21. Eric R. Kandel - Wikipedia, Den Fria Encyklopedin Eric R. Kandel, född i Wien, Österrike, 1929, amerikansk Nobelpristagare i fysiologi eller medicin år 2000. Han tilldelades priset för sina upptäckter http://sv.wikipedia.org/wiki/Eric_R._Kandel

Eric R. Kandel Fr¥n Wikipedia, den fria encyklopedin. Nobelpriset i fysiologi eller medicin Eric R. Kandel , f¶dd i Wien, –sterrike, , amerikansk Nobelpristagare i fysiologi eller medicin ¥r . Han tilldelades priset f¶r sina " uppt¤ckter r¶rande signalsubstanser i nervsystemet ". Han delade priset med sin landsman Paul Greengard och svensken Arvid Carlsson Signalerna fr¥n en nervcell till en annan ¶verf¶rs med hj¤lp av olika signalsubstanser . Signal¶verf¶ringen sker i speciella kontaktpunkter, synapser . En enda nervcell kan ha tusentals kontaktpunkter med andra nervceller. Carlsson har uppt¤ckt att dopamin ¤r en s¥dan signalsubstans i hj¤rnan och att dopamin har stor betydelse f¶r kontroll av v¥ra r¶relser. Hans forskningsr¶n ledde i sin tur till insikten att Parkinsons sjukdom orsakas av dopaminbrist i vissa delar av hj¤rnan och till att man kunde f¥ fram ett effektivt l¤kemedel (L-dopa) mot denna sjukdom. Greengard uppt¤ckte hur dopamin och en rad andra signalsubstanser ut¶var sina effekter i nervsystemet. Signalsubstanserna p¥verkar f¶rst en receptor p¥ cellens yta. Det utl¶ser en kaskad av reaktioner som p¥verkar vissa "nyckelproteiner" som i sin tur reglerar olika funktioner i cellen. Proteinernas form och funktion f¶r¤ndras genom att fosfatgrupper tillf¶rs (fosforylering) eller tas bort (defosforylering). Genom denna mekanism kan signalsubstanser ¶verf¶ra sina budskap mellan nervceller. Kandel uppt¤ckte sedan hur synapsernas effektivitet kan f¶r¤ndras och med vilka molekyl¤ra mekanismer detta sker. Han visade att synapsernas funktion ¤r central f¶r inl¤rning och minne. F¶r uppkomsten av en form av korttidsminne spelar proteinfosforylering i synapsen en viktig roll. F¶r att ett l¥ngtidsminne ska uppst¥ kr¤vs dessutom nybildning av proteiner som bl.a. leder till att synapsens form och funktion f¶r¤ndras.

22. Thomas Hunt Morgan At Columbia University Essay by eric R. kandel which explores Hunt's work and achievements, and his relationship with the University. Includes a bibliography. http://www.columbia.edu/cu/alumni/Magazine/Legacies/Morgan/

THOMAS HUNT MORGAN AT COLUMBIA UNIVERSITY Genes, Chromosomes, and the Origins of Modern Biology Eric R. Kandel . . . . the rise and development of genetics to mature age is another instance of an all-comprising and all-affecting generalization based upon an overwhelming body of integrated facts, . . . [and] will rank in the history of science with such other great events as mentioned, . . . The basic tenets of genetics have already influenced decisively all parts of biology after what has been only a short span in the history of science; and further that beyond this, many other fields of science have fallen under the spell and we have every reason to believe that genetics is bound to remain in a pivotal position in the future. Richard B. Goldschmidt, The Impact of Genetics Upon Science When future historians turn to examine the major intellectual accomplishments of the twentieth century, they will undoubtedly give a special place to the extraordinary achievements in biology, achievements that have revolutionized our understanding of life's processes and of disease. Important intimations of what was to happen in biology were already apparent in the second half of the nineteenth century. Darwin had delineated the evolution of animal species, Mendel had discovered some basic rules about inheritance, and Weissman, Roux, Driesch, de Vries, and other embryologists were beginning to decipher how an organism develops from a single cell. What was lacking at the end of the nineteenth century, however, was an overarching sense of how these bold advances were related to one another.

23. Eric R. Kandel - Prize Award Photo eric R. kandel and His Majesty the King. eric R. kandel receiving his Nobel Prize from His Majesty the King. Photo Hans Mehlin, Nobelprize.org http://nobelprize.org/medicine/laureates/2000/kandel-award.html

HOME SITE HELP ABOUT SEARCH ... EDUCATIONAL Eric R. Kandel receiving his Nobel Prize from His Majesty the King. Photo: Hans Mehlin, Nobelprize.org The Nobel Prize in Physiology or Medicine 2000 Press Release Presentation Speech Educational ... Other Resources The 2000 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Nobelprize.org Get to know all 770 Prize Winners! » Games and Simulations » SITE FEEDBACK ... TELL A FRIEND Last modified April 14, 2005

24. Medicine 2000 Arvid Carlsson, Paul Greengard, eric R. kandel. third 1/3 of the prize, third 1/3 of the prize, third 1/3 of the prize http://nobelprize.org/medicine/laureates/2000/

HOME SITE HELP ABOUT SEARCH ... EDUCATIONAL The Nobel Prize in Physiology or Medicine 2000 "for their discoveries concerning signal transduction in the nervous system" Arvid Carlsson Paul Greengard Eric R. Kandel 1/3 of the prize 1/3 of the prize 1/3 of the prize Sweden USA USA Göteborg University Gothenburg, Sweden Rockefeller University New York, NY, USA Columbia University New York, NY, USA b. 1923 b. 1925 b. 1929 (in Vienna, Austria) The Nobel Prize in Physiology or Medicine 2000 Press Release Presentation Speech Educational ... Other Resources The 2000 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Nobelprize.org Get to know all 770 Prize Winners! » Games and Simulations » SITE FEEDBACK ... TELL A FRIEND Last modified April 14, 2005

25. Eric R. Kandel Summary eric kandel s lab is studying examples of the major forms of memory storage. The lab is studying explicit memory storage (the eric R. kandel http://www.hhmi.org/research/investigators/kandel.html

HHMI-NIH Research Scholars Learn about the HHMI-NIH Research Scholars Program, also known as the Cloister Program. More Janelia Farm Research Campus Learn about the new HHMI research campus located in Virginia. More Cell and Molecular Biological Studies of Memory Storage Summary: Eric Kandel's lab is studying examples of the major forms of memory storage. The lab is studying explicit memory storage (the conscious recall of information about people, places, and objects) in mice and implicit memory storage (the unconscious recall of perceptual and motor skills) in the snail Aplysia . In Aplysia , the lab has focused on the implicit memory for sensitization, a simple form of learned fear, and the mechanisms for achieving synapse-specific anatomical changes. In mice, they have examined the synaptic mechanisms contributing to memory for space, a complex form of explicit memory storage. The general finding that long-term plasticity and long-term memory recruit transcription in the nucleus, an organelle shared by all synapses of a neuron, has raised a question we have begun to explore in Aplysia and mice: Are long-term changes cell-wide, or can induced gene products be spatially compartmentalized, so that they selectively alter the function of some synapses and not others? In mice we have also explored the molecular mechanisms whereby attention modifies and stabilizes internal representation of space.

26. Eric R. Kandel, M.D. eric R. kandel. By probing the synaptic connections between nerve cells in the humble sea slug, eric kandel has uncovered some of the basic molecular http://www.hhmi.org/research/investigators/kandel_bio.html

HHMI-NIH Research Scholars Learn about the HHMI-NIH Research Scholars Program, also known as the Cloister Program. More Janelia Farm Research Campus Learn about the new HHMI research campus located in Virginia. More Eric R. Kandel, M.D. By probing the synaptic connections between nerve cells in the humble sea slug, Eric Kandel has uncovered some of the basic molecular mechanisms underlying learning and memory in animals ranging from snails to flies to mice and even in humans. His groundbreaking studies have demonstrated the fundamental ways that nerve cells alter their response to chemical signals to produce coordinated changes in behavior. This work is central to understanding not only normal memory but also dementia and other mental illnesses that affect memory. Kandel's research has shown that learning produces changes in behavior by modifying the strength of connections between nerve cells, rather than by altering the brain's basic circuitry. He went on to determine the biochemical changes that accompany memory formation, showing that short-term memory involves a functional modulation of the synapses while long-term memory requires the activation of genes and the synthesis of proteins to grow new synaptic connections. For this work, the Austrian-born Kandel was awarded the 2000 Nobel Prize in Physiology or Medicine. The traumatic events of Kandel's childhood likely influenced his later interest in the biological mechanisms of memory. He was only eight when, in 1938, Nazi Germany annexed his homeland, but the humiliation and discrimination that Kandel, his family, and other Jews suffered under this oppressive regime were forever seared into his memory. In 1939, on the eve of World War II, his family fled Austria for the United States.

27. [NeuroBio: Faculty And Labs] Eric R. Kandel, M.D., University Professor eric R. kandel, MD, University Professor. erk5@columbia.edu. CELL AND MOLECULAR MECHANISMS OF ASSOCIATIVE AND NONASSOCIATIVE LEARNING http://cpmcnet.columbia.edu/dept/neurobeh/Kandel.html

Faculty and Labs Neurobiology of Behavior and Learning Eric R. Kandel, M.D., University Professor erk5@columbia.edu CELL AND MOLECULAR MECHANISMS OF ASSOCIATIVE AND NON-ASSOCIATIVE LEARNING See Also: [ Kandel Lab Home Page ] and [ HHMI Page We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia. We study three elementary forms of learning: habituation, sensitization, and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short- and long-term memory. In vertebrates we use genetically modified mice to examine the mechanisms of long-term potentiation in the mammalian hippocampus and its relation to spacial memory and maintenance. Selected publications Bartsch D., Ghirardi M., Casadio A., Giustetto M., Karl K.A., Zhu H. and Kandel E.R. (2000). Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2. Cell, 103: 595-608.

28. [Physiology And Cellular Biophysics Faculty]Eric R. Kandel, M.D. eric R. kandel, MD PROFESSOR OF PHYSIOLOGY CELLULAR BIOPHYSICS, BIOCHEMISTRY AND MOLECULAR BIOPHYSICS, AND PSYCHIATRY http://cpmcnet.columbia.edu/dept/physio/physio2/kandel1.html

ERIC R. KANDEL, M.D. BIOCHEMISTRY AND MOLECULAR BIOPHYSICS, AND PSYCHIATRY erk5@columbia.edu Tel:(212) 543-5202 Fax:(212) 543-5474 CURRENT RESEARCH Cell and molecular mechanisms of associative and nonassociative learning. We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia . We study three elementary forms of learning: habituation, sensitization , and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short-and long-term memory. In vertebrates we use genetically modified mice to examine the mechanisms of long-term potentiation in the mammalian hippocampus and its relation to spatial memory and maintenance. RECENT PUBLICATIONS Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER (1998)

29. KANDEL, ERIC R. - CIRS kandel, eric R. Email erk5@columbia.edu Through studies of Aplysia and mutant mice, eric kandel is elucidating the genes and molecular circuits that http://www.cirs-tm.org/researchers/researchers.php?id=382

30. Eric R. Kandel: Books On Eric R. Kandel Search results for eric R. kandel, books on eric R. kandel. http://www.campusi.com/author_Eric_R._Kandel.htm

Find the best price on books. (with coupons) Search by: Keyword Title Author ISBN Advanced Search Rare Book Search Search Tips Browse Book Computer / Electronics New! Email Rare Book Movie Music ... Credit Card Search results for Author: Eric R. Kandel Total Results: Cannot find your book? Try Rare Book Search or free Locate book service Essentials of Neural Science and Behavior ISBN: Author: Eric R. R. Kandel James H. Schwarz Thomas M. Jessell With James H. Schwartz Edition: Hardcover Format: Textbook Number of pages: 540 All Editions Similar Books compare prices ... Psychiatry, Psychoanalysis, and the New Biology of Mind ISBN: Author: Eric R. Kandel Publisher: Amer Psychiatric Pub Inc Format: Hardcover All Editions Similar Books compare prices ... Essentials of Neural Science Value Pack ISBN: Author: Eric R. R. Kandel Edition: Paperback Format: Textbook All Editions Similar Books compare prices ... Essentials of Neural Science : A Behavior Study Guide/Problem Book ISBN: Author: Eric R. Kandel James H. Schwartz Thomas M. Jessell Publisher: McGraw-Hill Publishing Edition: Paperback Format: Textbook All Editions Similar Books compare prices ... Handbook of Physiology : The Nervous System, Vol. 2

31. Principles Of Neural Science (REV) By Eric R. Kandel, James H. Schwartz, Thomas Principles of Neural Science (REV) by eric R. kandel, James H. Schwartz, Thomas M. Jessell, isbn 0838577016. http://www.campusi.com/isbn_0838577016.htm

Find the best price on books. (with coupons) Search by: Keyword Title Author ISBN Advanced Search Rare Book Search Search Tips Browse Book Computer / Electronics New! Email Rare Book Movie Music ... Credit Card Search 100 bookstores, 80,000 sellers for Principles of Neural Science : ISBN: Principles of Neural Science Click here to compare prices for this book from 100 stores Author: Eric R. Kandel James H. Schwartz Thomas M. Jessell ISBN: Publisher: McGraw-Hill Medical Date published: Edition: REV Format: Hardcover Number of pages: Size: Related Books: All Editions Similar Books Click here to compare prices for this book from 100 stores Synopsis: Completely updated and reorganized, Principles of Neural Science, Fourth Edition provides an authoritative introduction to the brain: its structure, function, development, and control ofbehavior. It presents an in-depth summary of the state of the science as well as a full discussion of historical issues. Neuroanatomy, cell and molecular mechanisms of signaling, development and plasticity are thoroughly described in thecontext of cognitive approaches to behavior. Principles of Neural Science, Fourth Edition is an essential reference for your clinical practice or research. This edition features expanded treatment of:

32. National Academy Of Sciences - Members kandel, eric R. Columbia University. Elected to NAS, 1974. Scientific Discipline, Cellular and Molecular Neuroscience http://www4.nationalacademies.org/nas/naspub.nsf/(urllinks)/NAS-58N3M5?opendocum

33. MSN Encarta - Kandel, Eric R. kandel, eric R., born in 1929, Austrianborn American neuroscientist and Nobel laureate Other Features from Encarta. Search Encarta for kandel, eric R. http://encarta.msn.com/encyclopedia_681500375/Kandel_Eric_R.html

MSN Home My MSN Hotmail Shopping ... Sign In Web Search: Encarta Subscriber Sign In Help Home ... Upgrade your Encarta Experience Search Encarta Subscription Article MSN Encarta Premium: Get this article, plus 60,000 other articles, an interactive atlas, dictionaries, thesaurus, articles from 100 leading magazines, homework tools, daily math help and more for $4.95/month or $29.95/year (plus applicable taxes.) Learn more. This article is exclusively available for MSN Encarta Premium Subscribers. Already a subscriber? Sign in above. Kandel, Eric R. Kandel, Eric R. , born in 1929, Austrian-born American neuroscientist and Nobel laureate whose discoveries concerning biochemical mechanisms in the... Related Items Nobel Prize cowinners 2 items Want more Encarta? Become a subscriber today and gain access to: Daily Math Help Literature Guides Researcher Tools Paper-Writing Guides 60,000 + articles Interactive Atlas Magazine Center Find more about Kandel, Eric R. from Other Features from Encarta Search Encarta for Kandel, Eric R. © 2005 Microsoft MSN Privacy Legal Advertise Feedback ... Help

34. Eric Kandel Winner Of The 2000 Nobel Prize In Physiology Or Medicine eric kandel, the 2000 Nobel Prize Laureate in Physiology or Medicine, eric R. kandel Autobiography (submitted by Davis Brown); eric kandel Research http://almaz.com/nobel/medicine/2000c.html

E RIC K ANDEL 2000 Nobel Laureate in Physiology or Medicine for their discoveries concerning signal transduction in the nervous system Background Born: November 7, 1929 Place of birth: Vienna, Austria, American citizen. Residence: New York Affiliation: Center for Neurobiology and Behavior, Columbia University Address: Center for Neurobiology and Behavior Columbia University 1051 Riverside Drive New York, NY 10032, USA Telephone: (212) 960-2202 FAX: (212) 960-2410 E-mail: erk5@columbia.edu Book Store Principles of Neural Science, 4th Edition Books on Signal Transduction Books on the nervous system Books by Paul Greengard ... Books by Eric Kandel Featured Internet Links Prize co-recipient: Arvid Carlsson Prize co-recipient: Paul Greengard PubMedline search results for this laureate Official award announcement and background ... Curriculum vitae Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors HHMI Web Feature on Kandel (submitted by Andi McCarthy 1987 Gairdner Foundation International Award Eric R. Kandel - Autobiography (submitted by Davis Brown) Eric Kandel Research Laboratory (submitted by Jackson) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

35. KANDEL, ERIC R. *kandel, eric R. The Molecular Biology of Memory Storage A Dialog Between Genes *kandel, eric R., Cowan, WM Prospects for neurology and psychiatry. http://www.bbaw.de/pbl/kandelericr2001.html

BBAW Publikationen Publikationslisten 2001 KANDEL, ERIC R. KANDEL, ERIC R.: The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses. Reprint from Les Prix Nobel (2000), Sweden: Norstedts Tryckeri, 2001. KANDEL, ERIC R.: The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses. In: Les Prix Nobel, The Nobel Prizes, Stockholm, Sweden: Almquest and Wilksell International, 2001. KANDEL, ERIC R.: The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses. In: Science 294 (2001), 1030-1038. KANDEL, ERIC R., Cowan, W. M.: Prospects for neurology and psychiatry. In: JAMA 285 (2001), 594-600. KANDEL, ERIC R., Fedeles, B., Wilson, M. A., Younkin, S., Kirkwood, A., Shen, J., Yu, H., Saura, C. A., Choi, S., Sun, L. D., Yang, X., Handler, M., Kawarabayashi, T., Younkin, L.: APP processing and synaptic plasticity in Presenilin-1 conditional knockout mice. In: Neuron 31 (2001), 713-726. KANDEL, ERIC R., Hawkins, R. D., Antonov, I., Antonova, I.: The contribution of activity-dependent synaptic plasticity to classical conditioning in Aplysia. In: J. Neurosci 21 (2001), 6413-6422. KANDEL, ERIC R., Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C.: Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. In: Neuron 32 (2001), 123-140.

36. Eric R. Kandel -- Facts, Info, And Encyclopedia Article eric R. kandel. Categories Nobel Prize in Physiology or Medicine winners, Neuroscientists, 1929 births eric Richard kandel (born November 7, http://www.absoluteastronomy.com/encyclopedia/e/er/eric_r._kandel.htm

Eric R. Kandel [Categories: Nobel Prize in Physiology or Medicine winners, Neuroscientists, 1929 births] Eric Richard Kandel (born November 7, 1929) is a (A neurobiologist who specializes in the study of the brain) neuroscientist who won a (An annual award for outstanding contributions to chemistry or physics or physiology and medicine or literature or economics or peace) Nobel Prize in the year 2000 for his research on the (Click link for more info and facts about physiological) physiological basis of (An electronic memory device) memory storage in (A cell that is specialized to conduct nerve impulses) neuron s. He shared the prize with fellow recipients (Click link for more info and facts about Arvid Carlsson) Arvid Carlsson and (Click link for more info and facts about Paul Greengard) Paul Greengard . Kandel has been at (A university in New York City) Columbia University since 1974. Early years Eric Kandel's family roots are in Kolomyje in Eastern Poland (he used to joke "as with all bright people, my roots are in Poland"). Eric was born in (The capital and largest city of Austria; located on the Danube in northeastern Austria; was the home of Beethoven and Brahms and Haydn and Mozart and Schubert and Strauss)

37. Edge: THE WORLD QUESTION CENTER 2003 eric R. kandel The issues at the edge of neuroscience are clear. The first and most important issue at the edge is the biology underlying conscious http://www.edge.org/q2003/q03_kandel.html

Home About Edge Features Edge Editions ... Edge Search "I can repeat the question, but am I bright enough to ask it?" "What are the pressing scientific issues for the nation and the world, and what is your advice on how I can begin to deal with them?" Back to Index Page The first and most important issue at the edge is the biology underlying conscious experience, particularly the biology of self-awareness: How do you study it? Where is it located in the brain? How does it develop over time? Eric R. Kandel The issues at the edge of neuroscience are clear. The first and most important issue at the edge is the biology underlying conscious experience, particularly the biology of self-awareness: How do you study it? Where is it located in the brain? How does it develop over time? A second problem is how is memory perpetuated to last the lifetime of an individual. A third problem is the future of stem cell biology in the brain. To what degree will we be able to replace cells in the nervous system that die with stem cells that take on similar properties?

38. Books Written By Eric R. Kandel - Medical Textbook eric R. kandel January, 1976 ISBN 0716705222, Picture of Book eric R. kandel 01 February, 2006 ISBN 0393058638, Picture of Book http://www.medicaltextbook.com/textbooks/author/Eric R. Kandel

compare textbook prices medical school listing medical search engine contact us ... Bookmark Us Books Written By: Eric R. Kandel Principles of Neural Science Eric R. Kandel James H. Schwartz Thomas M. Jessell 05 January, 2000 ISBN: 0838577016 Essentials of Neural Science and Behavior Eric R. Kandel James H. Schwartz Thomas M. Jessell 30 September, 1996 ISBN: 0838522459 Memory: From Mind to Molecules (Scientific American Library) Larry R. Squire Eric R. Kandel February, 1999 ISBN: 0716750716 In Search of Memory: The Emergence of a New Science of Mind Eric R. Kandel 27 March, 2006 ISBN: 0393058638 Cellular Basis of Behavior: Human Endvr Eric R. Kandel January, 1976 ISBN: 0716705222 Princ­pios da Neurociªncia Eric R. Kandel James H. Schwartz ISBN: 8520412815 Cellular Biology of Neurons (Handbook of Physiology, Section 1) Eric R. Kandel June, 1977 ISBN: 0195206584 Eric R. Kandel January, 1979 ISBN: 0716710706 Mem³ria: da Mente  s Mol©culas Larry R. Squire Eric R. Kandel ISBN: 8536300523 Molecular Neurobiology in Neurology and Psychiatry (Research Publications (Association for Research in Nervous and Mental Disease)) Eric R. Kandel 01 June, 1987 ISBN: 0881673056 Page 1 of 2 Next Page get textbooks medical schools medical search ... contact us ©2000-2003 MedicalTextbook.com

39. Books Written By Eric R., M.D. Kandel - Medical Textbook Psychiatry, Psychoanalysis, And The New Biology Of Mind eric R., MD kandel 30 June, 2005 ISBN 1585621994, Picture of Book http://www.medicaltextbook.com/textbooks/author/Eric R., M.D. Kandel

compare textbook prices medical school listing medical search engine contact us ... Bookmark Us Books Written By: Eric R., M.D. Kandel There are no exact matches for the search. Page 1 of get textbooks medical schools medical search contact us ©2000-2003 MedicalTextbook.com

40. NARSAD: Research Center: Project Summary For Eric R. Kandel, M.D. eric R. kandel, MD (Distinguished Investigator 2000) of Columbia University, is undertaking a new series of studies on the molecular mechanisms in the http://www.narsad.org/research/summaries/kandelericr-2000.html

Eric R. Kandel, M.D. (Distinguished Investigator 2000) of Columbia University, is undertaking a new series of studies on the molecular mechanisms in the amygdala that govern the learned acquisition of anxiety, and the delineation of genes recruited during the acquisition of fear. Context conditioning of fear will be examined as a model of chronic anxiety and cued conditioning of fear as a model of anticipatory anxiety. The function of genes expressed during these two types of anxiety states will be determined using methods for regional gene expression restricted to the amygdala, behavioral analysis, and analysis of a phenomenon known as long-term potentiation in the amygdala. This work has promise for elucidating the neural circuits and genes that cause anxiety disorders. Program Area: ANXIETY DISORDERS Search Again NARSAD // 60 Cutter Mill Road, Suite 404, Great Neck, New York 11021 USA // phone 1 (800) 829-8289 // fax 516 487-6930 // e-mail info@narsad.org legal notice sitemap

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