41. NEXUS: Mad Cows, Mad Humans gajdusek, D. carleton, Unconventional viruses and the origin and disappearanceof kuru , Science (1977) 197943960. 6. Manuelidis, Elias E., Transmission http://www.nexusmagazine.com/articles/madcow.html

SEARCH: HOME CURRENT ISSUE BACK ISSUES ARTICLES ... SURVEY From Mad Cows to Humans THE NEXT GLOBAL PLAGUE? By underestimating the threat and not taking action sooner over the BSE and CJD crises, agricultural and health authorities in Britain and Europe may have unleashed a potentially global and fatal epidemic. Extracted from Nexus Magazine, Volume 5, #1 (December 1997 - January 1998). PO Box 30, Mapleton Qld 4560 Australia. editor@nexusmagazine.com Telephone: +61 (0)7 5442 9280; Fax: +61 (0)7 5442 9381 From our web page at: www.nexusmagazine.com by Lynette J. Dumble, Ph.D., M.Sc. Senior Research Fellow History and Philosophy of Science University of Melbourne Parkville, Victoria 3052, Australia Telephone: +61 (0)3 9344 6668 Fax: +61 (0)3 9344 7959 E-mail: lynette@myriad.unimelb.edu.au ACROSS THE SPECIES BARRIER-AND NO CURES IN SIGHT S peaking from Washington, DC, in October 1997 after hearing of his Nobel Prize win for discovering the role of molecules known as "prions" in the invariably fatal brain illnesses such as "mad cow disease" or bovine spongiform encephalopathy (BSE) in cattle, and Creutzfeldt-Jakob disease (CJD) in humans, Dr Stanley Prusiner from the University of California predicted that the first drug therapy, which would not necessarily be a cure for BSE or CJD, was at least five years away. At the same time, on the opposite side of the Atlantic, the post-mortem of Chris Warne, a 36-year-old fitness fanatic from Derbyshire, England, revealed that he was the 21st victim of the new variant of CJD which had spread from BSE-infected cattle to humans via the food chain.

42. Science -- Sign In Scientists in half a dozen countries have been vying to work with Nobel laureate D.carleton gajdusek, who was released from prison this week. http://www.sciencemag.org/content/vol280/issue5364/s-scope.shtml

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43. I Prioni. D. CARLETON GAJDUSEK Translate this page D. carleton gajdusek. Torna alla pagina precedente. Site Meter. http://www.minerva.unito.it/SIS/prioni/gajdusek.html

D. CARLETON GAJDUSEK Torna alla pagina precedente var site="s10minerva"

44. Index Of /~jmumm 1956 D. carleton gajdusek begins investigation of kuru. Subsequently in1956, a researcher from Harvard, D. carleton gajdusek set off for Papua New http://www.stanford.edu/group/virus/prion/prion2.html

PrP c PrP c PrP c Prions PrP Sc PrP Sc PrP Sc Mad Cows, Kuru and You! Introduction: What are prions? Originally thought to be viral mediators of disease that were described as transmissible encephalopathies, spongiform encephalopathies and slow virus diseases , prions, ( pro teinaceous in fectious particles) have been determined to be misfolded, protease resistant proteins which can mediate transmission of disease. Prions have been implicated in a quartet of human diseases, specifically kuru Creutzfeldt-Jakob disease,(CJD Gerstmann-Straussler-Scheinker , (GSS) disease, and fatal familial insomnia , (FFI). In sheep, scrapie is believed to be caused by prions and Bovine Spongiform Encephalopathy is a prion disease in cattle. Stanley Prusiner won the Nobel Prize in 1997 for first proposing the remarkable hypothesis that these prion diseases were caused by misfolded proteins, and furthermore, elucidating the gene and a mechanism by which the misfolded wild type protein might bring about the amyloid plaques observed clinically. The seminal paper in which some of this information was published is available here This is the third figure from the report

45. DAPs gajdusek, D. carleton Subacute Spongiform Virus Encephalopathies Caused byUnconventional Viruses in Subacute Pathogens of Plants and Animals Viroids and http://www.stanford.edu/~siegelr/DAPs.html

Spongiform Encephalopathies, Alzheimer's, and Other Diseases of Abnormal Polymerization: A Thermodynamic Model Introduction Prional diseases certainly are candidates for the most unusual afflictions of humanity and mammals generally. Originally, they came to light as scrapie, a disease of Icelandic sheep. Marked by a long time course and bizarre behavior, these diseases were referred to as "unconventional slow viral infections". They were unconventional in the sense that they were all uniformly fatal, evoked no inflammatory or immune response, showed no eclipse period , and resisted all attempts to isolate or visualize a virus-like agent. Among the first human prional diseases was kuru, allegedly transmitted by cannibalism, and Creutzfeldt-Jakob disease (CJD), notorious for its resistance to hospital sterilization procedures. Although linked by a common pathology, the prional diseases include those like kuru that are entirely acquired and those like Gerstmann-Straussler syndrome that are entirely genetic. PrP Stanley Prusiner and coworkers carried out numerous experiments demonstrating that a variety of agents that disrupt or modify nucleic acids have no apparent effect on infectivity or titer of the etiological agents of spongiform encephalopathies and that agents which affect the integrity of proteins almost uniformly diminished the infectivity of the so-called prions. Prional diseases carry the apparent distinction of being the only class of infectious disease that is transmitted independent of nucleic acid. (Recent papers by Wickner and others suggest that this distinction may be shared by so-called "non-Mendelian genetic elements" of [URE3] and [PSI] in Saccharomyces cerevisiae.) Early models included the unsatisfying suggestion that prions replicated by a novel form of nucleic independent protein synthesis.

46. Immunocytochemical Localization Of The Endogenous Neuroexcitotoxin Quinolinate I Contributed by D. carleton gajdusek, October 19, 1995 SK De, CNS Venkateshan, P.Seth, D. carleton gajdusek, and CJ Gibbs Jr http://www.pnas.org/cgi/content/abstract/93/4/1636

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My File Cabinet ... Cited by other online articles PubMed PubMed Citation Articles by Venkateshan, C. N. Articles by Namboodiri, M. A. A. Vol. 93, Issue 4, 1636-1641, February 20, 1996 Medical Sciences Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection quinolinic acid interferon kynurenine tryptophan neurotoxicity C. N. Venkateshan R. Narayanan M. G. Espey J. R. Moffett D. Carleton Gajdusek C. J. Gibbs Jr. , and M. A. A. Namboodiri Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; and Department of Biology, Georgetown University, Washington, DC 20057 Contributed by D. Carleton Gajdusek, October 19, 1995

47. PNAS -- Index By Author (Jun 1 1982, 79 (11)) Gabrion, Jacqueline Abstract gajdusek, D. carleton Abstract Gallwitz,Dieter Abstract Garcia, Roberto Abstract Gerschenfeld, HM Abstract http://www.pnas.org/content/vol79/issue11/aindex.shtml

Index by Author: Jun 1 1982; 79 (11) [Table of Contents] A B C ... W X Y Z A Adams, Julian [Abstract] Ambron, Richard T. [Abstract] Araneo, Barbara A. [Abstract] Austin, R. H. [Abstract] B Babiss, Lee E. [Abstract] Balakir, Richard [Abstract] Barchi, R. L. [Abstract] Barnes, Janice [Abstract] Benjamin, Thomas L. [Abstract] Benyamin, Yves [Abstract] Bitensky, Mark W. [Abstract] Bollman, Susan [Abstract] Brown, Michael S. [Abstract] Brown, T. R. [Abstract] C Cahnmann, Hans J. [Abstract] Carmichael, Gordon G. [Abstract] Carpenter, D. A. [Abstract] Cavadore, Jean-Claude [Abstract] Cedar, H. [Abstract] Cheng, Linda [Abstract] Cooper, Geoffrey M. [Abstract] Cornett, C.V. [Abstract] Cote, Jean [Abstract] Coy, David H. [Abstract] Crick, Francis [Abstract] Cuatrecasas, Pedro [Abstract] Culbertson, Michael R. [Abstract] Cummins, Claudia M. [Abstract] D Davis, C. Geoffrey [Abstract] Demaille, Jacques G. [Abstract] den Hollander, Jan A. [Abstract] Der, Channing J. [Abstract] Diamond, Ivan [Abstract] Donahue, Thomas F. [Abstract] Dorsky, David I. [Abstract] Duerr, Janet S. [Abstract] E Edelman, Gerald M. [Abstract] Esser, Karl

48. September 9 - Today In Science History gajdusek D. carleton. Born 9 Sep 1923 American physician and medical researcher,corecipient (with Baruch S. Blumberg) of the 1976 Nobel Prize for http://www.todayinsci.com/9/9_09.htm

Visit our new gallery of Perpetual Motion Machines through the centuries SEPTEMBER 9 - BIRTHS Gajdusek D. Carleton Born 9 Sep 1923 American physician and medical researcher, corecipient (with Baruch S. Blumberg) of the 1976 Nobel Prize for Physiology or Medicine for his research on the causal agents of various degenerative neurological disorders. Hans Georg Dehmelt Born 9 Sep 1922 German-born American physicist who shared one-half of the Nobel Prize for Physics in 1989 with the German physicist Wolfgang Paul. (The other half of the prize was awarded to the American physicist Norman F. Ramsey.) Dehmelt received his share of the prize for his development of the Penning trap, an electromagnetic device that can hold small... Kurt Lewin Born 9 Sep 1890 German-born American social psychologist known for his field theory of behaviour, which holds that human behaviour is a function of an individual's psychological environment. Pierre Marie Born 9 Sep 1853 French neurologist whose discovery that growth disorders are caused by pituitary disease contributed to the modern science of endocrinology. John Henry Poynting (source) Born 9 Sep 1852 British physicist who introduced a theorem (1884-85) that assigns a value to the rate of flow of electromagnetic energy known as the Poynting vector , introduced in his paper On the Transfer of Energy in the Electromagnetic Field (1884). In this he showed that the flow of energy at a point can be expressed by a simple formula in terms of the electric and magnetic forces at that point. He

49. Modification De D. Carleton Gajdusek - Modifier - Wikipédia MSN Encarta gajdusek, carleton - Translate this page 34,99 € par an (service d’accès à Internet non compris). gajdusek,carleton, (1923- ), virologiste américain colauréat du prix Nobel de médecine ou http://fr.wikipedia.com/w/index.php?title=D._Carleton_Gajdusek&action=edit

50. MSN Encarta - Résultats De La Recherche - Gajdusek Carleton gajdusek carleton 2005 Microsoft;Accord de confidentialité MSN Conditions d utilisation Annonceurs http://fr.encarta.msn.com/Gajdusek_Carleton.html

fdbkURL="/encnet/refpages/search.aspx?q=Gajdusek+Carleton#bottom"; errmsg1="Please select a rating."; errmsg2="Please select a reason for your rating."; Accueil MSN Mon MSN Hotmail Rechercher ... Tout savoir sur la gamme Encarta Rechercher sur Encarta R©serv© aux abonn©s MSN Encarta Premium. R©sultats de la recherche Encarta pour ' Gajdusek Carleton' Articles Gajdusek, Carleton Gajdusek, Carleton , (1923- ), virologiste am©ricain colaur©at du prix Nobel de m©decine ou physiologie de 1976 pour ses travaux sur une maladie... ... (1724-1808), g©n©ral et administrateur britannique, qui s'opposa en vain   la division du Canada en Haut- et... Afficher tous les r©sultats dans le contenu Articles (7) R©sultats avec MSN Search Plus de r©sultats avec MSN pour "Gajdusek Carleton" Publicit© Encyclop©die M©diath¨que Quiz Produits ... dans le monde Publicit© Nos partenaires Rue des ‰coles Tests de culture g©n©rale et de QI Quiz : ©valuez votre anglais © 2005 Microsoft Accord de confidentialit© MSN Conditions d'utilisation Annonceurs Aide

51. NINDS At 50: Celebrating 50 Years Of Brain Research - Demos Medical Publishing Five Lasker Awards and Six Nobels; Seymour S. Kety, MD; Louis Sokoloff, MD; Nancy S.Wexler, Ph.D.; Roscoe O. Brady, MD; D. carleton gajdusek, MD; http://www.demosmedpub.com/book142.html

346 pages Softcover Regular Price: Discount Price: For related titles see: General Neurology NINDS at 50: Celebrating 50 Years of Brain Research Lewis P. Rowland, M.D. For every neurologist and neuroscientist... "An excellent monograph on the 50 years of history of the National Institute of Neurological Disorders and Stroke... This volume should be a part of every Neuroinstitute's Library to inspire younger neuroscientists, not only to match but surpass the achievements of those who built this Institute." World Neurology, "It's amazing how (Dr. Rowland) made the people and the issues, both scientific and political, come alive. This is a fantastic intellectual resource for future historians of science, and a great crash course in neural science for the current generation of students." Dr. John Koester, Director of the Center for Neurobiology and Behavior, Columbia University "The story of how neurology has been transformed into one of the most rapidly expanding and exciting areas of current medical advance is intimately bound up with the story of the National Institute for Neurological Disease and Stroke (NINDS), which is engagingly told by Lewis P. Rowland in NINDS at 50. Dr Rowland has himself been at the heart of progress in neurology over the past half century, and, like so many of the major figures in the USA, spent a formative period in the institute." The Lancet Neurology "...Anyone interested in the development of neuroscience in the last half of the 20th century will benefit from reading this work." Journal of the American Medical Association

52. Daniel Carleton Gajdusek Biography .ms Autobiography, Les Prix Nobel, 1976. Karolinska Institutet, Press ReleaseThe 1976 Nobel Prize in Physiology or Medicine, 1976. esD. carleton gajdusek http://daniel-carleton-gajdusek.biography.ms/

Daniel Carleton Gajdusek Related Links Daniel Radcliffe quotes Daniel Boone quotes Daniel Craig quotes Brittany Daniel quotes ... Daniel Smith quotes Daniel Carleton Gajdusek (born September 9 Yonkers New York U.S.A. ) is an American physician and medical researcher, who was the corecipient (along with Baruch S. Blumberg ) of the Nobel Prize in Physiology or Medicine in 1976. He received the award in recognition of his study of a remarkable disease, Kuru ( Fore word for "trembling"). This disease was rampant among the South Fore people of New Guinea in the 1950's and 1960's. Gajdusek correctly connected the prevalence of the disease with the practice of funerary cannibalism , practiced by the South Fore. With elimination of this practice, Kuru disappeared among the South Fore within a generation. Gajdusek graduated in 1943 from the University of Rochester New York ) , where he studies Physics Biology Chemistry and Mathematics . He obtained an M.D. from Harvard University in 1946. He performed postdoctoral research at both Caltech and Harvard before being drafted to complete military service at the Walter Reed Army Medical Service Graduate School as a research virologist . He held a position at the Institut Pasteur in Tehran from 1952 to 1953, where he was excited by the challenges "offered by urgent opportunistic investigations of epidemiological problems in exotic and isolated populations". In 1954 he went to work as a visiting investigator at the Walter and Eliza Institute of Medical Research in

53. Chronic Wasting Disease Guiroy, DC, ES Williams, R. Yanagihara and D. carleton gajdusek. 1991.Immunolocalization of scrapie amyloid (PrP2730) in chronic wasting disease of Rocky http://www.aphis.usda.gov/vs/nahps/cwd/cwd-research.html

CWD History Distribution of CWD State Information Farmed Cervids ... Wild Cervids Research Photos CWD Research There are a number of ongoing research efforts related to CWD being conducted by State, University, DOI, and USDA researchers. Research groups in the USDA currently conducting CWD research include the Agriculture Research Service (ARS) and the APHIS Wildlife Services National Wildlife Research Center. Some of the USDA research efforts involve the development of faster, high throughput tests as well as live-animal diagnostic tools, host range studies, vaccine development, and techniques to improve separation and prevent transmission of CWD between captive and free-ranging populations. Click the links below to visit CWD research web sites or to view the literature list. Colorado State University's Spatial and Temporal Dynamics of Prion Diseases in Wildlife study is examining the dynamics of TSE transmission over space and time. Note: by following this link you will exit the APHIS web site. Please read the

54. HistoryForSale - Nobel Prize Autographs Autographs D. carleton gajdusek ANNOTATED FIRST DAY COVER SIGNED 06/15/ D.carleton gajdusek - ANNOTATED FIRST DAY COVER SIGNED 06/15/1982 CO-SIGNED http://www.historyforsale.com/html/display.aspx?page=62&start=19&sort=0&signer=&

55. Mad Cow Disease-Key Text In 1957, D. carleton gajdusek (United States National Institutes of Health) andVincent Zigas (Australian Public Health Service) described a strange disease http://www.science.org.au/nova/003/003key.htm

Key text Published by Australian Academy of Science Sponsored by The possibility that a form of mad cow disease can be transmitted to humans has sparked a worldwide scare about eating beef. You will get more from this topic if you have mastered the basics of DNA and genes Printer-friendly version of complete topic Symptoms and pathology of mad cow disease The first diagnosis was in 1986 BSE was first diagnosed in Britain in 1986. It is very similar to scrapie, a well-known disease in sheep that has been recorded for more than 100 years. Scrapie is also a spongiform encephalopathy and is nearly always fatal. Why did mad cow disease suddenly appear? Mad cow disease started in Britain after cattle were fed a protein In 1957, D. Carleton Gajdusek (United States National Institutes of Health) and Vincent Zigas (Australian Public Health Service) described a strange disease among the Fore highlanders of Papua New Guinea. Victims of the condition showed a gradual loss of coordination, and then a sort of premature dementia and an early death. Smart scientific detective work showed that the disease, called kuru, was caused by something that was passed on during ritual cannibalism, when the brains of recently deceased people were eaten. This work involved inoculating chimpanzees with material from the brains of people who had died of kuru. (In 1976, Dr Gajdusek and Dr Baruch Blumberg shared the Nobel prize. Gajdusek for his work on kuru, Blumberg for his work on the hepatitis B virus.)

56. Invisible Victims Of Mad Cow Creutzfeldt-Jakob Disease Science 1970; 169 10881090. 7; 6.gajdusek, D. carleton. Unconventional virusesand the origin and disappearance of kuru. Science 1977; 197 943-960. http://www.geocities.com/HotSprings/3468/dumble.html

57. G21: THE DAILIES American pediatrician and virologist , Dr. D. carleton gajdusek (Guydew-sheck).gajdusek had stopped by New Guinea in 1957, after a research project in http://www.g21.net/daily0707.htm

COVER -> RECOMMENDED DAILY REQUIREMENT RECOMMENDED DAILY REQUIREMENT DATELINE: 7 July, 2000 Transmitted by: Ed Cantarella, USA The World's Magazine: g21.net Event # 222: SOMETHING SO RIGHT AMERICAN DREAMS CARTOONS BY GASPIRTZ DAY ONE G21 Digital Internet Postcards ... VOX POPULI EVERYONE LOVES "RECOMMENDED DAILY REQUIREMENT" but can't find their favorite article. No More! Here's *another* link to the complete ARCHIVES LAST WEEK's EDITION For Deep Background visit the OR get great books at the HOME Discover the MOIA Discussion List To read this article in Deutsch, Francaise, Italiano, Portuguese, Espanol , copy and paste the complete URL("http://www.g21.net/daily0707.htm") and enter it in the box after you click through. I EAT YOU - "In pity and mourning but also in eagerness, the dead woman's female relatives carried her cold, naked body down to her sweet-potato garden......The dead woman's daughter and the wife of her adopted son took up knives of split bamboo, their silicate skin sharp as glass. They began to cut the body for the feast." So begins the 1997 work of Pulitizer prize winning author Richard Rhodes

58. American Scientist Online - Kuru Culture he had the opportunity of spending time in the laboratory of D. carleton gajdusek, carleton, as Klitzman refers to gajdusek throughout the book, http://www.americanscientist.org/template/AssetDetail/assetid/15510

Home Current Issue Archives Bookshelf ... Subscribe In This Section Reviewed in This Issue Book Reviews by Issue New Books Received Publishers' Directory ... Virtual Bookshelf Archive Site Search Advanced Search Visitor Login Username Password Help with login Forgot your password? Change your username see list of all reviews from this issue: November-December 1998 Kuru Culture Donald J. McGraw The Trembling Mountain: A Personal Account of Kuru, Cannibals and Mad Cow Disease. Robert Klitzman. Plenum, 1998. $27.95. Every word in the subtitle is an irresistible lure: The promise, however, is only partially fulfilled. This book is very much a personal account of kuru and of its mechanism of spread, cannibalism. But there are only a few pages about bovine spongiform encephalopathy, or mad cow disease. That may easily be explained in two ways: There is yet little that can be said about this newest of the prion diseases, and this is not a book of science per se. Robert Klitzman's personal account is not meant to satisfy the biological scientist with new information on any aspect of the subtitle except to convey his discoveries in the field on certain aspects of kuru, or the "trembling," in the language of the Papua New Guinea tribe for whom the disease has been and still may be rampant. The Fore, as highlands cannibals, have long been victims of this frightening malady, and Klitzman tells of his findings in kuru's transmission, symptomology and the primary orientation of this account, its sociology.

59. D. Carleton Gajdusek - Wikipedia Translate this page D. carleton gajdusek. De Wikipedia, la enciclopedia libre. Daniel carleton gajduseknació en 1932 en Nueva York. Inicialmente estudió Química y Matemáticas http://es.wikipedia.org/wiki/D._Carleton_Gajdusek

D. Carleton Gajdusek De Wikipedia, la enciclopedia libre. Daniel Carleton Gajdusek naci³ en en Nueva York . Inicialmente estudi³ Qu­mica y Matem¡ticas en la Universidad de Rochester , posteriormente Medicina en la Universidad de Harvard . Ampli³ sus estudios de qu­mica en el Instituto Tecnol³gico de California . Trabaj³ como investigador de la Universidad de Harvard en Ir¡n y en Australia , form³ parte del equipo de investigaci³n del Instituto de Enfermedades Neurol³gicas de Bethesda Maryland En y a ra­z del descubrimiento del kuru , una enfermedad que afectaba a los ind­genas de Nueva Guinea , Gajdusek y Gibs inician sus trabajos sobre los virus lentos. Demostrando que el kuru no era una enfermedad hereditaria, como se cre­a, sino que era causada por lo que ellos llamaron un "virus lento". Posteriormente, Pruisner demostrar­a que era causada por un pri³n Recibi³ el Premio Nobel de Fisiolog­a o Medicina en que comparti³ con Baruch S. Blumberg Obtenido de " http://es.wikipedia.org/wiki/D._Carleton_Gajdusek Categor­as Premio Nobel de Fisiolog­a o Medicina Views Art­culo Discusi³n Editar Historial Herramientas personales Registrarse/Entrar Navegaci³n Portada Portal de la comunidad Actualidad Cambios recientes ... Donativos Buscar Herramientas Lo que enlaza aqu­ Cambios en enlazadas Subir P¡ginas especiales ... Enlace permanente Otros idiomas Deutsch English Portuguªs Esta p¡gina fue modificada por ºltima vez a las 14:20 2 sep, 2005.

60. Academe Today: Chronicle Archives D. carleton gajdusek, a Nobel Prizewinning biomedical researcher at the NationalInstitutes of Health, has been charged with sexually abusing a minor whom http://chronicle.com/data/articles.dir/eguid-42.dir/32eguide.htm

A Guide to the April 19, 1996, Issue of The Chronicle of Higher Education Items relevant to more than one category may appear more than once in this guide. To read the complete text of the article, click on the highlighted words. INTERNATIONAL IN KAZAKHSTAN, PROGRESS VIA EDUCATION Officials of the former republic of the Soviet Union are hoping that a Western-style education system will foster a Western-style economy. IN BRITAIN, A CALL TO DISARM Sir Michael Atiyah, a renowned University of Cambridge mathematician, took on the British nuclear-weapons industry in his farewell speech as president of the Royal Society. IN THE UNITED STATES, TOUGHER VISA RULES The United States Information Agency last week adopted a rule that will make it more difficult for foreign professors and researchers to win extensions of their visas. ALSO IN THE UNITED STATES, the Committee on Scholarly Communication with China is closing its Washington office. Its Beijing office will remain open. IN BOSNIA, CROATIA, AND HUNGARY,

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