Mac users: please note that our site is optimized for the Safari browser Supplements and ergogenic aids Androstenedione (made famous by baseball's Mark McGwire) Is it safe? Originally Published: October 23, 1998 Dear Alice, My question is about nutritional supplements, specifically androstenedione and its closely related cousins. I have a five-day-a-week workout routine, and I have been searching for a supplement that will give me the greatest benefit for all of that hard work. I am, however, very concerned about the negative effects of some of these unregulated supplements. My question then is, what kind of side effects can I truly expect from using one of the male hormone precursors like androstenedione? And, in your opinion, is it safe? Dear Reader, Let's first take a look at androstenedione. Androstenedione is a direct precursor hormone to testosterone, as well as to other hormones, including one type of estrogen. It is converted from cholesterol, as are all other steroid hormones. Biochemically, a reaction, or chain of reactions, occurs in order to convert molecule A into molecule B. Specific enzymes and hormones, among other things, must be present and ready to work, so to speak, for these conversions to take place. For example, luteinizing hormone, produced and released by the pituitary gland, plays a pivotal role in converting androstenedione to testosterone. Simply introducing extra androstenedione to your system does not automatically mean that all of the necessary players will be there to produce testosterone. | |
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