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You're not logged in login Register main page Language: en de Nina Brosh ID:339 No ads for registered users more pictures back to profile show comments ... add to favourites you can ... submit a picture suggest a modification get notified if... write a comment ... send as e-card First Name: Nina Last Name: Brosh Nationality: Israeli Ethnicity: Chinese / Russian Hair Color: Dark brown Eye Color: Blue Date of Birth: November 12 1975 Place of Birth: Ramat Yishai, Israel Height: Measurements: (US) 33.5-23.5-34.5 ; (EU) 85-60-88 Dress Size: (US) 6 ; (EU) 36 Shoe Size: (US) 7 ; (EU) 39 Agencies: Artform - Tel Aviv 'IMG', New York 'Marilyn', Paris 'Nova Models', Munich Advertisements: Magazine Covers: France: 'Vogue' - April 1994; 'BIBA' - July 1997 Italy: 'Donna' - April 1996 Japan: 'Gap' - November 1999 US: 'Sassy' - July 1994 Fashion Shows: Hobbies: Riding horses Notes: Nina was born Vick-Nina-Ruthi Brosh. She was asleep on a park bench when she was discovered by a photographer. Nina used to be a gymnast. Nina was in Duran Duran's "Femme Fatale" music video. features General Informations more pictures submit a picture Modify this model profile ... get notified if...

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60. National Institute On Aging, Robert M. Brosh, Jr., Ph.D. Photo of Dr. Robert brosh, Jr. and members of the Section on DNA. Section on DNA Helicases staff members (left to right) nina Rawtani; Bob brosh; http://www.grc.nia.nih.gov/branches/lmg/rbrosh.htm

National Institute on Aging National Institutes of Health NIA Home Research Programs ... Intramural Robert M. Brosh, Jr., Ph.D., Senior Investigator Section on DNA Helicases Laboratory of Molecular Gerontology Phone: 410-558-8578 Fax: 410-558-8157 E-mail: broshr@grc.nia.nih.gov Biography: Roles of DNA Helicases in Genomic Stability: Helicases are molecular motor proteins that couple the hydrolysis of nucleoside triphosphate to nucleic acid unwinding. Enzymes of this class function coordinately with other proteins as a complex machine and play essential roles in pathways of DNA metabolism that include replication, DNA repair, recombination, transcription, and chromosome segregation. Despite considerable efforts to understand biochemical, structural, and genetic aspects of helicase function, the precise mechanisms by which helicases catalyze strand separation and perform their biological roles are still under investigation. The growing number of DNA helicases implicated in human disease suggests that these enzymes have vital specialized roles in cellular pathways important for the maintenance of genome stability. RecQ Helicases as Caretakers of the Genome: To further understand the molecular functions of WRN protein, we have characterized the functional interaction of WRN with human Flap Endonuclease 1 (FEN-1), a structure-specific nuclease implicated in DNA repair, replication, and recombination. Our results indicate that WRN stimulates FEN-1 cleavage of important DNA intermediates by a unique mechanism whereby the efficiency of FEN-1 cleavage is dramatically enhanced. Our most recent work has elucidated a role for WRN in resolving stalled replication forks and recombination intermediates. Our hypothesis is that the aberrant mitotic recombination and genomic instability arises from inappropriate processing of replication/recombination intermediates in Werner syndrome cells. In vivo evidence for a role of WRN in cellular DNA replication was attained using a model genetic system for WRN structure-function studies.

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