41. Structure Of Human POT1 Bound To Telomeric Single-stranded DNA Provides A Model Ming Lei, Elaine R Podell thomas R cech. Howard Hughes Medical Institute, Correspondence should be addressed to thomas R cech thomas.cech@colorado.edu http://www.nature.com/nsmb/journal/v11/n12/abs/nsmb867.html

@import "/nsmb/style.css"; nature.com homepage Login My account ... Browse by subject Search This journal All of nature.com Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Cell Biology Nature Reviews Molecular Cell Biology The EMBO Journal ... Browse all publications Article Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA. Correspondence should be addressed to Thomas R Cech thomas.cech@colorado.edu The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the fission yeast Schizosaccharomyces pombe in vitro binding assays. The structure reveals that hPOT1 contains two oligonucleotide/ oligosaccharide-binding (OB) folds; the N-terminal OB fold binds the first six nucleotides, resembling the structure of the S. pombe

42. Entrez PubMed An interview with thomas R. cech, President of the Howard Hughes Medical Institutein Chevy Chase, MD. Interviewed by Holger Breithaupt. cech T. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

43. Cech Lab Home Laboratory homepage of thomas R. cech. University of Colorado at BoulderBoulder CO 803090215. Welcome to the cech Lab Web Page! http://cechlab.colorado.edu/

The Cech Laboratory Howard Hughes Medical Institute Department of Chemistry and Biochemistry University of Colorado at Boulder Boulder CO 80309-0215 Welcome to the Cech Lab Web Page! Research Publications Members Alumni ... Local Links This site was designed by Toru M. Nakamura. It is now maintained by: Art Zaug

44. AAAS - History And Archives thomas R. cech. AAAS awards and honors. AAAS Newcomb Cleveland Prize, 1986.With Arthur J. Zaug for a research article The Intervening Sequence RNA of http://archives.aaas.org/people.php?p_id=690

45. Funding Above And Beyond Scientific Research: An Interview With Thomas R. Cech, An interview with thomas R. cech, President of the Howard Hughes Medical Institutein Chevy Chase, MD. The interview was conducted by Holger Breithaupt. http://emboreports.npgjournals.com/cgi/content/full/2/9/751

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation EMBO Reports DOI: 10.1093/embo-reports/kve192 European Molecular Biology Organization Interview Funding above and beyond scientific research An interview with Thomas R. Cech, President of the Howard Hughes Medical Institute in Chevy Chase, MD The interview was conducted by Holger Breithaupt. EMBO reports (ER): Dr Cech, when you became President of the Howard Hughes Medical Institute did you already have some administrative or managerial experience? Thomas Cech (TC): Very little! I simply ran my research laboratory and I had had some experience in biotechnology. I had founded a biotech company in Boulder so I was somewhat familiar with annual reports, working with a board, doing budgets, human resources and how to deal with employees. This experience was probably

46. Commencement 2006 : University Of Vermont thomas R. cech received the Nobel Prize for Chemistry in 1989 and has served aspresident of the Howard Hughes Medical Institute, a scientific and http://www.uvm.edu/~cmncmt04/?Page=honorarydegree.html

47. Biology Laboratory Manual | Ribozymes thomas R. cech, Ph.D. Investigator, Department of Chemistry and BiochemistryUniversity of Colorado at Boulder. As a student at Grinnell College, http://highered.mcgraw-hill.com/sites/0073031216/student_view0/exercise10/ribozy

student Center instructor Center information Center Home ... Web Links Choose an exercise exercise 1 exercise 2 exercise 3 exercise 4 exercise 5 exercise 6 exercise 7 exercise 8 exercise 9 exercise 10 exercise 11 exercise 12 exercise 13 exercise 14 exercise 15 exercise 16 exercise 17 exercise 18 exercise 19 exercise 20 exercise 21 exercise 22 exercise 23 exercise 24 exercise 25 exercise 26 exercise 27 exercise 28 exercise 29 exercise 30 exercise 31 exercise 32 exercise 33 exercise 34 exercise 35 exercise 36 exercise 37 exercise 38 exercise 39 exercise 40 exercise 41 exercise 42 exercise 43 exercise 44 exercise 45 exercise 46 exercise 47 exercise 48 exercise 49 exercise 50 Enzmes Multiple Choice Quiz Essay Quiz Essential Study Partner ... Raven/Johnson: Chapter 8 Feedback Help Center Biology Laboratory Manual, 6/e Darrell S. Vodopich, Baylor University Randy Moore, University of MinnesotaMinneapolis Ribozymes Thomas R. Cech, Ph.D. Investigator, Department of Chemistry and Biochemistry University of Colorado at Boulder As a student at Grinnell College, I wanted to be a physical chemist. By the time I entered graduate school at UC Berkeley, however, I was very uncertain. Research in gas-phase physical chemistry depended on complex, custom-built machines, and a long time elapsed between designing an experiment and seeing the results. These features didn't match my impatient temperament. Fortunately, I met Professor John Hearst, a physical chemist bursting with excitement about unraveling chromosome structure and function. His enthusiasm was infectious, and as I took up my graduate research, I found myself spending more and more time catching up on molecular biology.

48. Nobel Prize Winning Chemists thomas R. cech. The Nobel Prize In Chemistry 1989. thomas R. cech was born inChicago on December 8, 1947. His father was a physician and his mother a http://www.sanbenito.k12.tx.us/district/webpages2002/judymedrano/Nobel Winners/t

Nobel Prize Winning Chemists Thomas R. Cech The Nobel Prize In Chemistry 1989 In Berkeley, 1970, his thesis advisor, John Hearst, had an enthusiasm for chromosome structure and function that proved infectious. In 1975 they obtained their Ph. D.'s and moved to postdoctoral positions in Cambridge, Massachusetts. Among his awards were the Pfizer Award in Enzyme Chemistry, the Award in Molecular Biology, the Heineken Prize and the Lasker Award. He was awarded the Nobel Prize jointly with Sidney Altman "for their discovery of catalytic properties of RNA." More recently, his life has been transformed by the addition to his family of two energetic daughters, Allison (born 1982) and Jennifer (1986). Because of his research group's discoveries, more than a dozen national and international awards preceded the Nobel Prize for Chemistry in 1989. Back To Main Page

49. SGD Colleagues Community Info Submit Data BLAST Primers PatMatch Gene/Seq Resources Advanced Search Virtual Library. SGD Colleagues. Help. thomas R. cech http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=8990

50. Nobel Lectures Website Dr. thomas R. cech * Howard Hughes Medical Institute, Boston, MA, USA and Universityof Colorado, Boulder, CO, USA. RNA Enzymes and the Origins of Life http://www.biozentrum.unibas.ch/nobellectures/review_0205.html

Review  Welcome  Preview  Nobel Lectures  Review ...  Contact February 7th 2005 Prof. Dr. Thomas R. Cech * Howard Hughes Medical Institute, Boston, MA, USA and University of Colorado, Boulder, CO, USA RNA Enzymes and the Origins of Life 18.15 h, Kollegienhaus, Room 102 Contact Person: Prof. J. Seelig RNA Enzymes and the Origins of Life Chemical reactions that take place within living cells are usually catalyzed by enzymes. It was long thought that all enzymes were proteins. In the first part of the talk, I will describe the discovery of the first “ribozyme” – an enzyme composed of ribonucleic acid (RNA). In the 23 years since this finding, multiple classes of ribozymes have been identified. Arguably the most important one is the large subunit of ribosomal RNA, which catalyzes the synthesis of proteins in all forms of life. In thinking about the origins of life, there is a “chicken and egg problem”: if even the simplest self-replicating system needs both an informational molecule (nucleic acid) and an enzyme to copy the information (protein enzyme), then which came first, the nucleic acid or the protein? Now that RNA is known to provide both functions, perhaps self-replicating RNA solved this problem early in evolution. I will discuss experimental advances that support the feasibility of this scenario. I will also talk about the limitations of science in answering what is ultimately a historical question.

51. Boston Globe Online / Table Of Contents If thomas R. cech, was surprised that he won this year s Nobel Prize for Chemistry,his colleagues and mentors were not. There was reason to suspect he was http://www.boston.com/globe/search/stories/nobel/1989/1989j.html

Archives Big Dig Book Reviews Boston Capital ... Week in Photos Search the Globe: Today Yesterday THOMAS R. CECH Author: By Alison Bass, Globe Staff Date: Friday, October 13, 1989 Page: Section: NATIONAL/FOREIGN If Thomas R. Cech, was surprised that he won this year's Nobel Prize for Chemistry, his colleagues and mentors were not. There was reason to suspect he was headed for scientific glory while he was still a schoolboy, winning state science fairs in Iowa year after year. Cech, a lanky 41-year-old Colorado resident, reminisced about those early years while sipping champagne with colleagues at the Whitehead Institute in Cambridge yesterday. He had just spoken on the phone with a reporter from a Des Moines newspaper, who remembered that Cech won a science fair in eastern Iowa while still in junior high. When one of his colleagues asked the topic of his winning entry, Cech joked, "I don't remember. I was in so many science fairs." Cech, born in Chicago, took that all-consuming passion for science to Grinnell College in Iowa, where he received a BA in chemistry, and then to the University of California at Berkeley, where he earned a doctorate. He joined the faculty at the University of Colorado at Boulder in 1978 after doing a postdoctoral fellowship at MIT. Many of the scientists who gathered around Cech yesterday remembered him fondly from his days at MIT.

52. Thomas Cech Dr. thomas R. cech of the University of Colorado received the Nobel Prize forChemistry in 1989 for his research in establishing a link between RNA and the http://www.cualum.org/heritage/virtual_tour/cech.html

Hall of Alumni Wurlitzer Glenn Miller Thomas Cech ... Derbur Atler Thomas Cech Distinguished Professor and Investigator Department of Molecular, Cellular, and Developmental Biology University of Colorado, Boulder Dr. Thomas R. Cech of the University of Colorado received the Nobel Prize for Chemistry in 1989 for his research in establishing a link between RNA and the evolutionary chain. His discoveries have shed new light on the mystery of the beginning of life and guided genetic engineers in their search for life-saving cures in the battle against cancer. Prior to Cech's RNA breakthroughs in the early 1980s, scientists believed DNA served as the warehouse of genetic information, that RNA decoded the information and that proteins used the information to create physical attributes such as skin, hair and eyes. These proteins were thought to be the only catalysts in determining cell development. Cech's research established that RNA, like a protein, can act as a catalyst in cellular processes.

53. UCLA Portal Feng Guo, Anne R. Gooding and thomas R. cech Structure of the Tetrahymena Feng Guo and thomas R. cech Evolution of Tetrahymena ribozyme mutants with http://dgsom.healthsciences.ucla.edu/institution/personnel?personnel_id=74933

54. Biochem. Soc. Trans (2002) 30, 1162-1166 - R. Cech - Ribozymes And RNA Catalysis group I intron, RNA structure, splicing, Xray crystallography. Abbreviationused IGS, internal guide sequence. 1E-mail thomas.cech@colorado.edu http://www.biochemsoctrans.org/bst/030/bst0301162.htm

About the journal Subscriptions Authors Users ... Download to Citation Matcher Biochem. Soc. Trans. (2001) Ribozymes, the first 20 years T. R. Cech Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, U.S.A., and University of Colorado, Boulder, CO 80309-0215, U.S.A. Key words: catalytic RNA, group I intron, RNA structure, splicing, X-ray crystallography. Abbreviation used: IGS, internal guide sequence. Abstract In 1982 we reported the first catalytic RNA or ribozyme: the self-splicing intron of the Tetrahymena pre-rRNA. Additional examples of natural ribozymes were soon found, and research in the field focused on their enzymic mechanism and secondary and tertiary structure. Ribozymes identified through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein facilitators of their activity. Journal home page Current issue Browse archive by issue Browse archive by meeting ... Email this article to a friend

55. Cech | Serwis Ewolucyjny | Ewolucjonisci cech. thomas R. cech. Urodzil sie w 1947 roku. Amerykanski biochemik, profesorUniwersytetu Kolorado oraz Instytutu Badan Medycznych im. Hughesa w Boulder. http://www.ewolucja.org/d7/d7a5.html

window.status="ewolucja" Wprowadzenie Nowo¶ci Artyku³y e-WWWolucja ... English info Szukaj w serwisie Thomas R. Cech Urodzi³ siê w 1947 roku. Amerykañski biochemik, profesor Uniwersytetu Kolorado oraz Instytutu Badañ Medycznych im. Hughesa w Boulder. W 1980 roku dokona³ jednego z najwiêkszych odkryæ w genetyce od czasu opracowania modelu podwójnej helisy: udowodni³, i¿ kwasy nukleinowe mog± wykazywaæ w³a¶ciwo¶ci katalityczne. Odkrycie to umo¿liwi³o Walterowi Gilbertowi sformu³owanie jednej z najpowszechniej obecnie przyjmowanych teorii powstania ¿ycia: hipotezy ¦wiata RNA Za swoje badania uhonorowany zosta³ w 1989 roku Nagrod± Nobla. Zainteresowanych tematyk± powstania ¿ycia zapraszamy do dzia³u Biogeneza naszego serwisu. Katarzyna Adamala autorzy: Katarzyna Adamala Karol Sabath

56. Grinnell College - Board Of Trustees thomas R. cech ’70 1998. Alt text. Dr. cech is President of the Howard HughesMedical Institute headquartered in Chevy Chase, Maryland. http://www.grinnell.edu/offices/president/trustee/memberintro/cech/

Board of Trustees Search Back Introducing the Members Thomas R. Cech ’70 1998 Dr. Cech is President of the Howard Hughes Medical Institute headquartered in Chevy Chase, Maryland. He also continues to hold the position of Distinguished Professor of Chemistry and Biochemistry at the University of Colorado-Boulder and is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He graduated from Grinnell College in 1970 with a degree in chemistry and from the University of California-Berkeley in 1975 with a Ph.D. In 1987 he received an honorary degree from Grinnell. He was the 1989 co-recipient of the Nobel Prize for Chemistry for his research finding that RNA can act as a catalyst for biologically important chemical reactions. In 1995, President Clinton awarded him the Medal of Science. Dr. Cech was part of a research team that discovered the human gene for the enzyme telomerase in 1997. Style: Text only/Printer Low-Graphics Viewbook Academics Admission Alumni Athletics ... ITS Grinnell, IA 50112-1690

57. Science -- Sign In thomas R. cech Howard Hughes Medical Institute, 4000 Jones Bridge Road, thomas R. cech Science 2003 299 165. (in Editorial) Summary http://www.sciencemag.org/cgi/content/full/300/5623/1236a

You do not have access to this item: Full Text : Roccanova; and Cech, Inoculating a Science Education Epidemic, Science You are on the site via Free Public Access. What content can I view with Free Public Access If you have a personal user name and password, please login below. SCIENCE Online Sign In Options For Viewing This Content User Name Password this computer. Help with Sign In If you don't use cookies, sign in here Join AAAS and subscribe to Science for free full access. Sign Up More Info Register for Free Partial Access including abstracts, summaries and special registered free full text content. Register More Info Pay per Article 24 hours for US $10.00 from your current computer Regain Access to a recent Pay per Article purchase Need More Help? Can't get past this page? Forgotten your user name or password? AAAS Members activate your FREE Subscription

58. Science -- Sign In thomas R. cech. In universities across the United States and in many other thomas R. cech is president of the Howard Hughes Medical Institute and for 22 http://www.sciencemag.org/cgi/content/summary/299/5604/165

You do not have access to this item: Summary : Cech, Rebalancing Teaching and Research, Science You are on the site via Free Public Access. What content can I view with Free Public Access If you have a personal user name and password, please login below. SCIENCE Online Sign In Options For Viewing This Content User Name Password this computer. Help with Sign In If you don't use cookies, sign in here Join AAAS and subscribe to Science for free full access. Sign Up More Info Register for Free Partial Access including abstracts, summaries and special registered free full text content. Register More Info Regain Access to a recent Pay per Article purchase Need More Help? Can't get past this page? Forgotten your user name or password? AAAS Members activate your FREE Subscription

59. Nobel Laureate Thomas Cech To Lecture March 27, Campus News (Bowdoin) Nobel laureate Dr. thomas R. cech will speak at Bowdoin College at 7 pm, Thursday,March 27, in Kresge Auditorium, Visual Arts Center. http://www.bowdoin.edu/news/archives/1bowdoincampus/001234.shtml

@import "/includes/global_new/base.css"; @import "/includes/global_new/newsdetails.css"; Skip Navigation and go to content You may be using a browser that will cause viewing problems on our web site... please visit our browser upgrade page to learn more. A-Z Index Directory Help ... Prospective Students Location: Bowdoin Campus News News Campus News Summer Research at Bowdoin Academic Spotlight ... Classifieds Events Featured Events Events Calendar Search Events Calendar Exhibits ... WBOR Nobel Laureate Thomas Cech to Lecture March 27 Go to Campus News Go to Academic Spotlight Story posted March 19, 2003 Nobel laureate Dr. Thomas R. Cech will speak at Bowdoin College at 7 p.m., Thursday, March 27, in Kresge Auditorium, Visual Arts Center. Cech, winner of the 1989 Nobel Prize in chemistry and president of the Howard Hughes Medical Institute, will give a talk titled “Where the Double Helix Ends: Telomeres and Telomerase.” Telomeres are unique DNA structures at the end of strands. Telomerase replicates telomeres and ceases to be made after birth. Telomerase is also active in cancer cells. Cech’s talk will address the questions: Are telomeres the yardstick that defines cell aging and death? Does telomerase control how cancer cells proliferate?

60. Cech, Thomas Robert. The Columbia Encyclopedia, Sixth Edition. 2001-05 cech, thomas Robert. The Columbia Encyclopedia, Sixth Edition. 200105. http://www.bartleby.com/65/ce/Cech-Tho.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. Cech, Thomas Robert

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