61. Biology Division - 1950s – Fungi, Flies And Phage Harry Rubin, George Streisinger, Naomi Franklin, andre lwoff, Charles Steinberg,Frank Stahl, Howard Temin, Matthew Meselson, Harriet EphrussiTaylor, http://biology.caltech.edu/about/history/1950s.html

@import url(http://biology.caltech.edu/ploneColumns.css); @import url(http://biology.caltech.edu/plone.css); @import url(http://biology.caltech.edu/ploneCustom.css); Skip to content. about the division calendar news ... contact About the Division of Biology 1950s – Fungi, Flies and Phage "Following World War II many outstanding advances in biology have been made in laboratories all over the world. To mention only a few of these: Bacteriology has been revolutionized by a group of young investigators using the methods of genetics, cytology, and biochemistry. Our knowledge of viruses has been greatly increased, particularly from a biological point of view. Through a growing interest by physicists and physical chemists in biological problems, biophysics has grown rapidly. It has made extensive use of the electron microscope, the preparative and analytical centrifuges, the Tiselius electrophoresis apparatus and other techniques completely unknown to the biology of a few years ago." Caltech Biology Annual Report, 1950. In terms of faculty appointments, the 1950s were quantitatively static. In the course of the decade all of the associate professors hired in the late 1940s became full professors, and four new faculty members joined the Division, all at the level of associate or full professors (Arthur Galston, 1951, Renato Dulbecco, 1952, Roger Sperry, 1954 and Robert Sinsheimer, 1957). By the 1957-58 school year, and until the end of the decade, there were no associate or assistant professors. Four faculty members departed in the '50s – MacGinitie retired in 1957, E.G. Anderson in 1959, Went departed (1959) to become head of the Missouri Botanical Garden, and Arthur Galston left to join the faculty at Yale in 1955.

62. Tetrahymena thermophila Genome Project a microbial animal model ever since Nobel Laureate andre lwoff succeededin growing T. pyriformis (then called Glaucoma piriformis) in pure culture. http://www.tigr.org/tdb/e2k1/tta1/intro.shtml

Tetrahymena thermophila Genome Project TIGR Home TIGR Database Genome Home Introduction ... Annotation Database Search Gene Name Search PFAM Search Sequence Search Download Sequences ... T. thermophila Links Introduction - The Tetrahymena thermophila Genome Database The T. thermophila genome For Comments/Questions send mail to jeisen@tigr.org

63. INTERNATIONAL * ***** * * * ****** SOCIETY FOR andre lwoff 19021994 andre lwoff, born near Vichy, France, on 8 May 1902, andpassing away in Paris on 30 September 1994, will probably go down in history http://megasun.bch.umontreal.ca/isep/news5.html

64. Annonces De Séminaires andre lwoff Salle de Conférences - bâtimentB - 3ème étage 7, rue Guy Moquet - 94801 Villejuif Cedex http://www.necker.fr/irnem/Seminaires.htm

Les Instituts et Organismes de recherche : Les séminaires du site Necker-Enfants Malades Tableau de Réservation de la salle de réunion de l'IRNEM (Salle n°24, 1er étage de la Faculté Necker) Nous vous informons qu'à compter du 1er septembre 2004 la salle de réunion de l'IFR située au 1er étage de la Faculté Necker (porte n° 24) ne sera pas accessible durant 7 mois environ, en raison des travaux de désamiantage. Nous vous invitons donc à prévoir une autre salle pour vos réunions dès la rentrée prochaine. TEL : 01 40 61 53 10 FAX : 01 43 06 04 43 Planning des Séminaires de Biologie de la « Tour Pasteur » CONFERENCES PHILIPPE LAUDAT (actuellement suspendues pour raisons budgétaires) Les séminaires de l'Institut Jacques Monod Les Conférences Jacques Monod Les séminaires du CUSP Les séminaires de l'Institut PASTEUR ... "Transfert de la recherche d’amont vers la clinique» Cette manifestation, dédiée à la communauté scientifique d’Ile de France (Genopole, AFM/Généthon, Pôle Meditech Santé, ) se déroulera: Lundi 19 septembre 2005 de 9h à 18h au Génocentre

65. Index To Scientists And Engineers Biographical File (Library Of Congress) LOWRY, OLIVER H. P, BIB. LUDWIG, HARVEY F. P, BIB. LURIA, ALEXANDER R. P. LUSH,JAY L. BIB, P. LUYTEN, WILLEM J. P. lwoff, andre BIB. LYNEN, FEODOR BIB http://www.loc.gov/rr/scitech/sci-eng-em.html

Index to the Scientists and Engineers Biographical File About the Scientists and Engineers Biographical File What is the Scientists and Engineers Biographical File? It is a collection of hard copy files with information on scientists who were prominent in the early 1970s. It consists of folders containing photographs, biographical information and bibliographies of 1200 American and 100 foreign scientists and engineers. How was the collection formed? The collection was formed during the years 1972 - 75. The Science and Technology Division contacted well known and lesser known scientists and engineers of the mid-twentieth century, and asked them to donate the materials. Those asked included: Members of the National Academy of Sciences and the National Academy of Engineers Scientists listed in Who's Who in Science and Engineers of Distinction Nobel Prize recipients and winners of the National Medal for Science Members of Scientists in Search of Their Consciences. Who should use the The Scientists and Engineers Biographical File?

66. ORNL's Unsung Discovery In 1965 French scientists Monod, Jacob, and andre lwoff received the Nobel Prizein Physiology or Medicine for elucidating the nature of mRNA from their http://www.ornl.gov/info/ornlreview/v37_3_04/article12.shtml

Search Magazine ORNL's Unsung Discovery Two ORNL researchers "discovered" messenger RNA in 1956, but the Nobel Prize went to other researchers who rediscovered it later. The original discovery of messenger RNA (mRNA) by two Oak Ridge National Laboratory scientists "has never received the acclaim it deserves," says Alvin M. Weinberg, former ORNL director and a distinguished fellow of Oak Ridge Associated Universities. Ken Volkin discovered messenger RNA in 1956 at ORNL but called it "DNA-like RNA." Weinberg is referring to Elliot "Ken" Volkin and Lazarus Astrachan's 1956 discovery of what they called "DNA-like-RNA," which François Jacob and Jacques Monod later identified as "messenger RNA." The discovery, for which Jacob and Monod received a Nobel Prize, was "next to the original discovery of the molecular structure of DNA, probably the most important event in the history of molecular biology," Weinberg says. Paul Berg, winner of the 1980 Nobel Prize in Chemistry, calls the ORNL research an "unsung but momentous discovery of a fundamental mechanism in genetic chemistry" and a "seminal discovery [that] has never received its proper due." Messenger RNA is the life-sustaining ribonucleic acid (RNA) that serves as the living cell's template for protein synthesis. Volkin and Astrachan first discovered the acid three years after James Watson and Francis Crick determined the structure of DNA, which makes up genes. For this 1953 discovery Watson, Crick, and Maurice Wilkins received the Nobel Prize for Medicine or Physiology in 1962.

67. Faculty Members The andre lwoff Professor of Neurogenetics. Room 427. Building Arthur andRochelle Belfer Building for Biomedical Research http://www.weizmann.ac.il/molgen/members/simantov.html

Rabi Simantov The Andre Lwoff Professor of Neurogenetics Room: Building: Arthur and Rochelle Belfer Building for Biomedical Research Tel: 972-8-934-2110 or 972-547-631-560 Fax: e-mail: rabi.simantov@weizmann.ac.il Identifying genes involved in neurodegenerative cell death and in psychoactive drug action The Psychoactive Drug MDMA (Ecstasy) Regulates in Concert a Group of Genes Associated with GABA Neurotransmission 3,4-Methylenedioxymethamphetamine (MDMA) is currently one of the most abundant psychoactive recreational drugs. It induces in vivo multiple neuropsychiatric behaviors, serotonergic neuron degeneration, hyperthermia and occasional death. Ecstasy also induces programmed death (apoptosis) of human (1) and other cultured cells. Using gene expression analysis in MDMA- treated mice, we identified changes in expression of two g Scheme: Pre- and Postsynaptic location of proteins involved in MDMA-induced GABA neurotrasmission. Genes Involved in Dopamine-Induced Apoptosis References 1. Simantov, R. and Tauber, M. (1997) The amphetamine analogue MDMA (Ecstasy) induces DNA fragmentation and cell death in human serotonergic cells : Involvement of nitric oxide. FASEB J. 11, 141-146.

68. Scientific Activities: Molecular Genetics The andre lwoff Professor of Neurogenetics; Talila Volk , Ph.D., Weizmann Instituteof Science, Rehovot, Israel The Professor Sir Ernest B. Chain Professor http://www.weizmann.ac.il/acadaff/Scientific_Activities/current/Molecular_Geneti

Department of Molecular Genetics Adi Kimchi, Head The Helena Rubinstein Chair in Cancer Research The department of Molecular Genetics focuses on molecular and genetic mechanisms underlying basic biological processes occurring either in the context of the entire organism or at the level of single cells. A wide range of biological problems are being addressed in the fields of human genetics, development, cell biology, cancer, and structure/ organization of genes. Additionally, the fields of bioinformatics and computational biology, which are being developed in the department, provide novel powerful approaches to address some of these biological issues. The specific topics include developmental studies in Drosophila and mouse model systems, a search for the molecular basis of a few human genetic diseases, the study of apoptosis and cancer promoting genes, study of cytokines and their receptors, virus-host interactions, control of gene expression, protein trafficking, and the structure, organization and evolution of genes. . They developed new strategies to inactivate or to activate receptors for the IL6 cytokine. A fusion protein of the soluble interleukin-6 receptor to interleukin-6 was found to stimulate myelin gene expression in vitro and of sciatic nerve remyelination. The chimera also enhances in vitro maintenance and proliferation of human stem cells (CD34(+)CD38(-/low). The lab of Menachem Rubinstein focuses on regulation and function of two other cytokines and their binding proteins. They identified a secreted protein capable of antagonizing IL18 and thus regulating the Th1 cytokine responses. Another studied cytokine is the leptin whose effects on ovarian steroidogenesis and on angiopoietin-2 expression in adipose tissues have been thoroughly investigated.

69. Elsevier.com - Biomedicine Pharmacotherapy ICIG, Hopital Paul Brousse, Bat andre lwoff, 14 av Paul Vaillant Couturier, 94800Villejuif, France, Tel 33 (0)1 49 58 11 53, Fax 33 (0)1 47 26 80 97, http://www.elsevier.com/wps/find/journaleditorialboard.cws_home/505810/editorial

Home Site map Regional Sites Advanced Product Search ... Select your view Entirely in English ISSN: 0753-3322 Editorial Board Founding Editor: G. Math© H´pital Suisse, F-92130 Issy-les-Moulineaux, France Editors-in-Chief: H. Tapiero France K D Tew USA G Bastist Canada Associate Editors: D. Machover H´pital Paul Brousse, F-94800 Villejuif, France M. Eriguchi Japan A. Carpi Italy Editorial Secretary M.C. Feuillet ICIG, Hopital Paul Brousse, Bat Andre Lwoff, 14 av Paul Vaillant Couturier, 94800 Villejuif, France, Tel: 33 (0)1 49 58 11 53, Fax: 33 (0)1 47 26 80 97, Email: feuillet@vjf.inserm.fr Editorial Board: L.C. Erickson USA P. Couvreur France J.S. Lazo USA B. Haendler Germany K. Umezawa Japan G. Powis USA A. Scalbert France A.P. Simopoulos USA H. Jakubowski USA P. Van Bladeren Switzerland Scientific Advisors: A. Harel-Bellan France M Alaoui-Jamali Canada S. Benita Israel R.V. Bensasson France A. Bensussan France M. Chevion Israel H.T. Duc France J.J. Ferguson, III USA H.W. Friedman France R. Giardino Italy P. Hermans Belgium A. Nicolini Italy J. Rappaport USA L. Robert France JP Routy Canada S.R. Steinhubl

70. Shulamit Michaeli, Ph.D. She has received the Clore Prize for Excellence, the Moshe Shilo Prize, and mostrecently in 1999 the andre lwoff Prize from the PasteurWeitzman Council http://www.hhmi.org/research/scholars/mich.html

HHMI-NIH Research Scholars Learn about the HHMI-NIH Research Scholars Program, also known as the Cloister Program. More Janelia Farm Research Campus Learn about the new HHMI research campus located in Virginia. More Shulamit Michaeli, Ph.D. BIOGRAPHY: Dr. Michaeli earned her Ph.D. in microbiology from Tel-Aviv University in 1985. She then did postdoctoral work until 1990 at the University of California in San Francisco and Berkeley. From 1990 to 1999 she worked at the Weizmann Institute of Science in Rehovot, Israel. She has received the Clore Prize for Excellence, the Moshe Shilo Prize, and most recently in 1999 the Andre Lwoff Prize from the Pasteur-Weitzman Council and French Academy of Science. Currently, she holds a position as Associate Professor of the Life Sciences Department of Bar-Ilan University in Israel. Dr. Michaeli is working on a project entitled " Trans -Splicing and Protein Translocation in Trypanosomes." RESEARCH ABSTRACT SUMMARY: Trans -Splicing and Protein Translocation in Trypanosomes Our research aims to understand the mechanism and machinery of trans trans -splicing, we now focus our research on RNA-binding proteins and splicing factors and their role in

71. Society Of Protozoologists: Portal To Protistology Evolutionary relationships In the 1930’s, andre lwoff and his collaboratorsidentified thiamine as a vitamin requirement. Subsequent work by others http://www.uga.edu/~protozoa/portal/acanthamoeba-Band.html

Acanthamoeb contributed by R. Neal Band and Frededrick L. Schuster Acanthamoeba spp. are found in a variety of soil, freshwater and brackish water environments, and some members of the genus are opportunistic pathogens of humans. In soil, they are part of a collection of organisms referred to as small amebae (compared to Amoeba proteus and other "large" amebae) which constitute a significant component of the soil habitat, reaching up to a million amebae per gram of soil. The Acanthamoeba life-cycle is comprised of a trophic (actively feeding) stage, and a thick-walled cystic (dormant) stage which forms under conditions of adversity, such as desiccation and lack of food. The trophic ameba has distinctive fine-pointed pseudopods (acanthopodia) that project from the surface. Cysts have been reported to remain viable under laboratory conditions for twenty-four years. With return of conditions optimal for growth, cysts germinate to give rise to trophic amebae. Differences in cyst morphology have been used to distinguish species of Acanthamoeba Ecology: Acanthamoeba spp. are found in virtually every type of soil and water habitat, and have even been isolated from Antarctic soil samples. The organism can also be isolated from home aquaria, humidifiers, flower pots, domestic water supplies and water taps, and other locations, which puts them in close contact with humans. Amebae isolated from nature are often found to harbor bacteria, implicating them as vectors of potentially pathogenic bacteria. They may, for example, play a role in the survival of bacteria such as

72. Tetrahymena Is A Eukaryotic Unicell (protozoan) That Has Been Used As An Animal It has been used as a microbial animal model for more than 75 years ever sinceNobel Laureate andre lwoff 1 in 1923 succeeded in growing this unicell http://www.lifesci.ucsb.edu/~genome/Tetrahymena/SeqInitiative/ConceptPaper.htm

Tetrahymena Whole-Genome Sequencing Project: A Concept Paper November 5, 2001 Preface . To facilitate access to the large diversity of information, this concept paper is organized into two components: Main and Appendix. The Main document contains the introductory overview of the case for sequencing the Tetrahymena genome, the concise description of the sequencing and annotation project, and the specific answers to the NonMammalian Models Committee questionnaire. The Appendix expands on the coverage of two topics in the main document: advanced molecular genetic tools and unique or very special studies that would be enabled by the availability of the genome sequence. The latter are grouped by topic into numbered tables for easy reference from the main document. All the cited references are listed in the Appendix, organized so that related references are generally clustered together. Page numbers in tables of contents (main and appendix) may be sensitive to software print settings and are therefore only approximate. Table of contents Section Topic Page Introduction: Why sequence the Tetrahymena genome?

73. Royal Society | About The Society | History Of Science | Biographies Of Fellows Lussac, Joseph Louis Gay. See Gay-Lussac, Joseph Louis. lwoff, andre Michel.Biographical Memoirs 1998 vol 44 pp 253-263, plate, by F Jacob and M Girard http://www.royalsoc.ac.uk/page.asp?id=2375

74. François Jacob Receives Lewis Thomas Prize joining andre lwoff s famed group at the Pasteur Institute in 1950. In 1965, Jacob shared the Nobel Prize in Medicine with Monod and lwoff for his http://www.rockefeller.edu/pubinfo/jacob.nr.html

Thursday, September 15, 2005 Calendar Directory Jobs Site Map ... Newswire University Quick Links Research News Events Academics Hospital Resource Centers Giving Departments About About Newswire For Journalists About the University Home ... Architect selected for north campus ‘bridging’ building An architect has been selected to design new laboratory buildings for the north end of the Rockefeller University campus, including the renovation of two existing structures and the construction of a new “bridging” building to connect them. Humanity in transition From a population perspective, the world is at a turning point. In the September issue of Scientific American, Rockefeller’s Joel Cohen describes how the population of the coming half century will be bigger, older, and more urban than ever before, and slower-growing than that of the previous 50 years. In flies, odorant receptors work together By tracing the location of nerve cells that produce specific odorant receptors, scientists have linked dozens of the proteins – important for detecting scents – to specific areas of the fruit fly brain. The findings suggest how the flies’ odorant receptors can work together to detect hundreds of scents despite their limited array of just 62 receptors. Rockefeller in the News September 14, 2005

75. English : PRESS Simantov holds the andre lwoff Chair of Neurogenetics. His team included graduatestudents and associates Helena Blinder, Shai Porat, Miriam Tauber, http://80.70.129.162/site/en/weizman.asp?pi=371&doc_id=901

76. English : Eurooean Committee andre lwoff, a Nobel prizewinner in medicine, and the first president of theFranceEurope committee. Working with Mrs. Simonne Veil, the former president http://80.70.129.162/site/en/weizman.asp?pi=427&doc_id=274

77. The Surprises Of Mammalian Molecular Cell Biology - Nature Medicine Thus I applied to andre lwoff, Chef de Service de Physiologie Microbienne at thePasteur Institute, in whose service Jacob worked. http://www.nature.com/nm/journal/v8/n10/full/nm773.html

@import "/nm/style.css"; nature.com homepage Login My account ... Browse by subject Search This journal All of nature.com Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology ... Browse all publications Commentary Nature Medicine doi:10.1038/nm773 The surprises of mammalian molecular cell biology James E. Darnell Jr. Laboratory of Molecular Cell Biology The Rockefeller University New York, New York, USA The opportunity provided by the Albert Lasker Award for Special Achievement in Medical Science to reflect on my 'career' does not, I am sure, give me license to dwell on the humid, sweltering summers of a childhood in Mississippi. But perhaps I may be permitted to say a brief word of thanks to my teachers at the University of Mississippi, especially Dean Parker, a Drosophila geneticist of the T.S. Painter School, and Robert Glaser, at the time an assistant professor of medicine at Washington University School of Medicine. Parker taught us what a gene was and how to observe its effects, but it was in Robert Glaser's rheumatic fever laboratory that I tried to do my first experiments. A colleague, Stephen Morse, and I infected rabbits in their tonsils with Group A streptococci in an effort, not completely unsuccessful, to mimic the secondary heart muscle damage that occurs in rheumatic fever as a sequel to infection by Group A streptococci After a year of internship, I had my introduction in 1956 to basic biomedical research in Harry Eagle's laboratory at the National Institutes of Health in Bethesda, Maryland. Eagle had worked on penicillin previously, but by the time I made it to Bethesda, he had developed a defined medium for reproducible propagation of mouse and human cells in culture, and had left behind his studies on penicillin. Eagle's work made homogeneous populations of human cells available for biochemical and virological studies. Perhaps because Eagle thought I had an abiding interest in infectious disease, it was strongly hinted that I should work on viruses. Good fortune can also favor the totally unprepared: I knew alarmingly little of viruses, but shared a room in the Eagle laboratory with Robert I. DeMars (

78. American Scientist Online - Forced To Choose Even more bizarre was the week I spent with heavyduty and little-known scientificdetective tales andre lwoff s Morphogenesis in Ciliates, http://www.americanscientist.org/template/AssetDetail/assetid/26578

Home Current Issue Archives Bookshelf ... Subscribe In This Section Reviewed in This Issue Book Reviews by Issue New Books Received Publishers' Directory ... Virtual Bookshelf Archive Site Search Advanced Search Visitor Login Username Password Help with login Forgot your password? Change your username see list of all reviews from this issue: November-December 1999 Forced to Choose Roald Hoffmann ROALD HOFFMANN Nobel Prize winner in chemistry; author of, most recently, Old Wine, New Flasks and co-writer (with Carl Djerassi) of the play Oxygen In a 1993 book ( Chemistry Imagined: Reflections on Science ) I write about the time in 1947 when I was 10 years old. We were in a DP ("displaced persons") camp in Wasseralfingen, then in the French Occupation Zone of postwar Germany, waiting for a visa to come to the United States. I read much, and somehow there came my way two books, biographies of scientists. One was of George Washington Carver, the black agricultural chemist, the other of Marie Curie by her daughter Eve. I read both in German translation. In the story of Carver I was fascinated by the transformations he wrought with the peanut and the sweet potato. Ink and coffee from peanuts, rubber and glue from the sweet potato! Perhaps part of the romance was that I had never seen or tasted either peanuts or sweet potatoes.

79. Nobel Prize Laureates With Russian Roots andre lwoff, was born in 1902 in family of emigrant from Russia. andre lwoff.Aleksandr Mikhailovich Prokhorov, was born in 1916 in family of emigrant http://www.rusalma.org/publ/nobel/Nobel Prize Laureates with Russian roots2004.h

add to Favorite Application form Registration form Discussion forum ... Home Alma Mater : Our publications Nobel Prize Laureates with Russian roots Vitaly L. Ginzburg was born in Moscow in1928. The Prize for pioneering contributions to the theory of superconductors and superfluids. , physics). Nobel Lectures. Alexei A. Abrikosov was born in The Prize for pioneering contributions to the theory of superconductors and superfluids , physics). Nobel Lectures. Zhores I. Alferov , was born in 1930. The Prize for developing semiconductor heterostructures used in high-speed and opto-electronics.( , physics). Nobel Lecture Mikhail Sergeyevich Gorbachev , was born in 1931. The Prize for his leading role in the peace process which today characterizes important parts of the international community. ( , peace).

80. ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY lwoff, andre, 1965. Lynen, Feodor, 1964. Macleod, John James Richard, 1923.Mechnikov, Ilya Ilyich, 1908. Medawar, Sir Peter Brian, 1960 http://www.bioscience.org/urllists/nobelc.htm

FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY, PHYSIOLOGY AND MEDICINE ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY Name Year Awarded Alder, Kurt Altman, Sidney Anfinsen, Christian B. Arrhenius, Svante August ... Zsigmondy, Richard Adolf ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Zinkernagel, Rolf M. Source: The Nobel Prize Internet Archive

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