41. Electronic Resources We can sleep later alfred D. hershey and the origins of molecular biology.Click to view the book via ebrary. Broad Subject, Biochemistry Biology http://sunzi1.lib.hku.hk/ER/detail/2606008

English Chinese Seek information advisory service One-stop search for info Ask a Librarian MetaFind HKUL We can sleep later : Alfred D. Hershey and the origins of molecular biology Click to view the book via ebrary Broad Subject Biochemistry Biology General - Science Genetics Subject Molecular biology. Molecular biologists - Biography. Publisher Old Spring Harbor Laboratory Press Language English Available at : Click to view the book via ebrary Authorized remote access from HKUVPN, EZproxy, Circle of Friends Format E-Books Location Web Mounted Warning: Licences prohibit excessive downloading

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43. Genome Biology | Research News With alfred D. hershey, she established DNA as the genetic material. Martha Chase,renowned for her part in the pivotal blender experiment, which firmly http://genomebiology.com/researchnews/default.asp?arx_id=gb-spotlight-20030820-0

44. McArdle Faculty - Waclaw Szybalski Szybalski, W. In Memoriam alfred D. hershey (19081997). In FW Stahl (Ed.), alfred D. hershey and the Origins of Molecular Biology, pp. 19-22. http://mcardle.oncology.wisc.edu/faculty/bio/szybalski_w.html

McArdle Lab Faculty Waclaw Szybalski, D.Sc. Professor Emeritus of Oncology Ch.Eng. M.Ch.Eng. , Institute of Technology, Gliwice, Poland D.Sc. , Institute of Technology, Gdansk, Poland Telephone: Fax: Email: szybalski@oncology.wisc.edu The objectives of our research on various aspects of genomics, including gene cloning, architecture and expression have been: (1) developing new methods for (i) ordering and in situ amplification of 30- to 100-kb fragments of large eukaryotic genomes, without conventional cloning, and (ii) ordered and automated sequencing of such large fragments by employing our SPEL-6 technique, based on primer assembly by hexamer ligation and primer walking; (2) developing improved derivatives of pBAC vectors allowing conditional in vivo excision and amplification of 3- to 10-kb (cDNA) or 30- to 200 kb (genomic DNA) inserts in E. coli hosts [for more details, please see this abstract (3) the design and construction of novel regulatory circuits; (4) the cloning of viral genes with dominant-lethal mutations as the basis for developing a new kind of immunity control against viral infection of plants and other organisms; and

45. McArdle Faculty - William F. Dove Dove, WF Closing the Circle AD hershey and Lambda I. In FW Stahl (Ed.), We CanSleep Later alfred D. hershey and the Origins of Molecular Biology, http://mcardle.oncology.wisc.edu/faculty/bio/dove_w.html

McArdle Lab Faculty William F. Dove, Ph.D. George Streisinger Professor of Experimental Biology Professor of Oncology and Medical Genetics A.B. , Amherst College Ph.D. , California Institute of Technology Postdoctoral research: Cambridge University, Stanford University Telephone: Email: dove@oncology.wisc.edu Lab Home Page A developmental mutation detected by its strong effect on neoplasia is the Multiple intestinal neoplasia ( Min ) allele of the murine Apc gene ( adenomatous polyposis coli ). A network of genes impinging on its neoplastic phenotypes is being discovered. One modifier locus, , confers tumor resistance by encoding a locally active secretory phospholipase. A second modifier locus, Dnmt , seems to control by DNA methylation the activity of a negative regulator of tumor growth. The range of action of modifying genes and their effects on the clonal structure of intestinal tumors are being studied in chimeric mice. Selected recent publications Thliveris, A. T., Halberg, R. B., Clipson, L., Dove, W. F., Sullivan, R., Washington , M. K., Stanhope, S., and Newton , M. A.

46. The Scientist :: Martha Chase Dies, Aug. 20, 2003 With alfred D. hershey, she established DNA as the genetic material. By Milly Dawson alfred D. hershey http//www.cshl.edu/History/hershey.html http://www.the-scientist.com/news/20030820/03

Please login or register DAILY E-MAIL RSS HANDHELD CURRENT ISSUE DAILY NEWS UPFRONT FEATURE ... ARCHIVES Aug. 20, 2003 Previous Archive Next DAILY NEWS Martha Chase dies With Alfred D. Hershey, she established DNA as the genetic material By Milly Dawson Martha Chase, renowned for her part in the pivotal " blender experiment ," which firmly established DNA as the substance that transmits genetic information, died of pneumonia on August 8 in Lorain, Ohio. She was 75. In 1952, Chase participated in what came to be known as the Hershey-Chase experiment in her capacity as a laboratory assistant to Alfred D. Hershey Peter Sherwood, a spokesman for Cold Spring Harbor Laboratory, where the work took place, described the Hershey-Chase study as "one of the most simple and elegant experiments in the early days of the emerging field of molecular biology." Szybalski attended the first staff presentation of the Hershey-Chase experiment and was so impressed that he invited Chase for dinner and dancing the same evening. "I had an impression that she did not realize what an important piece of work that she did, but I think that I convinced her that evening," he said. "Before, she was thinking that she was just an underpaid technician." In fact, said Szybalski, "Experimentally, she contributed very much. The laboratory of Alfred Hershey was very unusual. At that time there were just the two of them, and when you entered the laboratory there was absolute silence and just Al directing the experiments by pointing with his finger to Martha, always with a minimum of words. She was perfectly fitted to work with Hershey."

47. The Scientist :: Martha Chase Dies, Aug. 20, 2003 Martha Chase http//osulibrary.orst.edu/specialcollections/coll/pauling/dna/people/chase.html. alfred D. hershey http//www.cshl.edu/History/hershey.html http://www.the-scientist.com/news/20030820/03/printerfriendly

Aug. 20, 2003 return to webpage DAILY NEWS Martha Chase dies With Alfred D. Hershey, she established DNA as the genetic material By Milly Dawson Martha Chase, renowned for her part in the pivotal " blender experiment ," which firmly established DNA as the substance that transmits genetic information, died of pneumonia on August 8 in Lorain, Ohio. She was 75. In 1952, Chase participated in what came to be known as the Hershey-Chase experiment in her capacity as a laboratory assistant to Alfred D. Hershey Peter Sherwood, a spokesman for Cold Spring Harbor Laboratory, where the work took place, described the Hershey-Chase study as "one of the most simple and elegant experiments in the early days of the emerging field of molecular biology." Szybalski attended the first staff presentation of the Hershey-Chase experiment and was so impressed that he invited Chase for dinner and dancing the same evening. "I had an impression that she did not realize what an important piece of work that she did, but I think that I convinced her that evening," he said. "Before, she was thinking that she was just an underpaid technician." In fact, said Szybalski, "Experimentally, she contributed very much. The laboratory of Alfred Hershey was very unusual. At that time there were just the two of them, and when you entered the laboratory there was absolute silence and just Al directing the experiments by pointing with his finger to Martha, always with a minimum of words. She was perfectly fitted to work with Hershey."

48. Hershey Heaven - Nature Structural & Molecular Biology We can sleep later alfred D. hershey and the origins of molecular biology Editedby Franklin W. StahlCold Spring Harbor Press, Cold Spring Harbor, http://www.nature.com/nsmb/journal/v8/n1/full/nsb0101_18.html

@import "/nsmb/style.css"; nature.com homepage Login My account ... Browse by subject Search This journal All of nature.com Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Cell Biology Nature Reviews Molecular Cell Biology The EMBO Journal ... Browse all publications Book Review Nature Structural Biology doi:10.1038/82991 Hershey heaven Reviewed by: Angela N. H. Creager Angela N. H. Creager is in the Department of History and Program in History of Science, Princeton University, Princeton, New Jersey 08544, USA. creager@Princeton.edu We can sleep later: Alfred D. Hershey and the origins of molecular biology Edited by Franklin W. StahlCold Spring Harbor Press, Cold Spring Harbor, New York, USA; 2000. 357 pages, US $39 . ISBN 0-87969-567-6. When Alan Garen asked Alfred Hershey for his idea of scientific happiness, Hershey replied, "To have one experiment that works, and keep doing it all the time" . The first generation of molecular biologists referred to this as "Hershey heaven." Both Hershey's wit and his scientific achievements receive their due in We can sleep later: Alfred D. Hershey and the origins of molecular biology

49. Alfred Day Hershey, Pioneer In DNA Research alfred Day hershey, Ph.D., a Nobel laureate who spent the first 16 years of hiscareer at the School of Medicine, died Thursday, May 22, 1997, http://record.wustl.edu/archive/1997/06-12-97/7938.html

Alfred Day Hershey, pioneer in DNA research Alfred Day Hershey, Ph.D., a Nobel laureate who spent the first 16 years of his career at the School of Medicine, died Thursday, May 22, 1997, at his home in Syosset, N.Y. He was 88. Hershey joined the Washington University Department of Bacteriology and Immunology in 1934 after receiving a doctorate in chemistry from Michigan State College. Inspired by department head Jacques J. Bronfenbrenner, he began to work with bacteriophages viruses that infect bacterial cells. At a time when few people were studying the chemical or genetic properties of viruses, Hershey developed ways to recognize and analyze viral genetic traits, believing that studies with such a simple form of life might reveal basic hereditary principles. In 1946, he produced the first convincing evidence that two strains of a virus can exchange genetic material if they infect the same bacterial cell. Hershey moved to the Genetics Research Unit of the Carnegie Institution at Cold Spring Harbor Laboratory in New York in 1950. Two years later, he and geneticist Martha Chase discovered how bacterial viruses infect cells and provided a critical piece of evidence for the view that DNA, not protein, was the genetic material. They labeled the protein coat of one batch of phages with radioactive sulfur and the DNA core of another batch with radioactive phosphorus. Tracking the labels during infection, they observed that most of the protein label stayed outside the bacterial cell and could be removed with a blender, whereas the DNA label entered the bacterium and reappeared in progeny phage. This experiment proved that genetic information is in DNA, not protein, as some researchers had proposed.

50. DNA More Evidence The Genetic Material is DNA alfred D. hershey and Martha Chase,1952. hershey and Chase worked with viruses that infect bacteria called http://faculty.clintoncc.suny.edu/faculty/Michael.Gregory/files/Bio 100/Bio 100

The Biology Web (Home) General Biology 1 General Biology 2 Human Biology DNA The Search to Identify the Genetic Material Discovery of Nucleic Acids - Friedrich Miescher, 1869 Miescher isolated the nuclei of white blood cells obtained from pus cells. His experiments revealed that nuclei contained a chemical that contained nitrogen and phosphorus but no sulfur. He called the chemical nuclein because it came from nuclei. It later became known as nucleic acid. Proteins Produce Genetic Traits - Archibald Garrod, 1909 Garrod noticed that people with certain genetic abnormalities (inborn errors of metabolism) lacked certain enzymes. This observation linked proteins (enzymes) to genetic traits. Genetic Material can Transform Bacteria - Frederick Griffith, 1931 When Streptococcus pneumoniae (pneumococcus) bacteria are grown on a culture plate, some produce smooth shiny colonies (S) while others produce rough colonies (R). This is because the S strain bacteria have a mucous (polysaccharide) coat, while R strain does not. Mice infected with the S strain die from pneumonia infection but mice infected with the R strain do not develop pneumonia.

51. Micronotes, Vol. 5, No. 4 Many of you undoubtedly read of the recent death of alfred hershey, hershey received his BS in this Department in 1930 and a Ph.D. in Chemistry at MSU http://www.msu.edu/unit/mic/micnotes/note0504.html

52. Micronotes, Vol. 10, No. 2 2001 issue of ASM News contains Ron Luftig s review (67585) of Frank Stahl sbook on alfred hershey We Can Sleep Later alfred D. hershey and the Origins http://www.msu.edu/unit/mic/micnotes/note1002.html

53. Especiales Diario Médico Translate this page Max Delbrück, Salvador E. Luria y alfred D. hershey. Max Delbrück alfred D.hershey nació en 1908 en Owosso (Michigan, Estados Unidos). http://www.diariomedico.com/medicinasiglo/nobel1969.html

Mapa Web Contacto Publicidad Servicios Internet Sanitario Archivo Asesor Legal Congresos Deportes Dossieres Especiales DM Foros Imprescindibles DM Impuestos Informes Web Medline Multimedia Newsletters Ocio en DM Ofertas de trabajo Ondasalud.com Tienda de libros Especialidades Aparato Digestivo Enfermedades raras Ginec./Obstet. Infecciosas/Sida Med. Deportiva Med. Familiar Medicina Intensiva Med. Interna Medicina Legal Med. Nuclear Med. Preventiva Med. Trabajo Med. Urgencias Otorrinolaring. Trasplantes Form. continuada Telemedicina Secciones Sanidad Normativa Medicina Gestion Entorno Inicio Comentarios y sugerencias dminternet@recoletos.es Portada Salvador E. Luria Salvador E. Luria Alfred D. Hershey Alfred D. Hershey © Recoletos Medios Digitales S.L. Aviso Legal

54. Especiales Diario Médico Translate this page 1969 Max Delbrück, Salvador E. Luria y alfred D. hershey 1970 Bernard Katz, Ulf S.von Euler y Julius Axelrod 1971 Earl W. Sutherland http://www.diariomedico.com/medicinasiglo/nobeles.html

Mapa Web Contacto Publicidad Servicios Internet Sanitario Archivo Asesor Legal Congresos Deportes Dossieres Especiales DM Foros Imprescindibles DM Impuestos Informes Web Medline Multimedia Newsletters Ocio en DM Ofertas de trabajo Ondasalud.com Tienda de libros Especialidades Aparato Digestivo Enfermedades raras Ginec./Obstet. Infecciosas/Sida Med. Deportiva Med. Familiar Medicina Intensiva Med. Interna Medicina Legal Med. Nuclear Med. Preventiva Med. Trabajo Med. Urgencias Otorrinolaring. Trasplantes Form. continuada Telemedicina Secciones Sanidad Normativa Medicina Gestion Entorno Inicio Comentarios y sugerencias dminternet@recoletos.es Portada Los Premios Nobel de Medicina del Siglo XX El legado de Alfred Nobel Emil Adolf von Behring Sir Ronald Ross Niels Ryberg Finsen Ivan Petrovic Pavlov Robert Koch Santiago Ramón y Cajal y Camillo Golgi Charles Louis Alphonse Laveran Paul Ehrlich y Elie Metchnikov Emil Theodor Kocher Albrecht Kossel Allvar Gullstrand Alexis Carrel Charles Robert Richet Robert Barany Suspendido el premio por la Primera Guerra Mundial Jules Vincent Bordet August Krogh Otto Fritz Meyerhof y Archibald Hill Frederick Grant Banting y John J.R.

55. Dr. Alfred Day Hershey In 1967 he got an honorary D.Sc. at the University of Chicago. alfred Hersheymarried Harriet Davidson in 1945, they have one son, Peter. http://www.shiawasseehistory.com/hershey.html

Dr. Alfred Day Hershey Alfred Day Hershey was born Dember 4, 1908 at 515 E. Mason St. Owosso, MI, to Robert D. and Alma (Wilber) Hershey. He graduated from Owosso High School in about 1925 and later graduated from Michigan State University was a B.S. in Science in 1930 and a Ph.D. in 1934. In 1967 he got an honorary D.Sc. at the University of Chicago. From 1934 till 1950 he was engaged in teaching and research, at the Department of Bacteriology, Washington University School of Medicine. In 1950 he became a Staff Member, at the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor, New York; in 1962 he was appointed Director of the Genetics Research Unit of the same institution. Alfred Hershey married Harriet Davidson in 1945, they have one son, Peter. While researching bacteriophages (viruses which infect bacteria) at Washington University (St Louis) (1934-50), he eventually, in 1943, joined the informal ‘phage group’ forum begun by Max Delbruck and Salvador Luria. Hershey moved to the Carnegie Institution's laboratory in Cold Spring Harbor, NY (1950-74). Together with geneticist Martha Chase, he discovered (1952) that bacteriophage DNA alters genetic replication of the host bacterium, thus proving that DNA is the genetic material of the virus.

56. HersheyChase alfred hershey and Martha Chase hershey B. D. 1997 Chase B. - D. DNA is thegenetic material. Blender experiment in 1952 layed foundation for molecular http://www2.carthage.edu/~pfaffle/hgp/HersheyChase.html

Alfred Hershey and Martha Chase Hershey B. - D. 1997 Chase B. - D. DNA is the genetic material Blender experiment in 1952 layed foundation for molecular biology Radioactively labeled DNA or protein coat of bacteriophage (virus) Found that bacteriophage injected DNA into cells in order to replicate This meant that DNA is the genetic material, not proteins (which make up more than 50% of a chromosome) In 1969, Hershey won Nobel Prize for discovering that a virus can cause multiple mutations and carry multiple genes Hershey also worked on genetic recombination, found mRNA, and discovered that DNA in bacteria is in a circular plasmid Back

57. Landmarks In The History Of Genetics hershey, alfred D. and Martha Chase (1952). Independent functions of viral proteinand nucleic acid in growth of bacteriophage. http://cogweb.ucla.edu/ep/DNA_history.html

Can Matter Store Active Information? Landmarks In the History of Genetics (revised 7 February 2002) Year Event Theoretical implications Maupertuis proposes an adaptationist account of organic design Presupposes some mechanism for transmitting adaptations Darwin publishes Th e O rigin of Species , vastly strengthening the adaptationist hypothesis Gregory Mendel publishes evidence for the discreteness and combinatorial rules of inherited traits Traits are carried by discrete units, or genes; the results are not appreciated until 1900 Miescher discovers "nuclein" (DNA) in the cells from pus in open wounds cells composed mostly of nuclear material. It became known as nucleic acid after 1874, when Miescher separated it into a protein and an acid molecule. Suspected of exerting some function in the hereditary process Muller formulates the chief principles of spontaneous gene mutation as point effects of ultramicroscopic physico-chemical accidents; he induces such changes using X-rays The gene constitutes the basis of life and evolution by virtue of its property of reproducing its own internal changes Nucleic acid found to be a major component of the chromosomes Its molecular structure was thought to be simple, so it was not a good candidate for a carrier of genetic information

58. Robert C. Olby Collection, American Philosophical Society Herriott, Roger M. , TLS Cy to alfred D. hershey, 1951 November 16, 1 item hershey, alfred D. , TL Cy to Roger M. Herriott, 1951 November 20, 1 item http://www.amphilsoc.org/library/mole/o/olby.htm

Robert C. Olby Collection (0.25 linear feet) B OL1 American Philosophical Society 105 South Fifth Street * Philadelphia, PA 19106-3386 Table of contents Abstract The historian of science Robert C. Olby is a graduate of University College London and Oxford. Best known for his work on the history of genetics, especially the Bateson school, and for his study of the early history of molecular biology, Olby is currently a Research Professor in the History and Philosophy of Science at the University of Pittsburgh. He is the author of The Origins of Mendelism Charles Darwin The Path to the Double Helix (1994), and the Norton History of Biology . His current research is focused on the conceptual foundations of modern sensory neurophysiology and an intellectual biography of Francis Crick. The Olby Collection contains about 150 photocopies of correspondence and documents collected by Olby during research for The Path to the Double Helix . Among these is a copy of a manuscript by F. C. Crick and James D. Watson, "The Complementary Structure of Deoxyribonucleic Acid," prepared while Watson was at CalTech.

59. M. Chase Dies Diagram of hersheyChase blender experiment Martha Chase alfred D. hershey REPeterson, Al s pals reminisce, American Scientist, January–February 2001 http://www.vetscite.org/publish/items/001470/

27 August 2003 Martha Chase dies Martha Chase, renowned for her part in the pivotal "blender experiment," which firmly established DNA as the substance that transmits genetic information, died of pneumonia on August 8 in Lorain, Ohio. She was 75. Peter Sherwood, a spokesman for Cold Spring Harbor Laboratory, where the work took place, described the Hershey-Chase study as "one of the most simple and elegant experiments in the early days of the emerging field of molecular biology." Szybalski attended the first staff presentation of the Hershey-Chase experiment and was so impressed that he invited Chase for dinner and dancing the same evening. "I had an impression that she did not realize what an important piece of work that she did, but I think that I convinced her that evening," he said. "Before, she was thinking that she was just an underpaid technician." In fact, said Szybalski, "Experimentally, she contributed very much. The laboratory of Alfred Hershey was very unusual. At that time there were just the two of them, and when you entered the laboratory there was absolute silence and just Al directing the experiments by pointing with his finger to Martha, always with a minimum of words. She was perfectly fitted to work with Hershey."

60. 20th Century Year By Year1969 1981; hershey, alfred D., USA, Carnegie Institution of Washington, Long Island,New York, NY, b. 1908, d. 1997; and LURIA, SALVADOR E., USA, http://www.historycentral.com/20th/1969.html

Major Event/ Sports Nobel Prizes Pulitzer Prizes ... Popular Book s / Popular Television Shows Popular Music/ Grammy Awards/ Tony Awards Major Events of 1969 Juan Carlos Succeeds Non-Proliferation Agreement Violence in N. Ireland The Return of Okinawa ... Concorde Airborne Sports NBA: Boston Celtics vs. LA Lakers Series: 4-3 NCAA Football: Texas Record: 11-0-0 Heisman Trophy: Steve Owens, Oklahoma, HB points: 1,488 Stanley Cup: Montreal Canadiens vs. St. Louis Blues Series: 4-0 Super Bowl III: New York Jets vs. Baltimore Ravens Score: 16-7 US Open Golf: Orville Moody Score: 281 Course: Champions GC Location: Houston, TX World Series: New York Mets vs. Baltimore Orioles Series: 4-1 Top Songs of 1969 1."Crimson and Clover" ... Tommy Jones & the Shoulders 2."Everday People" ... Sly and the Family Stone 3."Dizzy" ... Tommy Roe 4."Aquarius/Let the Sunshine In" ... The Fifth Dimension 5."Get Back" ... The Beatles and Billy Preston 6."Love Theme From 'Romeo & Juliet'" ... Henry Mancini

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