41. Entrez PubMed Nobel Prizes for immunology 1984 (Niels K. Jerne, cesar milstein, GeorgeKohler) Article in Dutch Bolhuis RL, Haaijman JJ. Publication Types Biography http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6

42. VnExpress - Bac Si Doat Giai Nobel Cesar Milstein Qua Doi O Tuoi 75 Translate this page Bác si do?t gi?i Nobel cesar milstein qua d?i ? tu?i 75. Nghiên c?u c?a giáo sucesar milstein giúp hi?u rõ hon co ch? ho?t d?ng c?a h? mi?n d?ch. http://vnexpress.net/Vietnam/Suc-khoe/2002/03/3B9BA6AA/

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43. Modification De Cesar Milstein - Modifier - Wikipédia Pagina nueva 1 Translate this page 10 de abril, Día del Investigador - Gracias, Doctor cesar milstein ¿Está deacuerdo con el camino mostrado por César milstein? http://fr.wikipedia.com/w/index.php?title=Cesar_Milstein&action=edit

44. César Milstein - Wikipedia Translate this page cesar milstein fue uno de los científicos argentinos más prestigiosos del mundo.Estudió en el Colegio Nacional de Bahía Blanca y obtuvo su diploma en la http://es.wikipedia.org/wiki/César_Milstein

C©sar Milstein De Wikipedia, la enciclopedia libre. Cesar Milstein m©dico y bioqu­mico nacido en Bah­a Blanca Provincia de Buenos Aires Argentina Cesar Milstein fue uno de los cient­ficos argentinos m¡s prestigiosos del mundo. Estudi³ en el Colegio Nacional de Bah­a Blanca y obtuvo su diploma en la Universidad de Buenos Aires . para Milstein obtuvo su primer doctorado como bi³logo celular, por su tesis sobre enzimas . Fue becado por la Universidad de Cambridge donde logr³ su segundo doctorado en , trabajando bajo la direcci³n del bioqu­mico molecular Frederick Sanger Milstein regres³ a la Argentina en como jefe se la Divisi³n de Biolog­a Molecular del Instituto Nacional de Microbiolog­a, pero s³lo estuvo un a±o en el cargo para regresar a Inglaterra tras el golpe militar de Estando en Cambridge a los 36 a±os, pas³ a formar parte del Laboratorio de Biolog­a Molecular y trabaj³ en el estudio de las inmunoglobinas , adelantando el entendimiento a cerca del proceso por el cual la sangre produce anticuerpos –las prote­nas encargadas de combatir a la presencia de cuerpos extra±os o ant­genos . Junto a G. K¶hler

45. César Milstein - Autobiography César milstein – Autobiography. César milstein. My father was a Jewish immigrantwho settled in Argentina, and was left to his own devices at the age of 15. http://nobelprize.org/medicine/laureates/1984/milstein-autobio.html

HOME SITE HELP ABOUT SEARCH ... Fred Sanger Part-time clinical analyst at Laboratorios Liebeschutz (Universidad de Buenos Aires) British Council Fellowship at the Department of Biochemistry, University of Cambridge Ph.D. degree (University of Cambridge) Scientific staff of Medical Research Council at the Department of Biochemistry, University of Cambridge Scientific Staff of Medical Research Council Laboratory of Molecular Biology, Cambridge Head, Protein and Nucleic Acid Chemistry Division, Cambridge Prizes and Awards From Les Prix Nobel. The Nobel Prizes 1984 , Editor Wilhelm Odelberg, [Nobel Foundation], Stockholm, 1985 This autobiography/biography was written at the time of the award and later published in the book series Les Prix Nobel Nobel Lectures . The information is sometimes updated with an addendum submitted by the Laureate. To cite this document, always state the source as shown above. The Nobel Prize in Physiology or Medicine 1984 Press Release Presentation Speech Niels K. Jerne ... Other Resources The 1984 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Nobelprize.org

46. Medicine 1984 Niels K. Jerne, Georges JF Köhler, César milstein. Niels K. Jerne, Georges JFKöhler, César milstein. third 1/3 of the prize, third 1/3 of the prize http://nobelprize.org/medicine/laureates/1984/

HOME SITE HELP ABOUT SEARCH ... EDUCATIONAL The Nobel Prize in Physiology or Medicine 1984 "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies" Niels K. Jerne Georges J.F. Köhler César Milstein 1/3 of the prize 1/3 of the prize 1/3 of the prize Denmark Federal Republic of Germany Argentina and United Kingdom Basel Institute for Immunology Basel, Switzerland Basel Institute for Immunology Basel, Switzerland MRC Laboratory of Molecular Biology Cambridge, United Kingdom b. 1911 d. 1994 b. 1946 d. 1995 b. 1927 (in Bahia Blanca, Argentina) d. 2002 The Nobel Prize in Physiology or Medicine 1984 Press Release Presentation Speech Niels K. Jerne ... Other Resources The 1984 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Nobelprize.org Get to know all 770 Prize Winners! » Games and Simulations » SITE FEEDBACK ... TELL A FRIEND Last modified April 14, 2005

47. Fundación Konex Dr milstein graduated as Doctor in Chemistry at the School of Exact and Natural In 1975, Dr milstein discovered and prepared the first monoclonal http://www.fundacionkonex.com.ar/ingles/premios/curriculum.asp?ID=764

48. Milstein, César - Columbia Encyclopedia® Article About Milstein, César Columbia Encyclopedia® article about milstein, César. milstein, César. Informationabout milstein, César in the Columbia Encyclopedia®. http://columbia.thefreedictionary.com/Milstein, César

Domain='thefreedictionary.com' word='Milstein, César' Your help is needed: American Red Cross The Salvation Army join mailing list webmaster tools Word (phrase): Word Starts with Ends with Definition subscription: Dictionary/ thesaurus Computing dictionary Medical dictionary Legal dictionary Financial dictionary Acronyms Columbia encyclopedia Wikipedia encyclopedia Hutchinson encyclopedia Also found in: Hutchinson 0.03 sec. Page tools Printer friendly Cite / link Email Feedback Click the link for more information. , he developed the hybridoma technique for producing monoclonal antibodies monoclonal antibody, an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunity ) to a fast-growing cell, such as a cancer cell (sometimes referred to as an "immortal" cell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody. Click the link for more information.

49. Milstein, Nathan - Columbia Encyclopedia® Article About Milstein, Nathan milstein, Nathan. Information about milstein, Nathan in the Columbia Encyclopedia® . milstein, César milstein, Nathan Miltiades Milton Milton Keynes http://columbia.thefreedictionary.com/Milstein, Nathan

Domain='thefreedictionary.com' word='Milstein, Nathan' Your help is needed: American Red Cross The Salvation Army join mailing list webmaster tools Word (phrase): Word Starts with Ends with Definition subscription: Dictionary/ thesaurus Computing dictionary Medical dictionary Legal dictionary Financial dictionary Acronyms Columbia encyclopedia Wikipedia encyclopedia Hutchinson encyclopedia Milstein, Nathan Also found in: Hutchinson 0.03 sec. Page tools Printer friendly Cite / link Email Feedback Milstein, Nathan, Mentioned in References in classic literature No references found No references found Columbia browser Full browser Milos Milosevic, Slobodan Milosh Milosz, Czeslaw ... Milpitas Milstein, Nathan Miltiades Milton Milton Keynes Milton, John ... Milstein, César Milstein, Nathan MILSTEP MILSTICC MILSTICCS MILSTRAP ... Miltary advances of Genghis Khan Word (phrase): Word Starts with Ends with Definition Free Tools: For surfers: Browser extension Word of the Day NEW! Help For webmasters: Free content NEW!

50. Hispanos Famosos César milstein shared the Nobel Prize for pioneering contributions to the theoryand techniques of immunology, which were said to lay the basis for http://coloquio.com/famosos/milstein.html

César Milstein (1927- ), Argentina. Nobel Prize for Medicine and Physiology, 1980. César Milstein shared the Nobel Prize for "pioneering contributions to the theory and techniques of immunology, which were said to lay the basis for advances in medical areas such as cancer treatment and the detection of acquired immune deficiency syndrome (AIDS). In work with his colaureate Georges J. F. Koehler, Milstein developed the techniques for producing monoclonal antibodies, antibodies with a specific affinity for certain sites in the body that might find diseased cells but leave healthy cells

51. Milstein, César milstein, César. (b. Oct. 8, 1926, Bahía Blanca, Arg.), Argentine immunologistwho in 1984, with Georges Köhler and Niels K. Jerne, received the Nobel Prize http://www.britannica.com/nobel/micro/394_71.html

and Niels K. Jerne , received the Nobel Prize for Physiology or Medicine for his work in the development of monoclonal antibodies. Milstein attended the universities of Buenos Aires and Cambridge (Ph.D., 1960) and was on the staff of the National Institute of Microbiology in Buenos Aires (1957-63). Thereafter he was a member of the Medical Research Council Laboratory of Molecular Biology, Cambridge, Eng., and held dual Argentine and British citizenship. the cells of a myeloma, a type of tumour that can be made to reproduce indefinitely. The resulting hybrid cells retained the two desired properties: like the lymphocytes, they secreted a single species of antibody molecules, and, like myeloma cells, they perpetuated themselves, providing potentially unlimited amounts of any desired antibody. This technique enabled the production of large quantities of pure, uniform antibodies that are able to recognize single antigenic determinants ( i.e., a single characteristic of a particular microbial invader in the body). ( See also antibody In 1994 Milstein was made a Companion of Honour.

52. César Milstein milstein, César, 1927–2002, AngloArgentine immunologist, Ph.D. Cambridge Univ., 1960.He worked (1961–63) at the National Institute of Microbiology, http://www.factmonster.com/ce6/people/A0833249.html

Home U.S. People Word Wise ... Homework Center Fact Monster Favorites Hurricane Katrina Children as Authors Children Inventors The Doctor's In ... 2006 TFK Almanac Reference Desk Atlas Almanacs Dictionary Encyclopedia ... Encyclopedia , he developed the hybridoma technique for producing monoclonal antibodies , pure, mass-produced antibodies that recognize only one antigen (see immunity Jerne ) shared the Nobel Prize in Physiology or Medicine. The Columbia Electronic Encyclopedia, Page Tools: Cite Print See more Encyclopedia articles on: Medicine: Biographies AD AD AD ADS Business Cards Link to Fact Monster Add Fact Monster search ... Privacy Brought to you by: Information Please

53. Milstein, César milstein, César (1927). Argentine-born British molecular biologist who developedmonoclonal antibodies, giving immunity against specific diseases. http://www.cartage.org.lb/en/themes/Biographies/MainBiographies/M/Milstein/1.htm

Argentine-born British molecular biologist who developed monoclonal antibodies, giving immunity against specific diseases. He shared the Nobel Prize for Physiology or Medicine 1984 with and Niels Jerne Monoclonal antibodies are cloned cells that can be duplicated in limitless quantities and, when introduced into the body, can be targeted to seek out sites of disease. Milstein and his colleagues had thus devised a means of accessing the immune system for purposes of research, diagnosis, and treatment. Milstein was born in Bahia Blanca and studied at Buenos Aires. From 1963 he worked in the UK at the Laboratory of Molecular Biology, Cambridge, and later became joint head of its Protein Chemistry Division. Milstein and his colleagues were among the first to determine the complete sequence of the short, low-molecular-weight part of the immunoglobulin molecule (known as the light chain). He then determined the nucleotide sequence of a large portion of the messenger RNA for the light chain. His findings led him to the technique for preparing monoclonal antibodies.

54. International: Italiano: Salute: Medicina: Medici E Ricercatori: Milstein, Cé Translate this page Italiano Salute Medicina Medici e Ricercatori milstein, César - Open Site . In tutta la Directory, Solo in Medici_e_Ricercatori/milstein,_César http://open-site.org/International/Italiano/Salute/Medicina/Medici_e_Ricercatori

Open Site The Open Encyclopedia Project Pagina principale Aggiungi Contenuti Diventa Editore In tutta la Directory Solo in Medici_e_Ricercatori/Milstein,_C©sar Top International Italiano Salute ... Medici e Ricercatori : Milstein, C©sar Vedi anche: International: Italiano: Societ : Strutture Sociali: Persone: Biografie: Premio Nobel Questa Categoria ha bisogno di un Editore - Richiedila Open Site Code 0.5.3 robot company. Visit our sister sites dmoz.org mozilla.org chefmoz.org musicmoz.org ... modifica

55. Educ.ar Biblioteca Translate this page Entrevista a César milstein*. Celoso de su privacidad y renuente al diálogopúblico, César milstein concedió a educ.ar una entrevista telefónica desde la http://www.educ.ar/educar/superior/biblioteca_digital/verdocbiblio.jsp?url=S_B_P

56. César Milstein (1927 - ) César milstein (1927 ). Born in Bahía Blanca, Argentina, César milstein graduatedfrom Buenos Aires University with an undergraduate degree in chemistry http://www.accessexcellence.org/RC/AB/BC/Cesar_Milstein.html

Milstein conducted groundbreaking work into the synthesis of antibodies, proteins that are produced by the cells of the immune system in response to attacks by foreign bodies called antigens. His work was instrumental in the development of monoclonal antibody technology . By fusing antibody-producing B lymphocyte cells with tumor cells that are "immortal," his lab was able to produce a "hybridoma," which could continuously synthesize antibodies. All of the antibodies produced by this type of hybridoma cell were identical, the same as those produced by the B cell before it was fused. Because the antibodies that are produced by this process all come from a single clone of hybridoma cells, they are called monoclonal antibodies. This technique of monoclonal antibody production, developed in 1975 with Georges Kohler, has been used extensively in the commercial development of new drugs and diagnostic tests. For his efforts, Milstein was awarded the Nobel Prize for Physiology or Medicine with Georges Kohler and Niels Jerne in 1984. Go to next profile: Kary B. Mullis

57. César Milstein - Wikipedia, The Free Encyclopedia César milstein died in March 2002 at age 74 in Cambridge, United Kingdom.See also 1984 Nobel prize. This Argentine biographical article is a stub. http://en.wikipedia.org/wiki/Cesar_Milstein

C©sar Milstein From Wikipedia, the free encyclopedia. (Redirected from Cesar Milstein C©sar Milstein October 8 March 24 ), a British-Argentine scientist, was born in Bahia Blanca Argentina . He graduated from the University of Buenos Aires and obtained a PhD under Professor Stoppani (Professor of Biochemistry ) in the Medical School on kinetic studies with the enzyme aldehyde dehydrogenase. In , funded by the British Council , he joined the Biochemistry Department at the University of Cambridge to work for a PhD under Malcolm Dixon on the mechanism of metal activation of the enzyme phosphoglucomutase . During this work he collaborated with Frederick Sanger whose group he joined with a short-term Medical Research Council appointment. In , Milstein and K¶hler described the hybridoma technique for producing monoclonal antibodies . They immortalised antibody producing cells by fusing them with tumour cells. The resulting antibody cell and all its daughter cells produce identical antibody molecules. The method allows unlimited production of monoclonal antibodies with predetermined specificity. In recognition of this, he won a Nobel Prize in Medicine and Physiology in (shared with Georges J.F. K¶hler

58. César Milstein 1927-2002 César milstein died early on Sunday 24th March as a result of a heart conditionagainst which he had battled courageously for many years. http://www2.mrc-lmb.cam.ac.uk/Cesar_Milstein.html

Milstein himself made many major contributions to improvements and developments in monoclonal antibody technology - especially focussing on the use of monoclonal antibodies to provide markers that allow distinction between different cell types. He also foresaw the potential wealth of ligand-binding reagents that could result from applying recombinant DNA technology to monoclonal antibodies and inspired the development of the field of antibody engineering. Milstein was born in Argentina where he started his research career at the University of Buenos Aires in enzymology, working with Prof A Stoppani on aldehyde dehydrogenase. In 1958, he came to Cambridge, funded by the British Council, to work with Malcolm Dixon in the Biochemistry Department. Here he did a PhD, working on the mechanism of metal activation of phosphoglucomutase. He then returned to Argentina but, after two years, resigned his job there as a result of the political situation and came back to Cambridge in 1963 to work in the Division of Protein Chemistry in the MRC Laboratory of Molecular Biology. It was at this stage that, following the advice of Fred Sanger, Milstein changed his field of study from enzymes to antibodies. Obituaries The Guardian LMB Home Page

59. The Nobel Prize In Physiology Or Medicine 1984: César Milstein The Nobel Prize in Physiology or Medicine 1984 César milstein *1927, † 2002.External links. The Nobel Prize César milstein The Nobel Foundation http://www.nobelpreis.org/english/medizin/milstein.htm

The Nobel Prize in Physiology or Medicine 1984 Next Previous Search Home ... Economics (Argentina) "For theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies" ( jointly with Nils Kaj Jerne and External links The Nobel Foundation powered by xago.org - The World Heritage Sites Webmaster Services

60. Der Nobelpreis Für Physiologie Oder Medizin: César Milstein Kaj Jerne und Georges Köhler ). César milstein *1927, † 2002. PAGERANK SEO. http://www.nobelpreis.org/medizin/milstein.htm

vor suchen Home Chemie ... Wirtschaft (Argentinien) "Für ihre Theorien über den spezifischen Aufbau und die Steuerung des Immunsystems und die Entdeckung des Prinzips der Produktion von monoklonalen Antikörpern" ( gemeinsam mit Nils Kaj Jerne und

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