81. Medicines By Design: Molecules To Medicines|The G Switch One of the Nobel Prize winners, pharmacologist alfred G. gilman of The University of Texas Southwestern Medical Center at Dallas, uncovered the identity of http://www.nigms.nih.gov/medbydesign/molecules/gswitch/

A Visit to the Doctor ABCs of Pharmacology Body, Heal Thyself Drugs From Nature, Then and Now ... Careers in Pharmacology The G Switch Imagine yourself sitting on a cell hormone G proteins act like relay batons to pass messages from circulating hormones into cells. (a) A hormone (red) encounters a receptor (blue) in the membrane of a cell. (b) A G protein (green) becomes activated and makes contact with the receptor to which the hormone is attached. (c) The G protein passes the hormone's message to the cell by switching on a cell enzyme (purple) that triggers a response. How does it all happen so fast? Getting into a cell is a challenge, a strictly guarded process kept in control by a protective gate called the plasma membrane. Figuring out how molecular triggers like epinephrine communicate important messages to the inner parts of cells earned two scientists the Nobel Prize in physiology or medicine in 1994. Getting a cellular message across the membrane is called signal transduction , and it occurs in three steps. First, a message (such as epinephrine) encounters the outside of a cell and makes contact with a molecule on the surface called a

82. Allegro-Chronik 25 Jahre (2005) Translate this page gilman, alfred G. (2004) Goldstein, Joseph L. (1985) Hartwell, Leland H. (2001) Hitchings, George H. (1988) Horwitz, H. Robert (2002) Hubel, David H. (1981) http://www.allegro-c.de/chronik/a28m.htm

25 Jahre allegro Nobelpreis Medizin Jahr Nobelpreis Medizin Bancerraf, Baruj; Snell, George D.; Dausset, Jean Hubel, David H.; Sperry, Roger W.; Wiesel, Torsten Nils [Schweden] Bergstr¶m, Sune K.; Samuelsson, Bengt I.; Vane, John R. McClintock, Barbara Jerne, Niels K; K¶hler, Georges J.S.; Milstein, C©sar Brown, Michael S.; Goldstein, Joseph L. Levi-Montalcini [Italien]; Cohen, Stanley Tonegawa, Susumu Elion, Gertrude B; Hitchings, George H.; Black, James [UK] Bishop, J. Michael; Varmus, Harold E. Murray, Joseph E.;Thomas, E. Donnall Neher, Erwin; Sakmann, Bert Fischer, Edmond H.; Krebs, Edwin G. Roberts, Richard J.; Sharp, Phillip A. Lewis, Edward B.; N¼sslein-Volhard, Christiane; Wieschaus, Eric F. Doherty, Peter C. [Australien]; Zinkernagel, Rolf M. Prusiner, Stanley B. Furchgott, Robert F.; Ignarro, Luis J.; Murad, Ferid Blobel, G¼nter [Deutschland] Carlsson, Arvid [Schweden] Hartwell, Leland H.; Hunt, R. Timothy [UK]; Nurse, Paul M. [UK] Brenner, Sydney [UK]; Horwitz, H. Robert; Sulston, John E. [UK] Lauterbur, Paul C.; Mansfield, Sir Peter Gilman, Alfred G.; Rodbell, Martin

83. The Alfred B. Nobel Prize Winners: Physiology Or Medicine 1994, alfred G. gilman Martin Rodbell, United States United States. 1995, Edward B. Lewis Eric F. Wieschaus Christiane NüssleinVolhard, United States http://history1900s.about.com/library/misc/blnobelmed.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Homework Help 20th Century History Homework Help ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the 20th Century History newsletter! See Online Courses Search 20th Century History Nobel Prize Winners for Physiology or Medicine Chemistry Physics Literature Peace ... Economics Emil A. von Behring Germany Sir Ronald Ross Great Britain Niels R. Finsen Denmark Ivan P. Pavlov Russia Robert Koch Germany Camillo Golgi Santiago Ramon y Cajal Italy Spain Charles L. A. Laveran France Paul Ehrlich Elie Metchnikoff Germany France Emil Theodor Kocher Switzerland Albrecht Kossel Germany Allvar Gullstrand Sweden Alexis Carrel France Charles R. Richet France Robert Barany Austria Jules Bordet Belgium Schack A. S. Krogh Demmark Archibald V. Hill Otto F. Meyerhof Great Britain Germany Frederick G. Banting John J. R. Macleod Canada Scotland Willem Einthoven Netherlands Johannes A. G. Fibiger Danmark Julius Wagner-Jauregg Austria Charles J. H. Nicolle

84. NIH News Release-NIGMS Awards "Glue Grant" To Create Virtual Cell- - 09/05/2000 According to Dr. alfred G. gilman, a pharmacologist at the University of Texas Southwestern Medical Center at Dallas and leader of the AFCS effort, http://www.nih.gov/news/pr/sep2000/nigms-05.htm

NATIONAL INSTITUTES OF HEALTH National Institute of General Medical Sciences FOR IMMEDIATE RELEASE Tuesday, September 5, 2000 ... davisa@nigms.nih.gov NIGMS Awards "Glue Grant" to Create Virtual Cell In an effort to "glue" together large groups of scientists pursuing some of the biggest unsolved problems in biomedicine today, the National Institute of General Medical Sciences has provided $5 million for the first of five years to a consortium of basic scientists called the Alliance for Cellular Signaling (AFCS). NIGMS anticipates spending a projected total of $25 million on the project over the course of five years. This innovative way to fund science grew out of NIGMS' consultations with leaders in the scientific community who said repeatedly that the thorniest biological problems require the expertise and input of large, multifaceted groups of scientists. Glue grants aim to do just that. "The purpose of the glue grant is to help address problems that are beyond the reach of individual investigators," said Dr. Marvin Cassman, director of NIGMS. "The idea is to provide resources to a lot of people working together to collaboratively attack these problems." Just what will the AFCS tackle? How cells talk.

85. San Joaquin Apostolic Succession Datapgg 1945), Charles G. Marmion V Kentucky 527. . .1954, Richard B. Martin Suffragan, Long Island alfred A. gilman s ( 340. . 1925) listed consecrators were http://www.sjoaquin.net/aso/successiong.html

San Joaquin Apostolic Succession datapage: g Christopher E. Gadsden's (#35, 1840) listed consecrators were Alexander V. Griswold PB V (Eastern) George W. Doane II NJ Samuel A. McCoskry 1st of Michigan Thomas Frank Gailor's (#170, 1893) listed consecrators were Charles Quintard II TN Thomas Dudley II KY William S. Perry II Iowa John N. Galleher's (#124. . .1880, 3rd of Louisiana) listed consecrators were William M. Green 1st of Mississippi William B. Stevens IV PA Charles F. Robertson III MO Theophilus M. Gardiner's (#318 . . 1921, Liberia, suffragan) listed consecrators were Daniel S. Tuttle PB XIII (IV Missouri; prev. Missionary Bp to Montana, incl ID, MT, UT) Thomas F. Gailor III Tennessee Arthur S. Lloyd Suffragan, New York (prev., coadj., Virginia) Wallace John Gardner's (#395 . . 1936, New Jersey) listed consecrators were Paul Matthews V NJ William Moreland II Sacramento, ret. (now No.CAL) Phillip Cook IV Delaware Thomas J. Garland's (#256, 1911, Pennsylvania) listed consecrators were Daniel S. Tuttle PB XIII (IV Missouri; prev. 1st of Idaho) John Scarborough IV New Jersey Cortlandt Whitehead II Pittsburgh Luc Anatole Jacques Garnier's (#660. . 1971, Haiti) listed consecrators were

86. Accumulation Of Adenosine 3′:5′-Cyclic Monophosphate In Clonal G Free Full text in PMC; gilman, alfred G. A Protein Binding Assay for Adenosine 3?5?Cyclic Monophosphate. Proc Natl Acad Sci USA 1970 Sep;67(1)305–312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=426678

87. Cyclic Adenosine Monophosphate And Alteration Of Chinese Hamster Ovary Cell Morp PubMed; gilman, alfred G. A Protein Binding Assay for Adenosine 3?5?Cyclic Monophosphate. Proc Natl Acad Sci USA 1970 Sep;67(1)305–312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414999

88. Entrez PubMed 5, Lee SJ, Joffe S, Kim HT, Socie G, gilman AL, Wingard JR, Horowitz MM, Cella D, Syrjala KL. Related Articles, Links http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gilman A

89. FARMACOLOGIA RM 101 .C87 1988 CURRENT THERAPY LATEST APPROVED B644 1990 GOODMAND AND gilman S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS GOODMAN, C513 1992 GOTH S MEDICAL PHARMACOLOGY CLARK, WESLEY G. RM 300 . http://www.mty.itesm.mx/dcs/deptos/biblio-emis/ace_rm.htm

FARMACOLOGIA RM 101 .C87 1988 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 101 .C87 1990 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 101 .C87 1991 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 101 .C87 1993 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 101 .C87 1994 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 101 .C87 1996 CURRENT THERAPY: LATEST APPROVED METHODS OF TREATMENT FOR THE PRACTICING PHYSICIAN CONN, HOWARD FRANKLIN RM 105 .J33 1992 PHARMACOLOGY JACOB, LEORNARD S. RM 105 .J33 1992 c.1 PHARMACOLOGY JACOB, LEORNARD S. RM 105 .J33 1992 c.2 PHARMACOLOGY JACOB, LEONARD RM 16 .A76 1985 v.25 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY GEORGE, ROBERT RM 16 .A76 1986 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY GEORGE, ROBERT

90. The Political Graveyard: Index To Politicians: Foster Foster, Addison Gardner (18371917) — also known as Addison G. Foster — of Tacoma, Foster, gilman T. (b. 1859) — of Weston, Windsor County, http://politicalgraveyard.com/bio/foster.html

Questions? Return to The Political Graveyard main page Index to Politicians: Foster FOSTER: See also George Everett Adams Ephraim Foster Anderson Walter Wolfkiel Bacon Lucius K. Baker ... Ernest Foster Young Foster, A. Frank Suffolk County , Mass. Democrat. Delegate to Democratic National Convention from Massachusetts, . Still living as of 1960. Foster, A. Lawrence U.S. Representative from New York 23rd District, 1841-43. Burial location unknown See also congressional biography Foster, Abiel . Member of New Hampshire state legislature; Delegate to Continental Congress from New Hampshire ; state court judge in New Hampshire; U.S. Representative from New Hampshire at-large, 1789-91, 1795-1803. Died in . Interment at Center Cemetery , Canterbury, N.H. See also congressional biography Foster, Abiel Merrimack County , N.H. Member of New Hampshire state senate , 1792-95 (Rockingham County 1792-94, 4th District 1794-95). Burial location unknown Foster, Addison Gardner Addison G. Foster Pierce County , Wash. Born in Massachusetts, . Republican. U.S. Senator from Washington

91. Amherst College Biographical Record: Class Of 1885 S. of Edward P. and Martha G. (McMullin), b. Philadelphia, Penn., Je. 29, 1863. MD, Harvard, 1891. Hall, alfred Marvin. 2905. *Hallock, William Hall. http://www.amherst.edu/~rjyanco/genealogy/acbiorecord/1885.html

Home Genealogy Amherst College Biographical Record Amherst College Class of 1885 (from the Amherst College Biographical Record, Centennial Edition (1821-1921) Previous Class... Menu Index ... Abbott , Herbert Vaughan Ames , Herbert Brown Anthony , George Fort-Donalson Austin , Clarence Mason . S. of Frank Ensign and Louisa Plunkett (Rice), b. Skaneateles, N. Y., N. 17, 1861. Delta Upsilon. Prepared Skaneateles (N. Y.) Acad.; B. S. In wholesale coal business Chicago, Ill., 1885-89; bonds, mortgages and investment securities Seattle, Wash., 1889-. Address, Skaneateles, N. Y. Barrows , Franklin William Best , James Burt Brooks , Benjamin Burr , Hanford Montrose Butler , John Edward . S. of Edward P. and Martha G. (McMullin), b. Philadelphia, Penn., Je. 29, 1863. M. D., Harvard, 1891. Phi Beta Kappa; Chi Phi. Prepared Boston Latin School. Prin. Lincoln H. S., 1885-87; Harvard M. S., 1887-91; Rotunda Hospital, Dublin, Ireland, 1891; West London Post-grad. School of London, England, 1905; hospitals in Paris, France; Heidelberg, Germany, and Vienna, Austria, 1905; physician Roxbury, Boston, 1891-. Member visiting staff Boston City Hospital; instructor and clinical asst. Post-grad. School of Med., Harvard. Bro. Frank E. (A. C. 1884)

92. »²¤¯¤j¾Ç_²z¤u¾Ç°|_¥Íª«§Þ³N¬ãµo¤¤¤ß The summary for this Chinese (Traditional) page contains characters that cannot be correctly displayed in this language/character set. http://brc.se.fju.edu.tw/nobelist/199x/p1994.htm

1994¦~¿Õ¨©º¸¥Í²zÂå¾Ç¼ú «e¨¥¡G ¤º®e¡G Amplifierªºµ²¦X¬O¾aµÛ¤@¼ËªF¦èªºÀ°¦£¡C¦ÓAlfred G. Gilmanµ¥¤H«h§Q¥Î¤F°ò¦]»P¥Í¤Æ§Þ³N¡A¯Â¤Æ¥XG protein¡C¥L­Ì¥Î²O¤Ú½F²Ó­M¡A¦b¥¿±`ªº±¡ªp¤U¡A¥i¥H³Qreceptor¬¡¤Æ²£¥Ícyclic AMPªº¯S©Ê¨Ó°µ¹êÅç¡C A. Normal Lymphoma Cell receptor¡A©M¥¿±`ªºcyclic AMP-generating enzyme¡A¥i¬O¥¦«oµLªk¹ï¥~¬Éªº¨ë¿E²£¥Í¦^À³¡C ¦]¬°¥¦¯Ê¤Ö¤F±N receptor©Mamplifier±µ¦X¤@°_ªºªF¦è~G protein¡C B .Mutated Lymphoma Cell 2¡^ ¦b²Ó­M¤ºªº°T®§¶Ç¾É ²Ó­M¦b§Ú­ÌªºÅ餺¬O³Q¤@¼h¯×½èªº½¤©Ò¥]³òªº¡Cºc¦¨²Ó­M½¤ªº ¤@­Ó first messenger¡]¤@­Óadrenalineªº¤À¤l¡^ (1)¡A »P±M¤@©Êªºadrenaline receptor µ²¦X¡A©Ò¥H§@¬°transducer ªºG protein´N³Q¬¡¤Æ¤F¡A¦ÓG protein¬O¥Ñalpha-, beta- and gamma ¤TºØsubunits©Òºc¦¨ªº¡C ±µ¤U¨Ó¡A amplifier ¡A¤]´N¬Oadenylate cyclase ³Q¨ë¿E¡AÂǵÛATP (adenosine- triphosphate) ªº§@¥Î¡A²£¥Í¤Fsecond messenger- cyclic AMP ¡CµM«á¤@³s¦êªº»¯À¤ÏÀ³ µo¥Í¤F¡AÂÇ¥Ñphosphorylation ¡Aglycogen ´N³Q¤À¸Ñ¦¨¬° glucose ¡A´£¨Ñ²Ó­M©Ò»Ýªº¯à¶q¡C Phosphorylation ¤]¥i¥H§ïÅܤ@¨Ç½¤¤Wªº³J¥Õ½è¡A¹³¬OÂ÷¤l³q³zªººÞ¹D ¡C 3¡^ G proteinªº¬¡¤Æ»P¡]4¡^ ¤£ G protein¥]§talpha-, beta- ©M gamma-subunits¡A¦b¤£¬¡¤Æªº®É­Ô¬O¥H

93. Bearbeiten Von Alfred G. Gilman - Seite Bearbeiten - Wikipedia UT Southwestern Graduate School of Biomedical SciencesUniversity of Texas Southwestern Medical Center at Dallas. http://de.wikipedia.org/?title=Alfred_G._Gilman&action=edit

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 5     81-93 of 93    Back | 1  | 2  | 3  | 4  | 5