar Milstein C©sar Milstein 8. Oktober in Bah­a Blanca Argentinien 24. M¤rz in Cambridge England ) war ein argentischer Molekularbiologe. erhielt er den Robert-Koch-Preis und , zusammen mit Niels K. Jerne und Georges J. F. K¶hler , den Nobelpreis in Physiologie oder Medizin Personendaten NAME Milstein, C©sar ALTERNATIVNAMEN KURZBESCHREIBUNG argentischer Molekularbiologe GEBURTSDATUM 8. Oktober GEBURTSORT Bah a Blanca Argentinien STERBEDATUM 24. M¤rz STERBEORT Cambridge England Von " http://lexikon.freenet.de/C%C3%A9sar_Milstein Einordnung Mann Argentinier ... Gestorben 2002 Dieser Artikel basiert auf dem Artikel " C©sar Milstein Wikipedia und steht unter der GNU Lizenz . Die Liste der Autoren ist unter dieser Seite bearbeitet werden.

75. Latino Heritage Museum César milstein Argentina In work with his colaureate Georges JF Koehler, milsteindeveloped the techniques for producing monoclonal antibodies, http://www.latinoheritage101.com/pages/4/page4.html?refresh=1113297867817

76. MSN Encarta - Milstein, César colauréat du prix Autres fonctionnalités Encarta. Rechercher milstein, César http://fr.ca.encarta.msn.com/encyclopedia_761566066/Milstein_César.html

Accueil MSN Ma page Hotmail Recherche ... Tout savoir sur la gamme Encarta Rechercher Article accessible sur abonnement MSN Encarta Premium : Acc©dez   30 000 articles encyclop©diques avec plus de 12 000 illustrations, un atlas mondial interactif et un guide du Web. En savoir plus. Cet article n'est accessible que si vous ªtes abonn©   MSN Encarta Premium. Dans ce cas, connectez-vous en cliquant sur le lien Aller sur MSN Encarta Premium (ci-dessus). Milstein, C©sar Pr©sentation Milstein, C©sar (1927-2002), immunologiste britannique d'origine argentine, colaur©at du prix Nobel de m©decine ou physiologie en 1984. De Buenos Aires   Cambridge Les anticorps monoclonaux M©dias Encarta vous int©resse ? Abonnez-vous d¨s maintenant et b©n©ficiez de : Plus de 30 000 articles 2 000 analyses d'oeuvre Plus de 12 000 m©dias (dont des extraits sonores, des vid©os et des m©dias interactifs) Un atlas mondial interactif Un guide du Web Plus de r©sultats pour Milstein, C©sar Autres fonctionnalit©s Encarta Rechercher Milstein, C©sar © 2005 Microsoft Politique de confidentialit© Conditions d'utilisation Publicit© Aide

77. MSN Encarta - Résultats De La Recherche - Milstein César milstein César César milstein ( TheNobel Foundation) César milstein ( The Nobel Foundation) http://fr.encarta.msn.com/Milstein_César.html

fdbkURL="/encnet/refpages/search.aspx?q=Milstein+C%c3%a9sar#bottom"; errmsg1="Please select a rating."; errmsg2="Please select a reason for your rating."; Accueil MSN Mon MSN Hotmail Rechercher ... Tout savoir sur la gamme Encarta Rechercher sur Encarta R©serv© aux abonn©s MSN Encarta Premium. R©sultats de la recherche Encarta pour ' Articles Milstein, C©sar Milstein, C©sar (1927-2002), immunologiste britannique d'origine argentine, colaur©at du prix Nobel de m©decine ou physiologie en 1984. ... , (1921-1998), artiste fran§ais, h©ritier de la tradition de la sculpture soud©e et inventeur de techniques nouvelles. Afficher tous les r©sultats dans le contenu Articles (189) M©dias C©sar Milstein Jules C©sar C©sar (Jules), ... Ge´le de C©sar Borgia Afficher tous les r©sultats dans le contenu M©dias (9) MSN Encarta Premium 28 r©sultats sur MSN Encarta 198 r©sultats sur MSN Encarta Premium Cliquez ici pour vous abonner ! Publicit© Encyclop©die M©diath¨que Quiz Produits ... dans le monde Publicit© Nos partenaires Rue des ‰coles Tests de culture g©n©rale et de QI Quiz : ©valuez votre anglais © 2005 Microsoft Accord de confidentialit© MSN Conditions d'utilisation Annonceurs Aide

78. Blackwell Synergy - Cookie Absent César milstein (1927 2002). Göran Möller. César milstein, Cambridge, Englandwas awarded the Nobel prize in Physiology or Medicine in 1984 for the http://www.blackwell-synergy.com/doi/abs/10.1046/j.0300-9475.2002.00001.x

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79. Monoclonal Antibody milstein, César César milstein, a molecular biologist and winner of the 1984Nobel Prize for Physiology or Medicine. This photograph was taken in the http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0022166.html

// Show bread crumbs navigation path. breadcrumbs('four'); //> From: www.tiscali.co.uk/reference/ ENCYCLOPAEDIA Hutchinson's Encyclopaedia Men's Health ... Wildlife Frames not supported Frames not supported Encyclopaedia Search Click a letter for the index A B C D ... Z Or search the encyclopaedia: monoclonal antibody Monoclonal antibody production. Antibodies are collected from a mouse after immunization and are fused with tumour cells grown in tissue culture to form antibody hybridomas. These are cloned to give large numbers from which the antibodies can be harvested. Antibody produced by fusing an antibody-producing lymphocyte (white blood cell) with a cancerous myeloma (bone-marrow) cell. The resulting fused cell, called a hybridoma, is immortal and can be used to produce large quantities of a single, specific antibody. By choosing antibodies that are directed against antigens found on cancer cells, and combining them with cytotoxic drugs, it is hoped to make so-called magic bullets that will be able to pick out and kill cancers. Related Links molecular biology antibody lymphocyte Wilkins, Maurice Hugh Frederick

80. Encyclopedia: César Milstein César milstein died in March 2002 in Cambridge, United Kingdom, aged 74. The cityof Cambridge is an old English university town and the regional centre of http://www.nationmaster.com/encyclopedia/César-Milstein

Supporter Benefits Signup Login Sources ... Pies Related Articles People who viewed "César Milstein" also viewed: Azerbaijan Airlines US Congressional Delegations from Tennessee What's new? Our next offering Latest newsletter Student area Lesson plans Recent Updates Hattie Jacques Haile Selassie I of Ethiopia HTTP HDvM ... More Recent Articles Top Graphs Richest Most Murderous Most Taxed Most Populous ... More Stats Encyclopedia: C©sar Milstein Updated 97 days 23 hours 29 minutes ago. Other descriptions of C©sar Milstein ) was born in Bahia Blanca Argentina . He graduated from the University of Buenos Aires and obtained a PhD under Professor Stoppani (Professor of Biochemistry ) in the Medical School on kinetic studies with the enzyme aldehyde dehydrogenase. In , funded by the British Council , he joined the Biochemistry Department at the University of Cambridge to work for a PhD under Malcolm Dixon on the mechanism of metal activation of the enzyme phosphoglucomutase . During this work he collaborated with Frederick Sanger whose group he joined with a short-term Medical Research Council appointment.

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