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Ýòîò îñîáûé áåëîê, òàê íàçûâàåìûé çðåëûé íåéðîòðîïíûé ôàêòîð ìîçãîâîãî ïðîèñõîæäåíèÿ - mature brain-derived neurotrophic factor (mBDNF), õèìè÷åñêè âëèÿåò íà íåðâíûå êëåòêè, òàêèì îáðàçîì ïîâûøàÿ èõ ñïîñîáíîñòü âçàèìîäåéñòâîâàòü äðóã ñ äðóãîì. Òî, ÷òî áåëîê brain-derived neurotrophic factor (BDNF) èãðàåò âàæíóþ ðîëü â ïðîöåññàõ ïàìÿòè, áûëî èçâåñòíî è ðàíüøå, íî, îêàçûâàåò ëè îí âëèÿíèå íåïîñðåäñòâåííî èëè â êîìáèíàöèè ñ äðóãèìè ôàêòîðàìè, ñòàëî èçâåñòíî òîëüêî ñåé÷àñ. Ïåðâîå îòêðûòèå ïðîèçîøëî â 1996 ãîäó, êîãäà â æóðíàëå "Nature" áûëè îïóáëèêîâàíû äàííûå î òîì, ÷òî ïðè âîçäåéñòâèè BDNF íà êëåòêè ìîçãà ãðûçóíîâ â íèõ ðåãèñòðèðóþòñÿ èçìåíåíèÿ, õàðàêòåðíûå äëÿ ïðîöåññîâ ôîðìèðîâàíèÿ ïàìÿòè.  1998 ãîäó íîáåëåâñêèé ëàóðåàò Ýðèê Êàíäåëü îïóáëèêîâàë äàííûå îá ó÷àñòèè â ôîðìèðîâàíèè äîëãîâðåìåííîé ïàìÿòè òêàíåâîãî àêòèâàòîðà ïëàçìèíîãåíà (tPA) - ýòî âåùåñòâî, îáû÷íî èñïîëüçóåìîå äëÿ ðàñòâîðåíèÿ òðîìáîâ ïðè èíñóëüòàõ è èíôàðêòàõ. Ïîñëå ÷åãî çàäà÷åé èññëåäîâàíèÿ ñòàëî âûÿñíåíèå âîïðîñà, íå âçàèìîäåéñòâóþò ëè ýòè äâà ôàêòîðà ìåæäó ñîáîé. Ïðîðûâ ïðîèçîøåë â 2001 ãîäó, êîãäà áûëà ðàñøèôðîâàíà õèìè÷åñêàÿ ðåàêöèÿ, â ðåçóëüòàòå êîòîðîé îáðàçóåòñÿ BDNF.  ïðîöåññå ýòîé ðåàêöèè ïîä âîçäåéñòâèåì ôåðìåíòà ïëàçìèíà ïðåäøåñòâåííèêè BDNF ïðåòåðïåâàþò õèìè÷åñêèå èçìåíåíèÿ è ïðåâðàùàþòñÿ íåïîñðåäñòâåííî â ñàì áåëîê. Åùå ðàíüøå äðóãàÿ ãðóïïà èññëåäîâàòåëåé îáíàðóæèëà, ÷òî tPA ïðåâðàùàåò âåùåñòâî, íàçûâàåìîå ïëàçìèíîãåí, â ïëàçìèí.

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