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Extractions: First Name: Nina Last Name: Brosh Nationality: Israeli Ethnicity: Chinese / Russian Hair Color: Dark brown Eye Color: Blue Date of Birth: November 12 1975 Place of Birth: Ramat Yishai, Israel Height: Measurements: (US) 33.5-23.5-34.5 ; (EU) 85-60-88 Dress Size: (US) 6 ; (EU) 36 Shoe Size: (US) 7 ; (EU) 39 Agencies:
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Extractions: View all userpics Name: Mudface Website: Linky Love Location: Saigon Viet Nam Birthdate: Bio: Champion bullfighter, stunning supermodel, Pulitzer prize-winning novelist, renowned pastry chef, harpist, puppeteer, beguiling wastrel and gadabout, Mensa card-holder, and mother of albino triplets, I spend my free time running a tandem skydiving operation in the Galapagos and speaking nine languages fluently. "Remember that there is only one important time and that is now. The present time is the time over which we have dominion. The most important person is always the person you are with, who is right before you, for who knows if you will have dealings with any other person in the future? The most important pursuit is making the person standing at your side happy, for that alone is the pursuit of life."
National Institute On Aging, Robert M. Brosh, Jr., Ph.D. Photo of Dr. Robert brosh, Jr. and members of the Section on DNA. Section on DNA Helicases staff members (left to right) nina Rawtani; Bob brosh; http://www.grc.nia.nih.gov/branches/lmg/rbrosh.htm
Extractions: E-mail: broshr@grc.nia.nih.gov Biography: Roles of DNA Helicases in Genomic Stability: Helicases are molecular motor proteins that couple the hydrolysis of nucleoside triphosphate to nucleic acid unwinding. Enzymes of this class function coordinately with other proteins as a complex machine and play essential roles in pathways of DNA metabolism that include replication, DNA repair, recombination, transcription, and chromosome segregation. Despite considerable efforts to understand biochemical, structural, and genetic aspects of helicase function, the precise mechanisms by which helicases catalyze strand separation and perform their biological roles are still under investigation. The growing number of DNA helicases implicated in human disease suggests that these enzymes have vital specialized roles in cellular pathways important for the maintenance of genome stability. RecQ Helicases as Caretakers of the Genome: To further understand the molecular functions of WRN protein, we have characterized the functional interaction of WRN with human Flap Endonuclease 1 (FEN-1), a structure-specific nuclease implicated in DNA repair, replication, and recombination. Our results indicate that WRN stimulates FEN-1 cleavage of important DNA intermediates by a unique mechanism whereby the efficiency of FEN-1 cleavage is dramatically enhanced. Our most recent work has elucidated a role for WRN in resolving stalled replication forks and recombination intermediates. Our hypothesis is that the aberrant mitotic recombination and genomic instability arises from inappropriate processing of replication/recombination intermediates in Werner syndrome cells. In vivo evidence for a role of WRN in cellular DNA replication was attained using a model genetic system for WRN structure-function studies.