81. 2005 GRC On Medicinal Chemistry medicinal chemistry. August 712, 2005 Colby-Sawyer College The Design andProfile of VX-950, an HCV NS3-4A Protease Inhibitor in clinical Development http://www.grc.uri.edu/programs/2005/medchem.htm

Medicinal Chemistry August 7-12, 2005 Colby-Sawyer College New London, NH Chair: S. David Kimball Vice Chair: John A Lowe Vice Chair Elect: George D Hartman Dear Colleagues, The 2005 Medicinal Chemistry Gordon Conference will be held August 7th through 12th at Colby-Sawyer College in New London, New Hampshire. Vice-Chair John Lowe ( john_a_lowe@groton.pfizer.com ) has done an outstanding job putting together the cutting edge program below. If you are interested in attending the conference and presenting a poster, please send an abstract of your poster to Frank Salituro at Vertex ( francesco_salituro@vrtx.com ), after you have applied to the conference. The conference scientific sessions will end with a Special Topics Session, comprised of late-breaking results from recent clinical compounds. This session will be organized by Mary Mader of Lilly; please contact her with any suggested contributions for Special Topics ( mader_mary@lilly.com ). Finally, the conference will wrap up on Thursday evening with the traditional lobster dinner and Chair's Talk, which will be given by Roy Vagelos, formerly of Merck. The Medicinal Chemistry GRC will continue the tradition of outstanding science presented in a relaxed atmosphere. Social events for the week will be organized by Vice-Chair Elect George Hartman of Merck and will feature the Monday Hike to the peak of Mt. Kearsarge, the Tuesday East/West Softball Game (Krantz Cup) and the Wednesday Vice-Chair Elect Golf Tournament. Please contact George with any questions or suggestions for activities (

82. Analytical Medicinal Chemistry Associate Professor of medicinal chemistry; Ray Bakhtiar, Ph.D. pdf;clinical Proteomics Are We There Yet? Analytical chemistry, 2003, November, http://www.rci.rutgers.edu/~layla/AnalMedChem511/AnalMedChem511.html

Instructors: Longqin Hu , Ph.D. (Coordinator) Associate Professor of Medicinal Chemistry Ray Bakhtiar , Ph.D. Senior Research Fellow, Merck Research Laboratory Course Announcements: Comprehensive Final Exam on Monday, March 21st. 20% - Dr. Hu's portion 80% - Dr. Bakhtiar's portion Term paper due on April 20th Presentation Schedule: 30 min each Date and Time Presenter Title Monday, April 25, 4:30 pm - Guoxiang Shen SELDI-TOF MS for Diagnostic Proteomics Kristi Cappuccio multidimensional analysis on LC-LC or GC-GC or another combination Jianying Ding NMR Spectroscopy Tools for Structure-Aided Drug Design Yu Chen TBA Wednesay, April 27, 4:30 pm - Kumar Pabbisetty Proteomics approaches in the search for disease biomarkers Prathima Surabhi TBA Liang Cheng TBA Course Material Class Schedule (pdf file) Course Syllabus (pdf file) FDA Guidance for Industry: Bioanalytical Method Validation Chiral Method Development Screen in Drug Discovery - Lab Wall Chart ... The First Step in Solving LC-MS Method Development Challenges -New Quadrupole Ion-Trap Mass Analyzer - EAS Workshop on November 15, 2004

83. Faculty Of Pharmacy Pharmaceutical Sciences Advanced Organic chemistry, Advanced medicinal chemistry, Analytical andClinical chemistry. (3) Pharmaceutics and Pharmacological Science Field http://www.fukuyama-u.ac.jp/pharm/htmls/english/english.html

84. Center For Cancer Research - Lab Pages CCR clinical Staff. CCR clinical Staff. The NIH clinical Center The Laboratoryof medicinal chemistry (LMC) is a multidisciplinary laboratory, http://ccr.cancer.gov/labs/lab.asp?labid=101

85. Units Indexed By Faculty: Victorian College Of Pharmacy Emerging Technologies in Drug Discovery; PRU0001 Research in medicinal chemistry VCP3051 clinical pharmacy I; VCP3061 Pharmaceutical microbiology II http://www.monash.edu.au/pubs/2005handbooks/units/index-byFaculty-PHA.html

Skip to content Change text size Monash home About Monash ... Site map SEARCH Handbooks All of Monash for Monash Handbooks 2005 Index by unit code 2005 Index by unit name 2005 Units by faculty Other indices Faculty of Art and Design Faculty of Arts Faculty of Business and Economics Faculty of Education ... Faculty of Science Units indexed by Faculty: Victorian College of Pharmacy Introduction to Medicinal Chemistry Synthetic Chemistry A Synthetic Chemistry B Biomolecules Structure and Function Analytical Methods Computational Chemistry Physiology Introduction to Spectroscopy Drug Formulation and Delivery Synthetic Medicinal Chemistry Chemistry of Drug Action Research Project Spectroscopy Functional Pharmacology in Drug Design Lead Identification Drug Discovery and Development Emerging Technologies in Drug Discovery Research in pharmacy practice Pharmacy practice and planning The Australian Healthcare and Pharmaceutical Environment Risk Management for Pharmacy Chemistry I A Chemistry I B Formulation Chemistry I A Formulation Chemistry I B Physiology I Physiology II Mathematics, calculus

86. Units Indexed By Faculty: Victorian College Of Pharmacy BMC1021 Introduction to medicinal chemistry; BMC2021 Synthetic chemistry A VCP3051 clinical pharmacy I; VCP3061 Pharmaceutical microbiology II http://www.monash.edu.au/pubs/handbooks/units/index-byFaculty-PHA.html

Skip to content Change text size Monash home About Monash ... Site map SEARCH Handbooks All of Monash for Monash Handbooks 2005 Index by unit code 2005 Index by unit name 2005 Units by faculty Other indices Faculty of Art and Design Faculty of Arts Faculty of Business and Economics Faculty of Education ... Faculty of Science Units indexed by Faculty: Victorian College of Pharmacy Introduction to Medicinal Chemistry Synthetic Chemistry A Synthetic Chemistry B Biomolecules Structure and Function Analytical Methods Computational Chemistry Physiology Introduction to Spectroscopy Drug Formulation and Delivery Synthetic Medicinal Chemistry Chemistry of Drug Action Research Project Spectroscopy Functional Pharmacology in Drug Design Lead Identification Drug Discovery and Development Emerging Technologies in Drug Discovery Research in pharmacy practice Pharmacy practice and planning The Australian Healthcare and Pharmaceutical Environment Risk Management for Pharmacy Chemistry I A Chemistry I B Formulation Chemistry I A Formulation Chemistry I B Physiology I Physiology II Mathematics, calculus

87. Internet Links - Medicinal Chemistry (CHM 4790) - Dr. Howard Black Medical Matrix A good links site for Internet clinical medicine resources. ACS Division of medicinal chemistry - the usual ACS divisional info http://www.ux1.eiu.edu/~cfthb/classes/4790/links.htm

Chemistry 4790 - Dr. Howard Black Eastern Illinois University Important: The information on this page is for informational purposes only, and is not intended to replace medical consulation with your doctor. The aim is to help people become more informed health care consumers and to illustrate what vast data are available on the internet; it should never be construed as a substitute for consultation with your health care professional. Inclusion of a site does not imply any endorsement of the site, its stated positions, or its sponsor. Table of Contents Drug Information Resources on Diseases/Disorders Most Useful Medical Websites Drug Development ... Databases/Misc. Drug Information Clinical Pharmacology Online - a listing of hundreds of drugs, contains much pharmacological data on each drug, even in combined-product formulations. Includes mechanism of action and pharmacokinetics, including metabolism. CVS On-Line Pharmacy Store - A true on-line pharmacy providing wholesale pricing information; this particular page lists their top-selling several hundred products. Very informative, especially for comparing the retail price of a drug you or a friend may take with the wholesale price.

88. Welcome To Pharmacy School medicinal chemistry, Introduction, Curricula of Undergraduate Programs clinical Pharmacology, 56, 56. Biopharmaceutics Pharmacokinetics, 72, 48, 24 http://www.shmu.edu.cn/yxy/english/Admissions.htm

89. Graduate School Of Pharmaceutical Sciences Sc., Professor, (pharmaceutical analytical chemistry, clinical analytical Sc., Research Associate, (medicinal organic chemistry, pharmaceutical http://www.chiba-u.ac.jp/EN/catalogue/page/GR_PHARMACEUTICAL.htm

GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES 1-33, Yayoi-cho, Inage-ku, Chiba-shi, Chiba, 263-8522 Japan Tel. +81-43-290-2897 Fax. +81-43-290-2974 Dean: Prof. Kazuei Igarashi Overview The Graduate School of Pharmaceutical Sciences consists of a two-year master's program and a subsequent three or four-year program leading to a Ph.D. degree. The Graduate School is organized into two courses; the General Pharmaceutical Sciences Course and the Clinical Pharmacy Course. Advanced studies and research in various fields of pharmaceutical sciences are carried out in twenty-three laboratories. The graduate program includes interdisciplinary work in the pharmaceutical sciences and medicine in collaboration with the School of Medicine, the School of Nursing, and the Research Center for Pathogenic Fungi and Microbial Toxicoses. History The Graduate School of Pharmaceutical Sciences was founded in 1964 to prepare students for a master's degree. A doctoral program in pharmaceutical sciences was established in 1979 and the Graduate School was organized into one course, the General Pharmaceutical Sciences Course. In 1997, the Clinical Pharmacy Course was founded to prepare students to attain master's and doctor's degrees in clinical pharmacy. The Graduate School was newly started as the Graduate School of Medical and Pharmaceutical Sciences under educational collaboration program with the Graduate School of Medicine in 2001. The Graduate School is composed of master and doctor courses. The master course is participated by pharmaceutical science area, whereas the doctor course by both areas of medicine and pharmaceutical sciences.

90. Drug Development Technology - Onyx Scientific - Lead Optimisation, Medicinal Che We specialise in lead optimisation, medicinal chemistry, custom synthesis, Preclinical development requires larger quantities of high quality material http://www.drugdevelopment-technology.com/contractors/synthesis/onyx/

Home Products and Services Custom Synthesis and Purification Onyx Scientific ONYX SCIENTIFIC - LEAD OPTIMISATION, MEDICINAL CHEMISTRY, CUSTOM SYNTHESIS, CONTRACT RESEARCH AND GMP MANUFACTURE Onyx Scientific provides a wide range of chemical services to the life sciences industry. We specialise in lead optimisation, medicinal chemistry, custom synthesis, contract research and GMP manufacture, in addition to providing a comprehensive range of stand alone analytical services. Whether sourcing a research, process development or synthesis partner, Onyx Scientific can provide extensive experience in all areas. The company is dedicated to providing the industry with the highest level of service possible from its state of the art laboratories in the North East of England. CUSTOM SYNTHESIS AND CONTRACT RESEARCH Our complete custom synthesis and contract research service can supply key intermediates, competitor compounds, analogues, as well as final APIs. Our team of chemists are predominantly PhD qualified and as a result we can take on difficult and complex multi-stage work. We have access to a complete range of scientific literature procedures and online scientific databases all that can be implemented into our route discovery service. Thus Onyx Scientific provides a fast, responsive turnaround from initial enquiry to final delivery of material with comprehensive reporting throughout. LEAD OPTIMISATION - MOLECULAR VISUALISATION SOFTWARE We aim to maximise efficiency in the field of lead optimisation by combining our experience in medicinal chemistry and drug design with molecular visualisation software and chemoinformatics packages to provide a targeted, knowledge based approach to project management. In this way we can design high quality lead and drug-like candidates and reduce downstream attrition rates with an early onset consideration for molecular properties and ADME characteristics. We produce small, highly focussed libraries, specialising in the area of multiple parallel solution phase library synthesis using a range of specialist equipment to facilitate the process.

91. Current Medicinal Chemistry, Volume 11, No. 4, 2004 Current medicinal chemistry, Volume 11, No. 4, 2004. Contents. Taxanes Nanoparticles of Biodegradable Polymers for clinical Administration of Paclitaxel http://www.bentham.org/cmc/cmc11-4.htm

[Back to Contents Page] [Back to Home Page] C urrent Medicinal Chemistry, Volume 11, No. 4, 2004 Contents Taxanes Guest Editor: Michel Page Intravenous and Regional Paclitaxel Formulations Pp.397-402 Rajendra Pawar, Ariella Shikanov, Boris Vaisman and Abraham J. Domb [Abstract] Glucocorticoids Selectively Inhibit Paclitaxel-Induced Apoptosis: Mechanisms and Its Clinical Impact Pp.403-411 Weimin Fan, Meihua Sui and Yi Huang [Abstract] Nanoparticles of Biodegradable Polymers for Clinical Administration of Paclitaxel Pp.413-424 Si-Shen Feng, Li Mu, Khin Yin Win and Guofeng Huang [Abstract] Chronic Administration of Single Weekly Paclitaxel in Heavily Pretreated Ovarian Cancer Patients Pp.425-428 Kenji Yamamoto, Shirei Oogi, Hiromi Inoue, Kazuya Kudoh, Tsunekazu Kita and Yoshihiro Kikuchi [Abstract] Tumor Specific Novel Taxoid-Monoclonal Antibody Conjugates Pp.429-438 X. Wu and I. Ojima [Abstract] Paclitaxel Antibody Conjugates and Trehalose for Preserving the Immunulogical Activity After Freeze-Drying Pp.439-446

92. Current Topics In Medicinal Chemistry, Volume 4, No. 10, 2004 Current Topics in medicinal chemistry, Volume 4, No. 10, 2004. Contents Early clinical trial data now also confirms that these types of agents will have http://www.bentham.org/ctmc/ctmc4-10.htm

[Back to Contents Page] [Back to Home Page] C urrent Topics in Medicinal Chemistry, Volume 4, No. 10, 2004 Contents Recent Advances in the Treatment of HIV Infection Guest Editor: Jayaram R. Tagat Chemokine Receptor-directed Agents as Novel Anti-HIV-1 Therapies Pp. 1017-1033 Sander G. Mills and Julie A. DeMartino [Abstract] Biochemical and Mechanistic Basis for the Activity of Nucleoside Analogue Inhibitors of HIV Reverse Transcriptase Pp. 1035-1044 George R. Painter, Merrick R. Almond, Shuli Mao and Dennis C. Liotta [Abstract] Recent Advances in the Development of Next Generation Non-nucleoside Reverse Transcriptase Inhibitors Pp. 1045-1057 Christine M. Tarby [Abstract] HIV-1 Integrase Inhibitors: A Decade of Research and Two Drugs in Clinical Trial Pp. 1059-1077 Allison A. Johnson, Christophe Marchand and Yves Pommier [Abstract] Peptidomimetic Inhibitors of HIV Protease Pp. 1079-1095 John T. Randolph and David A. DeGoey [Abstract] Non-Peptidic HIV Protease Inhibitors Pp. 1097-1114 R. Alan Chrusciel and Joseph W. Strohbach [Abstract] Abstracts [Back to top] Chemokine Receptor-directed Agents as Novel Anti-HIV-1 Therapies Sander G. Mills and Julie A. DeMartino

93. CEREP - Products & Services- Chemistry- Lead Optimization & Medicinal Chemistry Cerep has developed an Accelerated medicinal chemistry approach, which is based on Cerep chemists have brought numerous compounds to clinical trials for http://www.cerep.fr/Cerep/Users/pages/ProductsServices/lead.asp

Home Experienced medicinal chemists Proven track record Lead discovery and optimization guided by Strong parallel synthesis skills Integration of chemistry and unique High throughput profiling platform In the last two years we have initiated and successfully advanced 11 different programs including large collaborations with major pharmaceutical companies, fee for service hit-to-lead and lead optimization projects or custom medicinal chemistry projects. Cerep chemists have brought numerous compounds to clinical trials for pharmaceutical companies and have been awarded over 100 patents for the past 10 years. In September 2003, collaboration with Bristol-Myers Squibb resulted in an IND filing of a new ICAM1/LFA-1 antagonist, currently under evaluation in Phase I clinical trials. We have been working on a wide range of targets and projects from the very early stage of hit identification to the late stage of preclinical development. In the entire process, our chemists take advantage of information from our unique profiling platform which provides data regarding specificity, selectivity and ADME properties. Contact Chemistry Diverse libraries Corporate HTS library Odyssey II ... Credits

94. Elsevier.com - Advances In Clinical Chemistry, 35 Advances in clinical chemistry 36. Book, 2001, by Spiegel Proceedings of theXIIIth International Symposium on medicinal chemistry. Book, 1995 http://www.elsevier.com/wps/find/products_in_subject_and_group.cws_home/674833

Home Site map Regional Sites Advanced Product Search ... Advances in Clinical Chemistry, 35 Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view Other books within Medicinal Chemistry (18 books, sorted by title) Title Actualites de Chimie Therapeutique 1997 Book, 1997, by Combet Farnoux Actualites de Chimie Therapeutique 1998 24e Serie 24th Series Book, 1998, by Combet Farnoux Actualites de Chimie Therapeutique 1999 25e Serie 25th Series Book, 1999, by Lafont Advances in Clinical Chemistry 36 Book, 2001, by Spiegel Advances in Medicinal Chemistry Volume 4 Book, 1999, by Maryanoff Advances in Medicinal Chemistry Volume 5 Book, 2000, by Reitz Advances in Organometallic Chemistry 42 Book, 1998, by West Advances in Organometallic Chemistry 43 Book, 1999, by West Approaches to Design and Synthesis of Antiparasitic Drugs Book, 1997, by Anand Chemical Bond The Book, 1992, by Zewail

95. Elsevier.com - Advances In Clinical Chemistry, 36 Advances in clinical chemistry 35. Book, 2001, by Spiegel Proceedings of theXIIIth International Symposium on medicinal chemistry. Book, 1995 http://www.elsevier.com/wps/find/products_in_subject_and_group.cws_home/675775

Home Site map Regional Sites Advanced Product Search ... Advances in Clinical Chemistry, 36 Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view Other books within Medicinal Chemistry (18 books, sorted by title) Title Actualites de Chimie Therapeutique 1997 Book, 1997, by Combet Farnoux Actualites de Chimie Therapeutique 1998 24e Serie 24th Series Book, 1998, by Combet Farnoux Actualites de Chimie Therapeutique 1999 25e Serie 25th Series Book, 1999, by Lafont Advances in Clinical Chemistry 35 Book, 2001, by Spiegel Advances in Medicinal Chemistry Volume 4 Book, 1999, by Maryanoff Advances in Medicinal Chemistry Volume 5 Book, 2000, by Reitz Advances in Organometallic Chemistry 42 Book, 1998, by West Advances in Organometallic Chemistry 43 Book, 1999, by West Approaches to Design and Synthesis of Antiparasitic Drugs Book, 1997, by Anand Chemical Bond The Book, 1992, by Zewail

96. UCL Chemistry Department - Degree In Medicinal Chemistry concerned with the discovery, design and synthesis of new drugs for clinicaluse. Our strong tradition of medicinal chemistry is sustained by Robin http://www.chem.ucl.ac.uk/admissions/medicalchemistry.html

Search A dmissions P eople ... ontact UCL Admissions Undergraduate Admissions Information for Prospective ... contact BSc and MSci Medicinal Chemistry All degrees are structured in modules or units, each student taking half and full unit courses totaling to four units each year. The system allows considerable flexibility in tailoring degrees to individual requirements and in transfer between related degree programmes. Most units are based on a set of lectures, assigned course work and tutorials in small groups with an academic staff member, and many courses have associated laboratory work. Typically students spend two afternoons each week in the chemistry laboratories. Each unit or half-unit is individually assessed. The following section describes the structure of the BSc and MSci degree in MEDICINAL CHEMISTRY. Medicinal Chemistry (BSc F150; MSci F153) ( Entry requirements and Degree Structure This century has seen the beginnings of the realization of one of our most fundamental ambitions: the conquest of disease by the effective use of drugs. Medicinal chemistry is concerned with the discovery, design and synthesis of new drugs for clinical use. These degree programmes include courses in biology, physiology, biochemistry and pharmacology, along with the fundamentals of chemistry necessary to design and synthesize drugs. These provide an understanding of the link between chemical structure and clinical effectiveness, which underlies the courses on drug design.

97. VC2: Careers: Medicinal Chemistry medicinal chemistry is the application of chemical research techniques to thesynthesis of During the early stages of medicinal chemistry development, http://www.chemistry.org/portal/a/c/s/1/acsdisplay.html?DOC=vc2\3wk\wk3_med.html

98. Introduction - College Of Pharmacy At The University Of Minnesota Department Experimental and clinical Pharmacology Department MedicinalChemistry; Lab 8120 Weaver-Densford Hall; Primary Research Hazards http://www.pharmacy.umn.edu/research/safety/plan/introduction/home.html

Return to: College of Pharmacy Academic Health Center myU U of M Home ... COP Home Quick Links PharmD Professional Program College of Pharmacy, Duluth Home Research ... Laboratory Safety Plan > Introduction Introduction University of Minnesota College of Pharmacy Laboratory Safety Plan Updated February 24, 2004 Chapter 1 - Introduction 1. Purpose This Laboratory Safety Plan (LSP) describes policies, procedures, equipment, personal protective equipment and work practices that are capable of protecting employees from the health hazards in laboratories. This Plan is intended to meet the requirements of both the federal Laboratory Safety Standard, formally known as "Occupational Exposure to Hazardous Chemicals in Laboratories," a copy of which is found in Appendix A, and the Minnesota Employee Right To Know Act (MERTKA). This LSP is intended to safely limit laboratory workers' exposure to OSHA- and MERTKA-regulated substances. Laboratory workers must not be exposed to substances in excess of the permissible exposure limits (PEL) specified in OSHA rule 29 CFR 1910, Subpart Z, Toxic and Hazardous Substances. PELs for regulated substances are provided in Appendix B. PELs refer to airborne concentrations of substances and are averaged over an eight-hour day. A few substances (listed under Individual Chemical Standard in the Federal column in Appendix C) also have "action levels." Action levels are air concentrations below the PEL which nevertheless require that certain actions such as medical surveillance and workplace monitoring take place.

99. University Of The Pacific Pharmacy Practice, clinical Experience Program. Xiaoling Li, Ph.D. Pharmaceutics andMedicinal chemistry. Tamara Little, PT, DMT. Physical Therapy http://pharmacy.pacific.edu/faculty.html

Faculty Richard R. Abood, J.D. Pharmacy Practice Sandra Bellamy, PT, DPT Physical Therapy James W. Blankenship, Ph.D. Gordon U. Burton, Ph.D. Physical Therapy Sian Carr-Lopez, Pharm.D. Pharmacy Practice, Clinical Experience Program Patrick N. Catania, Ph.D. Pharmacy Practice William K. Chan, Pharm.D., Ph.D. Pharmaceutics and Medicinal Chemistry Nancy L. DeGuire, Pharm.D. University Advancement Jesika S. Faridi , Ph.D. George C. Ferguson, D.V.M. Donald G. Floriddia, Ph.D. Pharmaceutics and Medicinal Chemistry Paul T. Fogle, Ph.D. Speech-Language Pathology David S. Fries, Ph.D. Pharmaceutics and Medicinal Chemistry Karen A. Gibbs, PT, DPT, CWS

100. Prospective Students Current Students Alumni Friends Guests PEMS Clerkship Manual Clerkship Site Selection clinical Scholars MedicinalChemistry Natural Products Division Overview Welcome Division Brochure http://www.pharmacy.unc.edu/index.cfm?fuseaction=graduate.showMedChem

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