41. Znomics, Inc. Functional genomics drug discovery company working on the zebrafish as a system to identify genes underlying human disease. http://www.znomics.com

Znomics is a functional genomics company located in Portland, Oregon OR. Using zebrafish, retroviral mutagenesis techniques and other capabilities, the company will improve and speed development of medicines for human health. biotechnology, functional genomics, zebrafish, disease models, drug discovery

42. CuraGen Corporation Simplifying in order to accelerate genomics based product discovery and development. Has created technologies to better understand the role of genes in improving human health, animal health and agricultural vitality. http://www.curagen.com/

September 13, 2005 CuraGen and TopoTarget Initiate Phase Ib Clinical Trial with PXD101 for Ovarian Cancer September 12, 2005 CuraGen Presents at the Bear Stearns 18th Annual Healthcare Conference Webcast: Click here for replay August 10, 2005 CuraGen Announces Pricing of Common Stock Offering August 1, 2005 454 Life Sciences Publishes Breakthrough Genome Sequencing Technique July 26, 2005 454 Life Sciences Receives $11.5 Million in Milestones from Roche July 25, 2005 CuraGen Repurchases $39.9 Million of Outstanding 2007 Convertible Debt 2004 Annual Report and 10K Reprint of Data Presented at ASCO (PDF)

43. Genomics And Its Impact On Science And Society: 2003 Primer A primer on basic genetics; the science of the human Genome Project; genomic medicine; ethical, legal, and social issues; and postgenomics research - from the U.S. Dept. of Energy human Genome Program. http://www.ornl.gov/sci/techresources/Human_Genome/publicat/primer2001/index.sht

Genomics and Its Impact on Science and Society The Human Genome Project and Beyond a publication of the U.S. Department of Energy Human Genome Program March 2003 Use the buttons to navigate between chapters and the button to return to this table of contents. This document is also available in printer-friendly PDF format , viewable with Adobe Acrobat. Or for better quality, use the high-resolution verison PDF (longer download time). Powerpoint slides are available to accompany this Primer. Genomics 101: A Primer The Human Genome Project: 1990-2003 Early Insights from the Human DNA Sequence Medicine and the New Genetics ... Dictionary of Genetic Terms Search This Report: This document may be cited in the following style: Human Genome Program, U.S. Department of Energy, Genomics and Its Impact on Science and Society: A 2003 Primer For printed copies, please complete this form . Send questions or comments to the author

44. SpringerLink - Publication Focuses on the experimental, theoretical, and technical aspects of genomics and genetics in mouse, human, and other species, particularly those aspects bearing on studies of gene function. http://link.springer.de/link/service/journals/00335/index.htm

Articles Publications Publishers Home Publication Mammalian Genome Publisher: Springer-Verlag New York, LLC ISSN: 0938-8990 (Paper) 1432-1777 (Online) Subject: Biomedical and Life Sciences Medicine Issues in bold contain content you are entitled to view. Volume 16 Number 7 / July 2005 Number 6 / June 2005 Number 5 / May 2005 Number 4 / April 2005 ... Request a sample Volume 15 Number 12 / December 2004 Number 11 / November 2004 Number 10 / October 2004 Number 9 / September 2004 ... Number 1 / January 2004 Volume 14 Number 12 / December 2003 Number 11 / November 2003 Number 10 / October 2003 Number 9 / September 2003 ... Number 1 / January 2003 Volume 13 Number 12 / December 2002 Number 11 / November 2002 Number 10 / October 2002 Number 9 / September 2002 ... Number 1 / January 2002 Jump to volumes: Most Recent 12 to 9 8 to 7 First page Previous page Next page Last page Jump to Volumes Most Recent 12 to 9 8 to 7 Linking Options About This Journal Editorial Board Manuscript Submission Quick Search Search within this publication...

45. Genomics|HuGENet globe and dna human Genome Epidemiology Network, or HuGENet™ is a global collaboration of individuals and organizations committed to the assessment of the http://www.cdc.gov/genomics/hugenet/default.htm

Archived: 1/2000 What's New HuGE Facts Sheets HuGE Funding HuGE Reviews ... Feedback Top of page OGDP Home About Us Contact Us Sitemap ... FOIA Last Updated September 15, 2005

46. Genome News Network - Home Resource for news about research, human medicine, stem cells, cloning, biotechnology and agriculture worldwide. Maintained by the Center for the Advancement of genomics, Rockville, Maryland. http://www.genomenewsnetwork.org/

Home About Topics FEATURE Genomes of the World Quick Guide NEWS STORIES Bioterrorism Cloning , and Stem Cells Diseases and Personalized Medicine Cancer Cystic Fibrosis Depression and Bipolar Disorder ... Drugs and Gene Tests Antibiotics Drug Development Vaccines ... Energy and the Environment Extremophiles Oceans Toxic Cleanup ... GNN gratefully acknowledges its collaboration with the Albert and Mary Lasker Foundation. Genome News Network is an editorially independent online publication of the J. Craig Venter Institute.

47. Genomics|Home Welcome to the Office of genomics and Disease Prevention (OGDP) at CDC. This site provides information about human genomic discoveries how they can be http://www.cdc.gov/genomics/

Genomic Profiling: Not Ready for Prime Time While genomic profiling may holds promise for predicting an individual's future health risks, the science is still in the early stages. FHx Initative Fact sheets Publications Links ... Weekly Update October 6-7, 2005 Cambridge, UK PAST MEETINGS: EGAPP Working Group Meetings May 18-19, 2005 July 18-19, 2005 Atlanta, GA more... Programs in Brief provide a one-page summary of OGDP's six major initi- atives. more... Top of page OGDP Home About Us Contact Us Sitemap ... FOIA Last Updated September 15, 2005

48. Nature Genome Gateway - Home Resource for academic journals, current studies, and human genome sequences. http://www.nature.com/genomics/

Nature Journals Nature Nature Reviews home page Nature Reviews Cancer Nature Reviews Drug Discovery Nature Reviews Genetics Nature Reviews Immunology Nature Reviews Molecular Cell Biology Nature Reviews Neuroscience Nature Biotechnology Nature Cell Biology Nature Genetics Nature Immunology Nature Materials Nature Medicine Nature Neuroscience Nature Structural Biology Gateways Asia Gateway German Gateway Japan Gateway Bioentrepreneur Cancer Update Genome Gateway Drug Discovery@nature.com Materials Update Physics Gateway Signaling Gateway Academic Journals Bone Marrow Transplantation British Dental Journal British Journal of Cancer British Journal of Pharmacology Cancer Gene Therapy EMBO Reports The EMBO Journal European Journal of Clinical Nutrition European Journal of Human Genetics Evidence-Based Dentistry Eye Gene Therapy Genes and Immunity Heredity International Journal of Impotence Research International Journal of Obesity J of Exposure Analysis and Environmental Epidemiology J of Human Hypertension J of Perinatology Laboratory Investigation Leukemia Microcirculation Modern Pathology Molecular Psychiatry Neuropsychopharmacology Oncogene Prostate Cancer Spinal Cord The Hematology Journal The Pharmacogenomics Journal welcome to Nature 's genome gateway...

49. Wallenberg Consortium North (WCN) Collaboration of seven Swedish Universities focusing on functional genomics. Current research work on expression and function of mouse and human antisense RNAi transcripts. http://www.wcn.se/

Home About WCN Research Services ... Search WALLENBERG CONSORTIUM NORTH (WCN) Wallenberg Consortium North (WCN) is a multicenter consortium in the area of functional genomics, funded by the Knut and Alice Wallenberg Foundation (KAW). Seven universities from central and northern Sweden are affiliated, providing service for the participating researchers. The research acitivities are organised in platforms Read more... applied bioinformatics and methodologies in SNP genotyping Read more... Geners effekt på människor och djurs beteende Read more... Graduate course Read more... More news The WCN newsletters Home ... Search

50. Origins Of The Human Genome Project The human genome project was borne of technology, grew into a science 31 Bertrand R. Jordan, The French human Genome Program, 9 genomics 562 (1991). http://www.fplc.edu/risk/vol5/spring/cookdeeg.htm

Origins of the Human Genome Project Robert Mullan Cook-Deegan* Introduction The earliest and most obvious applications of genome research are tests for genetic disorders, but less obvious diagnostic uses may prove at least as important, such as forensic uses to establish identity (to determine paternity, to link suspects of physical evidence of rape or murder, or as a molecular "dog-tag" in the military). Genome research also promises to find genes expeditiously, making the genetic approach attractive as a first step in the study not only of complex diseases, but also of normal biological function. Each new gene is a potential target for drug development to fix it when broken, to shut it down, to attenuate or amplify its expression, or to change its product, usually a protein. Finding a gene gives investigators a molecular handle on problems that have proven intractable. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. Faith that that scientific power will translate to products, jobs and wealth underlies the recent substantial investments in private genome research startup companies and the diversification of pharmaceutical and agricultural research firms into genome research. The human genome project was borne of technology, grew into a science bureaucracy in the U.S. and throughout the world and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, exploiting the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits.

51. 2005 GRC On Human Genetics & Genomics The FineScale Landscape of Recombination in the human Genome Segmental Duplications and Structural Variation of the human Genome http://www.grc.uri.edu/programs/2005/humangen.htm

July 24-29, 2005 Salve Regina University Newport, RI Chair: Eric Green Vice Chair: James Lupski SUNDAY 2:00 pm - 9:00 pm Arrival and Check-in 6:00 pm Dinner 7:30 pm - 9:30 pm Eric Green (NHGRI) 7:30 pm - 7:45 pm Welcome and Introductory Remarks 7:45 pm - 8:30 pm Opening Keynote: Francis Collins (NHGRI) "Making Genomic Medicine a Reality" 8:30 pm - 9:00 pm David Altshuler (Broad Institute) "Human Genetic Variation and Disease" 9:00 pm - 9:30 pm Eddy Rubin (Joint Genome Institute) "Comparative Genomics at the Extremes" MONDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm THE HUMAN HAPMAP: CONSTRUCTION AND UTILITY Robert Nussbaum (NHGRI) 9:00 am - 9:30 am Peter Donnelly (Oxford University) "The Fine-Scale Landscape of Recombination in the Human Genome" 9:30 am - 10:00 am Kelly Frazer (Perlegen Sciences) "Human Genetic Variation and Common Disease: A Short Term Approach for Improving Human Health" 10:00 am - 10:30 am Coffee Break / Group Photo (10:15 am) 10:30 am - 11:00 am Yusuke Nakamura (RIKEN and University of Tokyo) "Biobank Project in Japan" 11:00 am - 11:30 am Matthew Hurles (Sanger Institute) "Sequence Evolution and Haplotype Variation within Segmental Duplications" 11:30 am - 12:00 pm Mark Daly (Broad Institute) "Applying Haplotype Maps in Human and Mouse Genetics" 12:00 pm - 12:30 pm General Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm HUMAN MONOGENIC DISEASES Huntington Willard (Duke University) 7:30 pm - 8:00 pm Robert Nussbaum (NHGRI)

52. 2003 GRC On Human Genetics & Genomics Finescale recombination mapping of the human genome . WEDNESDAY Characteristics and Applications of Haplotypes in the human Genome http://www.grc.uri.edu/programs/2003/humangen.htm

August 3-8, 2003 Colby College Waterville, ME Chair: Aravinda Chakravarti Vice Chair: Eric Green SUNDAY 2:00 pm - 9:00 pm Arrival and Check-in 6:00 pm Dinner 7:30 pm - 9:30 pm GENOME STRUCTURE Chair: Aravinda Chakravarti (Johns Hopkins University) Each talk has 10 minute discussion 7:30 pm - 8:30 pm Keynote Speaker: Eric Lander (Whitehead Institute, MIT) "Comparative Genomics" 8:30 pm - 9:00 pm Evan Eichler (Case Western Reserve University) "Segmental Duplications and the Human Genome" 9:00 pm - 9:30 pm Eric Green (National Human Genome Research Institute) "New Frontiers in Comparative Sequencing" MONDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm FUNCTIONAL DISSECTION OF THE HUMAN GENOME Chair: Eddy Rubin (University of California, Berkeley) Each talk has 10-minute discussion 9:00 am - 9:30 am Chris Burge (Massachusetts Institute of Technology) "Bioinformatics of MicroRNAs" 9:30 am - 10:00 am Thomas Gingeras (Affymetrix, Inc) "Evidence of Hidden Transcriptome and Strategies Employed to Regulate Expression of RNA Transcripts" 10:00 am - 10:30 am Harry Dietz (Howard Hughes Medical Institute) "Physiologic Substrates for mRNA Surveillance: Mechanistic and Therapeutic Implications" 10:30 am Coffee Break / Photo 11:00 am - 11:30 am Eddy Rubin (University of California, Berkeley)

53. Beyond The Human Genome Project The completion of the human genome project, and the sequencing of other organims Note that public (human Genome Project) and private (Celera genomics) http://www2.dof.hmc.edu/hgp/default.html

Beyond the Human Genome Project On June 26, 2000, President Clinton and the leaders of the Human Genome Project and Celera Genomics announced the completion of a rough draft of the human genome, meaning that scientists have nearly finished determining the DNA sequence for all 23 pairs of chromosomes of the human species. The completion of the human genome project, and the sequencing of other organims' DNA, is widely regarded as a turning point in biology and medicine. As we usher in the "post-genomic" era, we are faced with an explosion of new information, which is leading to dramatic changes in the way we are able to study and manipulate life. During the 2000-2001 academic year, Harvey Mudd College is hosting a series of distinguished speakers who will address the impact of the human genome project on basic research, medical research and biotechnology, and the broader impacts that these rapid advances in science will have on society as a whole. Schedule Useful web links Questions? Overview What is the human genome project?

54. Genome Project - Bioethics Resources On The Web - NIH human Genome Project The human Genome Organisation (HUGO) is the international organisation of scientists involved in the human Genome Project (HGP), http://www.nih.gov/sigs/bioethics/genomics.html

Directory Genetics Human Genome Project Maps The following links will take investigators directly to three different (but complementary) assembled views of the human genome, together useful useful with browsing tools that provide a wide variety of annotations of the sequence: University of California at Santa Cruz National Center for Biotechnology Information (NCBI) - click "map viewer" Project Ensembl (genome browser) Organizations Genetics Resources on the Web (GROW) - seeks to provide an effective forum that encourages communication and collaboration among individuals interested in Web-based provision of high-quality information about human genetics, especially those aspects of human genetics dealing with health, to health professionals and the public. Centers for Disease Control (CDC) Office of Genomics and Disease Prevention - provides public health professionals with current information on the impact of human genetic research and gene discoveries on disease prevention and health promotion. The Human Genome Organisation (HUGO) - is the international organisation of scientists involved in the Human Genome Project (HGP), the global initiative to map and sequence the human genome. HUGO was established in 1989 by a group of the world's leading genome scientists to promote international collaboration within the project.

55. How The Human Genome Is Transforming Medicine - Science Mysteries - MSNBC.com Systems biology is converting the masses of data collected through genomics into personalized treatments for disease. Find out more from the journal http://www.msnbc.msn.com/id/6291903/

Skip navigation Tech / Science Science Space News ... Most Popular NBC NEWS MSNBC TV Today Show Nightly News Meet the Press ... Mysteries of the Universe How the human genome is transforming medicine 'Systems biology' focuses on turning masses of genetic data into personalized treatments for disease Myriam Kirkman-Oh A computational method enables rapid analysis of the blocklike pattern of genetic variation in the mouse genome, which can be used in analyzing mouse models of human disease. The cover stories in the journal Science explore new approaches to understanding how genes are expressed and how they function. By By Kathleen Wren Science WASHINGTON - Ten or 20 years from now, a droplet of blood may be all your doctor needs to catch a cancer in its earliest stages. That droplet could also reveal which genetic diseases you might develop later in life and which medicines, tailored to your genetic makeup, are right for you. This vision of medicine comes from genomics pioneer Leroy Hood, courtesy of a sizzling new field called "systems biology." Hood, who recently founded the Institute for Systems Biology in Seattle, also helped invent the automated gene sequencer and several other technologies that made sequencing the human genome possible. Writing in Friday's issue of the journal Science - published by AAAS, the nonprofit science society - Hood describes the medical transformations that he thinks are imminent.

56. GNN - Celera Human Genome Sequence Will Be Public The human genome sequence created by Celera genomics will soon be deposited in GenBank, the online DNA database funded by the US National Institutes of http://www.genomenewsnetwork.org/articles/2004/02/06/celera.php

Home About Topics Celera Human Genome Sequence Will Be Public By Edward R. Winstead Posted: February 6, 2004 Email Page Printer Friendly Email GNN GNN News Alerts ... Human Genome An historic scientific document is about to emerge from private hands. The human genome sequence created by Celera Genomics will soon be deposited in GenBank, the online DNA database funded by the U.S. National Institutes of Health. Celera is the private company that completed a draft of the human genome sequence three years ago. The Human Genome Project (HGP), an international consortium of publicly funded researchers, completed its own draft at the same time, and leaders of both groups announced the milestone at a White House ceremony. Now the complete Celera sequence, which included publicly available data generated by the HGP, will be in the public domain. A second Celera human genome sequence, this one created months after the first and never made public, will also be placed in GenBank. The second sequence includes only DNA sequences generated at Celera. Their report, to be published online in the

57. Genomics Glossary Portions of the human genome are unsequenceable with today s technology. DOE Department of Energy human Genome Initiative announced by DOE OHER Office http://www.genomicglossaries.com/content/genomics_glossary.asp

You are here Biopharmaceutical/ Genomics glossaries homepage/Search Genomics Genomics glossary Evolving terminology for emerging technologies Comments? Revisions? Questions? mchitty@healthtech.com Last revised August 19, 2005 View a Printer-Friendly Version of this Web Page! Registration policy has details Mr. Ms. Mrs. Dr. Prof. First: Last: Title: Dept.: Company: Address: City: State: Zip: Country: Email: Opt-out of Email YES NO Telephone: Would you like to receive CHI event updates via fax? Yes No Fax: document.FrontPage_Form1.interest.value = 'GFN'; Guide to terms in these glossaries Genomic applications map Site Map starts with a brief explanation of differences between genetics and genomics Other related glossaries include Genomics Cancer genomics Molecular Medicine Genomic categories Applications Functional Genomics Proteomics Technologies Sequencing Biology DNA Gene Definitions Maps is closely intertwined with this glossary , and ultimately, Proteins, Protein structures are all important annotation: Bioinformatics glossary behavior genetics, behavior genomics:

58. HUMAN GENOME PROJECTS human GENOME PROJECTS. OMIM, Online Mendelian Inheritance in Man; GENATLAS, human genes atlas; GeneClinics, Medical genetics database; GDB, Genome Data Base http://www.dbbm.fiocruz.br/genomics/human.htm

HUMAN GENOME PROJECTS OMIM , Online Mendelian Inheritance in Man GENATLAS , Human genes atlas GeneClinics , Medical genetics database GDB , Genome Data Base GeneCards , Human genes database HGMD , Human Gene Mutation database TIGR HGI , TIGR Human Gene Index Hs UniGene , Human EST clusters in GenBank STACK , Human EST consensus sequences GenLink , Human genetics resource GENOTK , Human cDNA database CGAP , Cancer Genome Program (NIH) , Human chromosome 1 (Rockefeller University) , Human chromosome 3 database (University of Texas) , Human chromosome 7 database (Ontario Hospital) , Human chromosome 9 database GTC Chr10 data , Human chromosome 10 data (Genome Therapeutics Corporation) , Human chromosome 11 database (Imperial College U.K.) , Human chromosome 13 database (Columbia) Chr16 LANL , Human chromosome 16 database (Los Alamos National Laboratory) Chr16 TIGR , Human chromosome 16 database (TIGR) Chr17 UDB , Human chromosome 17 (Weizmann Israel) , Human chromosome 18 (Boston Children's Hospital) Chr21 at Tokyo Univ. , Human chromosome 21 Sequence Map (University of Tokyo) Chr21 at ERI , Human chromosome 21 genomic sequence database (Eleanor Roosevelt Institute) Chr22 at HGC , Human chromosome 22 IXDB , X chromosome db

59. Sequencing The Human Genome The Genomic Revolution Putting the genome to work raises questions and dilemmas for us as individuals, families, nations and even as a species. http://www.amnh.org/exhibitions/genomics/conference/

Sequencing the Human Genome: New Frontiers in Science and Technology American Museum of Natural History Just as the first landing on the Moon opened a new frontier, the recent completion of the "first draft" sequence of the human genome marks the beginning of an extraordinary new era in science and technology, and raises important questions about the social and economic impacts of advancing genetic technologies. Sequencing the Human Genome: New Frontiers in Science and Technology , a free two-day conference organized by the Molecular Program at the Museum is the first major public forum since the release of the draft sequence to examine the implications of the Human Genome Project for the next century. Renowned scientists including two Nobel Prize winners, bioethicists, biotechnology entrepreneurs, and others will participate in a mix of lectures and panel discussions that explore the ramifications of the Human Genome Project and address the social, economic, and ethical impacts of advancing genetic technologies and their effect on our understanding of natural history. Sponsored by the Molecular Program at the American Museum of Natural History This conference was developed with support from

60. Genomics Directory - ActionBioscience.org The human Genome Project A Scientific and Ethical Overview by M. Carroll J. Ciaffa. Genetic information and privacy Does Genetic Research Threaten Our http://www.actionbioscience.org/genomic/

home search author directory updates signup ... education issues in genomics "educator resources" section with downloadable lesson available in spanish (en español) Understanding the genome "The Human Genome Project: A Scientific and Ethical Overview" Genetic information and privacy "Does Genetic Research Threaten Our Civil Liberties?" by Philip Bereano "For Sale: Iceland's Genetic History" by Oksana Hlodan Ethics of DNA patenting "DNA Patents Create Monopolies on Living Organisms" from Council for Responsible Genetics Applications of genomic mapping "Species: Comparing Their Genome" from the Howard Hughes Medical Institute "Ethical Issues in Pharmacogenetics"

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