101. CNN Specials - Blueprint Of The Body Overview The findings of the publicly funded AngloUS human Genome Project were Collins heads the human Genome Project, a consortium of 1100 scientists from four http://www.cnn.com/SPECIALS/2000/genome/story/overview/

102. Genome Research DOE supports both human and microbial genome research. The human Genome Program was initiated by DOE in 1986 to map and determine the complete DNA sequence http://www.er.doe.gov/production/ober/genome.html

Genome Research DOE supports both human and microbial genome research. The Human Genome Program was initiated by DOE in 1986 to map and determine the complete DNA sequence of the human genome. The principal goal of this international program is to determine a representative human DNA sequence of all 3 billion base pairs in the human genome. The U.S. Human Genome Project is jointly managed by DOE and the National Institutes of Health (NIH) In October 1998, Science magazine published the new DOE and NIH plan, New Goals for the U.S. Human Genome Project: 1998-2003 , in which human DNA sequencing is the major emphasis. An ambitious schedule has been set to complete the full sequence by the end of 2003, two years ahead of previous projections. In the course of completing the sequence, a "working draft" of the human sequence will be produced by the end of 2001. The plan also includes goals for sequencing technology development; for studying human genome sequence variation; for developing technology for functional genomics; for completing the sequence of Caenorhabditis elegans and Drosophila melanogaster and starting the mouse genome; for studying the ethical, legal, and social implications of genome research; for bioinformatics and computational studies; and for training of genome scientists.

103. Stanford - Morrison Institute - HGDP Alghero Summary Report and the ability of nations to sustain socioeconomic development. This Report is the Alghero Summary of the human Genome Diversity Project. http://www.stanford.edu/group/morrinst/hgdp/summary93.html

Home About the Institute Colloquia Financial Assistance (Stanford) Human Genome Diversity Project Related Organizations SUMMARY DOCUMENT incorporating the HGD Project outline and development, proposed guidelines, and report of the International Planning Workshop held in Porto Conte, Sardinia (Italy) 9-12th September 1993 Financial support for the workshop was provided by the Porto Conte Research and Training Laboratories Foundation, Sardinia; the European Commission; the Soros Foundation; the United States National Science Foundation, National Institutes of Health, and Department of Energy; HUGO Europe. This report has been compiled on behalf of the Human Genome Diversity (HGD) Committee of HUGO, the Executive Committee for the global HGD Project: Dr Julia Bodmer (UK) Dr Walter Bodmer (UK) Dr Luca Cavalli-Sforza (USA) Chairman Dr Marc Feldman (USA) Dr Takashi Gojobori (Japan) Dr Ken Kidd (USA) Dr Mary-Claire King (USA) Dr Partha Majumder (India) Dr Onesmo ole-MoiYoi (Kenya) Dr Alberto Piazza (ltaly) Dr Marcello Siniscalco (Italy) Dr Ken Weiss (USA) Dr Liz Evans Secretary, HGD Executive Committee

104. The Institute For Genomic Research to the Department of Health and human Services on federally conducted or TIGR and African Institute Team Up to Decipher Deadly Parasite Genome http://www.tigr.org/

Home Site Map FAQ Careers Staff Lookup Advanced Search About TIGR Search Since it was founded in 1992, TIGR has been at the forefront of the genomics revolution, deepening the understanding of life and producing results with wide-ranging applications in medicine, agriculture, energy, the environment and biodefense. In 1995, TIGR helped launch the genome era with its landmark publication of the first full DNA sequence of a free-living organism, the bacterium Haemophilus influenzae . That project brought international acclaim to TIGR, which followed up that achievement with a rapid-fire series of scientific accomplishments, including: Deciphering the genome of the smallest bacterial genome, Mycoplasma genitalium , and investigating the minimum complement of genes required to support life. Sequencing the first complete genome from a representative of the third domain of life, the archaea.

105. Special Focus On Genome Patents - The Center For The Study Of Technology And Soc The human Genome Project is a public effort funded largely by the US and UK If global capitalism gets hold of complete control of the human genome, http://www.tecsoc.org/biotech/focuspatents.htm

Special Focus Genome Patents (By the Center staff) Latest News U.S. Gov't: Gene Patents Are Legal (Wired, 5 Jan 01) The U.S. Patent and Trademark Office issued new guidelines regarding gene patents, which repeat their longstanding position: gene patents are legal as long as they are for an entire gene, and demonstrate the usefulness of they gene. Read the press release here , and the guidelines here Other News Genome Teams in Access Dispute (BBC, 12 Feb 01) Celera Will Share Human Genetic Map (Washington Post, 8 Feb 01) The Secret of Life is Free on the Web (London Independent, 29 Jan 01) OLDER ARTICLES ARCHIVED BELOW The Problem Several private businesses are applying for patents for fragments of gene sequences. If these patents are approved, the companies could license their data so researchers would have to pay for access. Some critics believe that would stifle research. Background on Genome Research Although many patent applications are being submitted for non-human genes, like

106. Human Genome Project Newsroom Media guide to the human Genome Project for journalists including HGP history, progress, goals, images, quick facts, and other resources. http://genome.gsc.riken.go.jp/hgmis/resource/media.html

skip navigation Human Genome Project Newsroom Images free, reproducible, high resolution HGP Logos and Overview Images Genetics, Genomics, Proteomics Tools and Technologies Ethical, Legal, and Social Issues ... Medicine Genome Science Primer PDF How is sequencing done? SNPs ... Working Draft Sequence Papers Downloadable PDF Publications Genomics and Its Impact on Medicine and Society: A 2001 Primer Human Genome Project Fact Sheet DNA Sequencing Process Genomes to Life Roadmap (Post-HGP research) Your Genes, Your Choices (ELSI document) Vital Legacy (50 yrs of DOE BER Research) Microbial Genome Program Report Related Topics Genomic Medicine Pharmacogenomics Gene Testing Gene Therapy ... DNA in the Courtroom HGP Background Information History Progress Goals Timeline ... Archives DOE and the HGP Fact Sheet about DOE's involvement in the Human Genome Project DOE investments that contributed to the success of the Human Genome Project Website of the DOE Human Genome Program Post HGP Information Images Genomes to Life What we still don't know Spin-off Research Programs DOE Genomes to Life Program DOE Microbial Genome Project Environmental Genome Project Cancer Genome Anatomy Project ... SNP Consortium Ethical, Legal, and Social Issues Online Publications

107. Human Genome Project Primers Downloadable and interactive educational primers on molecular genetics, medicine and the new genetics, ethical, legal, and social issues associated with http://genome.gsc.riken.go.jp/hgmis/publicat/primer/intro.html

skip navigation DOE HGP Genomics Primers Genomics and Its Impact on Medicine and Society: A Primer This primer updates the 1992 Primer on Molecular Genetics and the booklet To Know Ourselves . The current edition covers basic science, the Human Genome Project, what we know so far, ELSI, medicine, benefits and more. This primer is available in the following formats HTML Acrobat (pdf), suitable for printing. Visit Adobe for free Acrobat Reader software. PowerPoint (You can download the slides from here. Just right click on the 'PowerPoint' link to the left and choose the "save link as" option.) A supplementary Human Genome Project Fact Sheet (May 2001) covering issues such as the public/private partnership, patenting, and future challenges is also available for download in PDF format. 1992 Primer on Molecular Genetics The Primer on Molecular Genetics from the U.S. Department of Energy is still available in the following formats

108. Working With The Human Genome Sequence Home Advanced courses Working with the human Genome Sequence are for all scientists involved in the present and future study of the human genome, http://www.wellcome.ac.uk/doc_WTD003018.html

var g_HttpRelativeWebRoot = "/stellent/"; var SSContributor = false; g_HttpRelativeWebRoot = "/stellent/";SSContributor = false; About this site Sitemap Contact us Funding ... Advanced courses Working with the Human Genome Sequence Activities Courses and conferences Advanced courses Conferences and seminars ... Roadshows Working with the Human Genome Sequence 14-16 November 2005 (application deadline 16 September 2005) Venue: Wellcome Trust Genome Campus , Hinxton, Cambridge, UK The Open Door Workshops are for all scientists involved in the present and future study of the human genome, including laboratory and clinical staff, as well as specialists in related disciplines. The workshops are geared towards researchers with a minimum of a first degree in a biological discipline. Workshop module topics include: Genes, genomes and DNA sequence Diseases and candidate gene identification From gene to function Comparisons with other genomes De novo sequence analysis and sequence variation The following websites are explored: ENSEMBL UCSC NCBI EBI ... BCM Please visit the Sanger Institute website for further details and on-line application, or to express interest in future workshops.

109. The Human Genome - The GEEE! In GENOME Your genome contains all the information needed to create you, and to determine how your cells function throughout your whole life. http://www.nature.ca/genome/03/a/03a_11_e.cfm

The human genome The human genome is like a blueprint for creating humans. Your genome contains all the information needed to create you, and to determine how your cells function throughout your whole life. Every one of your body cells, whether a heart cell, muscle cell, or nerve cell, contains a copy of your genome. Parents even pass on part of their genome to their children. What is a genome and why is it so important? The human genome How big is the human genome? Genomics research Our genome is involved in every aspect of our behaviour and bodily processes - seeing, breathing, digesting, walking, talking, sleeping, even thinking. Anatomical drawing by Leonardo Da Vinci, 1507. The genome is necessary, but by itself is not enough to determine everything about us. Our surroundings, including physical, nutritional, social and cultural environments, also influence how we act or even how we look. Each individual human has a slightly different version of the human genome. But we differ by only less than one-hundredth of one percent.

110. Issues And Bioethics Introduction The human Genome Project - the why s of identifying our Ethical Issues of the human Genome Project - high costs limit sequencing http://www.accessexcellence.org/RC/AB/IE/

Issues and Bioethics Issues focuses on scientific breakthroughs that have propelled biotechnololgy at a dizzying pace into the 21st century. Evolving in tandem with biotech innovations, ethics looks at complex decisions that affect a few individuals or an entire social group or society. Table of Contents Issues Bioethics Overview Environmental Management ... Plant Genome Projects Issues Overview Biotechnology Industry Review - overview of the biotechnology industry from dairy farming to waste management The Future Of Genetic Research - 1991 report looks at the perils and problems of gene manipulation Animal Genome Projects Introduction - The Human Genome Project - the "why's" of identifying our genetic instructions Ethical Issues of the Human Genome Project - high costs limit sequencing efforts to non-coding regions with complete sequencing to follow Research Update - Animals and Animal Health - efforts to determine the genetic makeup of domestic animals A Short History of Mapping - the grand plan to map the human genome What Can We Expect from the Human Genome Project?

111. Frequently Ask Questions About The Human Genome What is the working draft of the human genome sequence ? For genomes like the human genome, it is necessary to proceed with a redundancy factor of 8 to http://www.genoscope.cns.fr/externe/English/Questions/FAQ.html

Frequently ask questions about the Human genome What is a genome ? What is the DNA sequence ? Why sequence DNA ? How is DNA sequenced ? ... Questions list What is a genome? Cells of living organisms contain a program of instructions (the genome), which enables them to stay alive and reproduce. The instructions of this program (the genes) are coded in chemical form along giant molecules, the DNA molecules which form the chromosomes. The genome corresponds to the totality of genes of an organism, i.e. all the DNA or all the chromosomes. Questions list What is the DNA sequence ? The instructions contained in the DNA are coded in a chemical alphabet composed of 4 characters, the nucleotides (or bases), which are symbolized by the letters A, T, G and C. The molecules of DNA consist of a sequence of millions of these elementary characters, like a necklace in which each pearl can be one of 4 possible colors. The order of bases in each sequence is the way that biological information is stored, analogous to the storage of information in a computer as a succession of magnetic bytes. In other words, DNA is the chemical memory of living organisms . The illustration below illustrates the analogy between two sequences of equal length (a succession of the letters A, T, G and C) and necklaces composed of 4 different colors of pearls. The order of bases (or pearls) is different in these two sequences (or necklaces); therefore they contain different information.

112. Adam Therefore, the scientists can explain their presence in the human genome by a The human genome is made up of about three billion neucleotides (the http://www.sitchin.com/adam.htm

Sensational Human Genome Discovery THE CASE OF ADAM’S ALIEN GENES In whose image was The Adam – the prototype of modern humans, Homo sapiens – created? The Bible asserts that the Elohim said: “Let us fashion the Adam in our image and after our likeness.” But if one is to accept a tentative explanation for enigmatic genes that humans possess, offered when the deciphering of the human genome was announced in mid-February, the feat was decided upon by a group of bacteria! “Humbling” was the prevalent adjective used by the scientific teams and the media to describe the principal finding – that the human genome contains not the anticipated 100,000 - 140,000 genes (the stretches of DNA that direct the production of amino-acids and proteins) but only some 30,000+ little more than double the 13,601 genes of a fruit fly and barely fifty percent more than the roundworm’s 19,098. What a comedown from the pinnacle of the genomic Tree of Life! Moreover, there was hardly any uniqueness to the human genes. They are comparative to not the presumed 95 percent but to almost 99 percent of the chimpanzees, and 70 percent of the mouse. Human genes, with the same functions, were found to be identical to genes of other vertebrates, as well as invertebrates, plants, fungi, even yeast. The findings not only confirmed that there was one source of DNA for all life on Earth, but also enabled the scientists to trace the evolutionary process – how more complex organisms evolved, genetically, from simpler ones, adopting at each stage the genes of a lower life form to create a more complex higher life form – culminating with Homo sapiens.

113. Database Mining Tools In The Human Genome Initiative The human Genome Initiative is an international research program for the creation of As described in the survey of Pearson and Soll,(1) the human Genome http://www.biodatabases.com/whitepaper01.html

Database Mining in the Human Genome Initiative John L. Houle, a Wanda Cadigan, b Sylvain Henry, b Anu Pinnamaneni b and Sonny Lundahl c a Scientific Author, b Scientific Reviewer, c Senior Manager Bio-databases.com, Amita Corporation, 1420 Blair Place, Suite 500, Ottawa, Ontario, Canada, K1J 9L8 info@bio-databases.com Abstract The Human Genome Initiative is an international research program for the creation of detailed genetic and physical maps of the human genome. Genome research projects generate enormous quantities of data. Database mining is the process of finding and extracting useful information from raw datasets. Computational genomics has identified a classification of three successive levels for the management and analysis of genetic data in scientific databases: Genomics. Gene expression. Proteomics. Genome database mining is the identification of the protein-encoding regions of a genome and the assignment of functions to these genes on the basis of sequence similarity homologies against other genes of known function. Gene expression database mining is the identification of intrinsic patterns and relationships in transcriptional expression data generated by large-scale gene expression experiments. Proteome database mining is the identification of intrinsic patterns and relationships in translational expression data generated by large-scale proteomics experiments. Improvements in genome, gene expression and proteome database mining algorithms will enable the prediction of protein function in the context of higher order processes such as the regulation of gene expression, metabolic pathways and signalling cascades. Thus, the final objective of such higher-level functional analysis will be the elucidation of high-resolution structural and functional maps of the human genome.

114. Products human Genome Sciences is a biopharmaceutical company with a pipeline of novel Following are highlights of human Genome Sciences’ clinical development http://www.hgsi.com/products/

Suzanne Valadon Femme aux Seins Nus Human Genome Sciences is a biopharmaceutical company with a pipeline of novel protein and antibody drugs directed toward large markets that have significant medical need. We focus our internal research and development efforts on novel protein and antibody drug candidates discovered through genomics-based research, and on new long-acting versions of existing drugs created using our albumin fusion technology. We are able to produce our own protein and antibody drugs for preclinical studies and clinical trials. We are in the final construction phase of a large-scale manufacturing facility to increase our capacity for protein and antibody drug production. We are strengthening our commercial operations staff, and our intent is to add marketing and sales staff as needed as our products approach commercialization. IMMUNOLOGY/INFECTIOUS DISEASE Click here for more information on LymphoStat-B (albumin-interferon alpha) Click here for more information on Albuferon CCR5 mAb CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5. The CCR5 receptor is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1), which causes acquired immunodeficiency syndrome (AIDS). Preclinical studies of CCR5 mAb show that it prevents CCR5-dependent HIV-1 entry into human cells, cell-cell fusion and viral transmission. Human Genome Sciences has begun dosing patients in a Phase 1 clinical trial to evaluate the safety, tolerability and pharmacology of CCR5 mAb in patients who are infected with HIV-1 and are not receiving concurrent antiretroviral therapy.

115. GSC: Home We play a leadership role in The human Genome Project , constructing the To better understand the human genome sequence and to advance the study of http://genome.wustl.edu/

Home Information Genomes Research ... Tools In the News New Genome Comparison Finds Chimps, Humans Very Similar at the DNA Level 31 Aug 2005 The first comprehensive comparison of the genetic blueprints ... (more) Gene Sequence Study Takes a Stab at Personalized Medicine 20 May 2005 Since its beginning 15 years ago, the Human ... (more) Leading Genome Sequencing Center Turns to BlueArc Titan for DNA Analysis and Storage 17 May 2005 BlueArc; Corporation, provider of the world's highest performance, ... (more) Scientists Analyze Chromosomes 2 and 4 6 Apr 2005 Human chromosome 2 is unique to the human ... (more) View All News Items Quick Links Nematode.net WU Finishing Guidelines for the Mouse Genome Mission Statement The Genome Sequencing Center is a world-leader in the generation and public dissemination of high-quality genomic sequence. We seek to advance the states of science and medicine by (1) providing sequence data with ever-improving economy, (2) developing and refining the general theories and practices of DNA sequencing, (3) providing value-added biologically and clinically-relevant sequence analysis, and (4) fostering public understanding of science through various educational and outreach efforts. Announcements: August 1, 2005:

116. BioethicsWeb - The Gateway For Internet Resources In Biomedical Ethics, Provided It provides access to information about the human Genome Project, the Genomes to Life Of particular interest is a history of the human Genome Project. http://bioethicsweb.ac.uk/browse/mesh/D016045.html

low graphics Top Biomedicine Genomics ... Human Genome Project Human Genome Project Bioethics The Bioethics section of the Woodrow Wilson Leadership Program in Biology which is part of the Woodrow Wilson National Fellowship Foundation, an 'independent, nonprofit organization dedicated to the encouragement of excellence in education through the identification of critical needs and the development of effective national programs to address them'. The page is split into topics (Introduction, Ethical Systems, Process, Case Studies, Biotechnology, New Reproductive Techniques (NRT) and Environmental) containing links to detailed lesson plans (Objectives, Materials, Tasks sheets and References). Other links include the Biology Institute participants and staff, The National Science Foundation, Access Excellence and the Woodrow Wilson National Fellowship Foundation. A search facility is available. United States Transplantation Scientific Misconduct Plants, Genetically Modified ... Bioethics Website.ca The Bioethics Website.ca is hosted by The Bioethics Initiative of SouthWestern Ontario, a 'collaborative venture of the region's health care, research, and academic communities' whose mission is 'leading the search for ethically sound options.' The home page contains a bulletin board with links to announcements and events (past and present). Other sections of the site include What is Bioethics; Headlines (links to newspaper and journal articles); Thinking in Bioethics (case studies, discussion guides); Education; People in Bioethics; Resources in Bioethics (links to other projects); Bioethics Initiative (detailed information about the organization and Advisory Group reports downloadable in Adobe Acrobat pdf); and Site Map (site navigation).

117. New Theory About Human Genome Evolution - Tracking 'stealth' DNA Elements A group of LSU researchers, led by biological sciences Professor Mark Batzer, have unraveled the details of a 25million-year-old evolutionary process in http://www.medicalnewstoday.com/medicalnews.php?newsid=26858

118. Human Genome Segmental Duplication Database data of other species are located at http//projects.tcag.ca/xenodup Most recent analysis is based on the May 2004 human Genome Assembly (hg17) http://projects.tcag.ca/humandup/

Human Genome Segmental Duplication Database T he C entre for A pplied G enomics The Hospital for Sick Children, Toronto Project GBrowse Data Publications ... Previous Analyses Segmental duplication data of other species are located at http://projects.tcag.ca/xenodup Most recent analysis is based on the May 2004 Human Genome Assembly (hg17) Keyword Search You may search by key words (e.g. accession number, cytoband, location). BLAT Search Enter DNA sequence in FASTA format here: Human Genome (May 2004 Assembly) (hg17) Human Genome (July 2003 Assembly) (hg16) Contact us: Department of Genetics and Genomic Biology, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada The Centre for Applied Genomics The Hospital for Sick Children Contact Us

119. Cold Spring Harbor Laboratory Research in cancer biology, plant genetics, genomics and bioinformatics, and neurobiology. http://www.cshl.org/

Saturday, September 17, 2005 CSHL is a research and educational institution. The Laboratory has research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics, and a broad educational mission, including the recently established Watson School of Biological Sciences. Research Staff Cancer Research Plant Genetics Neurobiology ... Library and Archives RNAi Library Search Engine of shRNA constructs from Cold Spring Harbor Laboratory's RNAi library. CSHL Press CSHL Press publishes monographs, technical manuals, handbooks, review volumes, conference proceedings, scholarly journals and videotapes. CSHL's academic program serves to communicate new discoveries, concepts, and methodologies to an international community of scientists. The Watson School of Biological Sciences The Watson School of Biological Sciences offers a novel curriculum that will challenge its graduate students—the biologists of the new millennium—to become leaders in science and in society.

120. Untitled Document is led by the Baylor College of Medicine human Genome Sequencing Center, A threeway comparison of human and mouse to rat chromosomes found using http://www.hgsc.bcm.tmc.edu/projects/rat/

1 Dec 2004 Assembled rat genomic sequence: 2.57 Gb in 419 ultrabactigs spanning 2.74 Gb with ultrabactig N50 = 18.5 Mb and contig N50 = 36.9 kb Also 22,267 BACs and 38,571,029 reads available at the NCBI Recent Assemblies Bactigs BAC Fisher ... Rat QTL The HGSC is sequencing the genome of the rat ( Rattus norvegicus ). This rodent is important as a model organism for cardiovascular and psychological research, and has a legacy of decades of study of its physiology in academia and industry. An updated public release draft genome assembly (v.3.4) covering more than 90% of the estimated 2.8 Gb genome is available for download . This version incorporates 54.6 Mb of finished sequence into the draft genome assembly. Genome browsers for this data are listed in the resource section below. A brief description of the assembly is available The National Institutes of Health (NIH) Rat Genome Sequencing network is funded by the National Heart, Lung, and Blood Institute (NHLBI) and the National Human Genome Research Institute (NHGRI) . See the press releases The Rat Genome Sequencing Consortium is led by the Baylor College of Medicine Human Genome Sequencing Center, and is a collaboration with

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